成年近视眼角膜非球面性及其相关因素的分析

目的：探讨成年近视眼角膜非球面参数（Q值）及其相关因素。方法：163例（326眼）近视者按低、中、高度近视程度分为3组,采用i-Trace视觉功能分析仪对Q值进行测量。对Q值与角膜散光和曲率、屈光度、中央角膜厚度及6 mm角膜下、上方平均屈光度差值（I-S值）之间进行相关性分析。结果：所有成年近视眼平均Q值为-0.088±0.095。3组平均Q值分别为-0.083±0.107,-0.085±0.094和-0.099±0.085。Q值与角膜散光呈负相关性（r=-0.27,P〈0.05）。Q值与角膜曲率、屈光度、中央角膜厚度及6 mm区I-S值之间无相关性。结论：近视眼Q值与角膜散光有弱的负相关性,与屈光度及角膜其它参数相对独立。     

Incidence of delirium in the critical care unit and risk factors in the Central Region,Saudi Arabia

Objectives:To determine the incidence and risk factors of delirium in the cardiac care unit (CCU) and intensive care unit (ICU).Methods:This multicenter prospective observational study was conducted between July 2019 and November 2019 in the central region of Saudi Arabia. All patients admitted to the critical care units were enrolled, and their demographic data and risk factors of delirium were reported.Results:A total of 165 patients were included: 76 (46.1%) admitted to the CCU and 89 (53.9%) admitted to the ICU. The mean age was 55.1±18 years, and 45 (27.3%) were women. We found that 24/165 (14.5%) patients developed delirium during admission. Importantly, variables significantly associated with delirium group were female gender: (24.5% versus 10.8%, p=0.028), malnutrition (29.2% versus 5%, p<0.001), the presence of urinary catheter (75% versus 30.5%, p=0.001), septicemia (50% versus 14.9%, p<0.001), intubation (41.7% versus 10.6%, p=0.001), low hemoglobin (10.79±2.91 versus 12.05±2.77, p=048), and prolonged prothrombin time (PT) (15.87±5.17 versus 13.60±3.28, p=0.011).Conclusion:The incidence of delirium was 14.5% among patients admitted to critical care units in the central region of Saudi Arabia. Septicemia, prolonged PT, malnutrition, and urinary catheter are significant predictors of delirium.     

Disease phenotype and diagnostic delay in Saudi patients with primary Sjögren’s syndrome: An exploratory cross-sectional study

Objectives:To describe primary Sjögren’s syndrome (pSS) cohort in Saudi Arabiain view in of clinical/serological/histopathological phentotype, and, diagnostic delay.Methods:A cross-sectional study conducted between October 2018 and May 2019. Diagnostic delay was calculated from symptoms onset to clinical diagnosis. The European League Against Rheumatism (EULAR) Sjögren’s Syndrome Disease Activity Index (ESSDAI) and EULAR Sjogren’s Syndrome Patient Reported Index (ESSPRI) were calculated.Results:Forty-one patients were included in the study. There were predominantly females (78%) with a mean (±SD) age of 58.76±12.7 and disease duration of 4.6±2.28 years. The mean diagnostic delay was 2.2±2.4 (range 1-11) years. Minor salivary gland biopsy was performed on 38 (92.7%) patients with a mean focus score of 2.3± 1.2 points. Interstitial lung disease and arthritis were the most common extra-glandular manifestations (EGM) affecting 27 (65.9%) patients for both. The mean ESSDAI was 9.95±7.73 and ESSPRI was 5.17±2.4.Conclusion:Saudi primary Sjogren’s syndrome patients have a high prevalence of EGM predominantly arthritis and ILD. The diagnostic delay is variable in our cohort.     

准分子激光屈光性角膜切削术治疗近视和近视散光3年疗效分析

OBJECTIVE: To evaluate the efficacy of excimer laser photorefractive keratectomy(PRK) on myopia and myopia astigmatism. METHODS: PRK was performed with VISXC20/20 on 377 eyes of 209 patients. Treated eyes were divided into two groups, according to their conditions before operation: Group I included 238 eyes (-1.50 to -6.00 D); Group II, 139 eyes (-6.25 to -16.00 D). All patients were followed-up for more than three years. RESULTS: Percentages of uncorrected visual acuity (UCVA) > or = 10/20 and 20/20 were 99.6% and 85.3% in Group I, and 79.9% and 48.2% in Group II respectively. Percentage of diopter < +/- 1.00 in Group I was 94.5%, and 61.9% in Group II. The rate of corneal haze of grade 0 was 100% in Group I, and 98.6% in Group II, but corneal haze of grade 2 was found in 1.2% of eyes in Group II. The postoperative intraocular pressure (IOP) of all operated eyes was normal. CONCLUSION: The results suggest that excimer laser PRK is an effective method for treating myopia and myopic astigmatism, especially for low and moderate myopia.     

