| 成人Still病诊疗进展 |
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| 引用本文： | 易晓晴,罗帅寒天,张桂英,陆前进.成人Still病诊疗进展[J].中华皮肤科杂志,2021,54(2):165-169. |
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| 作者姓名： | 易晓晴 罗帅寒天 张桂英 陆前进 |
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| 作者单位： | 中南大学湘雅二医院皮肤科，长沙410011 |
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| 基金项目： | 国家自然科学基金(81703133);中南大学中央高校基本科研业务费专项资金(502211904)。 |
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| 摘 要： | 【摘要】 成人Still病是一类病因未明的全身炎症性疾病，临床表现多样，其诊断和治疗存在一定困难。近年来发现，血红素加氧酶1、钙网蛋白、炎症细胞因子、糖基化终末产物等新型标志物可对成人Still病的活动程度和严重程度进行全面评估，而新研发的生物制剂如肿瘤坏死因子抑制剂、白细胞介素1（IL-1）抑制剂、IL-6抑制剂、重组IL-18结合蛋白也有望用于治疗。本文主要综述成人Still病的诊断和治疗进展。
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| 关 键 词： | 诊断 生物学标记 治疗 生物制剂 成人Still病 |
| 收稿时间： | 2019-07-26 |
Diagnosis and treatment of adult-onset Still′s disease |
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| Yi Xiaoqing,Luo Shuaihantian,Zhang Guiying,Lu Qianjin.Diagnosis and treatment of adult-onset Still′s disease[J].Chinese Journal of Dermatology,2021,54(2):165-169. |
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| Authors: | Yi Xiaoqing Luo Shuaihantian Zhang Guiying Lu Qianjin |
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| Institution: | Department of Dermatology, The Second Xiangya Hospital of Central South University, Changsha 410011, China |
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| Abstract: | Adult-onset Still′s disease(AOSD)is a type of systemic inflammatory disease of unknown etiology,with diverse clinical manifestations,and there are some difficulties in its diagnosis and treatment.In recent years,it has been found that some new markers,such as heme oxygenase 1,calreticulin,inflammatory cytokines and advanced glycation end products,can be used for a comprehensive assessment of the activity and severity of AOSD.Moreover,new biological agents,such as tumor necrosis factor inhibitors,interleukin-1(IL-1)inhibitors,IL-6 inhibitors and recombinant IL-18 binding proteins,bring new hope for the treatment of AOSD.This review mainly summarizes progress in the diagnosis and treatment of AOSD. |
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| Keywords: | Diagnosis Biological markers Therapy Biological agents Adult-onset Still′s disease |
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