化学固化体系对复合树脂性能影响的研究

目的：研究化学固化体系中固化剂对复合树脂性能的影响,确定化学固化复合树脂固化体系的配方。方法：在确定比例的树脂基质中,加入不同配比的引发剂BPO和促进剂DHET,制作标准试件,通过弯曲性能测试、凝胶化试验和红外光谱分析,确定最佳化学固化体系。结果：不同配比的BPO／DHET化学固化引发体系对树脂浇铸体弯曲强度和弯曲弹性模量的影响具有显著性差异（P〈0．05）,当BPO的含量为0．8％,DHET的含量为0．4％时,复合树脂的弯曲性能与工艺性能最佳,弯曲强度和弯曲弹性模量分别为87．78MPa和2．91GPa,单体转化率为80．19％,凝胶时间为5min。结论：BPO／DHET化学固化引发体系中,BPO和DHET含量对树脂浇铸体弯曲强度和弯曲弹性模量有不同影响,BPO／DHET化学固化引发体系的最佳配比是：BPO的含量为0．8％,DHET的含量为0．4％。     

三种不同处理方法对老年牙本质与复合树脂间微拉伸粘结强度的影响

目的比较三种不同方法处理后,老年牙本质与复合树脂间微拉伸粘结强度以及牙本质微观形态的差异。评价Er,Cr∶YSGG激光用于老年人窝洞预备及蚀刻对粘结效果的影响。方法收集完整无龋坏的65岁以上老年人磨牙27颗,随机分成3组。A组:传统牙钻预备+自酸蚀;B组:4 W Er,Cr∶YSGG激光预备+自酸蚀;C组:4 W Er,Cr∶YSGG激光预备+1.5 W Er,Cr∶YSGG激光蚀刻,各组均采用Z350复合树脂充填,37℃水浴中储存24 h后,进行微拉伸粘结强度测试。每组随机选取3颗离体牙标本,扫描电镜下观察老年牙本质微观结构。结果各组微拉伸粘结强度值,B组最高(26.14±4.83)MPa,A组次之(24.68±5.56)MPa,A、B组比较差异无显著意义(P0.05)。C组最低(20.14±3.38)MPa,与A、B组比较差异均有显著意义(P0.05)。结论 Er,Cr∶YSGG激光用于老年牙本质窝洞预备可获得较理想的粘结效果,Er,Cr∶YSGG激光单独用于老年牙本质蚀刻会降低其粘结强度,尚需结合其他牙本质处理方法。     

温脐巴布剂基质处方的优选

目的优选出温脐巴布剂的最佳基质配比处方。方法采用均匀设计法,以初黏力、持黏力及综合感官等为评价指标,对巴布剂基质的种类及其用量进行筛选。结果巴布剂基质最佳配比为：聚丙烯酸钠-卡波姆-明胶-丙二醇-甘油-高岭土-甘羟铝-柠檬酸（质量比1.8∶0.3∶1.5∶3.0∶14.0∶1.6∶0.16∶0.32）。结论制备的温脐巴布剂基质具有良好的延展性,外观平整光滑,且能满足黏性要求。     

四种黏结方法在离体氟斑牙上正畸托槽黏结强度实验研究

目的筛选出一种与氟斑牙有较高黏结强度的临床可行的正畸黏结方法。方法本研究分四组，A组：在干性环境下以京津化学固化型釉质黏合剂黏结托槽，作为对照组；B组：在干性环境下以日本可乐丽公司的化学固化型釉质黏合剂黏结托槽：C、D组：分别在干性、湿性环境下以日本可乐丽公司的SE-BOND光聚合型牙科树脂黏合剂＋可乐丽AP—X光固化复合树脂黏结托槽。黏结后置于37℃温箱中，半小时后进行剪切强度测试及ARI计分。结果A、B组的剪切强度分别为2．212MPa和2．233MPa，C、D组的剪切强度分别为4．268MPa和4．253MPa，C、D组与A、B组之间存在显著差异，A组与B组、c组与D组之间无显著差异。各组样本在祛除托槽时牙面残留黏结剂情况无显著差异。结论可乐丽菲露”SE-BOND牙质粘合用处理剂与氟斑牙界面所达到剪切黏结强度与临床要求有差距，但较传统方法有了很大提高。     

