顺气通腑合剂对胃肠动力障碍大鼠血浆胃动素、乙酰胆碱和生长抑素的影响

目的探讨中药顺气通腑合剂对胃肠动力障碍大鼠血浆胃动素(MTL)、乙酰胆碱(Ach)和生长抑素(SS)的影响。方法选取SD大鼠随机分为正常对照组、阴性对照组、顺气通腑合剂组和莫沙比利组,除正常对照组外,其余3组制备胃肠动力障碍模型,并给以相应药物灌胃,腹主动脉采血,Elisa法测定血浆MTL、Ach和SS水平。结果1造模成功给予治疗后,顺气通腑合剂组大鼠体质量与阴性对照组比较有显著性差异(P<0.05)。2模型组大鼠血浆Ach、MTL含量降低,SS含量升高,与正常组比较差异有统计学意义(P<0.05);治疗后,顺气通腑合剂组升高大鼠血清Ach、MTL含量,降低SS含量,与阴性对照组比较差异有统计学意义(P<0.05)。结论顺气通腑合剂促进胃肠动力作用机制可能为:1通过升高血浆MTL和Ach含量,而促进胃肠平滑肌收缩;2通过抑制SS分泌,促进胃肠道及胰腺外分泌,并激活对胃肠粘膜及机体的保护作用,维持胃肠道正常生理功能。     

自拟通腑顺气汤对妇科腹部手术后胃肠功能恢复的临床观察

目的观察自拟通腑顺气汤对妇科腹部手术后患者胃肠功能恢复的临床疗效。方法将60例妇科腹部手术患者随机分成2组,中药组在术后常规处理的基础上予自拟通腑顺气汤口服;对照组予术后常规处理。结果术后肠鸣音恢复时间、首次排气时间、首次排便时间中药组均低于对照组,2组相比均有显著性差异（P〈0.05）。术后24 h症状总积分中药组低于对照组,2组无显著差异（P〉0.05）;术后72 h症状总积分中药组低于对照组,2组有显著性差异（P〈0.05）。2组患者疗效比较有显著性差异,具有可比性（P〈0.05）。结论自拟通腑顺气汤可加快妇科腹部手术后患者的肠鸣音恢复及首次排气、排便,改善术后患者腹痛腹胀、恶心呕吐等症状。     

中药灌肠联合穴位按摩对术后肠功能恢复的影响

目的 探究中药灌肠联合穴位按摩对腹部手术后肠功能恢复的影响。方法 选取2022年1月至2023年6月湖州师范学院附属第一医院收治的80例腹部手术患者,根据随机数字表法将其分为研究组和对照组,每组各40例。对照组患者采用常规西医治疗,研究组患者在常规西医治疗的基础上加用中药灌肠联合穴位按摩,比较两组患者的治疗疗效、术后恢复时间、胃肠激素水平、腹部胀痛和胃肠反应评分。结果 研究组患者的术后肠鸣音恢复时间、首次肛门排便时间和恢复全流饮食时间均显著短于对照组（P<0.05）。术后5d,两组患者的胃动素（motilin,MTL）、胃泌素（gastrin,GAS）、抑胃肽（gastric inhibitory peptide,GIP）水平均显著高于本组术后1d（P<0.05）,且研究组患者的MTL、GAS、GIP水平均显著高于对照组（P<0.05）。术后5d,两组患者的腹部胀痛评分、胃肠反应评分均显著低于本组术后1d（P<0.05）,且研究组患者的腹部胀痛评分、胃肠反应评分均显著低于对照组（P<0.05）。研究组患者的治疗总有效率显著高于对照组（2=3.914,P=0.048）。结论 中药灌肠联合穴位按摩可有效缩短腹部手术后患者的肠功能恢复时间,改善胃肠激素水平,减轻腹部胀痛和胃肠反应,疗效显著,值得临床推广应用。     

