泻痢康胶囊治疗艾滋病慢性腹泻临床研究

目的：观察泻痢康胶囊治疗艾滋病慢性腹泻的临床疗效。方法：选择艾滋病慢性腹泻患者130例,随机分为治疗组与对照组,每组各65例,治疗组口服泻痢康胶囊,每次3粒,每日3次;对照组口服参苓白术散,每次2袋,每日3次。两组均以14 d为1个疗程,观察两组患者症状体征积分及临床疗效。结果：治疗组症状体征积分优于对照组,腹泻次数、大便性状、腹胀腹痛的改善情况与对照组相比,差异有统计学意义（P<0.05）;治疗组有效率100.00%,对照组有效率95.38%,差异有统计学意义（P<0.05）。结论：泻痢康胶囊治疗艾滋病慢性腹泻效果显著。     

参苓白术散联合西药治疗脾肾阳虚型慢性腹泻疗效观察

目的:探讨参苓白术散联合西药治疗脾肾阳虚型慢性腹泻的疗效。方法:选取80例脾肾阳虚型慢性腹泻患者,用随机数字表法分为对照组与研究组各40例,对照组接受蒙脱石散联合枯草杆菌二联活菌汤溶胶囊治疗,研究组在对照组基础上接受参苓白术散治疗,比较两组疗效。结果:研究组治疗总有效率92.50%高于对照组55.00%,差异有统计学意义(P<0.05)。两组间治疗前,比较差异无统计学意义(P>0.05);治疗后,研究组症状积分低于对照组,差异有统计学意义(P<0.05)。研究组不良反应率2.50%低于对照组30.0%,差异有统计学意义(P<0.05)。结论:参苓白术散联合西药治疗脾肾阳虚型慢性腹泻疗效突出,效果优于单用西药治疗。     

痛泻四神汤治疗腹泻型肠易激综合征的疗效观察

目的观察痛泻四神汤治疗腹泻型肠易激综合症的疗效。方法选取2012年1月至2014年6月兰考县中心医院收治的69例腹泻型肠易激综合征患者,随机分为治疗组35例和对照组34例,治疗组给予痛泻四神汤;对照组给予培菲康胶囊。两组均治疗4周,观察两组患者的治疗效果。结果治疗组总有效率91.43%,对照组总有效率68.57%,治疗组总有效率明显高于对照组,差异有统计学意义(P<0.05)。结论痛泻四神汤治疗腹泻型肠易激综合征疗效确切,值得推广。     

双歧杆菌三联活菌胶囊联合肠胃康治疗腹泻型肠易激综合征的疗效观察

目的:观察双歧杆菌三联活菌胶囊联合肠胃康胶囊治疗腹泻型肠易激综合征(IBS)的疗效。方法:将64例腹泻型肠易激综合征患者随机分为两组,治疗组和对照组各32例。治疗组口服双歧杆菌三联活菌胶囊3粒,2次/d,肠胃康胶囊2粒,3次/d;对照组口服肠胃康胶囊2粒,3次/d。疗程均为4周,观察两组临床症状改善情况。结果:治疗组临床症状改善明显优于对照组,两组比较差异有统计学意义(P<0.05),两组均未发现明显不良反应。结论:双歧杆菌三联活菌胶囊联合肠胃康胶囊治疗腹泻型肠易激综合征疗效显著。     

双歧三联活菌联合补中益气丸治疗腹腔镜胆囊切除术后腹泻临床观察

目的探讨双歧三联活菌联合补中益气丸治疗腹腔镜胆囊切除术后腹泻患者的临床疗效及安全性。方法将2014年3月—2015年3月我院收治的68例腹腔镜胆囊切除术后腹泻患者随机分成观察组和对照组(每组34例),观察组患者给予双歧三联活菌联合补中益气丸治疗,对照组患者给予双歧三联活菌治疗,比较两组患者治疗前后的临床症状积分,总体临床疗效以及不良反应。结果治疗4周后,观察组和对照组患者大便次数、大便性状积分和腹痛/腹部不适积分均明显低于治疗前(P<0.05),同时观察组患者大便次数、大便性状积分和腹痛/腹部不适积分低于对照组患者(P<0.05);观察组和对照组患者临床症状总积分均低于治疗前(P<0.05),且观察组患者临床症状总积分低于对照组患者(P<0.05);观察组患者临床疗效总有效率(91.2%)高于对照组患者临床疗效总有效率为(70.6%)(P=0.03);观察组和对照组患者治疗期间均未出现明显药物不良反应。结论双歧三联活菌联合补中益气丸治疗腹腔镜胆囊切除术后腹泻能明显改善患者的临床症状,总体疗效较好,不良反应率较低,值得在临床上推广应用。     