丹参中丹酚酸B纯化工艺研究

摘要：目的对丹参药材中丹酚酸B的提取工艺进行研究，比较两种大孔树脂的吸附能力和洗脱能力。方法以丹酚酸B为考察指标，用反相高效液相色谱法考察了丹参药材在6倍量水时的最佳提取时间以及丹参提取液在两种大孔树脂吸附工艺中的最大吸附量和最佳洗脱条件。结果丹参水煮提取时间以40min时，丹酚酸B含量最大。AB-8型大孔树脂最大吸附量是16．8mg·g^-1，最佳洗脱浓度是50％的乙醇，最佳洗脱体积是4BV；1400型树脂的最大吸附量是17．2mg·g^-1，最佳洗脱浓度是60％的乙醇，最佳洗脱体积是5BV。结论利用大孔树脂精制丹参水溶性成分，在有效地保留丹酚酸B等有效成分的同时，可有效减少丹参提取物中非酚酸类及杂质的含量，有利于提高制剂载药量。为丹参水溶性成分新制剂的工业化生产应用确定基础。     

妥洛特罗控释透皮贴剂的处方、工艺及其体外透皮吸收研究

目的 对脂溶性妥洛特罗贴剂的处方与制备工艺进行筛选和研究,获得一种有效控制药物透过的工艺方法.方法 采用正交设计实验,考察聚异丁烯B50和PB1300与环烷烃油Naphsol 200(N200)等3种因素对妥洛特罗药物透过速率、贴剂持黏力及初黏力的影响,确定最优处方;考察不同的涂布方法对妥洛特罗贴剂透皮速率的影响,得到最佳制备工艺.结果 与结论以最优处方配比B50∶PB1300∶N200=1.5∶1∶1,确立了药胶用量比为2∶1的两层涂布法为最佳工艺方法.获得的贴剂黏性适宜,达到了匀速、稳态透皮的制剂学要求.     

光强度对双固化树脂黏接剂与牙本质黏接强度的影响

 目的 比较不同光强度对双固化树脂黏接剂与牙本质的黏接强度影响。方法 将40颗恒磨牙,暴露咬合面牙本质后随机分为两组,每组20颗牙。DC组用双重固化树脂黏接剂Clearfil DC Bond处理,SE组用光固化树脂黏接剂Clearfil SE Bond处理后,端端对接从近中方向光照。将黏接试样沿光照方向切成5片(1 mm/片,L_1~5),再将每片垂直黏接界面切出5个微拉伸样本(1 mm×1 mm),测试两组黏接强度(mTBS)。结果 随着穿透牙本质厚度增加,光强度降低导致黏接强度下降。部分样本在制备时发生界面折断,SE组存留样本L₁ 70%,L₂ 30%,L_3~5为0;DC组L_1~5分别为68%,86%,56%,44%和38%。SE 组L_1~5黏接强度分别为:(13.22±8.64)MPa,(7.49±3.88)MPa,0、0、0 MPa;DC组为:(11.25±4.11)MPa,(9.69±5.07) MPa,(8.13±4.88)MPa,(6.83±3.53)MPa和(5.56±2.95) MPa。两组表面两层黏接强度无统计学差异。结论 双固化黏接剂与牙本质的黏接强度随着固化光穿透牙本质深度的增加而降低。     

复合树脂与Er∶YAG激光制备的窝洞壁间微渗漏研究

目的观察使用Excite黏接剂和XENOⅢ自酸蚀黏结剂,光固化复合树脂与脉冲Er∶YAG激光及常规牙钻所制备窝洞壁间的微渗漏差异。方法选用30颗前磨牙随机分为3组,每组10颗牙齿,A组:Er∶YAG激光 Excite黏接剂;B组:Er∶YAG激光 XENOⅢ自酸蚀黏结剂;C组(对照组):牙钻 Excite黏接剂。使用脉冲Er∶YAG激光或牙钻在前磨牙颈部制备Ⅴ类洞,涂黏结剂,光固化复合树脂充填;染液渗透法观察树脂与洞壁间的微渗漏。结果脉冲Er∶YAG激光组和常规牙钻组的光固化复合树脂与洞壁间的染液渗透无统计学差异;脉冲Er∶YAG激光备洞后,使用XENOⅢ自酸蚀黏结剂和Exicite黏结剂间染液微渗漏无统计学差异。结论脉冲Er∶YAG激光备洞后,充填的复合树脂与洞壁有着良好的密合度。     

