138对近亲婚配后代遗传效应调查

对河南省五个县的部分乡镇共138对近亲婚配后代遗传效应进行了调查,并以非近亲婚配组作对照。近亲婚配类型中,姨表亲占55.08%,姑表亲占44.02%,其他少见。近亲婚配子女20岁前死亡率(10.26%)远高于非近亲婚配组(0.94%),近亲与非近亲婚配子代畸形、智力低下、聋哑等遗传性疾病的患病率有高度显着性差异。     

撒拉族近亲婚配的遗传学研究

目的　了解撒拉族近亲婚配及后代的健康状况。方法　采用回顾性调查方法对撒拉族近亲和非近亲婚配的遗传效应进行对比观察 ,并进行遗传分析。结果　撒拉族近亲婚配子女的流产率、早亡率和患病率均高于非近亲婚配子女。结论　近亲婚配将增加人群的遗传负荷     

长海县部分先天性及遗传性疾病调查

本文报告对长海县部分先天性及遗传性疾病进行初步调查。总调查人数72523人,调查有关疾病41种,发现病人380人,发病率5.2%。其中最多为智力低下,发病率为1.8‰,低于四川南部地区报告。近亲婚配110对,近亲婚配率(6.3‰),今后需杜绝近亲婚配,对患病个体以后生育时应做好产前诊断,限制患儿出生,以提高人口素质。     

固原地区农村回,汉族近亲婚配调查分析

本文对同原地区农村回、汉民族近亲婚配进行了抽样调查,共调查2024对婚配夫妇及其生育的8489名子代,结果表明回族近亲婚配率明显高于汉族,近亲婚配者所生子女在20岁以前的死亡率和先天性疾病发病率都明显高于非近亲婚配,充分证明了近亲婚配危害性是严重的,并为禁止近亲婚配提供了理论依据。     

近亲婚配与子代出生缺陷关系的调查

1.本文报告了宁夏西吉县回族近亲婚配情况:近亲婚配率为4.15％,畸形发生率为12.00％;估算实际近亲婚配为8～10％,畸形发生率为24.00％左右。 2.通过回顾性群组调查和病例一对照研究,相对危险度RR=1.60,相对危险性近似估算值OR=24,x~2>x~20.01(1)故P<0.01,说明近亲婚配是当地致使畸形发生的重要因素。 3.由于历史原因、宗教信仰、风俗习惯、经济文化和政治因素,促使本地区回族群众间近亲婚配率较高,且延续不断。     

青海省少数民族近亲婚配调查

近亲婚配是人类遗传学和优生学的重要研究课题之一。为了解青海省各世居少数民族的近亲婚配情况 ,笔者自 1 988年以来 ,对青海省 5个世居少数民族进行了调查 ,现报告如下。方法与结果1　方法　选各少数民族较集中的青海省大通县、互助县、循化县、海西州、果洛州等地区进行 5个少数民族近亲婚配的问卷调查 ,共收集1 31 8对家庭 (回收率为 89% ) ,调查结果可信。2　结果2 .1　近亲婚配情况　见表 1。　　结果显示 ,在我们所调查的 5个民族近亲婚配率平均为 4.1 0 % ,只有撒拉族和土族高于平均值 ,其余均低于平均值。 5个民族的平均近婚系数平…     

宜春市城乡近亲婚配的调查研究

目的：调查宜春市城乡近亲婚配车,探讨近亲婚配对子代２０岁前早亡率及子代遗传性疾病发生率的影响。方法：采用整群抽样的方法作现况调查。结果：城乡总近婚率为３．６２％,其中农村为４．３８％,高于市区（０．８５％）。调查表明,结婚年代,男性结婚年龄与近亲婚配有关,而男、女双方结婚次数,女性结婚年龄对近亲婚配影响不大,同时近亲婚配对子代２０岁前早亡率及子代遗传性疾病发生率有明显影响。结论：农村近亲婚配率高于城市,近亲婚配增加子代２０岁前早亡率及子代遗传性疾病的发生率。     

近亲婚配有什么害处

在三代内有血缘关系的人结婚叫近亲婚配,没有血缘关系的人结婚叫非近亲婚配。我国的传统习惯,近亲结婚系指姑表兄妹(姐弟)或姨表兄妹(姐弟)而言。从生物遗传学来看,近亲婚配所生的子女,遗传病及某些疾病的发病率显著增高,所以近亲婚配     

鄂西自治州宝水、卯洞土家族近亲婚配率与类型的调查

近亲婚配的频率与类型是决定群体异质性的主要因子,近亲婚配子代的染色体隐性遗传病将显著增多,因此研究近亲婚配对人类及医学遗传学和优生学都具有一定的意义。     

宁夏回民近亲婚配的调查

近亲婚配是遗传病蔓延的重要原因,所以,在人类遗传学上是一个越来越被重视的问题,因为近亲的个体携带相同有害等位基因的机会较非近亲者多,所以在子女中,常染色体隐性遗传缺陷的发生率比非近亲婚配者高出14.4倍,这些给家庭和社会都带来了极大的不幸,为了提高人口质量,改善人民素质,为禁止近亲婚配提出理论依据,我们对宁夏回民集居的泾源县泾北公社近亲婚配进行了调查,现报告如下。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…