A Randomized Trial of Chinese Medicine Lirukang Granule (利乳康颗粒) Combined with Psychological Intervention for Cyclomastopathy and Menoxenia

Objective:To observe the influence of therapy with Chinese medicine Lirukang Granule（利乳康颗粒）,LRKG) combined with psychological intervention on anxiety states and sex hormones in patients with cyclomastopathy and menoxenia.Methods:A total of 470 subjects were randomly assigned to three groups by the net-central randomization system,the treatment group（161 patients,treated with LRKG and psychological intervention）,the Chinese medicine group（157 patients,treated with LRKG）,and the psychological intervention group（152 patients,treated with psychological intervention）.The dose of LRKG was 12 g three times per day; psychological intervention included establishing relations,cognitive intervention and psychological persuasion, 30-40 min per session,once a week.The therapy duration for all groups was three months.The efficacy was compared and anxiety state/State-Trait Anxiety Invertory（STAI） scoring was measured before and after treatment.The serum estradiol（E₂）,progesterone（P）,prolactin（PRL） and follicle stimulating hormone（FSH） levels of 60 patients selected randomly from each group during the luteal phase were measured before and after treatment,and a group of 20 healthy women were evaluated for comparison.A follow-up was arranged for one year after treatment.Results:Thirty subjects were lost to follow-up.（1） Comparison of efficacy:the markedly effective rate and the total effective rate of the treatment group were 86.67%（131/150） and 98.00%（147/150）, respectively;of the Chinese medicine group,64.58%（93/144） and 90.27%（130/144）,respectively;and of the psychological intervention group,0%（0/146） and 3.42%（5/146）,respectively.The markedly effective rate and the total effective rate in the treatment group were significantly higher than those in the Chinese medicine and psychological intervention groups（P<0.05）.（2） Comparison of STAI scoring:STAI scoring was decreased dramatically in the treatment group after treatment compared with that of the Chinese medicine group（P<0.01）, but there was no significant difference compared with the psychological intervention group.（3） Comparison of levels of sex hormones:E₂,P,PRL and FSH of the three patient groups were disordered before treatment,and significantly different from healthy women（P<0.01）.After treatment,the levels of P and FSH of the treatment group were significantly increased（P<0.01）,E₂ and PRL were significantly reduced,which were also significantly decreased compared with the psychological intervention groups（P<0.01）.（4） Follow-up:the markedly effective rate and the total effective rate of the treatment group remained higher than those of the other two groups after one year of treatment（P<0.05）.（5） Adverse reactions:no obvious adverse reactions were found among the three groups.Conclusions:Therapy with Chinese medicine combined with psychological intervention was effective for short-term and long-term treatment of cyclomastopathy and menoxenia.The mechanism might be related to the regulation of sex hormones.     

冬末初春换季养生

寒冬即将过去,春天悄悄来临,又到了冬末初春的季节。我们的身体也面临着换季的变化,对养生保健来说,这是个重要的转折时期。起居有常以养阳,防风御寒中医学认为,人体五脏与四时相应,因此四季养生总的原则是     

漫话甲状腺疾病的调理（上）

甲状腺疾病是常见的慢性病，例如．许多甲减和甲状腺癌患者需要终身服药、甲亢患者服药需数年以上、甲状腺结节手术后容易再长。常言道．慢性病要靠“三分治七分养”，甲状腺病治疗是关键．自我调养是保障，二者缺一不可。患者若不积极自我配合，不按医嘱用药、检查，或只被动地接受治疗，不注意自身调理．治疗效果就会大打折扣。     

前舒安与乙酰胆碱对离体大鼠膀胱平滑肌收缩作用的比较

前舒安胶囊（ＱＳＡ）系中国中医研究院王琦教授治疗前列腺增生症的经验方，由黄柏、三七、虎杖、乌药和冬瓜子等组成，具有祛瘀泄浊，清利下焦的作用，临床用于慢性前列腺炎及前列腺增生，症见小便涩痛，余沥不尽，滴白及会阴部不适等，特别是其改善膀胱刺激症状的有效率...     

