急性心肌梗死诊断中不同心肌标损伤标志物联合应用方案的比较

目的比较不同心肌损伤标志物组合诊断急性心肌梗死(AMI)的价值,探讨心肌型脂肪酸结合蛋白(H-FABP)在增加心肌标志物组合诊断效能方面的作用。方法随机纳入急诊就诊的急性胸痛患者组成待研究人群,定量测定每位患者入院第一管血的血清H-FABP及临床常用的心肌损伤标志物(cTnI,Myo),随后根据WHO标准将研究对象分为AMI与心梗疑似患者。绘制3种标志物用于诊断AMI的ROC曲线。通过ROC曲线确定3种心肌损伤标志物诊断AMI的最佳Cutoff值,并对设计出的3种诊断AMI的心肌损伤标志物组合试验(cTnI Myo、cTnI H-FABP、cTnI Myo H-FABP)的各诊断准确度指标进行比较。结果3种标志物诊断AMI的ROC曲线下面积分别为:AUCcTnI0．938(95％CI 0．888-0．988),AUCMyo0．743(95％CI 0．651-0．836),AUCH-FABP 0．919 (95％CI 0．873-0．964);根据ROC曲线确定的各指标用于诊断AMI的cutoff值分别为CutoffcTnI 0．5 ng／mL,CutoffMyo90 ng／mL,CutoffH-FABP 5．7 ng／mL。据此推算的各心肌损伤标志物及其组合诊断AMI的敏感度(按cTnI、Myo、H-FABP、cTnI Myo、cTnI H-FABP、cTnI Myo H-FABP的顺序)分别为0．804、0．674、0．783、0．957、0．957、0．957;特异度分别为0．966、0．747、0．954、0．724、0．92、0．724;诊断符合率分别为0．910、0.722、0．895、0．805、0．932、0．805。与“cTnI H-FABP”相比,敏感度cTnI(z=2．261,P=0．024)、Myo(Z=3．497,P<0．001)、H-FABP(Z=2．478,P=0．013)、特异度Myo (Z=3．062,P=0．002)、cTnI Myo(Z=3．378,P<0．001)、cTnI Myo H-FABP (Z=3．378,P<0．001)、诊断符合率Myo(Z=4．528,P<0．001)、cTnI Myo (Z=3．064,P=0．002)、cTnI Myo H-FABP(Z=3．064,P=0．002)与之的差异均具有统计学意义。结论“cTnI H-FABP”心肌损伤标志物组合诊断AMI表现出最高的诊断敏感度与较高的诊断特异度,其在临床出现急性胸痛人群中诊断AMI的价值优于目前临床使用的心肌损伤标志物组合。     

心型脂肪酸结合蛋白在急性心肌梗死早期诊断中价值

目的探讨血浆心型脂肪酸结合蛋白(heart-type fatty acid-binding protein,H-FABP)对早期诊断急性心肌梗死(acute myocardial infarction,AMI)的意义。方法发病6h内以急性胸痛就诊的疑似AMI患者83例,根据出院诊断分为AMI组32例与非AMI组51例,非AMI组又分为不稳定型心绞痛33例(UAP组)与非心源性胸痛18例(NCCP组),选择体检健康者40名为对照组,采用ELISA法检测各组血清H-FABP水平,并与传统心肌标志物的诊断效能进行比较。结果 AMI组血清H-FABP水平明显高于非AMI组和对照组(P均<0.01);ROC曲线显示,H-FABP的AUC为0.954(95%CI:0.912～0.997),H-FABP诊断AMI的最佳截断值为6.65ng/mL;H-FABP诊断发病6h内AMI的敏感度、特异度、阴性预测值及准确率分别为90.26%,80.39%,93.18%,84.34%;敏感度、阴性预测值及准确率明显高于传统心肌标志物肌红蛋白、肌酸激酶同工酶和肌钙蛋白I(P<0.05)。结论 H-FABP对发病早期的AMI有较好诊断价值。     

