腮腺腺淋巴瘤-结核联合性病变

腺淋巴瘤又称Warthin瘤、淋巴囊腺瘤或淋巴乳头状囊腺瘤,绝大多数发生于腮腺及腮腺的淋巴结,腮腺腺淋巴瘤伴结核感染极为少见,国内外仅有数例文献报道。我们报道一例新增的左腮腺区的腺淋巴瘤及腮腺结核。     

腮腺多灶性腺淋巴瘤一例报告

腺淋巴瘤又称乳头状淋巴囊腺瘤或 Warthin 血氏瘤,是发生在涎腺组织内的一种生长缓慢的良性肿瘤。据国外报道,腺淋巴瘤是腮腺的第二位常见良性肿瘤,占原发性腮腺肿瘤的0.6～30%。国内文献报告在不     

腮腺腺淋巴瘤与老年人的关系(附8例报告)

<正> 腺淋巴瘤(Adenolymphoma)又称为淋巴乳头状囊腺瘤(Papillary Cystdenoma Lymphomatsum)或瓦尔丁氏瘤(Warthin’s Tumor)。近年来,通过形态学的研究证明,本病发生于腮腺的淋巴结内异位腺管的肌上皮细胞,在胚胎的腮腺淋巴结中和肿瘤附近的淋巴结内,均可以找到这些腺管。免疫学的研究证明,肿瘤的淋巴结组织,主要是由T细胞和B细     

Warthin瘤粘液表皮样癌癌变1例

Warthin瘤为一种由腺上皮构成的肿瘤，在涎腺良性肿瘤中发生率仅次于多形性腺瘤，Warthin瘤占涎腺上皮性肿瘤的5％～10％。绝大多数发生于腮腺和腮腺的淋巴结，偶见于下颌下腺及小涎腺.Warthin瘤癌变是极为罕见的，近年偶见Warthin瘤有癌变的报道。现将我科1例Warthin瘤恶变，报告如下：     

Warthin样黏液表皮样癌、Warthin瘤合并黏液表皮样癌及伴黏液化生3例

Warthin样黏液表皮样癌是一种新近发现的涎腺黏液表皮样癌亚型,形态类似于Warthin瘤,但具有与黏液表皮样癌相似的t(11;19)(q21;p13)染色体易位.因此鉴别诊断非常重要.Warthin瘤合并黏液表皮样癌极为罕见.本文报告了1例Warthin样黏液表皮样癌、1例Warthin瘤合并黏液表皮样癌、1例Wa...     

牙源性角化囊性瘤恶变1例

牙源性角化囊性瘤（KCOT）是一种常见的颌骨牙源性囊性病损,临床上牙源性角化囊性瘤复发常见,而恶变较少见。本文报道1例由牙源性角化囊性瘤恶变为原发性骨内鳞状细胞癌的病例。     

Warthin氏瘤中上皮成份的免疫组织学研究

Warthin 氏瘤(腺淋巴瘤)是一种涎腺的良性肿瘤,主要发生于腮腺。对其上皮成份的组织来源一直有争论。为此,作者采用免疫组织学研究,以观察6种标记蛋白在正常腮腺中的分布以及Warthin 氏瘤上皮成份的染色特征。     

良性淋巴上皮病恶变为淋巴瘤2例报告

良性淋巴上皮病变中淋巴成份恶变即为涎腺内或涎腺外的恶性淋巴瘤，而上皮成份可恶变为恶性淋巴上皮病。类肿瘤型良性淋巴上皮病如发生恶变，其间隔时间可长达２０年，平均为０５～２９年，其发生率国外资料为０１６％，国内报道为０３１％。近期本院涎腺专科门诊有二例确诊为良性淋巴上皮病患者最后演变为恶性淋巴瘤。现报告如下。１　病例介绍　　病例１：女性，７１岁，５年前发现口咽鼻眼干燥，日渐加重，同时右腮腺区逐渐弥漫性肿大。３月前偶然发现右侧耳下一蚕豆大小肿块，唇腺活检示良性淋巴上皮病。给予ＳＳ糖浆、氯喹、地塞…     

