超重肥胖儿童代谢综合征组分的因子分析

目的 分析超重肥胖儿童代谢综合征(MS)各组分的聚集特征,探索儿童代谢综合征的病理生理机制.方法 研究对象来自前期工作收集的2批样本,为北京市835名14,15岁超重肥胖儿童,其中样本1有93人(超重62人,肥胖31人)、样本2有742人(超重371人,肥胖371人).先对样本1中超重和肥胖儿童代谢综合征的组分(包括体质指数、腰围、血糖、血脂、血压)进行因子分析,后对样本2进行因子分析用以验证和确认分析结果.结果 超重儿童MS组分共提取4个因子,脂代谢因子(LDL-C,TC,TG,HDL-C)、血压因子(SBP,DBP)、肥胖因子(WC,BMI)和糖代谢因子(FPG,HDL-C),累积方差贡献率达到77.44%;肥胖儿章MS组分共提取3个因子,肥胖-血压因子(WC.BMI,SBP,DBP)、脂代谢因子(LDL-C,TC,TG,HDL-C)和糖代谢因子(FPG),累积方差贡献率达到69.84%.结论 儿童MS的病理生理机制复杂,任何一个因子都不能单独解释MS的全部变量.     

杭州某社区人群血尿酸水平与代谢综合征各组分的相关性研究

目的 探讨杭州市某社区人群血尿酸水平与代谢综合征（MS）各组分肥胖、血压、血糖和血脂的相关性.方法 对2013年杭州市四季青社区参加体检的18岁以上居民2 288人进行调查,分别按该人群中男性和女性血尿酸水平的四分位数法将男女性各分为4组,测定体重指数（BMI）、腰围（WC）、收缩压（SBP）、舒张压（DBP）、空腹血糖（FPG）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）和尿酸（UA）等指标.结果 在男性人群中,SBP、DBP、WC、TC和TG均随着血UA水平的升高而显著升高（P＜0.05）,而HDL-C则显著降低（P＜0.05）;在女性人群中,年龄、SBP、DBP、WC、FPG、TC、TG和LDL-C均随着血UA水平的升高而显著升高（P＜0.05）,而HDL-C则显著降低（P＜0.05）;logistic回归分析显示,在男性人群中,BMI、SBP和TG与血UA水平升高呈显著正相关（P＜0.05）;在女性人群中,BMI、TG和FPG与血UA水平升高呈显著正相关（P＜0.05）.结论 高尿酸血症与中心性肥胖、血压高、血糖高及血脂异常等MS组分之间有密切关系,血UA水平与女性的相关性更强.因此,有效地控制血UA水平是预防和治疗MS的重要途径之一.     

体重与血压,血糖,血脂,血尿酸关系初探

为探讨高校知识分子各年龄段的标准体重及其与血压、血糖、血脂、血尿酸的关系，在排除可能的影响因素后，对535名知识分子健康普查样本进行统计分析。结果显示，男女BMI和SBP、DBP、FPG、TC、HDLC、TG、UA值随年龄递升而增加，但男性FPG、TG、UA至老年期有回落现象，存在有显著性差异（P＜0．01）；SBP、OBP、FPG、TC、TG、UA随BMI增加而增加，存在正相关关系（P＜0．05或＜0．01），HDL－C随BMI增加而减低，存在负相关关系（P＜0．05或＜0．01），其相关关系可被高龄、肥胖所掩盖。     

