安定对学龄前儿童静脉滴注氯胺酮药代动力学的影响

目的：探讨安定对学龄前儿童滴注氯胺酮的药代动力学影响。方法：１６例３．５～６岁择期手术学龄前儿童，随机分为两组，Ⅰ组为氯胺酮组，Ⅱ组为氯胺酮加安定组。用反向高效液相色谱法测定氯胺酮血药浓度，并计算药代动力学参数。结果：两组房室模型均拟合为二房室开放模型、药代动力学参数：Ⅰ组Ｔ１／２α＝（０．１５±０．０４）ｈ，Ｔ１／２β＝（２．８４±０．４４）ｈ，ＣＬ＝（０．３４±０．０６）Ｌ／ｋｇ·ｈ，Ｖｄ＝（０．６６±０．２９）Ｌ／ｋｇ。Ⅱ组Ｔ１／２α＝（０．１４±０．０６）ｈＴ１／２β＝（３．９２±０．５２）ｈ，ＣＬ＝（０．２６±０．０５）Ｌ／ｋｇ·ｈ，Ｖｄ＝（０．６５±０．０７）Ｌ／ｋｇ。结论：安定使氯胺酮清除半衰期延长，清除率降低     

免疫凝聚比浊试验对糖尿病肾病早期诊断的临床意义

比较了ＡＴ（Ｌａｔｅｘ免疫凝聚比浊测定法）和ＲＩＡ法（放射免疫测定法）检测新鲜的随机尿样微量白蛋白（ｍＡ），并评价其临床应用价值。健康对照组ＡＴ（－）（１１例），尿白蛋白６．０±２．３ｍｇ／Ｌ糖尿病组ＡＴ（－）（６１例），１１．０±８．７ｍｇ／Ｌ；ＡＴ（＋）组（１３例），３８．１±１０．２ｍｇ／Ｌ。用ＲＩＡ法测尿帆ｍＡ，以ｍＡ３０ｍｇ／Ｌ作为分割线，ＡＴ与ＲＩＡ法的一致率为８９．２％，结果表明ＡＴ可以作为早期糖尿病肾病尿微量白蛋白监测的简便迅速的方法。     

20例垂体微腺瘤MRI和CT的对比分析

对２０例病理证实为垂体微腺瘤患者进行ＭＲＩ和ＣＴ表现的对比观察。ＭＲＩ显示所有２０个病灶，ＣＴ发现１９个。增强前，在Ｔ＿１加权像上，９０％病变为低信号；ＣＴ片上，８５％为低密度。增强后，ＭＲＩ和ＣＴ各有４５％的肿瘤显示更加清晰。ＭＲＩ与ＣＴ相比，在判断垂体微腺瘤的位置、大小（５．１±２．０／５．２±１．９ｍｍ）、鞍隔上抬（１５／１６例）、垂体柄偏位（９／１０例）以及有无垂体增大（１６／１７例）上，两者结果相似。明确有无鞍底骨质侵蚀ＣＴ明显优于ＭＲＩ，二者有明显差异（Ｐ＜０．０５）。认为高分辨率ＣＴ是垂体微腺瘤的首选影像检查方法。     

免疫放射法新生儿TSH测定在碘缺乏监测中的特异性

通过分析比较贵州省加碘地区麻江县和非加碘城市上海的新生儿ＴＳＨ值分布，探讨免疫放射法（ＩＲＭＡ）纸片新生儿ＴＳＨ值测定在碘缺乏人群监测应用中的特异性。结果显示：１．麻江县新生儿ＴＳＨ值＜５ｍＩＵ／Ｌ者占６５．７％，上海市新生儿占７３．４％，两者比较无显著性差异（Ｐ＞０．０５）；２．麻江县孕妇尿碘值＞１００μｇ／Ｌ者占５５．８％，上海市孕妇占２７．４％，两者比较有极显著性差异（Ｐ＜０．０１）。结果表明，ＩＲＭＡ纸片新生儿ＴＳＨ测定在碘缺乏的监测中特异性似不强，可能会受到除碘缺乏以外的其它致甲状腺肿物质的影响     