心肌脂肪酸结合蛋白在老年急性心肌梗死患者中的临床诊断价值评估

目的探讨心肌型脂肪酸结合蛋白(H-FABP)在老年人急性心肌梗死(AMI)早期的诊断价值,明确H-FABP区分老年AMI患者与正常人的能力。方法根据研究对象入选标准,从样本人群随机选取病例组与对照组,其中病例组包括55例老年AMI患者,对照组包括56例体检正常者;采用双抗体夹心ELISA法对两组人群的血清H-FABP浓度进行定量检测,绘制H-FABP的受试者特征曲线(ROC曲线);根据Az值大小确定H-FABP诊断老年人AMI的价值。结果 H-FABP浓度检测值:对照组为(4.78±0.21)ng/ml,病例组为(14.99±4.05)ng/ml;Az为0.947(95%CI:0.910～0.985),与诊断临界值0.5相比,其差异具有统计学意义(Z=8.128,P=0.0000)。结论对于老年AMI患者,H-FABP具有在心肌梗死早期区分AMI与正常人的能力,H-FABP的定量检测对老年人AMI的早期确诊具有较高的诊断价值。     

心肌型脂肪酸结合蛋白用于急性心梗早期诊断的探索性研究

目的探讨心肌型脂肪酸结合蛋白(H-FABP)在急性心肌梗死(AMI)早期区分AMI患者与正常人的能力。方法人为纳入正常人、AMI确诊病人比例2:1的小样本人群,采用双抗体夹心ELISA法对40例正常人与19例AMI患者血清H-FABP浓度进行定量,绘制H-FABP在该人群中用于诊断AMI的受试者特征曲线(ROC曲线)并比较曲线下面积(AUC)与0.5的大小。0.5被认为是确定一项指标是否具有任何诊断意义的AUC临界值。结果H-FABP浓度定量正常人组为1.29±0.64 ng/mL AMI组为24.45±32.40 ng/mL;依此绘制出的ROC曲线其AUC为0.978(95%CI∶0.948-1.000),与0.5比较差异具有统计学意义。结论H-FABP具备在心梗早期区分AMI与正常人的能力,H-FABP定量检测用于AMI早期诊断是具备其可行性的。     

心肌型脂肪酸结合蛋白在钝性心脏损伤早期诊断中的价值

目的 探讨心肌型脂肪酸结合蛋白(heart-type fatty acid-binding protein,H-FABP)在钝性心脏损伤(blunt cardiac injury,BCI)早期诊断中的价值.方法前瞻性研究2007年1月至2008年6月间复旦大学附属上海市第五人民医院收治的42例钝性胸部损伤患者和同期本院健康体检中心42例健康体检者血清心肌标志物水平,采用双抗体夹心酶联免疫一步法定量检测42例健康体检者和42例钝性胸部损伤患者伤后3,6,12 h血清H-FABP、心肌肌钙蛋白Ⅰ(cardiac troponin Ⅰ,cTn Ⅰ)和肌红蛋白(Myoglobin,Myo)含量.以cTn Ⅰ作为诊断BCI的金标准,将42例钝性胸部损伤患者分为心肌损伤组(13例)和非心肌损伤组(29例).绘制H-FABP和cTn Ⅰ在胸部损伤患者伤后3,6,12 h诊断BCI的受试者特征曲线(receiver operating characteristic curve,ROC curve),并比较曲线下面积(area under the curve,AUC),分析伤后不同时间(3,6,12 h)血清H-FABP和cTn Ⅰ对BCI的诊断价值.多组均数间的差异性比较采用Kruskal Wallis检验,ROC曲线下面积比较采用delong.clarke-pearson检验.以P＜0.05为差异具有统计学意义.结果伤后3 h诊断BCI的AUCH-FABP和AUCcTnⅠ分别为0.9257和0.6844.AUCH-FABP大于AUCcTnⅠ,二者差异具有统计学意义(P=0.0125),伤后12 h诊断BCI的AUCH-FABP小于AUCcTn Ⅰ,差异具有统计学意义(0.9841 vs.0.8276,P=0.0278),二者对诊断伤后6 h BCI的ROC曲线下面积相比,差异无统计学意义(0.9655 vs.0.9125,P=0.2609).结论 H-FABP对BCI具有早期诊断价值,其伤后3 h的敏感性优于cTnⅠ.     

