31例意外胆囊癌的诊断和治疗分析

目的探讨意外胆囊癌的诊断和治疗。方法31例患者术前诊断慢性结石性胆囊炎症18例，急性结石性胆囊炎症5例，单纯胆囊结石3例，胆囊息肉5例。予开腹胆囊切除术11例，腹腔镜胆囊切除术20例。术中冰冻切片证实胆囊癌23例，术后病理确诊8例。行单纯胆囊切除8例，胆囊癌根治术15例，8例二期行胆囊癌根治术。结果术后获随访25例（80．6％），其中3例存活已超过8年，目前仍健在；5例存活超过5年，9例超过1年，存活1年以内8例。失访6例。结论意外胆囊癌术前诊断困难，重视高危因素、术中快速冰冻切片检查是意外胆囊癌诊断的重要依据。而尽快实施手术治疗，并力求根治性切除是其治疗原则。     

意外胆囊癌的临床诊断和治疗分析

目的探讨意外胆囊癌的诊断和治疗。方法对我院1998年5月-2007年4月35例意外胆囊癌的患者资料进行回顾性分析。结采术前诊断幔性结石性胆囊炎症21例,急性结石性胆囊炎症5例,单纯胆囊姑石3例,胆囊息肉6例。开腹胆囊切除术13例,腹腔镜胆囊切除术22例。术中冷冻切片证实胆囊癌25例,术后病理确诊10例。行单纯胆囊切除11例,胆囊癌根治术14例,10例二期行胆囊癌根治术。结论意外胆囊癌术前诊断困难,重视高危因素、术中快速冷冻切片检查是意外胆囊癌诊断的重要依据。而尽快实施手术治疗,并力求根治性切除是其治疗原则。手术为胆囊癌最有效的治疗手段,早期发现、合理治疗为提高胆囊癌生存的有效措施。     

意外胆囊癌11例诊治分析

目的探讨意外胆囊癌的诊治。方法分析11例意外胆囊癌的临床资料,总结临床诊治经验。结果11例患者中,术前诊断慢性结石性胆囊炎8例,Mirrizi综合征1例,胆囊息肉2例。2例行腹腔镜胆囊切除术,9例行开腹胆囊切除术。术中冰冻切片证实胆囊癌5例,术后病理确诊6例。Nevin分期：Ⅰ期2例,Ⅱ期5例,Ⅲ期3例,Ⅴ期1例。单纯胆囊切除术5例,胆囊癌根治术5例,胆囊癌根治术＋部分胆管切除肝总管空肠吻合术1例。二次手术2例。死亡3例,存活8例。结论重视胆囊癌的高危因素,术中对切除胆囊进行剖检及冰冻切片检查,术后行常规石蜡切片检查,有利于发现意外胆囊癌;术中及时或术后二次手术行胆囊癌根治术可以延长生存时间,改善预后。     

意外胆囊癌的临床诊断和治疗分析

目的 探讨意外胆囊癌的诊断和治疗.方法 对我院2001 -05 ～ 2010 - 05间12例意外胆囊癌的患者资料进行回顾性分析.结果 术前诊断慢性结石性胆囊炎症7例,急性结石性胆囊炎症3例,胆囊息肉2例.开腹胆囊切除术1例,腹腔镜胆囊切除术11例.术中冷冻切片证实胆囊癌3例,术后病理确诊9例.行单纯胆囊切除10例...     

意外胆囊癌的诊治探讨

目的：探讨意外胆囊癌（UGC）的诊断和治疗。方法：回顾性分析24例腹腔镜胆囊切除术（LC）术中、术后发现的UGC的诊治过程。结果：10例术中快速冰冻病理证实为胆囊癌,即中转开腹;14例术后病理证实,二次手术行肝床切除加淋巴结清扫。结论：UGC多为早期胆囊癌,高危病例应重视术中快速病理检查,NevinⅡ~Ⅳ期宜扩大根治,晚期病人联合胰十二指肠切除无益生存率的提高。     

意外胆囊癌的诊治探讨

目的:探讨意外胆囊癌(UGC)的诊断和治疗。方法:回顾性分析24例腹腔镜胆囊切除术(LC)术中、术后发现的UGC的诊治过程。结果:10例术中快速冰冻病理证实为胆囊癌,即中转开腹;14例术后病理证实,二次手术行肝床切除加淋巴结清扫。结论:UGC多为早期胆囊癌,高危病例应重视术中快速病理检查,NevinⅡ~Ⅳ期宜扩大根治,晚期病人联合胰十二指肠切除无益生存率的提高。     

