柴楝六君子汤加味治疗肝郁脾虚型消化性溃疡38例

方法：运用自拟柴楝六君子汤加味治疗肝郁脾虚型消化性溃疡38例。结果：治愈33例，好转3例，无效2例，总有效率为94.74％。提示：本方有疏肝理气，健脾和胃，促进胃肠动力作用且对胃膜有保护作用及促进溃疡愈合。     

双极雄激素序贯免疫检查点抑制剂治疗转移性去势抵抗性前列腺癌4例

The relationship between androgen and prostate cancer treatment has plagued the field of urologic oncology. To investigate the efficacy and safety of bipolar androgen therapy (BAT) followed by immune checkpoint inhibitor therapy in patients with metastatic castration resistant prostate cancer (mCRPC). In August 2020, Beijing Hospital conducted an investigator-initiated study: Bipolar androgen therapy followed by immune checkpoint inhibitor therapy in metastatic castration resistant prostate cancer. Up to now, the study has included 4 patients who completed the entire cycle of treatment. The mean age of the patients was 74.5 (68 to 82) years old, the mean prostate-specific antigen (PSA) was 20.8 (9.9 to 8.36) μg/L, the mean testosterone was 0.50 (0.00 to 1.81) μg/L, and the Gleason score were 10 and 9, 7, 7 respectively. The pain scale score before treatment was 1.5 (1 to 2). In this study, 4 patients completed the entire cycle of treatment, and the treatment effect of the patients showed great heterogeneity. PSA in case 1 decreased from 24.0 μg/L to 0.47 μg/L, testosterone increased from 0.175 6 μg/L to 2.62 μg/L. PSA in case 2 increased from 9.939 μg/L to 168.536 μg/L, and testosterone increased from 0.0 μg/L increased to 2.85 μg/L. PSA increased from 13.31 μg/L to 39.278 μg/L in case 3, testosterone increased from 0.0 μg/L to 2.54 μg/L. and PSA increased from 36.0 μg/L to 350.2 μg/L in the case 4, testosterone increased from 1.81 μg/L to 3.85 μg/L. Except for one patient who showed significant PSA remission, the PSA levels of the remaining three patients remained high overall. There were no adverse reactions reported in 4 patients. In the follow-up, case 1 continued to use PD-1 monoclonal antibody (median progression free survival time was 10 months). Two patients who had previously been resistant to enzalutamide received enzalutamide again after the whole cycle of treatment, and their PSA decreased again, which indicated that the patient was sensitive to enzalutamide again. BAT had a certain therapeutic effect on mCRPC patients, and the safety was controllable. Its tumor control effect still needed long-term follow-up verification in large-sample clinical trials. BAT has a certain therapeutic effect on mCRPC patient, especially the resensitivity of tumors to enzalutamide can be restored. Immune checkpoint inhibitors may have therapeutic potential in patients with prostate cancer treated with BAT and enzalutamide.     

相控阵激励信号对经颅HIFU焦域影响的仿真研究

目的:研究相控阵激励信号对高强度聚焦超声（HIFU）经颅骨聚焦形成焦域的影响,解决HIFU经颅聚焦焦点偏离并对颅骨及其周边组织造成热损伤的问题。方法:基于时间反转法提出利用互相关关系调制阵元激励信号相位及幅值的方法,根据临床实际建立人头颅CT数据和相控阵的三维头颅数值仿真模型,以时域有限差分法数值仿真HIFU经颅形成的声压及温度场,分析相控阵激励信号对HIFU经颅形成焦域的影响。结果:通过调制相控阵激励信号的相位,可使HIFU在设定焦点处聚焦;通过调制激励信号的幅值,可使焦点处最大声压和最高温度升高;通过调制不同环阵元激励信号的幅值,可降低聚焦时颅骨处的温度。结论:调制相控阵激励信号可实现经颅HIFU精准高效聚焦,增大在焦点处的声能量聚积;调制不同环阵元激励信号的幅值,可降低颅骨的温度,防止对颅骨周边组织造成热损伤。     

达格列净与沙格列汀对老年2型糖尿病患者炎症指标和肾功能的影响

目的 观察达格列净与沙格列汀对老年2型糖尿病(T2DM)患者炎症指标和肾功能的影响.方法 选取2018年9月至2020年11月于徐州医科大学附属医院诊治的144例老年T2DM患者为研究对象,将患者随机分为达格列净组和沙格列汀组.除外退出研究、失访等病例,达格列净组有50例患者纳入统计,沙格列汀组有67例患者纳入统计.比...     

供受者血型不合肝移植2例病理观察

解放军南京军区福州总医院收治2例血型不合肝移植患者,病例1:患者男,因"原发性肝癌"在全麻下行经典式原位肝移植,供体血型为A型,受体为O型.病例2:患者女,患乙型肝炎病史,因"妊娠合并重症肝病,凝血功能障碍"行经典式原位肝移植,供体血型为B型,受体为O型.免疫组织化学染色后光镜下观察2例供受体血型不合肝移植的病理改变以及肝组织中各种免疫球蛋白和补体的沉积情况;探讨移植肝体液排异反应的诊断标准.结果显示2例移植肝的肝血窦内皮细胞上有不同程度IgG、IgM、IgA、C4c、C4d和C1q线状或颗粒状沉积,提示IgG等免疫球蛋白在肝窦内皮细胞上弥漫强阳性沉积,并伴有C4d等补体成分表达,可作为移植肝组织中存在体液排异反应的证据.     

粉防己碱增敏长春新碱通过MAPK信号通路诱导SGC-7901/VCR细胞凋亡的分子机制研究

目的 阐明粉防己碱(tetrandrine)增敏长春新碱(vincristine)诱导胃癌SGC-7901/VCR 细胞凋亡的分子机制.方法 用不同浓度(0、2、4、6、8μmol/L)粉防己碱及不同浓度(0、50、100、150、200 nmol/L)长春新碱单用或联用处理SGC-7901/VCR细胞48 h,MTT...     

奥普佐米协同三氧化二砷抑制急性早幼粒白血病细胞增殖的分子机制

目的 探讨奥普佐米协同三氧化二砷抑制急性早幼粒白血病细胞增殖分子机制.方法 MTr法检测不同联合用药对急性早幼粒白血病NB4、HL-60细胞存活率的影响:①梯度浓度三氧化二砷(NB4细胞:0、0.1、0.2、0.3、0.4、0.5 μmol/L;HL-60细胞:0、0.4、0.8、1.2、1.6、2.0 μmol/L)...     

抗痤疮药物模型研究进展

痤疮发病机制复杂,其药理研究模型主要分为体内模型和体外模型,且针对不同的发病机制采用的药理模型也不相同。本文针对目前痤疮研究现状,综述了药理模型及其应用进展,以利于在实际应用中选择合适的模型,为治疗痤疮药物和化妆品研发提供参考。     

经方半夏泻心汤在临床中的应用

半夏泻心汤是仲景寒热并用的代表方,临床多用于治疗胃肠道疾病,然临床异病同证时,仍可一方治疗多种疾病。临床中医家明辨病机,扩大了本方的治病范围。