自拟通腑汤治疗腹部非胃肠吻合手术术后胃肠动力功能紊乱的临床观察

目的观察自拟通腑汤对腹部非胃肠吻合手术术后胃肠动力功能紊乱的疗效及安全性。方法选取腹部非胃肠吻合手术术后胃肠动力功能紊乱患者72例,采用随机双盲法分为观察组和对照组各36例,分别给予通腑汤和西沙必利,观察2组患者肠鸣音恢复时间、肛门排气时间及中医证候积分的变化。结果观察组肠鸣音恢复、排气时间均明显短于对照组(P<0.05),痊愈率(63.9%)优于对照组(33.3%),中医证候积分及疗效指数均优于对照组(P<0.05,P<0.01),未见明显不良反应。结论自拟通腑汤可安全有效促进腹部非胃肠吻合手术术后患者胃肠动力功能恢复。     

中药胃肠舒片对胃肠动力障碍大鼠血浆胃动素、P物质和生长抑素的影响

目的探讨胃肠舒促胃肠动力的作用机制。方法选择SD大白鼠随机分为正常对照组、左旋精氨酸（L-Arg）模型对照组、L-Arg加胃肠舒组和L-Arg加西沙比利组,除正常对照组外,其余三组腹腔注射L-Arg,各组分别给等容积的受试药物灌胃,腹主动脉采血,放射免疫法测定血浆胃动素（MTL）、P物质（SP）和生长抑素（SS）。结果 L-Arg模型对照组与正常对照组比较,MTL、SP、SS含量均显著降低（P〈0.01）;用药后胃肠舒组与L-Arg模型对照组比较,血浆MTL、SP、SS水平显著升高（P〈0.05）。结论胃肠舒促进胃肠动力作用机制可能是：①通过调节血浆中胃肠激素的协调平衡而促进胃肠动力;②通过升高血浆MTL和SP含量,使胃肠平滑肌细胞内Ca2＋浓度增加,Ca2＋信号系统引发一系列生理功能而促进胃肠平滑肌收缩。     

腹腔镜辅助近端胃切除双通道吻合术与全胃切除Roux-en-Y消化道重建术治疗早期近端胃癌患者的效果比较

目的：比较腹腔镜辅助近端胃切除双通道吻合术与全胃切除Roux-en-Y消化道重建术治疗早期近端胃癌患者的效果。方法：回顾性分析2018年1月至2021年12月该院收治的128例早期近端胃癌患者的临床资料,根据手术方式不同将其分为对照组和研究组各64例。对照组采用全胃切除Roux-en-Y消化道重建术治疗,研究组采用腹腔镜辅助近端胃切除双通道吻合术治疗,比较两组手术相关指标（手术时间、术中出血量、淋巴结清扫数量、术后肛门首次排气时间、肠鸣音恢复时间、首次进流食时间、首次下床活动时间、住院时间）、手术前后胃肠功能指标[胃动素（MTL）、血管活性肠肽（VIP）、生长抑素（SS）]、营养指标（白蛋白、血红蛋白）水平,以及手术前后体质量减少率和并发症发生率。结果：两组手术时间、术中出血量比较,差异均无统计学意义（P>0.05）;研究组淋巴结清扫数量少于对照组,术后肛门首次排气时间、肠鸣音恢复时间、首次进流食时间、首次下床活动时间、住院时间均短于对照组,差异有统计学意义（P<0.05）;术后,对照组血清MTL水平低于术前,VIP水平高于术前,两组血清SS水平均低于术前,但研究组血清MT...     