利血生与地榆升白片治疗慢性苯中毒致外周血细胞减少的效果比较

目的 探讨利血生与地榆升白片治疗慢性苯中毒致外周血细胞减少的效果.方法 选取2018年3月至2019年4月本院收治的106例慢性苯中毒患者,按照抽签法分为两组,各53例.对照组给予利血生片治疗,研究组给予利血生片联合地榆升白片治疗.比较两组治疗效果.结果 治疗后,研究组治疗总有效率为84.9％,明显高于对照组的66.0％(P<0.05);研究组外周血白细胞值变化情况优于对照组(P<0.05);研究组不良反应总发生率为9.4％,明显低于对照组的28.3％(P<0.05);研究组细胞减少症复发率为9.4％,明显低于对照组的28.3％(P<0.05).结论 慢性苯中毒致外周血细胞减少患者应用利血生片联合地榆升白片治疗可改善患者的外周血白细胞值,降低不良反应的发生率以及白细胞减少症的复发率,提高患者的治疗效果.     

七味白术散合痛泻要方加味治疗腹泻型肠易激综合征临床研究

目的：观察七味白术散合痛泻要方加味治疗腹泻型肠易激综合征（D-IBS）的疗效。方法：67例D-IBS患者完全随机分为观察组（n=34）与对照组（n=33）。观察组给予七味白术散合痛泻要方加味治疗,1剂/d;对照组给予匹维溴铵50 mg,3次/d;两组疗程均为8周。比较两组治疗前与治疗2、4、8周后腹痛评分、腹泻评分、症状总评分及总有效率的差异。结果：与治疗前比较,两组腹痛、腹泻评分及症状总评分在治疗2、4、8周后均显著降低（P〈0.01）;治疗2周后,观察组的腹泻评分及症状总评分显著低于对照组（P〈0.01）;治疗4、8周后,观察组的腹痛、腹泻评分及症状总评分均显著低于对照组（P〈0.01）;治疗8周后,观察组的总有效率显著高于对照组（P〈0.05）,而两组不良反应发生率无显著性差异（P〉0.05）。结论：七味白术散合痛泻要方加味治疗腹泻型肠易激综合征疗效显著,无明显不良反应。     

美常安治疗慢性腹泻的疗效观察

目的分析来该院接受美常安治疗的慢性腹泻患者的治疗效果。方法随机选用120例来该院接治疗的慢性腹泻患者,采用美常安进行治疗。另选用慢性腹泻患者80例作为对照组,采用美常安之外的药物进行治疗,治疗方法与治疗组相同。通过观察期对慢性腹泻患者治疗前后症状缓解的情况（观察患者的大便性状、每天大便次数的变化）等来对比分析两组的临床治疗效果。结果在治疗2周之后,两组患者的慢性腹泻症状都有明显的改善,治疗组的总治愈率为95.84%,并无不良反应;对照组总治愈率为81.55%,2组进行比较,差异有统计学意义（P〈0.05）。结论美常安对慢性腹泻的临床治疗效果明显,具有临床治疗推广及应用价值。     

脉血康胶囊联合黄芪参归汤治疗脑梗塞的临床观察

目的：探讨脉血康胶囊联合黄芪参归汤治疗脑梗塞的临床疗效。方法：141例脑梗死患者按照治疗方法分为研究组和对照组,在传统西药治疗基础上,对照组给予脉血康胶囊,研究组给予脉血康胶囊联合黄芪参归汤。评价两组的临床疗效、血液流变学指标和不良反应。结果：研究组的基本痊愈率为41.89%,总有效率为93.24%,明显高于对照组的26.87%和80.60%,差异均具有统计学意义（P〈0.05）。两组治疗后血浆黏度、纤维蛋白原、血小板聚集率、全血高切黏度和全血低切黏度都明显降低,与治疗前比较差异均具有统计学意义（P〈0.05）,但研究组改变更明显,与对照组比较差异均具有统计学意义（P〈0.05）。两组未见明显的不良反应。结论：脉血康胶囊联合黄芪参归汤治疗脑梗塞能明显改善血液流变学指标,提高临床疗效,安全性可耐受。     