Er,Cr∶YSGG激光备洞对老年人非龋性硬化牙本质微拉伸粘接强度的影响

目的评价Er,Cr∶YSGG激光备洞对硬化牙本质微拉伸粘接强度的影响,并比较其对两种不同充填材料粘接强度的影响。方法 40颗带有楔状缺损的老年人前磨牙,表面有典型硬化牙本质,随机分成实验组和对照组。实验组用Er,Cr∶YSGG激光备洞,对照组用牙科高速涡轮手机备洞,实验组和对照组再各分两个亚组,均分别用复合树脂和玻璃离子水门汀充填。所有样本在37℃蒸馏水中放置24 h,然后制备成厚度约1 mm的哑铃型片状试件,在Instron 5848微力试验机上测定微拉伸粘接强度,在扫描电镜下观察牙本质断面的表面形态。结果实验组中复合树脂组的微拉伸粘接强度为（35.24 7.05）Mpa,玻璃离子水门汀组微粒伸粘接强度（17.71 5.74）Mpa,对照组中复合树脂组微粒伸粘接强度（27.56 4.79）Mpa,玻璃离子水门汀组微粒伸粘接强度（11.47 5.12）Mpa。实验组和对照组的微拉伸粘接强度比较差异有显著意义（P〈0.05）,两组复合树脂组和玻璃离子水门汀组的微拉伸粘接强度比较;差异有显著意义（P〈0.05）。结论 Er,Cr∶YSGG激光备洞老年人非龋性硬化牙本质后的粘接强度高于高速涡轮手机预备者,复合树脂的粘接强度优于玻璃离子水门汀。     

风湿宁贴片中透皮吸收促进剂的筛选研究

目的 :对风湿宁贴片中的透皮吸收促进剂进行筛选研究。方法 :应用均匀设计法从氮酮、丙二醇、油酸中选择风湿宁贴片的透皮吸收促进剂及最佳配比。结果 :氮酮、丙二醇、油酸的含量配比为 6 %∶10 %∶0 %时 ,风湿宁贴片中的青藤碱有最大的透皮速率常数。结论 :氮酮—丙二醇 (6 %∶10 % )是风湿宁贴片较理想的透皮吸收促进剂。     

新型低弹高强度β钛合金对大鼠骨质疏松性骨折愈合的影响

目的 评价新型低弹β钛合金内置物对大鼠骨质疏松骨折愈合的作用及应力遮挡效应.方法 40只SD雌性大鼠去势,建立骨质疏松动物模型,采用Utvag方法制备双股骨骨折模型,选用弹性模量分别为110 Gpa和33 Gpa的钛合金制成髓内针固定骨折,左侧为高弹组,右侧为低弹组,分别于术后6,12周行组织学、Micro-CT及牛物力学检测,Micro-CT检测指标为骨小梁的体积(BV)、样本体积(TV)及骨体积分数(BVF),牛物力学检测指标为最大载荷,比较两种弹性模昔钛合金置入物对骨折骨痂形成及力学特性的影响,并进行统计学分析.结果 低弹组显示了更多的胶原及骨痂形成,骨小梁更厚,板层骨排列更加规则.骨质疏松大鼠股骨骨折后6周,低弹组ROI 1区TV值高于高弹组(P<0.05),其余差异无统计学意义;术后12周,低弹组R0I 1区TV值、BV值均高于高弹组(P<0.05).低弹组ROI 2区BV高于高弹组(P<0.05).生物力学检测提示低弹组最大载倚优于高弹组.结论 新型低弹β钛合金内置物有利于大鼠骨质疏松骨折早期骨痂的形成,并提高骨折愈合的远期质量,减少了骨折同定节段的骨量丢失.     