颌下腺腺淋巴瘤1例报告

<正> 腺淋巴瘤又名淋巴乳头状囊腺瘤或 Warthin 氏瘤。1895年由 Hilde brand 氏首次描述;1929年 Wa-rthin 将该瘤命名为乳头状淋巴囊腺瘤。该瘤属于涎腺的良性肿瘤,几乎全部发生于腮腺,约占96.2％～99.2％,极少数见于颔下腺以及其它小腺体。本例通过病理学检查结合临床手术证实为发生于颌下腺的腺淋巴瘤。患者女,26岁。主诉:左颌下区有一无痛性肿块8年,近半月左右肿块增大较速。患者因左颌下肿块于1988年4月28日入院。3年前,患者自觉左颌下有一豌豆大小的肿块,无痛不痒,无其他症状,时大时     

老年人常见涎腺肿瘤及类肿瘤疾病的诊断治疗

老年人常见的涎腺肿瘤和类肿瘤病变为Warthin瘤,嗜酸细胞腺瘤,涎腺良性肥大,坏死性涎腺化生,良性淋巴上皮病,慢性硬化性颌下腺炎,腺癌,导管癌等.在诊断方面,除了99m锝对Warthin Tumor具有特殊意义外,绝大多数依据病理诊断.坏死性涎腺化生、硬化性颌下腺炎易误诊为肿瘤.治疗除一些炎性病变外,则是以手术为主.     

Lymphoid lesions of salivary glands: malignant and benign

Lesions of salivary glands with a prominent lymphoid component are a heterogeneous group of diseases that include benign reactive lesions and malignant neoplasms. Occasionally, these pathologic entities present difficulties in the clinical and pathological diagnosis and prognosis. Lymphoepithelial sialadenitis, HIV-associated salivary gland disease, chronic sclerosing sialadenitis, Warthin tumor, and extranodal marginal zone B-cell lymphoma are examples of this pathology that are sometimes problematic to differentiate from one another. In this paper the author reviewed the main clinical, pathological and prognostic features of these lesions.     

Lymphoma of mucosa-associated lymphoid tissue (MALT) arising in the parotid gland

Malignant lymphoma of the parotid gland is a rare condition. The authors present the case of a 59-year-old woman with primary malignant lymphoma arising from the parotid gland, in which they resected the tumors and surrounding lymph nodes. Histopathologic examination of the tumor demonstrated a lymphoma of mucosa-associated lymphoid tissue (MALT). Chemotherapy and radiotherapy were performed after surgery. The clinical manifestation, treatment, and postoperative course are described.     

Primary malt lymphoma of the tongue

Primitive malignant lymphoma mucosa associated lymphoid tissue (MALT) on the tongue are rare entities. We report here a case of an old woman (80 years old) with a tumor in the dorsum of the tongue, which was histologically diagnosed as an extra-nodal marginal B cell lymphoma. An inflammatory reaction resembling myoepithelial sialoadenitis was observed in the minor salivary glands adjacent at the tumour, suggesting a possible derivation of the lymphoma from a previous reactive process of unknown origin.     

Brucella melitensis infection within warthin tumor of the parotid gland

Brucellosis is a zoonotic systemic infectious disease, and multiorgan involvement is commonly seen, but involvement of the neck is a rare presentation of brucellosis. Granulomatous infections of the parotid gland are extremely rare. Warthin tumor is a well-known benign neoplasm of the salivary glands. In this report, we describe a Warthin tumor associated with Brucella melitensis in the same parotid gland.     

