单磷酸阿糖腺苷联合强的松治疗老年带状疱疹疗效分析

目的探讨单磷酸阿糖腺苷联合强的松治疗老年带状疱疹的临床疗效。方法患者随机分为两组:治疗组静滴单磷酸阿糖腺苷10mg/kg,1次/d,连续7天,同时口服强的松10mg,3次/d,连服5天;对照组仅静滴单磷酸阿糖腺苷,用量及疗程同治疗组。结果治疗组在止疱、止痛、结痂时间均显著低于对照组(P<0.01),后遗神经痛(PHN)发生率明显降低(P<0.05)。结论单磷酸阿糖腺苷联合强的松治疗老年带状疱疹起效快,能有效缩短病程、降低后遗神经痛发生率。     

中西药结合治疗带状疱疹后遗神经痛疗效观察

目的评价中西药结合治疗带状疱疹后遗神经痛的疗效。方法 60例带状疱疹后遗神经痛的患者随机分成2组,治疗组30例采用活血理气通络方口服,同时口服呋喃硫胺片(50 mg/次,3次/d)、甲钴胺片(0.5 mg/次,3次/d)、盐酸阿米替林片(25 mg/次,2次/d)、盐酸曲马多缓释片(100 mg/次,1次/晚)。对照组30例只采用后4种西药治疗。治疗10 d后进行疗效评价。结果有效率治疗组为93.33%,对照组为73.33%,2组比较差异有统计学意义(P0.05)。结论中西药结合治疗带状疱疹后遗神经痛的疗效较西药更好。     

疏肝化瘀止痛汤加减联合LED红光治疗气滞血瘀证带状疱疹后遗神经痛临床观察

目的观察疏肝化瘀止痛汤加减联合LED红光治疗气滞血瘀证带状疱疹后遗神经痛(PHN)的疗效。方法 106例患者均来自我科门诊,随机分为两组,治疗组疏肝化瘀止痛汤加减温服,3次/d,联合LED红光照射治疗,1次/d。2周为1个疗程,2个疗程后判定疗效。对照组卡马西平片0.1g,3次/d;甲钴胺片,0.5mg,3次/d,口服;2周为1个疗程,2个疗程后判定疗效。结果治疗4周后,两组总有效率分别为88.89%和72.09%,治疗组明显高于对照组。结论疏肝化瘀止痛汤加减联合LED红光治疗气滞血瘀证PHN安全、有效,在临床中值得推广。     

青鹏膏联合泛昔洛韦治疗中老年带状疱疹疗效观察

目的 观察青鹏膏联合泛昔洛韦治疗中老年带状疱疹的临床疗效.方法 134例中老年带状疱疹患者随机分为两组,两组均口服泛昔洛韦,250mg/次,3次/d.治疗组局部外用青鹏膏;对照组局部外用1%喷昔洛韦乳膏,均2次/d,连续2周.用药后第8、15、29天进行随访观察判断疗效和带状疱疹后遗神经痛(PHN)发生率.结果 治疗组的治愈率、止痛和结痂时间、疼痛消失率、PHN发生率与对照组比较,差异有统计学意义(P＜0.01).结论 外用青鹏膏联合泛昔洛韦治疗中老年带状疱疹,起效快、病程明显缩短、止痛迅速、效果显著,能降低PHN的发生率.     

乙酰谷酰胺联合腺苷钴胺治疗带状疱疹后遗神经痛疗效观察

目的观察乙酰谷酰胺联合腺苷钴胺治疗带状疱疹后遗神经痛的临床疗效。方法 42例患者随机分为治疗组和对照组,治疗组给予肌注腺苷钴胺1.5mg,1次/d,静滴乙酰谷酰胺500mg/d,1次/d;对照组给予静滴乙酰谷酰胺500mg/d,1次/d。疗程均为2周,两组患者均给予口服吲哚美辛25mg,3次/d,溶菌酶肠溶片100mg,3次/d,维生素B110mg,3次/d。治疗结束时评价临床疗效。结果两组治疗2周后,治疗组有效率80.9%,对照组有效率47.6%,治疗组疗效优于对照组,差异有显著性(P0.05)。结论乙酰谷酰胺联合腺苷钴胺治疗带状疱疹后遗神经痛疗效好。     