不同营养状况儿童代谢综合征发生情况分析

目的了解超重、肥胖儿童代谢综合征及其组分的发生情况，为预防儿童肥胖和代谢综合征提供依据。方法选择北京市3所中学和2所小学，根据2005—2006年中小学生身高、体重体检结果进行体重正常、超重和肥胖学生的筛选，对自愿参加的1042名7～15岁学生进行身高、体重、腰围、血压的测量，并采集空腹肘静脉血测定血清总胆固醇（TC）、三酰甘油（TG）、高密度脂蛋白胆固醇（HDL—C）、低密度脂蛋白胆固醇（LDL—C）和空腹血糖（FPG）。结果除TC在不同体重组女生间差异无统计学意义外（P〉0．05），MS各组分均数在不同体重组男、女儿童间差异均具有统计学意义（P值均〈0．01）。SBP，DBP，WC，LDL—C，TG及FPG水平均为肥胖儿童〉超重儿童〉体重正常儿童，HDL—C水平为肥胖儿童〈超重儿童〈体重正常儿童。除高血糖检出率在不同体重组女生间差异无统计学意义外（P〉0．05），MS及MS各组分异常检出率在不同体重组男、女儿童间差异均有统计学意义（P值均〈0．05），检出率均为肥胖儿童〉超重儿童〉体重正常儿童。结论超重和肥胖儿童较体重正常儿童存在明显的血压、血脂和血糖异常等MS表现。应加强对超重和肥胖儿童MS各组分的检测，防治儿童肥胖，减少MS的发生。     

福州市体检人员代谢综合征患病率及相关因素研究

目的了解了福州市居民代谢综合征（MS）的患病率及其分布特征。方法采用横断面研究,对健康体检人员进行调查与体检,并进行血清学检查。结果MS患病率为5．58％,其中男性患病率为7.38％,高于女性的3．19％,差别具有统计学意义（P〈0．05）;MS中各项代谢紊乱的检出率以肥胖为首,其次为高甘油三酯（TG）血症、高血压、空腹血糖（FPG）过高和低高密度脂蛋白（HDL—C）血症;随着年龄增加,MS患病率升高;MS中最多见的表现形式是肥胖＋高血压＋血脂紊乱。结论福州市体检人员MS及其组成成分患病率较高,应提倡合理膳食,戒烟限酒,控制体重,积极参加体育锻炼,定期体检,做好三级预防,尽量避免代谢综合征及相关组分异常对健康造成的危害。     

乌鲁木齐市体检人群中代谢综合征患者组分的因子分析

目的分析乌鲁木齐市体检人群代谢综合征的患病特点,探讨代谢综合征病理生理机制。方法选择乌鲁木齐市某体检中心代谢综合征患者数据,描述性分析不同年龄、不同性别的代谢综合征患者各组分患病情况及聚集情况。采用因子分析方法,探讨不同性别代谢综合征9项指标组分:体质指数、空腹血糖、收缩压、舒张压、高密度脂蛋白、低密度脂蛋白、腰围、甘油三酯、总胆固醇的潜在支配因子。结果 (1)代谢综合征各组分患病率由高到低依次为超重或肥胖、高血压、高血糖、高血脂。(2)最常见的代谢综合征组合形式为肥胖+高血压+高血糖。(3)不同性别因子分析显示,肥胖因子、血压因子、脂代谢因子、糖耐量因子是代谢综合征的潜在支配因子。共性因子的累积贡献率在男性和女性中分别为71.47%和67.38%。男性中主导因子为肥胖因子,女性为血压因子。结论乌鲁木齐市代谢综合征病理生理机制复杂,预防代谢综合征的发生应从以上4个因子出发。尤其是男性注意控制体重,女性注意控制血压。     

老年人群体质指数和腰围与心血管病危险因素聚集的研究

目的探讨老年人群体质指数、腰围与心血管病危险因素聚集的关系。方法对654名老年人进行健康查体,对不同体质指数（BMI）、腰围（WC）老年人的收缩压（SBP）、舒张压（DBP）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和空腹血糖（FPG）平均水平及高血压、高TC、高TG、低HDL-C、糖尿病检出率进行分析,对心血管病危险因素聚集性进行分析。结果BMI、WC升高是老年人最常见的心血管病危险因素。随着BMI、WC的增加,老年人SBP、DBP、TC、TG、FPG平均水平明显升高,HDL-C平均水平降低,高血压、高TC、高TG、糖尿病的检出率明显增高。BMI为24．0～27．9ks／m^2时,老年人高血压、高TC、高TG、糖尿病的检出率分别为59．74％、3．89％、28．57％、10．06％,患高血压、高TG、糖尿病的危险性分别是正常BMI的1．65、1．88、1．85倍;BMI≥28．0ks／m^2时,老年人高血压、高TC、高TG、糖尿病的检出率分别为83．05％、5．08％、35．59％、15．25％,患高血压、高TG、糖尿病的危险性分别是正常BMI的5．44、2．60、2．98倍。男性WC≥85cm、女性WC≥80cm时,老年人高血压、高TC、高TG、糖尿病的检出率分别为66．15％、4．47％、29．57％、10．12％,患高血压、高TC、高TG的危险性分别是正常WC的3．52、6．51、1．68倍。BMI≥24．0kg／m^2或男性WC≥85cm、女性WC≥80cm的老年人伴随多个心血管病危险因素的比例显著增高。结论BMI、WC升高是导致老年人群心血管病危险因素聚集的重要因素。     