新型心肌损伤标志物与传统心肌酶对诊断早期急性心肌梗死的敏感度和特异度评价

目的探讨新型心肌损伤标志物与传统心肌酶对诊断早期急性心肌梗死(AMI)的敏感度及特异度评价。方法选取2013年1月至2015年6月该院有AMI发病指征的疑似210例患者作为研究组,并选择同时间段有胸痛指征疑似AMI但确诊为非AMI的210例患者作为对照组。初诊患者均检测新型心肌损伤标志物心肌钙蛋白(cTnI)、心型脂肪酸结合蛋白(HFABP)、肌红蛋白(MYO)和传统心肌酶谱肌酸磷酸激酶(CK)、肌酸磷酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH),在发病后3h,3~6h,以3h间隔抽取静脉血离心血清。比较两组检测结果。结果研究组0~3h、3~6h的H-FABP、cTnI和MYO水平显著高于对照组,并且逐渐升高,升高幅度明显大于传统心肌酶指标,差异具有统计学意义(P0.05);3~6h的CK-MB、LDH显著高于对照组,差异有统计学意义(P0.05);H-FABP、cTnI、MYO敏感度和特异度均相对高于传统心肌酶指标,差异具有统计学意义(P0.05),其中H-FABP在3~6h的特异度和敏感度均最高。结论传统心肌酶用于排除AMI疑似患者,缺乏敏感度和特异度,可采用连续监测法代替判断AMI。新型心肌损伤标志物用于诊断早期急性心肌梗死,敏感度及特异度均优于传统心肌酶法,值得推广应用。     

心肌型脂肪酸结合蛋白在诊断早期急性心肌梗死中的临床应用

目的:探讨疑似急性冠脉综合征(ACS)患者心肌型脂肪酸结合蛋白(H-FABP)在急性心肌梗死(AMI)早期诊断中的临床应用价值。方法 :回顾性分析深圳市龙岗中心医院急诊内科2010年7月至2013年5月疑似ACS患者143例的临床及血清H-FABP浓度变化资料。结果:在AMI发病3 h内,H-FABP的诊断敏感性(67.8%)优于c Tn I(0.0%)和CK-MB(0.0%),AMI发病4-6 h内,H-FABP敏感性(93.7%)仍高于c Tn I(60.9%)和CK-MB(51.2%)。AMI发病6 h内,H-FABP是最为敏感的心脏标志物,尤以发病3 h内,优于经典心肌损伤标志物c Tn I和CK-MB的诊断价值。结论:在早期诊断AMI的心脏标志物中,血清H-FABP的敏感性明显高于c Tn I和CK-MB,具有较高的特异性;在AMI发病3h内,H-FABP的诊断价值优于c Tn I和CK-MB。HFABP可作为AMI早期诊断的新指标。     

血清心肌型脂肪酸结合蛋白检测在急性心肌梗死诊断中的应用

目的探讨血清心肌型脂肪酸结合蛋白（H-FABP）在急性心肌梗死（AMI）诊断中的应用价值。方法选择95例疑似急性心肌梗死的胸痛患者,用快速检测试剂盒检测患者发病0～3、3～6h和6h后血清的H-FABP,并和心肌肌钙蛋白I（cTnI）、肌酸激酶同工酶（CK-MB）的检测结果进行比较,分析3种心肌标志物在AMI不同发病时间段诊断中的敏感性和特异性。结果 3种指标在所有胸痛患者中检出率差异无统计学意义（P〉0.05）,但在AMI组患者中,H-FABP的阳性率为72.9%,显著高于cTnI（66.7%）及CK-MB（62.5%）,差异有统计学意义（P〈0.05）。H-FABP检测诊断AMI的敏感性在0～3h（70.00%）和3～6h（82.61%）时间段显著高于cTnT（20.00%与65.22%）和CK-MB（10.00%与65.22%）;在诊断特异性上,H-FABP高于CK-MB,但比cTnI低。结论 H-FABP对于诊断早期AMI具有较高的敏感性和良好的特异性,适合于临床AMI的早期诊断。     

