17G同轴套管活检枪在肺亚厘米结节CT引导下穿刺活检中的应用

目的 探讨在CT引导下应用17G同轴套管活检枪对肺内亚厘米结节进行穿刺活检的技术技巧及价值.方法 回顾性分析总结24例直径在0.6～1.0 cm肺内亚厘米结节病变应用17G同轴套管活检枪进行CT引导下穿刺活检的技术技巧及准确率、并发症.结果 24例患者在充分完善的术前准备下,术中均顺利完成活检术,穿刺活检成功率为100％,标本特异性为100％,气胸、胸痛、咳血及穿刺针道少量出血发生率为25％、20％、25％、87.5％.结论 在CT引导下应用17G同轴套管活检枪对肺内亚厘米结节进行穿刺活检,具有较高的技术技巧含量,其明显提高了穿刺成功率,准确率高,临床应用价值大,值得推广应用.     

CT引导下改良式活检枪在肺占位性病变穿刺活检中的应用价值

目的探讨CT引导下改良式活检枪在肺占位性病变穿刺活检中的应用价值。方法 CT引导下对比分析改良式活检枪(Angiotech 21G)与传统活检枪(Angiotech 21G)在肺占位性病变中进行穿刺取材的体积的大小、活检阳性率、诊断准确率及并发症的发生率有无统计学差异。结果改良式活检枪与传统活检枪进行比较:穿刺成功率均为100%;取材体积(mm3)均数±标准差分别为59.22±34.96、32.04±28.57,统计学分析差异有统计学意义(Z=-7.32,P0.01);活检阳性率分别为98.88%、86.96%,统计学分析差异有统计学意义(P=0.0030.05);诊断准确率分别为97.75%、89.86%,统计学分析差异有统计学意义(P=0.0420.05);气胸发生率分别为8.99%、13.04%,统计学分析差异无统计学意义(P=0.4470.05);咯血及肺出血发生率分别为3.37%、14.49%,统计学分析差异有统计学意义(P=0.0170.05)。结论 CT引导下肺部占位性病变取材活检过程中,改良式活检枪较传统活检枪一次取材体积更多、活检阳性率更高、诊断准确率更高、气胸及肺出血咯血并发症发生率并不增加,临床上有很高的使用价值,值得推广使用。     

CT引导经皮穿刺活检技术在肺部微结节诊断中的价值

【摘要】目的：评价CT引导经皮穿刺活检对肺部微结节（直径≤5mm）的诊断价值及安全性,另探索有效的穿刺方法。方法：在CT引导下对58例肺部微结节行经皮穿刺活检术,其中18例采用Angiotech 20G软组织活检针穿刺,40例采用Angiotech 17G同轴套管针配以 Biopince18G自动活检针,穿刺结果与手术或临床随访诊断结果进行对比,分析其准确性及并发症情况,比较采用不同穿刺针诊断的准确性及安全性。结果：经74次穿刺所有患者均获取足够的组织标本,其中对29例恶性微结节的诊断敏感性为89.7%（26/29）,特异性为100%（29/29）;对29例良性微结节的诊断敏感性为100%,特异性为89.7%（26/29）;总诊断符合率为94.8%（55/58）。两种穿刺针诊断的准确率无统计学差异（P=1.000）,第一次穿刺成功率差异具有统计学意义（χ2=5.038,P=0.025）,气胸发生率差异无统计学意义（χ2=1.987,P=0.159）,咳血发生率差异具有统计学意义（χ2=3.882,P=0.049）。结论：CT引导经皮穿刺活检术对微结节的诊断准确性高,并发症少,是一种安全可行的诊断技术,且同轴套管针配以自动活检针穿刺安全性更高。     

