神经内镜在经颅治疗脑室相关深部肿瘤手术中的应用

目的 探讨神经内镜在经颅治疗脑室相关深部肿瘤手术中的应用.方法 回顾性分析本院2016年1月至2019年3月利用神经内镜及其辅助技术治疗21例脑室相关的深部实质性肿瘤患者的临床资料,评价其手术全切率、术后并发症及神经功能情况.结果 15例患者肿瘤全切除,6例患者肿瘤次全切除.术后3例颅内感染,1例新发脑积水并再次手术,1例癫痫发作,3例皮下积液,无严重血肿水肿并发症;术后3例颅神经功能障碍改善,3例肌力下降症状改善,无神经功能障碍加重病例.21例患者随访18～36个月,其中全切组均未发现肿瘤复发,次全切组有2例肿瘤复发并再次手术.结论 神经内镜在经颅治疗脑室相关深部肿瘤手术中可提供良好的术区可视化效果,有助于重建脑脊液循环,结合术中辅助工具的使用,为肿瘤的切除效果和手术安全性提供保证.     

枕下乙状窦后入路切除听神经鞘瘤术中神经功能的保护（附22例分析）

目的：探讨枕下乙状窦后入路切除听神经瘤术中神经功能的保护技术。方法：对22例听神经瘤采用显微技术条件下神经内窥镜辅助、配合术中脑干诱发电位实时监测技术,避免脑干不可逆性损伤,对患者面、听神及其血供经行解剖保留,进行肿瘤切除。结果：手术全切除率59,次全切41,术中面神经解剖保留17例（77.2）,耳蜗神经解剖保留14例（63.6）,术后12周面神经功能保留15例（68.2）,仅3例患者术后2周保持听力。结论：枕下乙状窦后入路切除听神经鞘瘤是一种安全有效的入路;显微外科手术配合神经内镜辅助及脑干诱发电位实时监测技术,能最大限度安全地全切肿瘤,保留面听神经解剖结构,并最大程度保留面听神经功能。     

显微手术切除大型听神经瘤及相关颅神经与血管保护研究

目的探讨大型听神经瘤显微外科手术中颅神经及血管保留技术。方法采用枕下乙状窦后经内耳道入路显微手术治疗的31例大型听神经瘤,对肿瘤的临床表现和影像学特征、颅神经及血管与肿瘤的病理解剖关系以及显微手术技巧进行系统分析。结果肿瘤全切除26例,次全切除5例,面神经解剖保留24例,术后无死亡病例。结论应用显微神经外科技术切除大型听神经瘤,不仅能全切肿瘤,而且可以使颅神经及血管得到解剖与功能保护。     

岛叶区胶质瘤显微外科治疗的效果评价

目的：探讨经外侧裂显微手术切除岛叶区胶质瘤的方法并评价其疗效。 方法：选择经外侧裂显微手术切除岛叶区胶质瘤患者19例（观察组）和既往肉眼或镜下单纯经额、颞叶手术切除岛叶区胶质瘤患者17例（对照组）,对两组患者的岛叶区肿瘤切除程度、术后神经功能障碍和肿瘤复发等情况进行对比分析。结果：术中观察并经术后影像学检查证实：观察组近全切17例（89.5%）,大部切除2例;术后2例轻偏瘫,1例短暂性失语;随访3～19个月,除1例肿瘤复发外,余未见复发及明显神经功能障碍。对照组近全切10例（58.8%）,大部切除7例;术后2例轻偏瘫,3例不全运动性失语;随访4～21个月,有5例癫痫发作加重,6例复发（35.3%）。两组数据经χ²检验比较,肿瘤近全切率、术后并发症发生率和短期肿瘤复发率之间差异均有显著性（P<0.05）。 结论：经外侧裂显微手术切除肿瘤可显著提高肿瘤近全切率,减少术后神经功能障碍并发症,避免短期肿瘤复发,是目前岛叶区胶质瘤治疗的首选方法。恰当的手术入路,对周围重要结构的精确辨认和保护是提高疗效的关键。     