科学适量补碘,必不可少

碘营养不良会严重损害健康.预防碘缺乏疾病是我国公共卫生基本政策。我们大部分人天天都在吃碘盐,可对其了解并不多。有些人则担心吃碘盐会引起甲状腺病。5月15曰是全国"碘缺乏病防治宣传日",借此机会,让我们来谈谈如何科学补碘这个与生活和健康息息相关的问题。     

应用德尔菲法确立甲状腺癌中医证候的调查研究

目的运用德尔菲法对甲状腺癌的证候及各证候指标进行专家调研,初步确立甲状腺癌证候和证候指标,为临床辨治提供参考与依据。方法在文献调研的基础上,编制两轮《甲状腺癌中医辨证专家问卷调查表》,对全国30多位专家进行两轮问卷调查并进行统计分析。问卷调查表主要包括甲状腺癌证候及证候指标的重要性和熟悉性判定、术前术后证候分类、证候判定标准等内容。筛选、整理问卷条目,初步建立甲状腺癌中医辨证专家共识。结果两轮调查问卷分别回收有效问卷33份和36份,专家积极系数分别为100%与92.31%。第一轮专家调函克郎巴赫(Cronbaeh’sα)系数为0.297,经调整与修订,第二轮专家调函Cronbaeh’sα系数为0.696,调函内部一致性较高,可以接受。第一轮调查肯德尔和谐系数(W系数)为0.214,第二轮调查W系数为0.382,提示专家对甲状腺癌证候的评价意见协调性较为一致。最终将本病的中医证候确定为痰瘀互结证、肝郁气滞证、瘀热伤阴证、气血两虚证、气阴两虚证、脾肾阳虚证。痰瘀互结证术前为多,气阴两虚证术后多见。结论基本建立了甲状腺癌中医辨证专家共识,对促进甲状腺癌辨证规范,提高临床诊疗水平具有积极意义。     

甲状腺癌术后中医证候聚类分析

目的通过对甲状腺癌术后患者四诊信息进行聚类分析,探讨该病的证候分布特点及中医辨证方法。方法采用横断面流行病学调查研究方法,收集304例甲状腺癌术后患者四诊信息,并进行量化分级,建立数据库,根据每例患者的量化得分情况,运用"样品聚类分析方法(Q聚类)"进行聚类,得出每一类别的四诊信息比重。根据四诊信息比重、前期德尔菲法专家调查形成的甲状腺癌证候初步标准,并结合临床实际进行证候判断。结果将304例甲状腺癌术后患者聚成9类,分别用A1~A9表示,其中A1类频数为77例、A2类7例、A3类1例、A4类7例、A5类105例、A6类7例、A7类87例、A8类11例、A9类2例,结合临床实际和专家经验将A1、A7;A5、A6;A3、A4合并,分别判断为气阴两虚证(164例,占53.9%);肝郁气滞证(112例,占36.8%);脾肾阳虚证(8例,占2.6%);A2判断为瘀热伤阴证(7例,占2.3%);A8、A9四诊信息比重分散判断为其他类证候(13例,占4.4%)。结论甲状腺癌术后中医证候分布具有规律性,聚类分析结合专家经验进行中医证候的判断具有可行性。     

《医宗金鉴·外科心法要诀》乳腺病治疗学术特点拾遗探幽

《医宗金鉴外科心法要诀》被后世奉为中医外科经典书籍,对乳腺病病因、病机、治法、内服方药记载详备,创立了许多独特的外治方法等,许多理论及方药沿用至今。但缺乏系统整理。对《医宗金鉴·外科心法要诀》中记载的乳腺病章节内容方进行了梳理总结,将其主要学术观点归纳为:乳腺病按疮疡论治并重视外治药、创立红升、白降二丹用于乳岩治疗、乳岩分阶段论治、火针治疗不乳儿乳痈等,并对其处方用药特点进行了分析。溯本求源,古为今用使其指导临床治疗,并为治疗当前临床难治乳腺病提供思路。     

王琦教授论治亚健康学术思想概要

简要介绍了王琦教授论治亚健康的学术思想。阐明用中医学理论及方法预防和治疗亚健康的意义。发现心神失养和气虚肝郁是亚健康的核心病机，应用中医体质医学理论有利于亚健康的预防。以及运用益气养心、疏肝解郁的原则和方药治疗亚健康，基本体现了王琦教授近年来对亚健康的研究成果，对于提高防治亚健康水平及发展中医学理论均具有重要的指导作用。     

实践呼唤新的中医理论思维

中医基本理论是中医学术之根,它直接关系到中医学的兴衰与未来,本文就中医理论存在的主要问题进行了探讨,并分析了中医理论发展濡滞的原因,强调今后中医理论研究总的指导原则应是继承、移植、创新三者相结合,在继承的基础上发展创新,使之更完善、更科学、更好地为现代临床服务。