Mechanical properties of metal-ceramic systems from nickel-chromium and cobalt-chromium alloys

BACKGROUND/AIM: Metal-ceramic bond strength and alloys' elastic modulus clearly determine the potential of alloy application, because the ceramic integrity during mastication depends on these two characteristics. The aim of this study was to evaluate metal-ceramic bond strenght and elastic modulus of cobalt-chromium alloys in making porcelain-fused-to-metal restorations, regarding the application of the most frequent nickel-chromium alloy. METHODS: The research was performed as an experimental study. Six metal-ceramic samples were made from nickel-chromium alloy (Wiron 99) and cobalt-chromium alloy (Wirobond C), according to the manufactures manuals and instructions from ISO 9693: 1996. Three-point bending test was performed up to the ceramic fracture. The fracture load was measured on an universal testing machine (Zwick, type 1464), with cross-head speed of 0,05mm/min. RESULTS: The results of this study confirmed the significant differences between the metal-ceramic bond strength (p < 0.01) and elastic modulus (p < 0.001) of nickel-chromium and cobalt-chromium alloys, where cobalt-chromium alloys showed higher values for both tested parameters. CONCLUSION: Cobalt-chromium metal-ceramic alloys can successfully replace nickel-chromium alloys, especially for fabrication of long-span metal-ceramic bridges due to the great flexural strength.     

Effect of recasting on the elastic modulus of metal-ceramic systems from nickel-chromium and cobalt-chromium alloys

BACKGROUND/AIM: Elastic modulus of metal-ceramic systems determines their flexural strenght and prevents damages on ceramics during mastication. Recycling of basic alloys is often a clinical practice, despite the possible effects on the quality of the future metal-ceramic dentures. This research was done to establish recasting effects of nickel-chromium and cobalt-chromium alloys on the elastic modulus of metal-ceramic systems in making fixed partial dentures. METHODS: The research was performed as an experimental study. Six metal-ceramic samples of nickel-chromium alloy (Wiron 99) and cobalt-chromium alloy (Wirobond C) were made. Alloy residues were recycled through twelve casting generations with the addition of 50% of new alloy on the occasion of every recasting. Three- point bending test was used to determine elastic modulus, recommended by the standard ISO 9693:1999. Fracture load for damaging ceramic layer was recorded on the universal testing machine (Zwick, type 1464), with the speed of 0,05 mm/min. RESULTS: The results of this research revealed significant differences between elasticity modules of metal-ceramic samples in every examined recycle generation. Recasting had negative effect on the elastic modulus of the examined alloys. This research showed the slight linear reduction of elastic modulus up to the 6th generation of recycling. After the 6th recycling there was a sudden fall of elastic modulus. CONCLUSION: Recasting of nickel-chromium and cobalt-chromium alloys is not recommended because of the reduced elastic modulus of these alloys. Instead of reusing previously recasted alloys, the alloy residues should be returned to the manufacturer.     

转化生长因子-β1与乳腺病变弹性特征的相关性

目的探讨转化生长因子-β1(TGF-β1)与乳腺病变弹性特征的相关性。资料与方法选取经手术、穿刺活检或旋切活检的130例患者135个乳腺病变,其中良性84个,恶性51个。于手术或活检前对其进行剪切波弹性成像检查,记录病变的最大弹性模量、平均弹性模量、最小弹性模量,与周围组织弹性比值及“硬环征”等,采用免疫组化法检测TGF-β1的表达水平。比较良、恶性病变弹性特征及TGF-β1表达水平的差异,分析TGF-β1表达水平与上述弹性参数的相关性。结果恶性病变与良性病变的最大弹性模量[(161.9±79.5)kPa比(58.2±50.5)kPa]、平均弹性模量[(99.6±51.9)kPa比(35.9±26.4)kPa]、病变与周围组织弹性比值(6.0±4.1比2.1±1.7)、“硬环征”检出率[74.5%(38/51)比4.8%(4/84)]及TGF-β1表达水平(0.299±0.011比0.104±0.009)比较,差异均有统计学意义(P均<0.001);TGF-β1表达水平与最大弹性模量、平均弹性模量、病变与周围组织弹性比值均呈强正相关(r=0.879、0.821、0.741,P<0.001);有无“硬环征”的病变TGF-β1表达水平比较,差异有统计学意义(0.308±0.010比0.115±0.010,P<0.001)。结论乳腺病变的TGF-β1表达水平与最大弹性模量、平均弹性模量、病变与周围组织弹性比值及病变边缘“硬环征”等均具有相关性。     

Early E‐modulus of healing Achilles tendons correlates with late function: Similar results with or without surgery