中老年腰围与血脂水平及脂代谢异常的关系

目的探讨中老年人群腰围（WC）与血脂水平及脂代谢异常的关系。方法于2008年采用分层整群抽样的方法,抽取成都地区40～79岁的居民5205人进行身高、体重、腰围、血脂等测量,并进行问卷调查。结果中老年腹型肥胖人群三酰甘油（TG）及低密度脂蛋白胆固醇（LDL—C）水平均明显高于非腹型肥胖人群,高密度脂蛋白胆固醇（HDL—C）水平明显低于非腹型肥胖人群;中老年女性腹型肥胖人群总胆固醇（TC）水平明显高于中老年女性非腹型肥胖人群。中老年腹型肥胖人群高TG血症、低HDL—C血症、高LDL—C血症患病率均明显高于非腹型肥胖人群;中老年女性腹型肥胖人群高TC血症患病率高于非腹型肥胖人群,差异均有统计学意义（P〈0．01）。结论中老年人群TG、LDL—C、HDL—C水平及中老年女性人群TC水平,中老年人群高TG血症、低HDL—C血症、高LDL—C血症及中老年女性人群高TC血症患病率均与WC相关,是心血管危险因素之一。进行中老年人群超重肥胖的干预,尤对腹型肥胖人群加强干预,对于脂代谢异常的防治有着重要意义。     

603例新诊断2型糖尿病患者的临床特征分析

目的分析新诊断2型糖尿病（T2DM）患者的临床特征。方法纳入2011年6月-2013年6月就诊的新诊断T2DM患者,随机选择287例,同期于我院体检中心体检发现的新诊断T2DM患者316例;记录患者性别、年龄、体重指数（BMI）等基本资料及血糖、血脂及慢性合并症等病历资料,根据年龄、BMI、性别及诊断原因分组,采用1．1检验统计学方法对比各组间的差异;结果患者发病平均年龄（48±13）岁,青年（年龄≤45岁）占39％,中年（46—59岁）占43％,老年（年龄≥60岁）占18％。诊断时BMI为（26．1±3．6）kg／m2,超重占42％,肥胖占27％;既往最高BMI为（28．3±3．7）kg／m2,其中,超重占39％,肥胖占51％。有症状组年龄、BMI、血糖、血脂及糖化血红蛋白（Crib）较高,与无症状组比较,差异有统计学意K（p〈0．05）;男性组年龄、GHN较低,BMI、甘油三酯（TG）较高,与女性组比较,差异有统计学意义（p〈0．05）。BMI_if-常组TG、胆固醇（TC）、GHB、空腹血糖（FPG）、低密度脂蛋白胆固醇（LDL—C）明显低于超重组,高密度脂蛋白胆固醇（HDL—c）明显高于超重组,差异有统计学意义（p〈0．05）;正常组TG、TC、GHB、餐后2小时血糖（2HPG）、LDL—C明显低于肥胖组,HDL—C、年龄明显低于肥胖组,差异有统计学意义（p〈0．05）。超重组TG、TC、LDL—C明显低于肥胖组,HDL—C明显高于肥胖组,差异有统计学意K（p〈0．05）。青年组2HPG、BMI、GHB高于中年组,LDL—c低于中年组,差异有统计学意义（p〈0．05）。青年组taPG、2HPG、BMI、TG、TC、GHB明显高于老年组,差异有统计学意义（p〈0．05）。中年组FPG、TG、TC、HDL-C明显大于老年组,差异有统计学意义（p〈0．05）。结论本组新诊断T2DM患者发病年龄低,诊断不及时,肥胖、尤以既往肥胖较为显著,合并血脂异常、慢性并发症     