腹腔镜胃肠穿孔修补术对患者胃肠动力恢复及胃肠激素的影响

目的 探讨腹腔镜胃肠穿孔修补术对患者胃肠动力恢复及胃肠激素的影响.方法 将2013年6月～2014年1月行腹腔镜胃肠穿孔修补术患者30例,设立为腹腔镜组,另选择同期行传统开腹胃十二指肠穿孔修补术患者32例,设立为对照组,比较腹腔镜组及对照组手术时间、术中出血量、术后住院时间及胃肠动力恢复指标包括术后肛门排气时间、肠鸣音恢复时间、胃肠减压解除时间及术前术后血浆MTL和VIP水平的变化情况.结果 腹腔镜组与对照组患者的手术时间比较,差异无统计学意义,但腹腔镜组的术中出血量明显少于对照组,而腹腔镜组术后住院时间短于对照组,差异有统计学意义（P＜0.05）.腹腔镜组患者的术后肛门排气时间、肠鸣音恢复时间、胃肠减压解除时间均短于对照组,差异有统计学意义（P＜0.05）.腹腔镜组与对照组患者术前MTL和VIP水平分别比较,差异无统计学意义（P＞0.05）.术后腹腔镜组与对照组患者的MTL和VIP水平分别较术前显著提高,且腹腔镜组患者的MTL和VIP水平均分别显著高于对照组,差异有统计学意义（P＜0.05）.结论 腹腔镜胃肠穿孔修补术具有出血少、患者术后胃肠功能恢复快等优点,考虑可能与其提高胃肠激素水平有关.     

针刺对腹部术后胃肠功能恢复及胃肠激素分泌的影响

目的 观察针刺对腹部术后胃肠功能的恢复作用及其对胃肠激素分泌的影响。方法 将100例行腹部外科手术患者随机分为研究组及对照组,每组50例。两组患者均接受外科常规治疗,研究组加用针刺疗法,疗程7 d。治疗后分别观察两组患者胃肠功能恢复情况,采用放射免疫法测定血清胃泌素及血浆生长抑素和血浆胃动素水平。结果 与对照组比较,研究组患者术后肛门排气时间、排便时间、肠鸣音恢复时间、拔除胃管时间、进食时间均明显缩短（P<0.05）。与对照组比较,研究组血清胃泌素水平显著降低,血浆生长抑素和胃动素水平显著升高（P<0.05）。两组并发症发生率比较,差异均无统计学意义（P>0.05）。结论 针刺对腹部外科术后患者胃肠功能的恢复作用与其调节胃肠激素分泌有关。     

产后康复治疗仪联合穴位按摩促进剖宫产术后胃肠功能恢复的效果观察

目的 探讨产后康复治疗仪联合穴位按摩在剖宫产产妇中的应用价值。方法 选择2017年5月—2021年11月于鄱阳县人民医院分娩的100例剖宫产产妇,按随机数字表法分为对照组（50例）和观察组（50例）。对照组采用常规治疗+产后康复治疗仪,观察组在对照组基础上联合穴位按摩,2组均观察至产妇出院。对比分析2组术后胃肠功能恢复情况、住院时间、初次泌乳时间、术后48 h泌乳量、术后疼痛程度[视觉模拟评分法（VAS）评分]、血浆胃肠激素[促胃动素（MTL）、生长抑素（SS）、胆囊收缩素（CCK）]水平、并发症发生情况。结果 观察组肠鸣音恢复、肛门排气、首次排便、住院时间及初次泌乳时间均短于对照组,术后48 h泌乳量评分、术后VAS评分、并发症发生率均低于对照组,术后48 h的MTL、SS、CCK水平均高于对照组,有统计学差异（P<0.05）。结论 产后康复治疗仪联合穴位按摩能够上调剖宫产产妇术后MTL、SS、CCK水平,加快术后胃肠功能恢复,且术后疼痛轻,可缩短初次泌乳时间,减少并发症的发生,有助于产妇尽早出院,临床价值更高。     

厚朴排气合剂对老年腹部手术后胃肠功能的影响

目的 观察厚朴排气合剂用于促进老年腹部手术后胃肠功能恢复治疗的疗效.方法 将实施腹部手术的老年患者86例随机分为治疗组43例和对照组43例.治疗组采用厚朴排气合剂50 ml,术后6、12 h胃管注入.对照组采用生理盐水50 ml术后6、12h胃管注入.比较2组术后首次肠鸣音出现时间、排气、排便时间及恶心、呕吐、腹胀发生情况.结果 治疗组术后首次肠鸣音出现时间、排气、排便时间均短于对照组(P＜0.05,P＜0.01);术后胃肠不适发生率低于对照组(30.2％VS88.4％,P＜0.01).结论 厚朴排气合剂对老年腹部手术后胃肠功能有促进作用.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.