Non‐operative treatment of Achilles tendon ruptures is associated with an increased risk of rerupture. We hypothesized that this is due to inferior mechanical properties during an early phase of healing, and performed a randomized trial, using a new method to measure the mechanical properties. Tantalum markers were inserted in the tendon stumps, and tendon strain at different loadings was measured by stereo‐radiography (Roentgen stereophotogrammetric analysis) at 3, 7 and 19 weeks and 18 months after injury. Thirty patients were randomized to operative or non‐operative treatment. The primary out‐come variable was an estimate for the modulus of elasticity at 7 weeks. Strain per force, cross‐sectional area and tendon elongation were also measured. The functional outcome variable was the heel‐raise index after 18 months. There was no difference in the mean modulus of elasticity or other mechanical or functional variables between operative and non‐operative treatments at any time‐point, but strain per force at 7 and 19 weeks had a significantly larger variation in the non‐operative group. This group, therefore, might contain more outliers with poor healing. The modulus of elasticity at 7 weeks correlated with the heel‐raise index after 18 months in both treatment groups (r²=0.75; P=0.0001). This correlation is an intriguing finding.     

Mechanical Properties of a 3 Dimensional–Printed Transparent Flexible Resin Used for Vascular Model Simulation Compared with Those of Porcine Arteries

PurposeTo develop a vascular intervention simulation model that replicates the characteristics of a human patient and to compare the mechanical properties of a 3-dimensional (3D)–printed transparent flexible resin with those of porcine arteries using the elastic modulus (E) and kinetic friction coefficient (μ_k).Materials and MethodsResin plates were created from a transparent flexible resin using a 3D printer. Porcine artery plates were prepared by excising the aorta. E values and the adhesive strengths of the resin and arterial surfaces toward a polyethylene plate, were measured with a tensile-compressive mechanical tester. Resin transparency was measured using an ultraviolet-visible light spectrometer. The μ_k value of the resin plate surface after applying silicone spray for 1–5 seconds and that of the artery were measured using a translational friction tester.ResultsE values differed significantly between the arteries and resin plates at each curing time (0.20 MPa ± 0.04 vs 8.53 MPa ± 2.37 for a curing time of 1 minute; P < .05). The resin was stiffer than the arteries, regardless of the curing times. The visible light transmittance and adhesive strength of the resin decreased as the curing time increased. The adhesive strength of the artery was the lowest. The μ_k value of the silicone-coated resin surface created by applying silicone for 2–3 seconds (thickness of the silicone layer, 1.6–2.0 μm) was comparable with that of the artery, indicating that the coating imparted a similar slippage to the resin as to the living artery.ConclusionsA transparent flexible resin is useful for creating a transparent and slippery vascular model for vascular intervention simulation.     

声触诊弹性成像对继发性下肢深静脉血栓临床分期的相关研究

目的 利用声触诊弹性成像（STE）技术定量测量骨折继发下肢深静脉血栓（DVT）弹性模量值，探讨血栓弹性模量值与临床分期的关系。 方法 纳入骨折后48 h内经常规超声确诊股静脉或腘静脉血栓的病人78例[平均年龄（55.7±14.3）岁]，利用STE技术进行弹性模量值随访测量，每例病人均选取股静脉或腘静脉中的1处血栓进行STE弹性模量值的随访测量，病人栓塞后管腔完全再通或血栓短径缩小至3 mm以下则停止随访。共测得144个弹性模量值，根据血栓所处时间将数据分为4组，急性1组（1~7 d）51个、急性2组（8~14 d）36个、亚急性组（15~30 d）33个、慢性组（31~180 d）24个。如急性1组和急性2组弹性模量值差异无统计学意义，将2组合并为急性期DVT组进一步分析。对4组弹性模量值单因素方差分析，组间两两比较采用Tamhane’s T2检验。采用受试者操作特征（ROC）曲线下面积（AUC）评估血栓弹性模量值对血栓分期的诊断效能。 结果 急性1组、急性2组、亚急性组和慢性组血栓的平均弹性模量值分别为（10.15±1.73）、（11.04±1.86）、（13.69±3.06）、（18.45±4.16） kPa。其中急性1组和急性2组弹性模量值差异无统计学意义（P>0.05）。急性组（1组和2组）、亚急性组和慢性组平均弹性模量值呈依次递增趋势（均P<0.05）。弹性模量值13.19 kPa时鉴别血栓急性期和亚急性期的AUC更大（0.806），敏感度和特异度分别为93.1%、63.6%。弹性模量值17.23 kPa时鉴别亚急性期和慢性期的AUC更大（0.828），敏感度和特异度分别为90.9%、66.7%。 结论 深静脉血栓的弹性模量值随时间延长而增加，STE技术对评估DVT临床分期有指导意义。     