安徽省2415名老年人群代谢综合征患病特征及因子分析

目的了解安徽省老年人群代谢综合征患病特征,分析男女代谢综合征各组分的聚集特征。方法在安徽省疾病监测地区按多阶段分层整群随机抽样的方法,对18岁及以上居民7182人进行调查体检,采集信息完整、60岁及以上人群样本共2 415人,分析人群代谢综合征的特点并进行因子分析。结果老年人群代谢综合征患病率为20.75%,男性患病率16.78%,低于女性患病率24.31%(χ2=20.754,P0.001)。男性腰围、低高密度脂蛋白血症(HDL-C)平均水平高于女性(P0.001),而女性低密度脂蛋白血症(LDL-C)、收缩压平均水平高于男性(P0.05)。因子分析提取了4个主要因子,因子方差贡献率:男性、女性分别为75.666%、75.614%;男性以超重肥胖是主要影响因子,其后依次是高血压因子、血糖因子、血脂紊乱因子,女性也以超重肥胖因子为首,其后依次是血脂紊乱因子、高血压因子、血糖因子。结论安徽省部分老年人群代谢综合征以超重肥胖、血脂紊乱、高血压、高血糖综合表现为主要特征。     

代谢综合征组分的正交因子分析

结合代谢综合征(MS)组分的正交因子分析实例,介绍正交因子分析模型的原理及其在医学研究中的应用.使用1998-2001年上海社区人群MS患病率的现况研究资料,选取35～65岁资料完整的1877例女性作为研究对象,使用SPSS统计软件对MS相关组分进行正交因子分析,并计算因子得分.因子分析提取的前6个互不相关的公共因子可以基本反映原始指标86%的信息.通过正交旋转后6个公共因子的实际意义很清晰,依次主要反映肥胖、血压、血糖、胰岛素、TG和HDL-C指标的信息.根据给出的因子得分矩阵计算个体各因子得分及总得分.结果表明,MS的同一组分(除血脂外)内的变量呈高度相关性,但不同组分间虽有统计学关联,但非高度相关.正交因子分析的价值在于探查有高度相关关系的变量群,进而为探究其共同的潜在病理生理机制提供线索.     

Use of confirmatory factor analysis for the identification of new components of the metabolic syndrome: the role of plasminogen activator inhibitor-1 and Haemoglobin A1c

BACKGROUND AND AIM: This study was aimed to identify additional components of metabolic syndrome from a set of cardiovascular risk markers. METHODS AND RESULTS: The homeostasis model assessment of insulin resistance (HOMA-IR), C-reactive protein, fibrinogen, plasminogen activator inhibitor-1 (PAI-1), von Willebrand factor, homocysteine, Haemoglobin A1c (HbA1c), and lipoprotein(a) were assessed in a population-based sample of 902 nondiabetic adult subjects. Those biomarkers that were associated with metabolic syndrome were evaluated by multiple regression analysis, along with other traditional cardiovascular risk factors. Confirmatory factor analysis (CFA) was used to test the hypothesis that both the established components of metabolic syndrome and the novel variables identified by the regression analysis were associated with a single underlying factor. HOMA-IR, PAI-1 and HbA1c were the only biomarkers independently related to metabolic syndrome. CFA validated a one-factor model that included these variables. Moreover, the indices of goodness of fit were better for this expanded model than those obtained for a previously validated one-factor model that was restricted to the conventional elements of the syndrome. CONCLUSIONS: These findings show that PAI-1 and HbA1c are singularly linked to metabolic syndrome. Their elevation is presumably another manifestation of the same pathophysiological mechanism that underlies the recognized traits of the syndrome.     

