CARD15 in inflammatory bowel disease and Crohn''s disease phenotypes: An association study and pooled analysis

BACKGROUND: Three major polymorphisms of the Caspase-Activation Recruitment Domain containing protein 15 gene have been described to be associated with Crohn's disease. Genotype-phenotype studies reported in literature provide conflicting data on disease localisation and behaviour. We investigated the relation of Caspase-Activation Recruitment Domain containing protein 15 with inflammatory bowel disease and Crohn's disease phenotypic characteristics in a large Dutch cohort and performed a pooled analysis on inflammatory bowel disease patients and Crohn's disease phenotypic characteristics reported in association studies. METHODS: We genotyped 781 cases and 315 controls for the R702W, G908R and 1007fsinsC variants and for six microsatellite markers in and close to Caspase-Activation Recruitment Domain containing protein 15. In the pooled analysis data of 7201 inflammatory bowel disease patients and 3720 controls from 20 studies were included. RESULTS: Association was found for Crohn's disease with R702W and 1007fsinsC, including several disease characteristics, and not for ulcerative colitis. In the pooled analysis all three common Caspase-Activation Recruitment Domain containing protein 15 variants showed strong association with Crohn's disease (p<0.00001; odds ratio varying from 3.0 for single heterozygotes to 14.7 for compound heterozygotes) and not with ulcerative colitis. Phenotype analysis showed association with small bowel involvement, stricturing and penetrating disease. CONCLUSION: Caspase-Activation Recruitment Domain containing protein 15 is associated with Crohn's disease and not with ulcerative colitis. All three common Crohn's disease-associated variants are associated with small bowel involvement, the G908R and 1007fsinsC alleles also being associated with a complicated disease course.     

1995～2004年广东省医院管理研究文献量的统计分析

引用中国生物医学光盘数据库(CBMdisc)收录全国及广东省十年间医院管理发表的文献量、全国10大城市医院管理的文献量排名和广东省内21个省市级医院发表医院管理文献量排名等进行统计分析,并且提出建议。     

Short National Early Warning Score — Developing a Modified Early Warning Score

Introduction

Early Warning Score (EWS) systems have been developed for detecting hospital patients clinical deterioration. Many studies show that a National Early Warning Score (NEWS) performs well in discriminating survival from death in acute medical and surgical hospital wards. NEWS is validated for Portugal and is available for use. A simpler EWS system may help to reduce the risk of error, as well as increase clinician compliance with the tool.

我院15年被收录论文分析

目的：对该院15年被国家收录的科技论文4635篇进行回顾分析，探索管理元素及要点。方法：根据国家科技部中国科技信息研究所论文统计分析中心提供的该院1990至2004年被收录并公布的论文数据库资料，以关系数据库系统Access2000进行统计，所获结果导入Excel中进行排序、分类整理、汇总。结果：15年来该院被收录的论文数量及收录比例逐年上升；对作者情况的具体分析显示：以高学历、高职称人员为主体，科室分类则以优势学科、重点科室、临床科室为多，论文产出情况与课题研究层次呈正相关。结论：证实论文管理的目的及意义；说明论文是人才实力的表达，是评价科研工作的平台，是科研管理出效应的结果，是学科建设力度的体现，是与国际接轨的标志。     

平顶山市1997-2036年报告病毒性肝炎病例统计分析

目的探讨病毒性肝炎（肝炎）的流行病学特征及变化趋势，为防治工作提供依据。方法依据《中华人民共和国传染病防治法》规定标准确诊的病例，通过CDC疫情年报表和疾病监测网络直报资料导出整理分析。结果1997-2006年报告肝炎（甲、乙、丙、戊型和粉型）4718例，年均发病率为95．65／10万，年发病率呈逐年上升趋势；乙肝发病率最高占86．31％；肝炎一年四季均匀有发病；农民、工人、学生发病较高；男性多于女性（1．52：1）。结论肝炎疫情形势严峻，防治工作艰巨，应加强肝炎疫情报告管理工作，以制订有效的防治措施。     

