糖微方治疗早期糖尿病视网膜病变疗效观察

正糖尿病视网膜病变(DR)是一种常见的眼科疾病,具有较高的致盲性,是糖尿病患者的一种常见并发症~[1]。现有的药物及手术等新技术治疗DR的循证医学证据不够充分,中医药治疗DR疗效满意~[2]。本研究旨在评估"糖微方"对治疗早期糖尿病视网膜病变的疗效。1临床资料1.1一般资料2014年5月—2015年5月我院收治的早期糖尿病视网膜病变患者40例,男22例,女     

中医药治疗糖尿病视网膜病变进展

糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病严重并发症之一。美国对2005—2008年40岁以上的糖尿病患者进行调查发现,DR患病率为28.5%[1]。几乎所有病程在20年以上的糖尿病患者都存在不同程度的视网膜病变[2]。DR导致的失明占所有失明人数的8.9%[3]。DR的患病率高,致盲率高,因此早期诊断、积极治疗是防治糖尿病并发症的一项重要内容。中医药在临床治疗DR上展示了独特的优势。本文就近5年有关文献概述如下。     

络泰治疗糖尿病视网膜病变

糖尿病视网膜病变(DR)是糖尿病最常见和严重的微血管并发症之一。研究发现,DR的发生率在糖尿病发病5年时为25%,15年后可高达75%～80%[1]。DR的致盲率很高,在西方国家被列为四大致盲眼病之一。我国因DR致盲的患者也在日益增多,DR的治疗也成为人们关注的焦点。我们对54例DR的患者应用络泰治疗,取得比较满意的疗效。1　对象和方法1.1　对象:我院内分泌科及眼科住院的糖尿病患者均符合WHO的糖尿病诊断标准。其中男性26例,女性28例,病程为5～20年,平均年龄64岁。DR的诊断按照1985年中华医学会眼科学会通过的DR分级和分型标准[2]。其中单…     

基层医务人员糖尿病视网膜病变认知度偏低的原因及对策?

糖尿病(DM)已成为临床常见病、多发病。糖尿病视网膜病变(DR)是 DM 最常见的微血管并发症之一,其发生率为30%~60%。在发达国家,其致盲率是工作年龄人群致盲疾病的第1位[1]。在我国,DR 是第4位的致盲性眼病[2]。DR 早期缺乏特异临床表现,很难引起患者重视。当患者到医院就诊时病变已处于中晚期并错过了最佳治疗时期[3]。防止 DR 的关键是早期发现、及时治疗[4]。而开展 DR 的筛查,提高 DR的筛查效率则是问题的关键[5]。医务人员的专业影响力对患者能否定期检查起着十分重要的作用。本研究对大足区人民医院医务人员 DR 防治知的认知度进行问卷调查,统计2013年12月至2014年11月相关内科医务人员所经治患者请眼科会诊的次数及与住院患者患者总数的比值,现报道如下。     

单纯型糖尿病视网膜病变的血液流变学变化临床观察

糖尿病视网膜病变(DR)是糖尿病的常见并发症之一,目前我国糖尿病患者逐年增多,DR患病率在城市糖尿病患者中约占50%[1]。其发病机制复杂,是以视网膜血管损害为主的一种重要的致盲性眼病[2],早期诊断和及时治疗对降低DR致盲率有重要的意义。笔者通过对400例糖尿病患者进行血液流变学的检测,并对其结果进行统计学处理,以探讨血液流变学对DR发生、发展及早期诊断的临床价值。     

糖尿病视网膜病变的治疗

糖尿病视网膜病变(diabetic retinopathy,DR)是糖尿病严重并发症之一,临床表现为视力下降、眼底出血、渗出、水肿,出现新生血管,最终因新生血管破裂致玻璃体出血、机化,牵拉视网膜引起视网膜脱离而失明。国内近年资料表明,糖尿病患病率大约为1%[1],1/4的糖尿病患者有糖尿病视网膜病变,约5%有增生性视网膜病变。目前糖尿病视网膜病变致盲率仍呈上升趋势,糖尿病病程越长,DR的发病率、致盲率也越高。目前的治疗方式可以分为药物治疗、手术治疗、激光治疗等。虽然还没有一种治疗方法能完全治愈DR,但是对于缓解病情,提高生活质量也都在不同程…     

复方丹参滴丸治疗糖尿病视网膜病变临床疗效及 对血清C肽水平的影响

糖尿病视网膜病变(diabeticretinopathy,DR)是糖尿病最严重的微血管并发症之一,也是成人致盲的重要原因,全球每年约有300～400万人因DR而失明,其致盲率是非糖尿病患者的10～25倍[1] .本文对2型糖尿病合并早期视网膜病变患者在常规治疗的基础上应用复方丹参滴丸进行联合治疗取得较好疗效,并进一步以患者血清C肽水平为研究指标,探讨其可能的作用途径.现报道下.     

球后注射曲安奈德联合黄斑部格栅样光凝治疗糖尿病性黄斑水肿的临床观察

糖尿病性黄斑水肿(diabetic macular edema,DME)是糖尿病性视网膜病变的组成部分,同时也是其视力损害或丧失的最常见原因。随着我国糖尿病人的日渐增多,因糖尿病性视网膜病变(DR)的致盲率也呈上升趋势[1]。黄斑水肿是非增殖性糖尿病视网膜病变视力减退最常见的原因。     

糖尿病视网膜病变的治疗进展

糖尿病视网膜病变是一种严重的致盲眼病 ,在我国已经成为致盲的四大原因之一。糖尿病视网膜病变发展到增生性糖尿病视网膜病变是引起患者失明的主要原因 ,而且糖尿病视网膜病变的危险性直接与糖尿病病程及其严重程度有关[1 ] 。近年来玻璃体切割手术、激光治疗和一系列药物治疗的发展DR的治疗带来了希望。本文就近年来DR(diabeticretinopathy,DR)的治疗进展作一综述。1　DR的药物治疗根据引起糖尿病视网膜病变的机制不同 ,DR的药物治疗可以分为以下几类1.1　严密的控制血糖血糖和糖化血红蛋白的高水平状态与视网膜病变的发生、发展有密…     

2型糖尿病合并视网膜病变216例临床分析

糖尿病视网膜病变(diabctic retinopatlty,DR)是糖尿病的常见并发症,也是致盲的主要原因之一。上海医科大学华山医院1960年报告致盲病例922例,其中DR占35.9%;北京协和医院1980年报告1 000例糖尿病患者,其中DR占63.5%;国外DR发病率为     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…