优化CT引导下穿刺活检技术在肺部亚厘米结节中的应用

目的通过优化的CT引导下穿刺活检技术联合17G同轴套管活检枪与传统的18G切割活检针旋转切割抽吸肺部亚厘米结节(sub-centimeter pulmonary nodules, sPN)方法及结果进行对比,探讨前者的应用技巧及两者在sPN穿刺中的阳性率、准确率、手术耗时及出血并发症等方面的差异。方法试验组:78例在CT引导下应用17G同轴套管活检枪联合优化的穿刺活检技术取得病理标本并获得病理结果。对照组:54例应用18G穿刺活检切割针及旋转切割负压抽吸穿刺活检技术并获得病理结果。计量资料采用t检验,计数资料采用χ~2检验。结果试验组中41例良性, 34例恶性,3例阴性。对照组16例为良性,22例恶性,无取得明确病理结果者16例。试验组平均完成时间(18.03±8.08) min较对照组(22.31±7.55)min缩短,试验组阳性率(96.15%)高于与对照组(70.37%),试验组出血发生率(26.92%)低于与对照组(35.18%),差异均有统计学意义(P=0.041,0.000,0.045)。结论应用优化的CT引导下穿刺活检技术联合同轴套管活检枪不但可以提高活检的阳性率及准确率,活检时间明显缩短,出血并发症明显减少。     

螺旋CT引导下自动切割针系统在肺活检中的应用价值

目的 研究螺旋CT引导下，采用自动可分离切割针系统经皮穿刺活检的诊断价值。方法 螺旋CT引导，使用自动弹射活检枪、16G～21G可调式同轴切割针，对287例肺内结节性病灶行经皮穿刺肺活检。结果 262例获定性诊断，其中恶性病变195例，良性病变67例，定性诊断率为91.3％，气胸、咯血等轻微并发症为21.3％。结论 螺旋CT引导下自动可分离切割针系统是一种安全、准确、有效的肺球形病灶检查方法，值得临床推广。     

CT导引下自动活检枪经皮肺穿刺活检的临床应用

目的:探讨CT导向下18G自动活检枪肺活检对肺部结节及肿块病变的临床诊断价值。方法:在CT导向下使用18G自动活检枪对125例患者进行活检取材并送病理检查。结果:穿刺成功率100%,取材成功率98.4%。取材后120例取得病检结果,其中原发性肺癌79例(鳞癌39例,腺癌28例,大细胞癌4例,小细胞癌6例,腺鳞癌2例),肺滑膜肉瘤1例,肺错构瘤2例,肺硬化性血管瘤1例,炎性肿块28例,结核9例。穿刺后4例出现少量气胸,8例针道周围出血,4例痰中带血。结论:CT导引下18G同轴自动活检枪肺活检具有定位精准、穿刺成功率高、获取组织标本可满足病理诊断要求、并发症较少等优点,对肺部结节及肿块病变的定性诊断具有较高的应用价值。     

Precisa活检针在螺旋CT引导下经皮肺穿刺活检诊断肺部病变准确性的分析

目的 分析影响螺旋CT引导下应用Precisa活检针经皮肺穿刺活检诊断肺部病变准确率的因素.方法 回顾性分析87例螺旋CT定位引导下应用Precisa活检针经皮肺穿刺活检资料,对切取病变组织肉眼观与手术病理结果的关系,穿刺的成功率以及并发症进行分析.结果 病灶穿刺成功率100%.确定病理诊断78例(89.65%),未明确诊断9例;术后并发症发生率19.5%,其中气胸8例,局部出血5例,咯血2例,经相应处理后缓解.结论 螺旋CT引导下用Precisa活检针经皮肺穿刺活检成功率与病理诊断率高,可为临床治疗方法的选择提供可靠依据.     

不同CT窗技术对引导经皮肺穿刺活检价值的对比研究

目的 分析不同CT窗技术对肺穿刺活检引导的价值.方法 回顾性分析同一工作组行CT引导下肺穿刺活检的连续性242病例.所有病例按使用不同的窗技术行穿刺者分为2组,单窗(纵隔窗)45例(A组)和多窗(肺窗+纵隔窗+中间窗)197例(B组).对比分析统计2组间穿刺结果 阳性率、气胸及肺出血发生率.结果 A组穿刺结果 阳性率88.9%(40/45),气胸发生率22.2%(10/45),肺出血发生率20.0%(9/45).B组穿刺结果 阳性率91.9%(181/197),气胸发生率9.1%(18/197),肺出血发生率5.1%(10/197).B组肺穿刺活检的气胸和肺出血发生率均明显低于A组,P<0.05.A、B 2组的穿刺结果 阳性率差异无显著性,P>0.05.结论 联合运用多窗CT引导技术较单一纵隔窗引导技术能有效降低经皮肺穿刺活术的气胸及出血并发症.     