Methicillin-resistant Staphylococcus aureus development in intensive care patients: A case-control study

Objectives:To determine the factors associated with the development of methicillin-resistant Staphylococcus aureus (MRSA), hospital stay and mortality, and early versus late MRSA infection.Methods:Cases (n=44) were intensive care unit (ICU) patients admitted to King Fahd Specialist Hospital, Al-Qassim, Saudi Arabia between 2015 and 2019 who developed MRSA during their hospital stay. Controls (n=48) were patients from the same place and period who did not develop MRSA. Data were abstracted from hospital records.Results:Admission with sepsis (case: 46% vs. control: 2%, p<0.001) and having at least one comorbid condition (case: 95% vs. control: 46%, p<0.001) were significantly associated with the development of MRSA. Age (mean ± SD: case: 65±18, control: 64±18, p=0.7) and gender (% male, case: 52%, control: 56%, p=0.70) were not associated with the development of MRSA. Approximately 73% of all MRSA cases developed within the first 2 weeks of admission. Among the early cases, 44% died during their ICU stay; the corresponding percentage among the late cases was 42% (p=0.69). There was no difference between early and late MRSA cases in terms of non-sepsis admissions (50% vs. 67%, p=0.32) or comorbid status (at least one: 97% vs. 92%, p=0.17).Conclusion:Sepsis and comorbid conditions were significant risk factors for MRSA development among hospital patients.     

Phototherapeutic Keratectomy Combined with Photorefractive Keratecto-my for Treatment of Myopia with Corneal Scars

Phototherapeutickeratectomy(PTK)hasbeenawel1--establishedmethodforthetreatmentofkeratOPathy['--']andphotorefractivekeratectomy(PRK)hasbeenprovedeffectiveinthetreatmentofmyopia.ButnoreportswereavailableonPTKcom-binedwithPRKtotreatmyopicpatientswithcornealscars.1PATIENTSANDMETHODSFromJune,l996toMay,l998,24myopiccas-es(30eyes)withcornealscarswerelncludedinthestudy.Meanagewas32.7years(agerangingfrom17to60y).Theyincluded10men(l2eyes)andl4women(18eyes).Meancourseofdiseasewasll.3y(rangi…     

COVID-19 in children ranging from asymptomatic to a multi-system inflammatory disease: A single-center study

Objectives:To identify clinical and laboratory characteristics of the Saudi children with confirmed COVID-19.Methods:Eighty-eight children (0-14 years) with COVID-19 who were admitted to Prince Sultan Military Medical City (PSMMC), Riyadh, Saudi Arabia from April to June 2020 were recruited.Results:Mean age was 5.74 ± 4.7 years with 41 (49.4%) males and 42 (50.6%) females. The length of hospital stay (LOS) ranged from 1 to 17 days. The main source of infection was infected family members. Mean values of C-reactive protein (CRP), serum ferritin, and lactate dehydrogenase (LDH) were noticeably above normal. Degree of severity and length of stay was significantly correlated with lymphopenia (r= -0.36; p=0.001), whereas it was positively correlated with absolute neutrophil count and with high inflammatory markers, such as CRP, LDH, and others.Conclusions:Identifying the clinical and laboratory characteristics of the Saudi children with confirmed COVID-19 will improve understanding of this disease’s presentation and will help put rapid and proper management strategies into place to face this pandemic. A high index of suspicion is needed for cases presenting with multi-system inflammatory disease, which represented 5.7% of the included study population.     