中国居民代谢综合征与脑卒中的相关性研究

目的探讨中国居民代谢综合征与脑卒中的关系。方法数据来源于2002年中国居民营养与健康状况调查,选择15岁以上人群48633例,其中男性23080例,女性25553例。代谢综合征的定义参考中华医学会糖尿病分会2004年建议的标准。结果单因素logistic回归分析表明,代谢综合征与脑卒中呈正相关,OR值为5.998(95%CI4.799~7.496),多因素分析调整年龄、性别、6类地区、教育程度、中重度体力活动时间、吸烟、饮酒后代谢综合征与脑卒中仍具有统计学相关性,OR值为3.114(95%CI2.432~3.987)。代谢综合征的所有组分中,高血压与脑卒中的相关性最强,且随着代谢综合征组分在个体聚集越多(趋势性检验P<0.0001),患脑卒中的可能性越大。结论中国居民代谢综合征与脑卒中的患病有关。     

11省市队列人群代谢综合征的流行病学研究

目的　探讨队列人群代谢综合征的流行病学特征。方法　在 1992年对 11省市队列人群 (35～ 6 4岁 ) 2 7739人进行基线危险因素的调查。计算队列人群代谢综合征患者各种因素的均值±标准差和标化患病率。结果　 (1) 11省市队列人群有代谢综合征者高腰围的百分率最高 ,男性为89 0 % ,女性为 85 1%。其他主要指标 (除高密度脂蛋白 )男性均高于女性 ;(2 )代谢综合征患病率为13 3% ,其中男性为 12 7% ,女性为 14 2 % ,且随年龄的增加而增长 ;(3)多元logistic分析结果表明 ,腰围和糖尿病家族史是男性代谢综合征患者的危险因素 ,女性为腰围和高血压家族史。高密度脂蛋白增高是代谢综合征的保护因素。结论　 11省市队列人群代谢综合征患病率较高 ,腰围增大是代谢综合征重要的危险因素。     

代谢综合征组分影响心脑血管疾病发生的前瞻性研究

目的 探讨代谢综合征(MS)组分聚集对人群心脑血管疾病发生风险的影响.方法 2004年对广西南宁市部分事业单位7917名进行MS流行病学横断面调查,并在此基础上采用整群抽样方法随机抽取其中一个事业单位500名无心脑血管疾病史的中老年人纳入研究,根据MS组分的聚集数量分为4组,随访3.5年,每年定期测量血糖、血压、血脂等生理生化指标,并按WHO-MONICA方案心血管病事件(CVD)的诊断标准确定发生的心血管病事件和死亡事件,作为终点事件.结果 (1)MS组分数量多的组别,其体重指数、腰围、收缩压、舒张压、空腹血糖、餐后血糖、甘油三酯生理生化指标的均数高于MS组分数量少的组别.(2)4个组别人群心脑血管疾病的发生率分别为2.97%、4.19%、7.97%、11.88%.(3)logistic回归分析:相对于非MS人群,MS人群发生心脑血管事件的RR=2.389(95%CI:1.2～4.756);相对于0组,1、2、MS组人群发生心脑血管事件的RR值分别为1.41、2.68、4.00,调整年龄和性别后Cox模型分析:相对于0组,1、2、MS组的人群发生心脑血管事件的RR值分别为1.29、2.47、3.67.(4)Kaplan-Meier分析:MS组人群患心脑血管疾病的累积风险高于0、1、2组人群.随访42个月结束时,MS组人群患心脑血管疾病的累积风险达12.7%.结论 随着MS组分聚集的增加,患者发生心脑血管疾病的风险增加;随着自然病程进展,MS组分聚集越多的患者发生心脑血管疾病的累积风险越大.     

Association of change in the type of job with prevalence of components of the metabolic syndrome-special reference to job stress