EBER1／2及LMP—1在不同类型非霍奇金淋巴瘤中的表达

目的 探讨ＥＢＥＲ１／２及ＬＭＰ－１在不同类型ＮＨＬ中的表达及意义。方法 用ＬＭＰ－１免疫组化与ＥＢＥＲ１／２原位杂交检测５４例ＴＣＬ,６３例ＢＣＬ及２６例ＮＫ／Ｔ淋巴瘤。结果 ＥＢＥＲ１／２阳性率在ＢＣＬ、ＴＣＬ、ＮＫ／Ｔ淋巴瘤中分别是９．５％、３７．０％、４６．２％,ＢＣＬ组和ＮＫ／Ｔ组比较,均有显著差异（Ｐ〈０．０１）,其中阳性病例大多数位于上呼吸道。ＬＭＰ－１阳性率在ＥＢＥＲ１／２阳性的Ｂ     

枸橼酸他莫昔芬片剂的药代动力学和相对生物利用度研究

采用高效液相色谱法进行枸橼酸他莫昔芬片的药代动力学和生物利用度研究。８名健康受试者分别随机ｐｏ屯溪产和上海产枸橼酸他莫昔芬片３０ｍｇ，其血药浓度－时间曲线均符合－房室模型。屯溪产枸橼酸他莫昔芬片的主要药代动力学参数Ｔ１／２ｋα＝０．７８±０．２３ｈ，Ｔ１／２ｋｅ＝１２．０９±２．４５ｈ，Ｔ（ｍａｘ）＝３．７３±０．８１ｈ，Ｃ（ｍａｘ）＝１１８．８±２９．０ｎｇ／ｍｌ，ＡＵＣ＝２３８４±４４５ｎｇ·ｈ·ｍｌ－１。其相对生物利用度为１０４．２％。     

血液透析对尿毒症患者血浆内皮素—1的影响

用ＲＩＡ法测定２４例尿毒症患者血液透析前、后和２０例健康成人血浆内皮素－１（ＥＴ－１）水平。结果：健康成人为２６．７３±７．３７ｐｍｏｌ／Ｌ：尿毒症患者血透前、后分别为９８．４６±１１．８５ｐｍｏｌ／Ｌ和８４．１０±１４．５６ｐｍｏｌ／Ｌ，均高于健康成人的水平（Ｐ＜０．０１）。血透后血浆ＥＴ－１显著低于血透前，但与Ｂｕｎ、Ｓｃｒ、平均动脉压（ＭＡＰ）变化及超滤量之间无显著相关性。     

剧烈运动对青年男子血清催乳素的影响

用双抗体放射免疫法测定３４名年轻消防队员剧烈运动前后血清催乳素（ＰＲＬ）水平。结果：平静状态时ＰＲＬ水平为（１７．７３±７．１４）μｇ／Ｌ，运动后升高至（３７．０６±１８．４１）μｇ／Ｌ，与平静时相比有显著性差异（Ｐ＝０．０００１），休息６０ｍｉｎ后恢复至（１７．４１±７．５４）μｇ／Ｌ，与平静时相比无差异（Ｐ＝１．０００）。提示：剧烈运动可以使血清ＰＲＬ水平升高，并能在较短时间内恢复到平静状态水平     

贵阳市新生儿TSH值分布的初步分析

用免疫放射法（ＩＲＭＡ）对贵阳市８０例新生儿的ＴＳＨ值分布进行了观察。结果如下：１．新生儿组ＴＳＨ值≥５ｍＩＵ／Ｌ者占３８．９％；２．新生儿ＴＳＨ值与其母亲尿碘值呈负相关（ｒ＝０．５，Ｐ＜０．０１）。该研究提示贵阳市虽经１／５万磺盐防治１０年多，仍存在碘缺乏。碘缺乏是导致新生儿ＴＳＨ值偏移的主要因素。     