The efficacy and safety of percutaneous balloon angioplasty for aortic coarctation in children: Acute and mid-term results in a single center experience

Objectives:To assess the efficacy and safety of balloon angioplasty (BAP) procedure for treatment of coarctation of the aorta (CoA) in children.Methods:A retrospective study included 27 consecutive children, underwent BAP for either native-CoA (Na-CoA) or recoarctation (Re-CoA). Medical records, echocardiographic findings, angiographic and hemodynamic data were collected from the hospital database. Follow-up was scheduled at 1, 3, 6, 12 months after the procedure. The study took place over a period of 4.5 years, from April 2014 to January 2019, in Madinah Cardiac Center, Madinah, Northwest region, Saudi Arabia.Results:The mean age of patients was 11.86±8.96 months. Seven children had Na-CoA and 20 children had Re-CoA. The success rate of the procedure was achieved in 23 children (85%), as BAP reduced the mean systolic pressure gradient across the CoA (Na-CoA: from 45.28± 18.3 to 9.8± 6.57 mm Hg, p=0.0009), and in Re-CoA groups (from 42.48±16.7 to 10.9±8.5 mm Hg, p<0.0001). In mid-term follow-up, the need for re-intervention occurred in 8 children of the cohort (3 children [42.8%] from the Na-CoA group, and 5 children [25%] from the Re-CoA group).Conclusions:Balloon angioplasty is considered a safe procedure for the management of CoA, but its efficacy remains questionable especially for young infants with Na-CoA type. However, it is a reliable option for managing Re-CoA children, with a lower rate of future re-intervention.     

Correlation of prognostic and predictive indicators in breast cancer patients from the eastern province of Saudi Arabia

Objectives:To highlight and correlate demographic and histopathological features of breast cancer along with prognostic and predictive biomarkers, in Saudi patients from the Eastern Province and compare it to a cohort of non-Saudi patients.Methods:In a retrospective study between January 1998 and December 2017, data were collected from the medical records of breast cancer patients who were admitted at King Fahd University Hospital (KFHU), Dammam, Saudi Arabia. The information included demographic, histopathological, and immunohistochemical findings.Results:Out of 482 breast cancer patients, 60% (n=286) were Saudis, and 40% (n=196) were non-Saudis. Data showed a wide age distribution; however, most cases (80%) were seen in the third through fifth decades, with a median age at diagnosis of 51 ±12 years. Over years, breast cancer in Saudi patients was increasingly seen at a younger age (p=0.003). While tumors were increasingly detected at earlier stages (p=0.003); however, stage III & IV tumors (p=0.033) and human epidermal growth factor receptor-2 overexpressed tumors (p=0.035) were more frequently seen at a younger age. Interestingly, these associations were not significant in non-Saudi patients.Conclusion:Although, the current findings might help future studies to identify variables that could lead to better management of breast cancer in this region; however, a wider investigation including other centers in the eastern province is needed.     

准分子激光角膜切削术治疗近视散光

目的：评价准分子激光角膜切削术（ＰＲＫ）治疗近视散光的临床效果。方法：对２６０眼近视散光用ＶＩＳＸ２０／２０准许分子激光系统治疗并随访一年。结果：术前近视散光－０．２５￣－４．００Ｄ，平均－１．００±０．６２Ｄ；术后６月为－０．０７±０．４０Ｄ；术后１年为－０．０６±０．３９Ｄ。术后较术前散光度明显降低（ｐ〈０．０５）。术后１年较术后６月散光理低（ｐ〉０．０５）。无明显回退现象。结论：ＰＲＫＣＦ     

Synergistic efficacies of thymoquinone and standard antibiotics against multi-drug resistant isolates

Objectives:To explore the antibacterial activity of thymoquinone (TQ), a quinone extracted from Nigella sativa.Methods:This study was conducted from May 2019 to March 2020 at the Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi Arabia. The antimicrobial activity, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) of TQ were determined using an agar well diffusion method and broth microdilution assays, and the synergistic effect was evaluated using antibiotics in parallel. The disruptive effect of TQ on bacterial cell membranes was determined using scanning electron microscopy. The antivirulence properties of TQ, which include adherence and biofilm formation, were also investigated using adherence and biofilm formation assays, respectively.Results:Thymoquinone demonstrated bactericidal efficacy against 4/14 bacterial strains, with MIC range of 1.04-8.3 µg/mL and and MBC range of 10.41–66.66 µg/mL. Thymoquinone showed synergism against Klebsiella pneumoniae, Staphylococcus epidermidis (American Type Culture Collection 12228), Staphylococcus aureus, and Staphylococcus epidermidis in combination with the tested antibiotics. Thymoquinone inhibited bacterial adhesion by 39%-54%, 48%-68%, and 61%-81% at 0.5 × MIC, 1 × MIC, and 2 × MIC, respectively. The tested bacterial strains significantly inhibited biofilm formation after treatment with various concentrations of TQ for 24 and 48 hours.Conclusion:The combinatory effect of TQ with antimicrobials should be considered when developing new antimicrobial therapy regimens to overcome multidrug-resistant.     

