顺铂5-Fu联合腹腔化疗+热疗与单纯腹腔化疗治疗癌性腹水疗效观察

目的观察顺铂5-Fu腹腔化疗结合微波局部热疗治疗癌性腹水与单纯腹腔化疗的临床疗效。方法41例癌性腹水病人随机分为两组，治疗组21例顺铂＋5-Fu腹腔化疗＋微波热疗，对照组20例，单用顺铂＋5-Fu腹腔灌注。结果治疗组有效率71．4％，KPS评分较对照组明显提高，对照组有效率35％，两组两项指标比较差异有显著意义（P〈0．05）。结论顺铂＋5-Fu腹腔化疗结合微波热疗能显著提高癌性腹水治疗有效率，改善患者生存质量，值得临床推广应用。     

顺铂腹腔热灌注并微波局部热疗对癌性腹水的初步效果

①目的　观察顺铂腹腔热灌注结合微波局部热疗治疗癌性腹水的临床效果。②方法　 72例癌性腹水病人随机分为两组 ,治疗组 4 0例采用顺铂腹腔热灌注并微波局部热疗 ;对照组 32例单用顺铂腹腔热灌注治疗。③结果　治疗组有效率及KPS评分较对照组明显提高 ,两组比较差异有显著意义 (χ2 =6 .16 ,t=2 .4 5 1,P <0 .0 5 )。④结论　顺铂腹腔热灌注并微波热疗能显著提高癌性腹水的治疗效果 ,改善病人生存质量 ,值得临床推广应用     

胸腔内灌注化疗联合深部热疗治疗癌性胸腔积液的临床分析

目的探索癌性胸腔积液热疗加腔内化疗的临床应用。方法本文对癌性胸腔积液42例患者随机分为两组:治疗组21例采用腔内化疗联合体外热疗方法;对照组21例行单纯腔内化疗治疗,观察两组疗效、体能状况和不良反应情况。结果治疗组临床疗效及体能状况明显高于对照组,副作用两组比较未见统计学差异。结论腔内化疗合并深部热疗治疗癌性胸腔积液近期疗效及体能状况改善明显优于单纯腔内化疗,统计学有显著性差异。两组无严重并发症发生。     

射频热疗治疗癌性疼痛的疗效观察

目的探讨射频热疗对癌性疼痛的疗效。方法83例晚期癌症随机分两组:热疗组41例(21例热疗加化疗),42例常规治疗组。热疗组采用SR—1000型射频热疗机透热治疗(热化疗的化疗完毕后紧接着行射频透热治疗)。每周2～3次,每次70min,8次一疗程,一疗程后比较两组止痛效果。结果热疗组的有效率90%,明显高于对照组32.7%,其中热疗组13例于第1～2次后即出现止痛效果。止痛效果有效率及持续时间与治疗次数成正比。结论射频热疗能有效控制恶性肿瘤的癌性疼痛,且无毒副作用,并能切实减轻患者痛苦,提高其生活质量。     

胸腹腔内灌注顺铂序贯微波热疗治疗癌性胸腹腔积液的临床观察

目的 观察腔内灌注化疗药物顺铂（DDP）联合热疗治疗癌性胸腹腔积液的疗效。方法 60例癌性胸腹腔积液病人随机分为两组，治疗组27例DDP胸腹腔内注入加热疗，对照组33例单用DDP胸腹腔内注入。结果 胸腹腔积液控制有效率治疗组为88．9％，对照组为60．6％，治疗组明显优于对照组（P＜0．05）。毒副作用无显差异（P＞0．05）。结论 DDP胸腹腔灌注化疗＋热疗有协同作用，能有效提高胸腹腔积液控制率，提高病人生存质量，值得临床推广使用。     

放疗与腔内微波热疗联用治疗直肠癌的效果观察

对于晚期直肠癌及其它原因不能手术的病人放疗是主要的治疗手段,为了提高放疗的治疗效果,我院自1996年采用放疗并腔内微波热疗治疗非手术直肠癌32例,获得较好的近期疗效,现报告如下。1　资料与方法1.1　临床资料　65例直肠癌病人经本院病理确定诊断,年龄58～76岁,平均69岁,男例48例,女性17例。其中腺癌63例,未分化癌1例,鳞癌2例;Ｄｕｋｅｓ’分期,Ｂ期8例,Ｃ期57例;ＫＳ评分均>60分,均为拒绝手术治疗或有其它疾病不能手术者,随机分为放疗(Ａ)组33例,放疗并腔内微波热疗(Ｂ)组32例。1.2　治疗方法　热疗采用国产ＭＨ-1型微波热疗和棒状施热器…     

内生场热疗配合放化疗对骨转移癌疗效的临床研究

目的:探究骨转移癌患者临床治疗中,内生场热疗配合放化疗效果。方法:选取82例骨转移癌患者为研究对象,随机分为热疗组和常规组,对比患者临床骨痛止痛疗效及患者临床治疗不良反应发生率。结果:热疗组患者临床骨痛止痛疗效显著优于常规组,差异有统计学意义(P<0.05),且热疗组患者临床治疗不良反应发生率显著低于常规组,差异有统计学意义(P<0.05)。结论:骨转移癌患者临床治疗中,内生场热疗配合放化疗治疗效果显著,为患者骨痛止痛奠定了基础,提升了患者临床治疗水平,满足了患者治疗方法选择需求。     

微波热疗联合放疗治疗扁桃体癌(附40例临床分析)

探讨微波热疗放疗治疗扁桃体癌的疗效。方法：对２０例扁桃体癌应用放射治疗,２０例应用微波与放射综合治疗,观察并比较其疗效。结果：热疗－放疗综合治疗组临床近期肿瘤消退率９０％,明显高于单纯放疗组,前者肿块消退速度亦明显优于单纯放疗组,且全部病例在治疗期内未发生严重毒副作用。结论微波热疗联合放疗对扁桃体癌的治疗具有协同增敏作用。     

45例骨转移癌放疗联合体外电场热疗治疗体会

目的观察放疗与热疗联合对骨转移癌疼痛的治疗效果.方法对45例骨转移癌患者进行三维立体适形放射治疗(3D-CRT)放疗同步联合体外电场热疗和单纯三维立体适形放疗治疗,观察治疗后疼痛缓解情况。结果两组有效率分别为95.7%和72.7%,有统计学差异。结论骨转移癌放疗联合体外电场热疗治疗较单独放疗镇痛疗效好。     

射频体外热疗配合放射治疗肺癌的观察

热疗治疗恶性肿瘤的方法，已为世界各国医学界所公认，热疗不仅可以直接杀伤肿瘤细胞，并可以使放疗效果提高。我科应用射频体外热疗配合放疗治疗肺癌39例，现报告如下。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…