心型脂肪酸结合蛋白在急性心肌梗死早期诊断中的价值

目的探讨血清心型脂肪酸结合蛋白(H-FABP)在急性心肌梗死(AMI)早期诊断中的临床应用价值。方法随机选择110例临床疑似AMI胸痛患者,采用时间分辨免疫荧光测定法(TRIFA)检测患者入院即刻血清中H-FABP含量,并与心肌肌钙蛋白I(cTnI)、肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、超敏C反应蛋白(hsCRP)和肌红蛋白(MYO)进行比较;对11例患者入院即刻和入院6 h后进行动态分析;以60例体检健康者作对照,绘制各心肌损伤标志物受试者工作特征(ROC)曲线并进行曲线下面积(AUC)比较,分析6种心肌损伤标志物诊断早期AMI的敏感度和特异度。结果 AMI患者入院即刻各心肌损伤标志物的AUC由大到小依次为H-FABP、hsCRP、cTnI、CK-MB、CK和MYO,最佳临界值诊断灵敏度分别为85.0%、78.7%、81.3%、73.8%、72.5%和61.3%,特异度分别为93.3%、95.0%、93.3%、100.0%、100.0%、98.3%。H-FABP的AUC与hsCRP、cTnI比较差异无统计学意义(P>0.05),与CK-MB、CK、MYO比较差异有统计学意义(P<0.05)。H-FABP诊断早期AMI的阳性率达85.0%。结论 H-FABP对于AMI早期诊断具有相对较早的检测窗口期和相对较好的特异度,在时效性、灵敏度和特异度等方面具有综合优势,可作为AMI早期诊断或排除诊断的血清标志物。多项心肌损伤指标联合检测可提高AMI实验室诊断的灵敏度、特异度及准确性。     

心肌标志物临界值在急性心肌梗死诊断中的应用

目的了解急性心肌梗死(AMI)时心肌标志物的临界值。方法测定AMI患者入院6天内不同时间血清心肌肌钙蛋白T(cTnT)、肌红蛋白(Mayo)、肌酸激酶MB同工酶(CK-MB)活性、CK-MB蛋白量等心肌标志物浓度,通过ROC曲线特性分析显示特性分析心肌标志物在AMI诊断时的临界值。结果AMI患者发病后不同时间各心肌标志物测定值都出现不同程度变化。ROC曲线显示,AMI患者发病后不同时间除cTnT外各心肌标志物的诊断临界值都呈不同程度变化。结论AMI患者入院后不同时间各心肌标志物测随时间不同而有变化。比较而言,cTnT的诊断窗口其明显更长,临床应用价值更高。     

Pathogenesis of acute encephalitis and acute encephalopathy

Many aspects of the pathogenesis of acute encephalitis and acute encephalopathy have been clarified in this decade, although many unknown mechanisms remain to be elucidated. According to progress of MRI and neuroimmunological analysis and the observation of clinical findings, many new syndromes were found, which enhanced our understanding of acute encephalitis and acute encephalopathy. The pathogenesis of encephalitis is divided into infection and immune mediated mechanisms. The antibodies to neuronal surface antigens(NSA) such as NMDA receptors, leucin-rich glioma inactivated 1 (LGI1) and aquaporin 4 were demonstrated in specific encephalitis, limbic encephalitis and neuromyelitis optica. Anti-NSA antibody encephalitis should be treated by immunotherapy such as corticosteroid and plasmapheresis. Acute encephalitis with refractory repetitive partial seizures (AERRPS) is a devastating postinfectious disease in children and adults, although the pathogenesis of AERRPS is poorly understood. Influenza associated encephalopathy(IAE) is characterized by it's high incidence in Japanese children between 1 year and 5 years of age, its onset in the first or the second day of illness and its high mortality (15-30%) and morbidity (25-40%). We proposed the classification of IAE with poor prognosis from the neuroradiological findings. Four types of encephalopathy seem to be differentiated from each other, acute necrotizing encephalopathy (ANE) type, hemorrhagic shock and encephalopathy syndrome (HSES) type, acute brain swelling (ABS) type, febrile convulsive status epilepticus (FCSE) type. The notable radiological features are thalamic lesions in ANE, diffuse cerebral cortical cytotoxic edema in HSES, reversible cerebral swelling in ABS which sometimes reaches lethal brain herniation, and in FCSE type, dendritic high signal in subcortical white matter by DWI ("bright tree appearance") appears simultaneously with the later onset of repetitive focal seizure. These four types are not specific to IAE but are noticed in another encephalopathies caused by HHV6, rotavirus, etc.     