准分子激光屈光性角膜切削术治疗近视和近视散光3年疗效分析

目的 :评价准分子激光角膜切削术 (photorefoactivekeratecomy ,PRK)治疗近视、近视散光的远期疗效。方法 :按术前屈光度将 2 0 9例 (3 77例 )屈光度为 - 1 5 0～ 1 6 0D的患者分为二组 ,低中度组 (I组 )为 - 1 5 0～ - 6 0 0D(2 3 8眼 ) ,高度组 (II组 )为 - 6 2 5～ - 1 6 0 0D(1 3 9眼 )。应用美国Visx2 0 /2 0准分子激光仪对上述二组患者行PRK治疗 ,并对患者术后 3年的屈光度、视力、角膜屈光力、角膜厚度、并发症进行随访观察。结果 :I组、II组中屈光度 <± 1D者分别占 94 5 %和 6 1 9% ;≥± 2 0 0D分别占 0 % ,2 3 7%。术后裸眼视力≥ 0 5者在I组、II组中分别占 99 6 %和 79 9% ;≥ 1 0者分别占 85 3 % ,48 2 %。角膜屈光力两组均在术后 6个月稳定 ,角膜上皮下雾状混浊O级在I组、II组分别为1 0 0 %和 98 6 % ,术后眼压两组均正常。结论 :准分子激光屈光性角膜切削术治疗近视、近视散光效果肯定 ,尤对低中度患者疗效更佳     

学龄期儿童近视进展的纵向性研究

目的：2年随访期调查学龄期近视儿童屈光变化,获得近视进展状态和规律,探讨与近视进展相关的因素。方法120例8~13岁的近视儿童自愿入选本项研究,以睫状肌麻痹后自动电脑验光获得的屈光度数以及眼轴长度作为主要研究参数,跟踪随访测量,每6个月1次,至24个月,分析其近视进展的状况及年龄、初始度数、散光等因素在近视进展中所起的作用。结果（1）共92例完成随访,其中男54例,女38例,年龄（10.18±1.03）岁。初始度数：-（2.46±1.03）D,年平均进展度数-（0.69±0.29）D。眼轴的年平均变化值为（0.33±0.11）mm;（2）各个年龄组间的近视进展量有差异统计学意义（F=2.724, P=0.049）。年龄越小,近视进展得越快;（3）初始度数＞-2.00D的受试者近视进展量大于初始度数＜-2.00D的受试者（F=8.168, P=0.006）;（4）初始有散光的受试者近视进展量比初始无散光的稍大（F=4.107,P=0.046）。结论学龄期近视儿童年近视进展量明显,近视度数年进展量0.50~1.00D,年龄小、初始度数高、存在散光是近视进展的相关因素。     

准分子激光原位角膜磨镶术治疗高度近视散光76例分析

目的探讨准分子激光原位角膜磨镶术(LASIK)治疗高度近视散光的临床疗效。方法应用鹰视准分子激光治疗系统对76例(147眼)高度近视散光患者进行LASIK手术治疗。随访1年以上,观察术后裸眼视力(UCVA)、散光度及其散光轴位的变化。结果141眼(95.9%)术后UCVA≥术前最佳矫正视力(BC-VA),其中55眼(37.4%)较术前BCVA提高1行以上。134眼(91.2%)散光度数为(-0.01±0.45)D,散光轴向平均较术前偏斜5.1度,散光矫正率99.3%。结论LASIK治疗高度近视散光效果明显,安全可靠。     

Clinical and sociodemographic characteristics of glaucoma patients at a tertiary referral facility in Zimbabwe

PurposeTo evaluate the clinical and socio-demographic profile of patients living with glaucoma and receiving care in a tertiary eye center in Zimbabwe.MethodA hospital-based retrospective study of clinical records of glaucoma patients from January 2014 to December 2018. The study involved collating demographic information of patients, visual acuities, (VA) intraocular pressure, (IOP), cup-to-disc ratios, (CDRs), average retinal nerve fibers thickness, (RNFL), cup volume, cup-to-disc area, vertical cup-to-disc ratio, (VCDR), rim area, disc area, glaucoma hemifield test, visual field indices and the management of glaucoma.ResultsNine thousand one hundred and eighty-five (9,185) folders were retrieved. Out of these, 432 (4.7%) qualified for the study and were analyzed. There were 267 (61.8%) males and 165 (38.2%) females. The mean age (± Standard deviation, SD) of the patients was 62.66 ± 15.94 years, (range 10 - 110 years). The means visual acuity (VA): OD =1.30 ± 1.06 Logarithm of the Minimum Angle of Resolution, (logMAR), OS = 1.33 ± 1.06 logMAR; IOP: OD = 29.51 ± 12.89 mmHg, OS: 29.17 ± 12.59 mmHg; CDRs: OD = 0.91 ± 0.14 D, OS = 0.92 ± 0.14 D; and the average RNFL thickness was 72.76 ± 18.26 µm and 71.24 ± 23.17 µm in the right and left eye respectively. The mainstay of treatment was medication only.ConclusionThere were more males than females receiving glaucoma care at the tertiary level. Glaucoma cases included juveniles but the mean age was mostly the elderly. It was characterized by high IOPs, large CDRs, and thin RNFL suggestive of late presentation.     