牛心包生物补片对后巩膜加固区的生物力学特性及其作用机制

 目的 应用不同交联程度的牛心包生物补片行后巩膜加固术,观察实验动物巩膜加固区的力学特性,并进一步探讨后巩膜加固术的作用机制。方法 健康成年纯种新西兰白兔48只,雌雄不拘。体重2.2～2.5 kg,随机分为4组,每组12只。A组使用未交联的牛心包生物补片;B 组使用中度交联的牛心包生物补片;C组使用高度交联的牛心包生物补片;D组使用人巩膜组织。分别分为术后2、4、12、24周观察期。手术前常规裂隙灯、间接检眼镜检查,排除有眼部疾患的动物。同期手术,各组术眼为左眼。后巩膜加固材料为长条形,5 mm×20 mm,每眼植入1条。手术前后观察外眼(结膜水肿、炎性反应)、前节、眼底情况。各组手术后2、4、12、24周取标本,摘除眼球,洗净血污,切取植片包括其附着的巩膜。应用BOSE ElectroForce动态力学试验仪对各不同交联度牛心包补片及各实验组巩膜加固区进行生物力学检测。结果 随植入时间的延长,A、D组组织逐渐被降解吸收,至24周时已大部被吸收。B、C组组织无明显降解。A、D组术后4、12周巩膜加固区的弹性模量和刚度与术后2周相比明显增大,刚度及强度则随着术后时间延长而下降。B、C组术后24周巩膜加固区的弹性模量较其余各时间点减少,术后12周与24周组刚度明显降低,尤其以术后24周组刚度最弱。术后24周 B、C组刚度及强度明显高于A、D组,差异有统计学意义(P＜0.05)。结论 交联后的牛心包机械强度大大提高,中、高度交联的牛心包均可用于后巩膜加固术,其远期效果优于人巩膜及未交联的牛心包。     

脉冲Nd:YAG激光照射牙硬组织后拉力实验

目的研究不同能量和不同频率脉冲Nd:YAG激光照射牙表面后,牙齿与光敏树脂间的拉力大小。方法选择一致性较好的新鲜离体人牙,用高速转头制备各类洞型。然后分别用磷酸腐蚀和不同能量和频率的脉冲Nd:YAG激光进行照射,以光敏树脂进行光固化后做拉力实验并进行比较。结果脉冲Nd:YAG激光刻蚀人牙光固化树脂平均拉力68.9-75.5Kg/cm2,酸腐蚀光固化树脂平均拉力为20.6Kg/cm2,差异有显著意义(P<0.05)。结论用脉冲Nd:YAG激光照射代替磷酸进行牙齿表面处理可增加牙齿与光敏树脂间的粘结力。     

高压氧干预对颈动脉弹性影响的定量评价

目的 应用回声跟踪( echo tracking,ET)技术对受试者双侧颈动脉参数进行分析,定量评价高压氧干预对颈动脉弹性的影响.方法 41例行高压氧治疗的患者为高压氧组,20名健康者为高气压组,另20名健康者为高流量组.前2组于进舱前及出舱后即刻、高流量组于吸氧前及吸氧后即刻,应用ET对双侧颈动脉弹性进行检测,检测参数包括血管的压力-应变弹性系数(Ep)、硬化参数(β)及血管顺应性(AC).结果 高压氧组干预后Ep[(112.38±50.94)kPa]及β值(8.29±3.66)较干预前均减小(129.04±52.4)kPa,(9,75±3.83),AC值增大[干预前(0.86±0.34) mm2/kPa,干预后(0.99±0.45)mm2/kpa],差异均有统计学意义(P＜0.01),高气压组干预后β及Ep较值进舱前减小,AC值较进舱前增加,差异均有统计学意义(P＜0.01或P＜0.05);高流量组吸氧前后Ep、β及AC值差异均无统计学意义(P＞0.05);年龄＜40岁的高压氧组及高气压组干预后Ep、β及AC值均有改善,且高压氧组较高气压组改善更明显,2组比较差异有统计学意义(P＜0.05或P＜0.01).结论 高压氧干预即刻即可改善颈动脉弹性.