Assessment of acute phase proteins in acute ischemic stroke

Acute phase proteins (APPs) have been implicated to play important roles during both acute and chronic inflammatory processes in different diseases including ischemic stroke. Though there are several studies showing the importance of APPs as inflammation markers in acute ischemic stroke (AIS), the time course of these proteins during acute phase of AIS is not well known. Thus, the aim of this study was to show the changes in plasma levels of six APPs (i.e., haptoglobin [Hp], ceruloplasmin [Cp], high-sensitive C-reactive protein [h-CRP], fibrinogen, complement 3 [C3] and complement 4 [C4]) during the first 10 days after acute stroke. The study group consisted of 34 female and 19 male patients (n = 53; mean age 65 +/- 12 years), who had first acute ischemic stroke (AIS). An age-matched control group (n = 53; 32 female and 21 male subjects, mean age 62 +/- 6 years) was also included. To evaluate the plasma levels of six APPs, the blood samples of patients with AIS were withdrawn on admission (day 1), and after 3, 5 and 10 days, whereas only one measurement was performed in the control group. In addition, several cerebrovascular risk factors were determined. The peak levels of APPs were higher in the AIS group than the control group (p < 0.0001). In serial measurements, the levels of h-CRP, Hp, C3 and C4 showed alterations during 10 days after AIS (p < 0.0001, p < 0.05, p < 0.0001, p < 0.0001, respectively). The alterations in levels of fibrinogen and Cp were not statistically significant (p > 0.05). After stroke, h-CRP, C3 and fibrinogen reached their highest values on the third day, Cp and C4 on the fifth day, and Hp on the tenth day. The plasma levels of h-CRP correlated positively with other five APPs studied (p < 0.05). These findings support the importance of inflammation processes after stroke. We suggest that the differences in levels of APPs could be used in predicting the outcome of stroke patients.     

高血脂症性急性胰腺炎误诊急性阑尾炎患者的护理

目的 探讨高血脂症性急性胰腺炎患者病情观察及护理的要点.方法 回顾分析3例高血脂症性急性胰腺炎误诊为急性阑尾炎病例的临床资料,并对护理方法进行总结.结果 3例误诊病例入院时均有明显的三酰甘油水平升高（14.1～61.0 mmol/L）,血标本呈乳糜状脂浊血清,1例存有明显诱发因素,临床特点除右下腹症状、体征外,上腹部症状、体征持续存在,早期B超提示有腹腔积液,血、尿淀粉酶升高不明显.确诊后经严密观察病情、心理护理、营养支持护理、降血脂护理及健康宣教等护理后均痊愈出院.结论 临床护理工作中应提高对高血脂症性胰腺炎的认识,入院后全面的护理评估、仔细病情观察有助临床医生分析、判断病情,综合的护理干预促进疾病康复,重视健康宣教,有效控制血脂,去除诱发因素是疾病防治重点.     

Concomitant acute sinusitis and acute lung rejection

Two lung transplant recipients had concomitant acute sinusitis and acute lung rejection. Antibiotics and decongestants alleviated the sinusitis, but the symptoms of cough and dyspnea as well as spirometric defects necessitated treatment of acute lung rejection. In patients with clinical evidence of acute sinusitis after lung transplantation, concomitant acute lung rejection should be suspected if dyspnea or pulmonary dysfunction is also present. This appears to be the first report of concomitant acute sinusitis and acute lung rejection.     

Epidemiology of acute lung injury and acute respiratory distress syndrome

PURPOSE OF REVIEW: Acute lung injury (ALI) and acute respiratory distress syndrome (ARDS) are diseases with a significant influence in the public health. A better knowledge of their epidemiology could help to improve the outcome of these diseases. RECENT FINDINGS: Although the clinical criteria of the American-European Consensus Conference definitions for ALI and ARDS are simple, there is a risk of misclassification due to a poor reliability. Except for new emerging infectious diseases, such as severe acute respiratory syndrome, the etiology of ALI/ARDS has remained the same for several years. The only recent innovation is the hypothesis that pulmonary ARDS and extrapulmonary ARDS could be different clinical entities. In recent years, there has been a special interest in the study of genetic predisposition to development ALI/ARDS. Recent studies have estimated the incidence of these diseases to be between 15 and 34 cases per 100,000 inhabitants per year. This wide range could stem from differences in the methodology used to calculate the incidence or could be a true variation due to regional differences. Mortality rate of ALI/ARDS have remained steady for several years. Respiratory failure is the cause of the death in less than 20% of the patients. SUMMARY: The epidemiology of ALI and ARDS has some issues to improve, such as the accuracy of the clinical criteria of ALI/ARDS. Future research must to include study of genetic polymorphisms of the mediators involve in the development of ALI/ARDS. Studies to define better the population at risk are necessary to estimate better their true incidence.     