胸膜外定位法CT导引下经肺穿刺活检

目的 探讨胸膜外定位(EPL)法行CT导引下经肺穿刺活检,在减少气胸发生率和气胸量方面的应用价值.方法 选取行CT导引下肺穿刺活检中肺内病变与相邻胸膜不接触的患者共115例,根据定位方法的不同,分为EPL组46例、病灶边缘定位(EEL)组69例,两组患者又根据病变外缘沿穿刺方向与胸壁内缘的距离分为近距组(距离≤2era)和远距组(距离>2cm),对比两组患者气胸发生率与气胸量,并进行行×列表X2检验.分别记录并计算两组活检针在肺内的滞留时间及其平均值.结果 EPL组气胸发生率为45.7%(21/46),脏壁层胸膜最大距离0.2～2.5cm,中位数0.4cm;IZL组气胸发生率为66.7%(46/69),脏壁层胸膜最大距离0.2～9.0cm,中位数0.3cm.病灶与胸膜距离≤2cm时,EPL组气胸发生率为39.4%(13/33);LEL组气胸发生率为73.2%(30/41),两组差异有统计学意义(X2=9.981,P=0.019).病灶与胸膜距离>2cm时,EPL组气胸发生率略低于LEL,但两组差异无统计学意义.EPL组活检针在肺内的滞留时间为(7.2±1.8)s,LEL组为(58.3±11.6)s.结论 EPL法CT导引下肺穿刺活检能明显缩短活检针在肺内的滞留时间,减少气胸发生率及产生的气胸量,具有一定价值,是一种值得推广的新方法.     

弹簧芯状活检针在CT引导经皮肺穿刺活检中的应用

目的：探讨CT引导下使用弹簧芯状活检针行比皮肺穿刺活检的诊断准确性和并发症发生率。方法：38例使用弹簧芯状活检针的经皮肺穿刺活检。CT扫描确定并引导穿刺途径,达预定位置取材。结果：35例有明显的病理诊断,诊断准确性92％,恶性肿瘤和良性病变的诊断准确性分别为97％和100％。活后并发气胸4例,咯血1例,结论：CT引导下使用弹簧芯状活检针行经皮肺穿刺活检的气胸发生率与细针抽吸相近,使弹簧芯状活检针行CT引导下肺穿刺活检可以提高诊断的准确性。     

改良的CT引导下同轴法经皮肺穿刺活检术应用

目的：探讨CT引导下同轴法经皮肺穿刺活检术的临床应用价值。方法：选择因肺内病变需活检的116例患者,所有患者均采用CT引导下自动活检枪同轴法经皮肺穿刺活检术。结果：116例患者均成功获取病理标本,穿刺成功率100％,病变阳性率94．8％,并发症6例（5．2％）,经对症处理后2～7天后患者身体逐渐恢复。结论：改良CT引导下经皮肺穿刺活检术器材简单易得,费用低廉操作简便,穿刺成功率高、并发症发生率低。     

Risk factor analysis of pulmonary hemorrhage complicating CT-guided lung biopsy in coaxial and non-coaxial core biopsy techniques in 650 patients

Purpose

To evaluate the risk factors involved in the development of pulmonary hemorrhage complicating CT-guided biopsy of pulmonary lesions in coaxial and non-coaxial techniques.

Materials and methods

Retrospective study included CT-guided percutaneous lung biopsies in 650 consecutive patients (407 males, 243 females; mean age 54.6 years, SD: 5.2) from November 2008 to June 2013. Patients were classified according to lung biopsy technique in coaxial group (318 lesions) and non-coaxial group (332 lesions). Exclusion criteria for biopsy were: lesions <5 mm in diameter, uncorrectable coagulopathy, positive-pressure ventilation, severe respiratory compromise, pulmonary arterial hypertension or refusal of the procedure. Risk factors for pulmonary hemorrhage complicating lung biopsy were classified into: (a) patient's related risk factors, (b) lesion's related risk factors and (d) technical risk factors. Radiological assessments were performed by two radiologists in consensus. Mann–Whitney U test and Fisher's exact tests for statistical analysis. p values <0.05 were considered statistically significant.