检影验光在圆锥角膜筛查与诊断中的应用研究

[目的]探讨分析利用检影验光在筛查与诊断圆锥角膜中的准确性。[方法]收集2008年11月—2011年11月期间利用检影验光观察瞳孔区影动形态异常方法诊断为疑似圆锥角膜病例32例53只眼,经角膜地形图仪检查明确诊断是否相符,并对诊断不符合病例进行分析。[结果]检影验光筛查诊断为疑似圆锥角膜32例53只眼中,经角膜地形图仪确诊圆锥角膜27例43只眼,不符合5例10只眼,不符合的主要原因为高度近视与散光,高度不规则散光引起的异常检影影动干扰所致。检影验光未诊断为疑似圆锥角膜的11只眼中,经角膜地形图仪确诊圆锥角膜4只眼,不符合的主要原因为圆锥角膜病变程度轻,病变位于周边角膜及散光度数较低,检影异常影动不明显。[结论]在角膜地形图检查对高度近视散光人群普查难以实现时,检影验光中影动形态异常反映了圆锥角膜的主要特征,对筛查圆锥角膜有较高的诊断价值。     

Modulatory effect of aquaporin 5 on estrogen-induced epithelial-mesenchymal transition in prostate epithelial cells

BackgroundEstrogen is involved in the pathophysiological process of benign prostatic hyperplasia (BPH), in which epithelial-mesenchymal transition (EMT) plays an important role. Upregulation of aquaporin (AQP) 5, which is directly activated by estrogen, has been reported to promote EMT in multiple cells. This study aimed to examine the effects of AQP5 on estrogen-induced EMT in the prostate.MethodsNormal prostate (NP) tissue samples without any histopathological changes and BPH tissue samples with pathologically confirmed hyperplasia were obtained. An EMT cell model was subsequently established by adding estradiol (E2) to RWPE-1 cells, after which AQP5 knockdown was performed. Tissue morphological and immunohistochemical features were examined using hematoxylin-eosin and immunohistochemical staining. Western blot analysis was performed to determine the expression of AQPs, estrogen receptors, and EMT-related proteins. Cell proliferation was assessed and supernatants were collected for enzyme-linked immunosorbent assay to determine transforming growth factor-β1 (TGF-β1) concentrations. Immunofluorescence staining was performed to assess protein expressions in RWPE-1 cells.ResultsBPH tissues exhibited greater EMT (TGF-β1: 1.362 ± 0.196 vs. 0.107 ± 0.067, P = 0.003; vimentin: 1.581 ± 0.508 vs. 0.221 ± 0.047, P < 0.001; E-cadherin: 0.197 ± 0.188 vs. 1.344 ± 0.088, P < 0.001), higher AQP5 (1.268 ± 0.136 vs. 0.227 ± 0.055, P < 0.001) and estrogen receptor (ER) α (1.250 ± 0.117 vs. 0.329 ± 0.134, P < 0.001) expression but lower ERβ (0.271 ± 0.184 vs. 1.564 ± 0.130, P < 0.001) expression than NP tissues. E2-stimulated cells had higher AQP5 expression (1.298 ± 0.058 vs. 1.085 ± 0.104, P = 0.049), increased cell proliferation (1.510 ± 0.089 vs.1.000 ± 0.038, P < 0.001), and EMT (TGF-β1 concentration: 0.352 ± 0.021 ng/mL vs. 0.125 ± 0.014 ng/mL, P < 0.001; vimentin: 1.641 ± 0.120 vs. 0.188 ± 0.020, P = 0.002; E-cadherin: 0.075 ± 0.030 vs. 0.843 ± 0.046, P < 0.001) than controls. E2-stimulated cells with AQP5 knockdown exhibited decreased EMT (TGF-β1 concentration: 0.223 ± 0.041 ng/mL vs. 0.352 ± 0.021 ng/mL, P = 0.016; vimentin: 0.675 ± 0.056 vs. 1.641 ± 0.120, P = 0.001; E-cadherin: 0.159 ± 0.037 vs. 0.075 ± 0.030, P = 0.040) than E2-stimulated cells with non-related small interfering RNA (siRNA).ConclusionOur findings suggest that estrogen induces BPH possibly by promoting AQP5 expression. Hence, AQP5 might be a novel target for modulating EMT in prostate epithelial cells.     