62例听神经瘤显微手术疗效及并发症分析

[摘要]　目的　探讨显微手术治疗听神经瘤的临床疗效及操作技巧,以期望提高肿瘤切除率,降低术后并发症。　方法　回顾性分析2009年1月—2014年1月采用显微外科经枕下乙状窦后入路手术治疗62例听神经瘤患者的疗效并统计并发症情况。　结果　肿瘤全切53例、次全切7例、大部分切2例。面神经解剖保留58例,功能保留40例。术后并发症：后组颅神经症状加重3例,脑脊液切口漏4例,脑膜炎3例,无死亡病例。　结论　经枕下乙状窦后入路显微手术切除听神经瘤是一种安全有效的方法,术中采取相关技巧能够提高全切率及减少各种并发症。     

神经导航在垂体瘤显微手术中的应用

目的 评价神经导航系统在垂体瘤显微手术中的应用价值.方法 在19例垂体瘤经蝶手术中应用神经导航系统指导手术操作,神经导航术中定位中线结构、蝶窦前壁、鞍底以及海绵窦、颈内动脉等,并用以判断肿瘤切除程度.结果 19例神经导航各例的平均坐标误差为1.14～3.62 mm(总平均1.53 mm).19例垂体瘤全切14例,次全切除4例,大部切除1例.术后11例出现一过性尿量增多,无脑脊液漏和颅内感染,无手术死亡.结论 对一些巨大或解剖定位结构不清的垂体瘤进行手术时,神经导航提供实时三维定位,有助于提高肿瘤全切除率,减少手术并发症.     

改良经皮层脑室入路切除丘脑肿瘤

目的探讨提高丘脑肿瘤的切除率和减少术后并发症的手术方法。方法对17例丘脑肿瘤采用改良经皮层脑室入路进行显微手术切除并获得6个月至3年的随访。结果肿瘤全切除11除、次全切除4例、大部切除1例，无手术死亡。结论改良经皮层脑室入路可提高丘脑肿瘤的手术全切率和减少术后并发症。     

神经导航辅助下中央区胶质瘤切除的应用研究

目的:研究神经导航技术在中央区胶质瘤显微手术中的应用价值.方法:对术前MRI诊断为中央区胶质瘤的20例患者行神经导航辅助下显微手术切除,对肿瘤的切除程度、患者术后的功能状态进行分析评价.结果:肿瘤全切15例,次全切3例,大部切除2例,未出现手术死亡,无新发神经功能障碍.结论:神经导航辅助下手术切除中央区胶质瘤时定位精确,能有效的提高肿瘤切除率,降低术后功能障碍的出现.     

神经导航引导下切除幕上胶质瘤的体会

目的:应用神经导航系统对成人幕上胶质瘤实施手术,研究肿瘤全切除与神经功能保护。方法:回顾性分析郑州大学附属肿瘤医院神经外科于2009年9月至2011年11月应用神经导航系引导进行幕上胶质瘤切除术的74例病例资料。病灶最大直径7.4 cm,最小1.9 cm,平均5.4 cm。结果:用神经导航系统进行幕上胶质瘤及其周围解剖结构定位准确,平均注册误差(2.12+0.51)mm。术后近期复查,CT或MRI证实肿瘤全切60例(81%),次全切除8例(10.8%),大部切除6例(8.2%)。结论:神经导航定位精确,有助于手术计划的精确实施。神经导航下切除幕上胶质瘤显微手术,有助于达到微侵袭效果和提高肿瘤全切除率。     

显微手术切除大型听神经瘤面神经保护的研究

目的:探讨大型听神经瘤显微外科手术中面神经保留技术。方法:采用枕下乙状窦后经内耳道入路显微手术治疗的31例大型听神经瘤,对肿瘤的临床表现和影像学特征、面神经与肿瘤的病理解剖关系以及显微手术技巧进行系统分析。结果:肿瘤手术全切除26例,次全切除5例,面神经解剖保留24例,术后无死亡病例。结论:应用显微神经外科技术切除大型听神经瘤,不仅能全切肿瘤,而且可以使面神经得到解剖与功能保护。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…