The endocannabinoid system: A new pharmacological target for obesity treatment?

Being a great threaten for human health, obesity has become a pandemic chronic disease. There have been several therapeutic treatments for this social health issue, including diet and exercise therapy, medication and surgery, among which the diet is still the most common way. However, none of these therapeutic measures available is ideal, making it necessary to find an effective medical treatment. The endocannabinoid system, which is well known for its contributions in certain mental processes such as relaxation, amelioration of pain and anxiety, and sedation initiation, has been recently reported to play an essential role in regulating appetite and metabolism to maintain energy balance, leading to the belief that endocannabinoid system is closely related to obesity. This new discovery deepens our understanding of obesity, and provides us with a new direction for clinical obesity treatment. Rimonabant is an antagonist for CB1, and has entered the market in some countries. However, although effective as an anti-obesity drug, rimonabant also causes obviously adverse side-effects, thus is being doubted and denied for medical usage.     

颅内病灶与癫痫

颅内病灶与癫痫曲元明，孙为群，栾立明，尹连虎，吴洪喜，丁峰１９８４～１９９６年５月间收治的颅内病变所致癫痫发作的病人，进行手术治疗３４０例，其中男２７０例，女７０例。按临床症状分为轻、中、重三型，以方便临床评估。本组经手术、病理证实：脑膜瘤１０１例，...     

不同服药时间对非勺型高血压病人降压疗效的影响

目的 探讨不同服药时间对非勺型高血压病人降压疗效的影响。方法 用动态血压监测法选取非勺型高血压病人66例，早上7时服药，3周后改为下午4时服药或加早上7时服药，另选勺型高血压病人72例作对照。结果 非勺型高血压病人服药时间更改后降压疗效得到改善，降压幅度增加（P＜0.05），40.3%病人的血压变为勺型（P＜0.05），尿微白蛋白减少（P＜0.01）。结论 非勺型高血压病人可将降压药延迟至下午服用，如服两种以上的药物，可将其中一种下午服用，以利非勺型血压转变为勺型，从而达到预防高血压靶器官损害的目的。     

大孔吸附树脂纯化胡芦巴提取物中4-羟基异亮氨酸的研究

目的：优选出纯化胡芦巴提取物中4-羟基异亮氨酸的大孔树脂,并确定相应的最佳工艺条件。方法：以胡芦巴提取物中4-羟基异亮氨酸含量为评价指标,采用柱前衍生-高效液相色谱法检测24种型号大孔树脂静态吸附试验前后4-羟基异亮氨酸（4-HIL）含量变化来考察其纯化效果。结果：24种型号大孔树脂对4-HIL吸附容量均很低,但ADS-5型大孔树脂可用于胡芦巴提取物中4-HIL初步纯化,最佳工艺条件为采用ADS-5型大孔树脂,上样液浓度为0.04g?mL^-1,上样量为60mL,上样流速为2BV?h^-1,收集续滤液蒸干可得。结论：ADS-5大孔树脂可用于其初步除杂。     

微创经皮肾镜手术四种体位的分析

总结了微创经皮肾镜碎石术中所应用的各种手术体位的基本情况和进展,主要包括俯卧位、仰卧位、侧卧位、斜卧位,认为微创经皮肾镜具有取石速度快、结石取净率高、手术时间短、步骤简化等优点。手术室护士应熟练掌握好各种体位的优缺点,提高护理服务质量。     

紫杉醇联合贝伐珠单抗治疗非小细胞肺癌恶性胸腔积液的临床研究

目的：观察胸腔内注射贝伐珠单抗联合紫杉醇治疗非小细胞肺癌伴恶性胸腔积液的疗效和安全性。方法选择2012年9月至2013年9月解放军总医院第一附属医院收治的晚期非小细胞肺癌伴恶性胸腔积液患者45例,所有入组患者均接受静脉紫杉醇和顺铂化疗,将所有患者分为贝伐珠单抗联合紫杉醇组（贝伐组）21例和紫杉醇组（化疗组）24例。胸腔给药,每3周为一周期。贝伐组采用贝伐珠单抗300 mg 联合紫杉醇60 mg 进行治疗;化疗组采用紫杉醇60 mg 进行治疗。根据 RECIST 1.1评价标准和 NCI-CTC-AE 3.0分级标准评估疗效和不良反应。结果两组患者治疗后胸腔积液均呈下降趋势,治疗胸腔积液的总有效率贝伐组为81.0%,化疗组为58.3%,差异有统计学意义（P<0.05）。两组患者治疗过程中均未出现不能耐受的不良反应。结论贝伐珠单抗联合紫杉醇可以更好地控制非小细胞肺癌胸腔积液的增长。