OBJECTIVE: It is well established that job stress is a leading cause of cardiovascular disease. The relationship with the metabolic syndrome, however, has received only limited attention. The present study was designed to investigate associations between change of the type of job and the prevalence of metabolic syndrome components from the aspect of on-the-job stress and alteration in life style. METHODS: Thirty-six male workers of the manufacturing department were transferred to the carsales department at the same automobile company in 1992 to 1993. These same workers were transferred back to the manufacturing department after two years. We compared the first health-check data before the transfer in 1992 (Term A), a second set of data two years after transfer in 1994-95 (Term B) and a third set of data two years following transfer back to the manufacturing department in 1996-1998 (Term C). The workers were requested to provide information about drinking and smoking habits, and answer Karasek's questionnaire and a simple stress questionnaire in order to clarify the possibility of job stress in occurrence of the metabolic syndrome, defined in terms of obesity, hypertension, dyslipidemia, and impaired glucose tolerance as components. RESULTS: Five workers had two or more components of the metabolic syndrome before the transfer to the car-sales department (Group I). One demonstrated improvement, three no change, and one increase in symptoms from A to B. Seven workers had more than two components after the transfer to car-sales department (Group II), and six of them exhibited decrease two years following transfer back to the manufacturing department. Five of them also showed elevated liver enzymes in serum with the appearance of the components, and three of them demonstrated recover. Three workers had two components of the metabolic syndrome only at time point C (Group III), while the remaining 21 workers had 0 to one component throughout the observation period (Group IV). Amount of drinking and smoking increased significantly when working in the sales department but these items returned to the previous values after rejoining manufacturing, though differences were not observed between workers with (Group II) and without (Group IV) components of the metabolic syndrome. Body mass index (BMI) and alanine aminotransferase (ALT) increased significantly when workers moved to the sales department and that was significant in Group II as compared to Group IV. Three components of Karasek's JCQ changed significantly during job transfer, though differences were not observed between the workers with (Group II) and without (Group IV) components of the metabolic syndrome. Logistic regression analysis with age, lifestyle, Karasek's JCQ, and ALT revealed that elevation of ALT value was associated with having two or more components of metabolic syndrome, while hours of sleep demonstrated an inverse association. CONCLUSION: Elevated ALT and reduction of sleep hours may be associated with development of the metabolic syndrome in workers who change their type of job.     

Physical activity patterns and metabolic syndrome in Costa Rica

ObjectiveTo examine whether total physical activity or activity patterns are associated with metabolic syndrome and its components.MethodsParticipants include 1994 controls from a case–control study of non-fatal myocardial infarction in Costa Rica (1994–2004). Physical activity was assessed via self-administered questionnaire and patterns were identified using principal components analysis. Metabolic syndrome was assessed via blood samples and anthropometry measurements from in-home study visits. Prevalence ratios (PRs) and 95% confidence intervals (CIs) were calculated using log binomial regression. Adjusted least squares means of metabolic syndrome components were calculated by quintile of total activity and pattern scores.ResultsFour activity patterns were identified: rest/sleep, agricultural, light indoor activity, and manual labor. Total activity was not associated with metabolic syndrome. Metabolic syndrome prevalence was 20% lower in participants with the highest scores on the agricultural job pattern compared to those with the lowest (PR: 0.80, 95% CI: 0.68–0.94). Higher total activity was associated with lower triglycerides and lower HDL cholesterol. Higher scores on each pattern were inversely associated with metabolic syndrome components, particularly waist circumference and fasting blood glucose.ConclusionsPatterns or types of physical activity may be more strongly associated with metabolic syndrome and its components than total activity levels.     

The association between food patterns and the metabolic syndrome using principal components analysis: The ATTICA Study