MRI在股骨头缺血坏死中的应用

为了确定ＭＲＩ对股骨头缺血坏死的诊断作用，尤其是在早期病变中的诊断价值，分析了１５例共２０个股骨头缺血坏死的ＭＲＩ，并与普通Ｘ线检查对比。结果发现ＭＲＩ在发现早期病变方面优于Ｘ线，ＳＴＩＲ（短时间反转回复）序列是发现早期病变的敏感序列。股骨头缺血坏死的ＭＲＩ表现为：（１）早期病变中央区Ｔ１ＷＩ高、Ｔ２ＷＩ中等信号；中期呈Ｔ１ＷＩ、Ｔ２ＷＩ高信号或Ｔ１ＷＩ低、Ｔ２ＷＩ高信号；晚期呈Ｔ１ＷＩ、Ｔ２ＷＩ低信号。（２）病变周围“双线征”。（３）软骨下骨折线。（４）关节积液。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Acupuncture Treatment of Vomiting

CASE HISTORY A female patient, 46 years old, head of the foreign affairs department of a certain university in Beijing, paid her first visit on October 9, 2006, with the chief complaint of vomiting for one month. She got vomiting after meals in early September. Before that, she had discomfortable sensation in the stomach due to angry with others, but she didn't pay much attention. Later, it developed into vomiting after eating. After the vomiting, the discomfort would be relieved, but with slight hypodynamia. She was once diagnosed as having 'neurogenic vomiting'. Having taken some western and Chinese drugs, the above symptoms were a little bit improved, but she would have nausea upon eating and with regurgitation. Because of the fear for vomiting, she did not dare to have food intake, with body weight reduction of 6 kilos in one month.     

Qiu Baoguo''''s Experience in Treating Consumptive Syndromes after Radio-Chemotherapies

Radiotherapy and chemotherapy are the important modern medical therapies for malignant tumors,yet they can also bring about serious local and systemic toxic side reactions so to decrease the patient;'s life quality,manifested by a series of consumptive symptoms.Having engaged in the combined work of Chinese and western medicine for nearly 50 years,the research fellow Qiu Baoguo in Henan Provincial Academy of TCM has developed his unique views on the TCM study of consumptive syndromes.The author of this essay had once the fortune tO follow Dr.Qiu in clinic,and specially would like to introduce in the following Dr.Qiu's experience in treating consumptive syndromes after radio-chemotherapies for patients with malignant tumor.     

Insomnia Due to Deficiency of Both the Heart and Spleen Treated by Acupuncture-Moxibustion and Chinese Tuina

OBJECTIVE: To observe therapeutic effects of the comprehensive therapy of acupuncture-moxibustion and Chinese Tuina for treatment of insomnia due to deficiency of both the heart and spleen. METHODS: 92 cases were divided randomly into the treatment group (treated by acupuncture-moxibustion and Chinese Tuina) and the control group (treated by acupuncture-moxibustion). RESULTS: The therapeutic effect of the treatment group was obviously superior to that of the control group (the CHI2 test showed P < 0.01). CONCLUSIONS: The comprehensive therapy of acupuncture-moxibustion and Chinese Tuina can give marked therapeutic effects for treatment of insomnia due to deficiency of both the heart and spleen.     

Analysis of CK-19,PDX-1,Nestin,Ngn3 in different donor islet purity in rats

Objective: To investigate if there are the CK-19, PDX-1, Nestin, Ngn3 positive cells in the donor islets of different purity in rats. Methods: Thirty male adult SD rats were randomly divided into 3 groups. Islets were isolated using digestion by ductal injection of collagenase. Group Ⅰ (n=10): Separating cell preparations were not purified, Group Ⅱ(n=10): Islet sediment was purified with 25% Ficoll400 ,Group Ⅲ (n=10): Islet sediment was purified with 25% and 11% Ficoll-400. The levels of protein of CK-19, PDX-1, Nestin and Ngn3 were detected by immunohistochemistry and the mRNA of CK-19, PDX-1, Nestin, Ngn3 was amplified by RT-PCR. Results: After two different purification methods applied, three islet preparations of different purities were obtained. The difference of islet purity was significant among various groups (P＜0.05). Compared with group Ⅱ and group Ⅲ,the protein and mRNA of CK-19, PDX-1, Nestin,Ngn3 were both higher in group Ⅰ; group Ⅲ was poorly expressed. Conclusions: The three different islet purity donor islet have different CK-19, PDX-1, Nestin, Ngn3 positive cells within them, indicating that there are some islet stem cells in the purified donor islet.     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.