Pathophysiology of acute coronary syndromes leading to acute myocardial infarction

Acute coronary syndromes, including unstable angina, myocardial infarction, and sudden death, account for more than 250,000 deaths annually. They are the manifestation of a progressive atherosclerotic process, which culminates in the rupture of atherosclerotic plaques and the formation of mural thrombi. This article reviews recent and current research, which has shed light on key events and evolutionary processes leading to acute coronary syndromes. The article details the development of vulnerable plaques, factors that promote plaque rupture, and triggering events related to plaque rupture. Also discussed are sequelae of acute coronary syndromes, including Q wave and non-Q wave infarction and left ventricular remodeling.     

急性坏死性液体积聚和包裹性坏死并感染的影像评价

目的基于新亚特兰大标准,对急性坏死性液体积聚(ANC)和胰腺包裹性坏死(WON)合并感染进行CT/MRI评价。方法 回顾性分析从2010年1月~2016年1月间在我院因并发感染性胰腺坏死(ANC或WON合并感染)行外科处理后将脓液标本培养证实有细菌或真菌生长者,且患者发病后3~10天首次CT或MRI检查,在感染性胰腺坏死外科治疗前后有CT或MRI复查者。综合观察感染性胰腺坏死灶的部位、数目、形态、大小、病灶密度及信号、增强特征,并计算首次CT或MR严重指数(CT/MR severity index,CTSI/MRSI);随访患者术后演变及临床预后。结果 纳入ANC或WON合并感染患者40例(男28例、女12例,年龄50.9±12.2岁),包括ANC合并感染3例和WON合并感染37例,从患者发病至发现感染性胰腺坏死的时间为38.4±20.9 d。所有患者首次积分CTSI/MRSI为7.8±1.7分(6~10分)。37例WON合并感染者共44个胰腺WON病灶,大小为8.7±3.6 cm;所有WON病灶内含“非液性物质影”;56.8%的WON合并感染者见“气泡”征、“气-液平”;13.5%的WON合并感染者见胰尾部WON侵犯脾脏、脾内呈脓腔样病灶伴花环样强化及内部分隔样强化。所有患者外科引流引出褐色脓性液体后送细菌培养:67.5%的患者出现多重感染。结论ANC或WON合并感染在CT/MRI上有较为特异的一些征象可提示诊断,能为外科治疗前后提供重要的参考价值。     

A focus on acute cholecystitis and acute cholangitis

Biliary infections are very common intra-abdominal infections. Laparoscopic cholecystectomy for acute cholecystitis and endoscopic retrograde management of acute cholangitis play important roles in the treatment of biliary infections. Also antimicrobial therapy is nevertheless important in the overall management of biliary infections. A multidisciplinary team of physicians, including surgeons trained in laparoscopic techniques, interventional gastroenterologists, and interventional radiologists may improve outcomes of patients with biliary infections. This review focuses the clinical presentation, diagnosis, and state of the art management of acute cholecystitis and acute cholangitis.     

急性髓系白血病与急性淋巴系白血病的蛋白质组比较研究

本研究通过对急性髓系白血病(AML)与急性淋巴系白血病(ALL)细胞比较蛋白质组分析,寻找亚型特异性的蛋白质表达谱。应用双向电泳分别分离AML不同亚型(M1、M2、M3)、ALL患者骨髓白血病细胞蛋白质,利用PDQuest 7.4软件分析双向电泳图谱差异蛋白质点,基质辅助的激光解析飞行时间质谱和生物信息学鉴定差异蛋白质。结果显示:经过电泳图谱分析得到21个差异蛋白质点,质谱鉴定提示15种蛋白有统计学意义。在AML中高表达的蛋白质包括髓过氧化物酶(MPO)、硫氧还蛋白依赖的过氧化物还原酶(PRDX3),钙网蛋白(CALR)、烯酰辅酶A水合酶ECH1等7种,在ALL中高表达的蛋白质包括ARHGDIB、肌动蛋白抑制蛋白1(PFN1)、肌动蛋白(ACTG1)等8种。结论:AML与ALL细胞存在差异蛋白质表达谱,这将有助于发现早期诊断的分子标志物及特异性治疗靶标。