腮腺沃辛瘤发病情况分析

本文总结２５年中诊治的１７６例腮腺沃辛瘤（Ｗａｒｔｈｉｎ瘤）的临床资料进行发病情况分析。腮腺沃辛瘤占同期所有腮腺上皮性肿瘤的１５．３％，良性肿瘤的２０．６％。将２５年平均分为５个研究周期，Ｗａｒｔｈｉｎ瘤在所有腮腺肿瘤以及良性肿瘤中的构成比均呈稳定上升趋势，９０年代初比７０年代初增长３倍。患者的性别差异无明显变化，女性患者的比例无明显上升，男女比例持续保持在６：１左右。发病年龄集中在５０～６９岁，６０岁以上有逐渐递增趋势     

骨桥蛋白在涎腺良、恶性肿瘤中的表达及意义的研究

目的 探讨骨桥蛋白(OPN)在涎腺良、恶性肿瘤中的表达及意义。方法 采用免疫组化SP法检测OPN在68例涎腺肿瘤(多形性腺瘤20例、腺样囊性癌24例、Warthin瘤24例)和20例瘤旁正常涎腺组织中的表达。结果 OPN在多形性腺瘤和Warthin瘤中均较正常涎腺组织增高(P<0.05);在腺样囊性癌中较正常涎腺组织增高,但两组间比较差异无显著性(P>0.05)。结论 OPN在正常涎腺组织和腺样囊性癌中有弱表达,在多形性腺瘤和Warthin瘤中表达增高。     

腮腺Warthin瘤及瘤旁腺泡细胞增殖与细胞凋亡的定量研究

目的：探讨细胞增殖与细胞凋亡在腮腺Warthin瘤及瘤旁腺泡中的作用。方法：取64例中部分Warthin瘤及瘤旁腺泡作流式细胞术（flow cqtometry,FCM)。以ModFit LT软件进行细胞增殖分析，以Sub-G1法检测凋亡率.结果：Warthin瘤的DNA指数（DNA index ,DI）、S期细胞比例（schizocqto%,S%)、PI增殖指数（proliferation index,PI）与凋亡率分别为1．13、8．83、9．95和8．24,属最高值，瘤旁腺泡的DI、S％、PI和凋亡率分别为1．08、8．94、8．66和6．67。正常腮腺为0．99、5．10、8．01和5．75。三者之间无显著差异（P＞0．05）。结论：腮腺Warthin瘤和瘤旁腺泡的细胞增殖与细胞凋亡水平稍高于正常腺泡，但差异不大，预示该肿瘤术后复发可能性较小。     

A case of primary diffuse large B‐cell non‐Hodgkin's lymphoma misdiagnosed as chronic periapical periodontitis

Lymphoma is a malignant neoplasm of component cells of the lymphoid system which is very rare in the jaws. Here we report a case of primary diffuse large B‐cell lymphoma located in the periapical region of a mandibular molar which was misdiagnosed as chronic periapical periodontitis. The present case was diagnosed at an early stage and effectively managed by chemotherapy. Although lymphoma of the mandible is rare, it must be considered in the differential diagnosis of radiolucent lesions in this region. Lack of knowledge of this rare presentation may lead to delays in diagnosis and poor prognosis.     

腮腺嗜酸细胞腺瘤合并Warthin瘤1例报告及文献复习

一侧腮腺区同时发生不同组织学类型的肿瘤极少见。本文报告1例发生在腮腺一侧瘤体内同时存在嗜酸细胞腺瘤与Warthin瘤2种不同成分的罕见病例,并结合相关文献复习,对其病因、临床特点、诊断及治疗进行讨论。     

B-cell lymphoblastic lymphoma in the maxilla of a child: A rare case report

Lymphoblastic lymphoma is a malignant neoplasia that originates from B or T lymphocyte precursors and rarely occurs in the mouth. The authors report a rare case of B-cell lymphoblastic lymphoma in the maxilla of a child. Clinical examination revealed facial asymmetry with a swelling of the right maxilla, covered by healthy mucosa and painful to palpation. Radiographic examination revealed a poorly defined radiolucent lesion. Based on the hypothesis of malignant neoplasia of hematopoietic origin, an incisional biopsy was performed. Histological examination revealed malignant neoplasia with proliferation of monomorphic, lymphoid cells. Immunohistochemical staining was positive for leucocyte common antigen (LCA), CD10, CD20, CD79, and terminal deoxynucleotidyl transferase (TdT). After the diagnosis of B-cell lymphoblastic lymphoma, the patient underwent chemotherapy, but died of leukoencephalopathy and demyelinization caused by high doses of methotrexate.