Results

Incidence of pulmonary hemorrhage was 19.6% (65/332) in non-coaxial group and 22.3% (71/318) in coaxial group. The difference in incidence between both groups was statistically insignificant (p = 0.27). Hemoptysis developed in 5.4% (18/332) and in 6.3% (20/318) in the non-coaxial and coaxial groups respectively. Traversing pulmonary vessels in the needle biopsy track was a significant risk factor of the development pulmonary hemorrhage (incidence: 55.4% (36/65, p = 0.0003) in the non-coaxial group and 57.7% (41/71, p = 0.0013) in coaxial group). Other significant risk factors included: lesions of less than 2 cm (p value of 0.01 and 0.02 in non-coaxial and coaxial groups respectively), basal and middle zonal lesions in comparison to upper zonal lung lesions (p = 0.002 and 0.03 in non-coaxial and coaxial groups respectively), increased lesion's depth from the pleural surface (p = 0.021 and 0.018 in non-coaxial and coaxial groups respectively), increased distance of traversed lung in the needle track of more than 2.5 cm (p = 0.001 in both groups). Insignificant risk factors were patient's age, gender or emphysema in both groups (p value >0.1 in both groups). Concomitant incidence of pneumothorax was 32.3% (21/65) in non-coaxial group and 36.6% (26/71) in coaxial group. Pulmonary hemorrhage in the majority of cases was treated conservatively.

Conclusion

Pulmonary hemorrhage complicating CT-guided core biopsy of pulmonary lesions, showed insignificant difference between coaxial and non-coaxial techniques. Significant risk factors of pulmonary hemorrhage included small and basal lesions, increased lesion's depth from pleural surface, increased length of aerated lung parenchyma crossed by biopsy needle and passing through vessels within the lung during puncture.     

超声导向穿刺活检对Duchenne型肌营养不良症的诊断价值

目的:探讨超声导向穿刺活检对Duchenne型肌营养不良症(DMD)的诊断价值。方法:回顾性分析14例DMD患者,在高频率超声导向下用Bard活检枪和18G切割活检针进行经皮穿刺活检。结果:穿刺活检成功率及诊断准确率为100%,且无并发症发生。结论:超声导向穿刺活检技术微创、安全,直接获取病变组织,诊断准确率高,为临床诊断DMD提供了一种有效方法。     

CT定位导向下软组织活检术的临床应用

目的探讨在CT导引下半自动活检枪经皮软组织活检术对病变的诊断价值及临床应用,提高CT导向经皮穿刺活检技术的水平。方法采用ToshibaXvision螺旋CT机和SiemensEmotion6型多层螺旋CT扫描仪及半自动活检枪(16G～22G),对100例胸、腹部占位性病变患者行CT导向经皮穿刺活检术。病灶直径1.5cm～11.7cm。结果99例患者穿刺成功,穿刺成功率为99%,其中,93例取得满意的细胞和组织学材料。本组患者均未发生与操作相关的严重并发症。结论CT导向经皮半自动活检枪穿刺活捡成功率和确诊率高,创伤小,并发症少,是胸、腹部占位性病变诊断及鉴别诊断的一种操作简便、安全可靠的检查方法。     

CT-guided transthoracic needle biopsy of pulmonary nodules smaller than 20 mm: results with an automated 20-gauge coaxial cutting needle