慢性肺源性心脏病合并消化道出血临床治疗观察

目的：对慢性肺源性心脏病合并消化道出血患者的临床疗效进行观察分析。方法将92例慢性肺源性心脏病合并消化道出血患者根据患者入院尾号的奇偶数分为研究组（47例）和对照组（45例），对照组给予镇咳、平喘以及祛痰等常规治疗，研究组患者在其基础上应用H2受体阻滞剂治疗。比较2组患者的治疗效果。结果研究组患者在此基础上胃液pH值、消化道出血停止时间均优于对照组（P<0.05）；研究组治疗总有效率明显较对照组高（P<0.05）；研究组不良反应率明显低于对照组（P<0.05）。结论治疗慢性肺源性心脏病合并消化道出血患者应用H2受体阻滞剂，能够明显缩短患者消化道出血停止时间，提高治疗有效率，值得临床推广。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Dr.Zhang Ren''''s Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

Luo Lingjie''''s Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

猪肺磷脂注射液联合经鼻持续气道正压通气对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性的影响

目的 探讨猪肺磷脂注射液联合经鼻持续气道正压通气(NCPAP)对呼吸衰竭早产儿的临床疗效及肌酸激酶同工酶活性(CK-MB)的影响.方法 选取呼吸衰竭早产儿80例,分为观察组和对照组各40例.对照组采用NCPAP给氧治疗,观察组给予NCPAP给氧联合猪肺磷脂气管内给药.观察两组患儿治疗前及治疗12h、24 h后PaO2、PaCO2、血氧饱和度(SaO2)、pH的变化情况,检测治疗前及治疗5d后血清CK-MB水平;评估两组患儿的临床治疗效果.结果 两组患儿PaO2、PaCO2、SaO2、pH比较,差异均有统计学意义(P＜0.05),其中观察组治疗后的PaO2、SaO2、pH均高于对照组,PaCO2则低于对照组.两组的PaO2、SaO2、pH均随观察时间延长而升高(P＜0.05),PaCO2均随观察时间的延长而降低(P＜0.05).观察组治疗有效率为87.5％,显著高于对照组的70.0％ (P ＜0.05).治疗5d后两组患儿血清CK-MB水平均较前降低(P＜0.05),且观察组明显低于对照组(P＜0.05).结论 猪肺磷脂注射液气管内给药联合NCPAP可以显著降低呼吸衰竭早产儿CK-MB的含量,提高治疗有效率,起到很好的呼吸循环支持作用.     

Survey and practice of reporting quality of randomized controlled clinical trials on traditional Chinese medicine

Evidence obtained from randomized controlled trials （RCTs） has been generally accepted as the gold standard in the evaluation of clinical effectiveness. Readers need to understand the trial design, implementation, results, analysis and interpretation, so as to fully Jnderstand the results of RCTs. Thus, the investigators of RCTs have to report these items in a complete, accurate and clear manner. Since 1998, we have conducted several evaluations on the reporting quality of RCTs published in Chinese journals on traditional Chinese medicine （TCM） and results have shown that there is an urgent need for higher quality RCTs on TCM.     

TCM Treatment of Ankylosing Spondylitis by Tonifying the Kidney and Strengthening the Governor Vessel

Ankylosing spondylitis is a chronic and progressive disorder with inflammation mainly involving the central axis joints. It mainly affects the cervical spine and the lumbosacral area, with the pathogenesis closely related to the kidney and the Governor Vessel (GV). TCM holds that the syndrome is deficiency in origin and excess in superficiality, which is due to insufficiency of the kidney, deficiency of GV, and blocking of the channels with the invasion of exogenous evil, leading to poor circulation of qi and blood and malnutrition of the bones, muscles and joints. The TCM method of tonifying the kidney and strengthening GV to regulate circulation of qi and blood and check the arthralgia pain should be adopted, with the Kidney-Tonifying and GV Strengthening Decoction (益肾强督汤) prescribed.     

IMPROVING P-gp EXPRESSION IN HUMAN MONONUCLEAR CELLS IN VITRO TRANSFECTED BY MULTIDRUG RESISTANCE-1 mRNA

CHEMOTHERAPY playsa greatrolein the treat- ment of malignanttumors,especiallyingynecolo- gicalones.But inanticancerchemotherapy,leuko-cytopeniaisfrequentlytheprimarydose-limitingsideeffect factor.Moreover,cancersarefrequentlychemoresistantbe-causeof overexpressionof P-glycoprotein(P-gp), which isencodedby multidrugresistancegene (MDR1 ) and detectableinup to50% ofhuman cancersand renderscellsresistancetoanticancerdrugs.The safetyand potentialtherapeuticbenefitof mdr1 gene transferredto h…