BACKGROUND: Dietary habits have been associated with the prevalence of the metabolic syndrome. OBJECTIVE: The associations between foods or food patterns and the characteristics of the metabolic syndrome were evaluated. DESIGN: Cross-sectional survey. SUBJECTS: During 2001 to 2002, 1,514 men (aged 18 to 87 years) and 1,528 women (aged 18 to 89 years) without any clinical evidence of cardiovascular disease were randomly enrolled, from the Attica region in Greece. MAIN OUTCOME MEASURES: Dietary habits were evaluated using a semiquantitative, food frequency questionnaire. Characteristics of the metabolic syndrome (ie, blood pressure, waist circumference, glucose, triglycerides, and high-density lipoprotein cholesterol) were also measured. STATISTICAL ANALYSIS: Principal components analysis was applied to extract dietary patterns from 22 foods or food groups. Multivariate regression analysis evaluated the associations between the extracted dietary patterns and characteristics of the metabolic syndrome. RESULTS: Six components were derived explaining 56% of the total variation in intake. Component 1 was characterized by the consumption of cereals, fish, legumes, vegetables, and fruits (explained variation 19.7%); component 2 was characterized by the intake of potatoes and meat (explained variation 11.7%), component 6 was characterized by alcohol intake (explained variation 4.8%), whereas the other components were mainly characterized by consumption of dairy and sweets. After adjusting for various confounders, component 1 was inversely associated with waist circumference, systolic blood pressure, triglycerides, positively associated with high-density lipoprotein cholesterol levels, and inversely with the likelihood of the metabolic syndrome (odds ratio [OR] 0.87, 95% confidence interval [CI] 0.79 to 0.97), whereas components 2 and 6 were positively correlated with the previous indexes, and the likelihood of having the metabolic syndrome (OR 1.13, 95% CI 1.05 to 1.21 and OR 1.26, 95% CI 1.21 to 1.33). CONCLUSIONS: A dietary pattern that includes cereals, fish, legumes, vegetables, and fruits was independently associated with reduced levels of clinical and biological markers linked to the metabolic syndrome, whereas meat and alcohol intake showed the opposite results.     

女性绝经前后代谢综合征与胆结石发病情况关联

  目的  分析金昌队列中女性人群胆结石发病率,探索绝经前后女性代谢综合征及其各组分与胆结石发病的关系。  方法  采用前瞻性队列研究方法,以队列人群基线资料中未患胆结石的女性为研究对象,分析代谢综合征及其各组分对胆结石发病的影响。  结果  本研究共纳入4 196人,随访结束时有胆结石者195例,占比4.65%。在绝经后女性人群中,有代谢综合征者胆结石发病率为10.91%,高于无代谢综合征者(5.68%,χ2 ＝19.982,P < 0.001)。随着异常组分个数的增加,胆结石发病率逐渐增高(χ2 _趋势＝30.340,P < 0.001),且在有多个代谢组分异常时达到最大,为12.24%。当调整混杂因素后,在绝经后女性人群中,多个代谢组分异常的胆结石发病风险是各代谢组分均正常人群的6.839倍(95% CI:1.665~28.084,P＝0.008)。在绝经后女性人群中,腰围、TG、HDL-C、血压和FPG异常者胆结石的发病率均高于正常者(均有P < 0.05)。当调整混杂因素后,绝经后女性人群中腰围(HR=1.805,95% CI:1.204~2.704,P＝0.004) 和HDL-C(HR=1.451,95% CI:1.071~1.965,P＝0.016)异常者胆结石的发病风险仍高于正常者。在代谢综合征有无分组、代谢综合征异常个数分组以及各组分正常或异常分组中,绝经后女性人群胆结石的发病率均高于绝经前(均有P < 0.05)。  结论  绝经后女性人群中胆结石发病与代谢综合征有关,且女性人群中胆结石发病率受绝经状态的影响。     

Le CAP (Controlled attenuation parameter), un indicateur de risque et de sévérité du syndrome métabolique ?

ObjectivesThe aim of this study is to investigate the relationship between CAP (Controlled Attenuation Parameter) values and the different components of the metabolic syndrome.Materials and methodsThis is a cross-sectional study including all patients over 18 years of age with chronic liver disease who were referred to our center for a non-invasive assessment of liver fibrosis. The measurement of hepatic elasticity and CAP was carried out concomitantly using the M or XL probe of Fibroscan® by trained operators.ResultsThe prevalence of metabolic syndrome in patients with CAP ≥ 238 dB/m was higher than in patients with CAP < 238 dB/m, and significantly increased with the severity of hepatic steatosis (p < 0.001). CAP values were higher in patients with metabolic syndrome and significantly increased with the increase in the number of metabolic syndrome components (p < 0.001). In univariate analysis, there was a statistically significant positive linear relationship between CAP values and components of metabolic syndrome except for blood glucose and HDLc level. In multivariate analysis, only waist circumference and triglycerides level were significantly related to CAP values.ConclusionThis study shows that there is a significant correlation between CAP and the different components of the metabolic syndrome. CAP could be an indicator of risk and severity of metabolic syndrome.