统计参数图在脑血氧水平依赖功能磁共振成像研究中的应用评价

目的：探讨统计参效图在脑血氧水平依赖功能磁共振成像研究中的应用价值。方法：本研究被试者共87例。其中中枢性运动功能异常组被试57例，正常对照组被试30例。本研究的运动功能刺激实验设计为组块设计（Block—Desk）。激活效据采集在双梯度1．5TMR扫描仪上完成，包括定位像、解剖像、功能像、全脑3D像。所有数据用统计参数图软件包离线后处理，经过一系列的预处理和统计分析，得到脑运动区激活统计参数图，研究脑激活区与脑解剖功能区的对应关系。并生成各种量化分析数据以进行相关性分析等统计学处理。结果：异常组被试57例脑血氧水平依赖功能磁共振成像原始资料，经统计参数图后处理，结果符合临床诊断要求的46例（80．70％），正常对照组被试30例。经统计参数图后处理，结果符合临床诊断要求的29例（96．60％），两组结果比较相差显著（X^2=4．21，P〈0．01），提示正常对照组被试数据经统计参数图后处理结果符合诊断要求的百分率大于异常被试组。结论：统计参数图内置多项顶处理步骤，可较有效地排除或减弱被试者的头动、心跳、呼吸及MRI设备系统噪声等干扰因素造成的伪影／影响。有效的预处理在肢体运动功能异常者的脑血氧水平依赖功能磁共振成像数据处理中起了至关重要的作用，是确保脑血氧水平依赖功能磁共振成像激活结果的灵敏性和可靠性的关键手段。     

南京军区南京总医院2004年度科技论文排名的思考和建议

为加强医院学术论文管理，促进科技创新和高质量学术论文产出，作者结合国家科技部2005年度“中国科技论文统计分析新闻发布会”的公布结果，对南京军区南京总医院2004年度科学引文索引（SCI）、MEDLINE、国内统计源期刊收录论文、国内论文被引用次数在全国医疗机构中的排名情况以及医院SCI、MEDLINE、国内统计源期刊收录论文产生的学科分布进行分析，认为要保持医院学术论文在全国同类医院领先，必须完善创新体系构建、规范制度化管理和加强论文产出的环节管理。     

重庆地区儿童皮肤病初诊病例统计分析

为了解重庆地区儿童皮肤病的发病率和常见病种,我们对１９９６年４月至１９９７年３月门诊儿童皮肤病初诊患者进行统计分析,常见皮肤病依次是湿疹、丘疹性荨麻疹、疥疮、皮炎、脓疱疮、荨麻疹、水痘、白色糠疹、体股癣、感染性红斑。多种皮肤病在年龄和季节上都有明显变化。     

Analyze multivariate phenotypes in genetic association studies by combining univariate association tests

Multivariate phenotypes are frequently encountered in genome‐wide association studies (GWAS). Such phenotypes contain more information than univariate phenotypes, but how to best exploit the information to increase the chance of detecting genetic variant of pleiotropic effect is not always clear. Moreover, when multivariate phenotypes contain a mixture of quantitative and qualitative measures, limited methods are applicable. In this paper, we first evaluated the approach originally proposed by O'Brien and by Wei and Johnson that combines the univariate test statistics and then we proposed two extensions to that approach. The original and proposed approaches are applicable to a multivariate phenotype containing any type of components including continuous, categorical and survival phenotypes, and applicable to samples consisting of families or unrelated samples. Simulation results suggested that all methods had valid type I error rates. Our extensions had a better power than O'Brien's method with heterogeneous means among univariate test statistics, but were less powerful than O'Brien's with homogeneous means among individual test statistics. All approaches have shown considerable increase in power compared to testing each component of a multivariate phenotype individually in some cases. We apply all the methods to GWAS of serum uric acid levels and gout with 550,000 single nucleotide polymorphisms in the Framingham Heart Study. Genet. Epidemiol. 34:444–454, 2010. © 2010 Wiley‐Liss, Inc.