AIMS: To evaluate the efficacy and the complication rate of CT-guided percutaneous lung biopsy of pulmonary nodules smaller than 20 mm in diameter using a 20-gauge coaxial automated biopsy device. MATERIAL AND METHODS: A prospective study was undertaken of 200 patients who underwent 202 consecutive biopsies of pulmonary nodules, performed with a single type of automated biopsy device. Sixty-seven biopsies of nodules smaller than 20 mm in diameter were performed in 66 patients (group A). One hundred and thirty-five biopsies of lesions of 20 mm or greater in size were performed in 134 patients (group B). Patient characteristics, lesion and procedure variables, the accuracy and complication rates were compared. RESULTS: In group A, the final diagnosis of the nodules was malignant in 47 and benign in 19 cases (prevalence of malignancy 71. 2%). In group B, there were 111 malignant and 21 benign diagnoses (prevalence of malignancy 82.2%). In group A, the sensitivity and specificity for a diagnosis of malignancy were 89.5 and 100%, respectively (positive predictive value 100%, negative predictive value 76%). A specific diagnosis of benignity was obtained in nine out of 19 (47%) biopsies. The pneumothorax rate was 15% (10 patients) of which two (3%) required drainage. CT signs thought to reflect alveolar haemorrhage were noted in 28 (43%) and haemoptysis occurred in five patients (5.9%). In group B, the sensitivity and specificity for a diagnosis of malignancy were 95.5% and 100%, respectively (positive predictive value 100%, negative predictive value 82.7%). A specific diagnosis of benignity was made in 14 cases (58.3%). Complications included pneumothoraces in 22 cases (16.2%) requiring drainage in one (0.7%). Presumed alveolar haemorrhage was recorded in 19 cases (14.1%) and haemoptysis occurred in seven (5. 2%). There were no significant differences between group A and group B, except for alveolar haemorrhage (P < 0.001). CONCLUSION: The accuracy and complication rate of percutaneous CT-guided biopsy of nodules smaller than 20 mm, performed using an automated 20-gauge coaxial biopsy device, are comparable to those for larger lesions.     

多层螺旋CT引导BARD活检枪经皮肺穿刺活检的临床应用

目的 探讨多层螺旋CT(MSCT)导向下,用BARD活检枪细针同轴多点多向经皮肺穿刺活检的临床应用价值.方法 MSCT引导下用BARD MAGNUM自动活检枪,对68例患者行肺穿刺活检.结果 68例患者穿刺成功率100%.以手术病理或临床随访结果 为标准,定性诊断的准确率为94.1%(64例),其中鳞癌30例,腺癌21例,转移瘤7例,炎性假瘤3例,肺脓肿2例,结核1例.假阴性率为5.9%,并发症的发生率为8.8%(6例).结论 采用MSCT引导,结合BARD活检枪同轴法多点多向肺穿活检,具有定位准确、安全可靠、穿刺成功率诊断准确率高、并发症少等优点.     

多层CT引导下经皮同轴穿刺活检技术的临床应用

目的探讨多层螺旋CT引导下经皮同轴穿刺肺内病变的诊断价值。方法回顾性分析143例肺部占位病变患者行152次多层螺旋CT引导下同轴穿刺活检,并计算其阳性率及并发症的发生率。结果活检阳性率94.9%,特异度100%;其中恶性肿瘤116例(鳞癌48例、腺癌34、小细胞未分化癌6例、大细胞癌4例、肺泡癌8例、转移癌16例),19例良性病变,包括结核7例,炎性假瘤9例,错构瘤1例,肺脓肿1例和隐球菌肺炎1例。结论多层螺旋CT引导下经皮同轴穿刺活检诊断准确率高,是安全的经皮肺内活检方法。     

A new motor-driven percutanoues bone biopsy system: Technical note

A new coaxial needle system was designed for percutaneous puncture of osteosclerotic lesions. Driven by a conventional motor unit, the instrument allows safe guidance even where difficult biopsy routes are used, and has been shown to penetrate radiopaque lesions. Preliminary clinical results from 29 patients are presented. The specimens obtained yielded a correct diagnosis in 28 cases. No major complications were observed.     

磁共振成像导航系统辅助经皮穿刺活检术的初步应用

目的 探讨MRI导航系统EMT-100辅助经皮精准穿刺活检术的有效性以及安全性.方法 使用MRI导航系统EMT-100辅助引导对42例胸、腹部病灶行经皮穿刺活检术.穿刺成功率作为有效性评价的主要依据,观察穿刺活检的成功率、总耗时、平均穿刺次数、平均扫描次数及并发症情况.结果 42例患者,1次穿刺成功率86％ (36/42),2次穿刺成功率14％(6/42),活检成功率100％;穿刺平均定位时间(11.5±5.5) min,平均穿刺次数(1.4±0.5)次,平均扫描次数(4.2±0.8)次,其中32例肺部病灶中2例(6.2％)痰中带血,1例(3.1％)少量气胸,其他患者均未出现严重并发症.结论 MRI导航系统辅助经皮穿刺活检术具有安全、定位准确、穿刺成功率高、适用范围广、无辐射等优点,为临床准确获取病变组织并获得病理诊断结果提供帮助,不失为一种有价值的导引技术选择.