Curve evolution during bracing in children with scoliosis secondary to early-onset neurofibromatosis type 1: indicators of rapid curve progression

Background:Scoliosis secondary to neurofibromatosis type 1 (NF1) in children aged <10 years is an important etiology of early-onset scoliosis (EOS). This study was performed to investigate the curve evolution of patients with EOS secondary to NF1 undergoing bracing treatment and to analyze high-risk indicators of rapid curve progression.Methods:Children with EOS due to NF1 who underwent bracing treatment from 2010 to 2017 were retrospectively reviewed. The angle velocity (AV) at each visit was calculated, and patients with rapid curve progression (AV of >10°/year) were identified. The age at modulation and the AV before and after modulation were obtained. Patients with (n = 18) and without rapid curve progression (n = 10) were statistically compared.Results:Twenty-eight patients with a mean age of 6.5 ± 1.9 years at the initial visit were reviewed. The mean Cobb angle of the main curve was 41.7° ± 2.4° at the initial visit and increased to 67.1° ± 8.6° during a mean follow-up of 44.1 ± 8.5 months. The overall AV was 6.6° ± 2.4°/year for all patients. At the last follow-up, all patients presented curve progression of >5°, and 20 (71%) patients had progressed by >20°. Rapid curve progression was observed in 18 (64%) patients and was associated with younger age at the initial visit and a higher incidence of modulation change during follow-up (t = 2.868, P = 0.008 and <0.001, respectively). The mean AV was 4.4° ± 1.2°/year before modulation and 11.8° ± 2.7°/year after modulation (t = 11.477, P < 0.010).Conclusions:Curve progression of >10°/year is associated with younger age at the initial visit, and modulation change indicated the occurrence of the rapid curve progression phase.     

角膜屈光手术SMILE的临床安全性、有效性及稳定性评估

[摘要]　小切口角膜基质透镜取出术(SMILE)是一种新型的角膜屈光手术方式,其无瓣、微创等特点在近视及散光矫正方面与既往的角膜屈光手术类型相比具有独特的优势。SMILE的安全性、有效性及可预测性经过临床大量数据研究已显示出满意的效果。但其长期稳定性尚需要进一步观察。本文针对SMILE手术技术的安全性、有效性及稳定性作一评述,以期为临床合理治疗提供参考。     

两品系豚鼠屈光状态和眼球径的发展和比较

【摘要】 目的 了解断奶后Zmu-1:DHP和DHP两个品系豚鼠屈光状态和眼球径的发展规律。方法 首先进行3周龄两品系豚鼠屈光检测,然后选择Zmu-1:DHP品系豚鼠12只,DHP品系8只,按品系分成两组。在4-12周龄,每隔一周检测屈光度、眼轴长和角膜曲率等参数。结果 3周龄,327只Zmu-1:DHP品系豚鼠,屈光度为-5.19?.92 D,近视率达85.1%;而117只DHP品系豚鼠屈光度为2.13?.40 D,近视率仅为22.6%。4-12周龄,Zmu-1:DHP品系豚鼠近视不断加深,屈光参差>1.5D;DHP品系豚鼠屈光发育稳定。T-检验,Zmu-1:DHP品系豚鼠眼轴长度、玻璃体腔深度显著高于DHP品系,视力低于DHP品系。多因素方差分析,Zmu-1:DHP品系豚鼠散光随时间变化显著（P＜0.01）,而DHP品系不显著（P=0.07）。相关性分析,Zmu-1:DHP品系豚鼠屈光状态与眼轴长相关系数为-0.79（P＜0.01）、与玻璃体腔深度相关系数为-0.75（P＜0.01）;而DHP品系相应相关系数为-0.19（P=0.09）和-0.34（P＜0.01）。结论 Zmu-1:DHP品系豚鼠近视高发,正视化过程难以完成,其近视与眼轴长度和玻璃体腔深度高度相关。