外科治疗胆囊癌32例临床分析

目的：分析胆囊癌的病因、诊断与治疗特点。方法：对我院1990年1月到2005年5月,收治的32例胆囊癌进行回顾性分析。结果：本组32例均行手术治疗,其中：3例行单纯胆囊切除术;21例行胆囊癌根治性切除术;1例行胆囊癌扩大根治术;7例行姑息性手术。术后随访4年,7例姑息性手术患者均于3个月到1年死亡;单纯性胆囊切除及胆囊癌根治术患者死亡24例;30例术后生存期为1-2年,1例术后3年现仍存活。结论：重视胆囊癌的早期诊断,手术切除为治疗胆囊癌首选。胆囊切除术后发现的意外胆囊癌应及时行二次根治性手术。     

意外胆囊癌的诊断与治疗

目的:总结意外胆囊癌(unsuspected gallbladder cancer)的诊断和治疗经验.方法:回顾性分析我院2000年1月至2007午12月收治的15例意外胆囊癌患者的临床资料,总结临床诊治经验.结果:15例患者术前诊断胆囊结石12例.胆囊息肉2倒.胆囊结石台并息肉1例.开腹胆囊切除术5例.行腹腔镜胆囊切除术10倒.术后均经病理证实为胆囊癌;Nevin分期Ⅰ期3例,Ⅱ期7例.Ⅲ期4例.Ⅳ期1例.NevinⅠ期密切观察随访.Ⅱ、Ⅲ期行标准胆囊癌根治术.Ⅳ期行扩大胆囊癌根治术.中位随访时间为5.0年.其中13例存活,2例死亡;5例存活超过5年,5年生存率达84.8%.结论:早期胆囊癌术前很难诊断,术中应常规剖视胆囊.对可疑病变行冰冻切片检查;对NevinⅡ～Ⅳ期的意外胆囊癌应再次开腹行根治性手术.     

腹腔镜胆囊切除术意外胆囊癌32例临床分析

目的探讨减少腹腔镜胆囊切除术（LC）意外胆囊癌的发生及对LC意外胆囊癌的正确处理。方法对医院普外科16412例LC术中或术后发现的意外胆囊癌32例,进行回顾性分析。结果本组病人中50岁以上的24例,胆囊结石病史10年以上16例,1年以内6例。术前均行B超检查,有8例怀疑胆囊癌,但未作进一步检查明确诊断。LC术中发现胆囊癌14例（Ⅰ期2例,Ⅱ期6例,Ⅲ期4例,Ⅳ期2例）,均经冰冻病检证实,Ⅰ期者均只行LC手术,Ⅱ～Ⅳ期病例中转开腹行根治性手术。LC术后病理切片发现胆囊癌18例（Ⅰ期8例,Ⅱ期10例）,Ⅰ期者均未再手术,Ⅱ期中4例再次行根治性手术（另6例未接受再次手术）。随访5个月～5年,4例失访,28例随访中死亡12例,4例肿瘤复发,带瘤生存。其余12例存活。结论把握好术前诊断、术中及时发现,是减少意外胆囊癌的关键。对高龄、结石病史5年以上的应视为高危病人高度警惕胆囊癌的可能性,应采取多种辅助检查手段,协助诊断。对意外胆囊癌,目前被大多数学者认同,无论术中或术后一旦发现,均应根据胆囊癌的分期进行中转或早期再次合理的手术。     

黄色肉芽肿性胆囊炎6例临床诊治探讨

目的:探讨基层医院对黄色肉芽肿性胆囊炎(XGC)的临床诊断和治疗策略.方法:回顾分析我院收治的6例XGC患者的临床资料.结果:6例中1例术前初步诊断为XGC,3例诊断为慢性胆囊炎,2例为可疑胆囊癌;6例中5例合并胆囊结石.行腹腔镜手术3例,开放手术3例.术中冰冻切片病理检查3例,分别诊断为XGC、慢性胆囊炎、不排除胆囊癌.5例行单纯胆囊切除,1例行胆囊癌根治术.6例术后常规病理检查证实为XGC,均顺利出院.结论:XGC临床表现无特异性,术前诊断困难,术中冰冻切片病理检查亦较困难,术后石蜡切片方能确诊.基层医院医师应根据不同情况采取相应的诊断和治疗策略.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…