复方甘草酸铵联合微波治疗带状疱疹后遗神经痛疗效观察

目的探讨复方甘草酸铵联合微波治疗带状疱疹后遗神经痛的疗效及安全性。方法76例患者随机分为治疗组和对照组。治疗组38例予复方甘草酸铵40mL 1次/d静滴联合微波局部照射1次/d治疗,对照组38例予维生素B1100mg、维生素B12500μg 1次/d肌内注射和布洛芬片0.3g口服,疗程均为2周。结果治疗组和对照组有效率分别为76.32%和39.47%,两组比较差异有显著性(P<0.01)。两组均未见明显不良反应。结论复方甘草酸铵联合微波治疗带状疱疹后遗神经痛安全有效。     

高压氧联合药物治疗带状疱疹后遗神经痛的随机对照研究

目的观察高压氧联合药物治疗带状疱疹后遗神经痛(PHN)的临床疗效。方法按随机数字表法将60例PHN患者分为两组,每组各30例。对照组采用药物治疗,口服吲哚美辛片25 mg,3次/d和甲钴胺分散片0.5mg,3次/d餐后口服,肌注维生素B_(12)100 mg,1次/d。观察组在上述药物治疗的基础上,给予高压氧治疗,两组治疗时间均为4周。两组分别于治疗前后采用视觉类比量表(VAS)评分和疼痛评估指数(PRI)进行疼痛评分和临床疗效判定。结果两组治疗后VAS评分和PRI均有所改善,且治疗前后的差异具有统计学意义(P0.05)。对照组与观察组治疗后VAS评分和PRI组间比较差异具有统计学意义(P0.05)。对照组的治疗总有效率为77.3%,观察组治疗总有效率为93.3%,观察组的临床疗效明显优于对照组,两组比较差异具有统计学意义(P0.05)。结论高压氧联合药物治疗可以有效缓解PHN患者的疼痛症状,促进患者康复。     

前列地尔注射液治疗带状疱疹后遗神经痛疗效观察

目的观察前列地尔注射液治疗带状疱疹后遗神经痛的疗效。方法 84例带状疱疹后遗神经痛住院患者随机分为两组各42例。对照组给予抗病毒、营养神经、消炎止痛常规治疗,观察组在对照组基础上加用前列地尔注射液。两组疗程均为14天,比较两组患者疼痛缓解情况。结果观察组疼痛缓解率高于对照组,差异有统计学意义(P0.05)。结论前列地尔注射液治疗带状疱疹后遗神经痛,可有效缓解疼痛症状。     

氨酚羟考酮联合牛痘疫苗致炎兔皮提取物治疗带状疱疹后遗神经痛39例临床观察

目的观察氨酚羟考酮联合牛痘疫苗致炎兔皮提取物治疗带状疱疹后遗神经痛的临床疗效及安全性。方法将入选的79例带状疱疹后遗神经痛患者随机分为两组,治疗组39例,予氨酚羟考酮片0.33g口服(3次/d),同时予牛痘疫苗致炎兔皮提取物针剂3.6U肌注(1次/d);对照组40例,予布洛芬胶囊0.3g口服(2次/d),并每天肌肉注射Vit Bl200mg和腺苷钴胺1.5mg各1次。结果治疗14d后,治疗组有效率为84.62%,对照组为65.00%,且两组患者的VAS评分和威斯康星简要疼痛目录评分各项评价指标均较治疗前有明显下降,治疗组的VAS评分也优于对照组,以上差异均有统计学意义(P均0.05)。两组患者不良反应发生率的差异无统计学意义(P0.10)。结论氨酚羟考酮联合牛痘疫苗致炎兔皮提取物治疗带状疱疹后遗神经痛疗效好,安全性高。     

穴位注射治疗带状疱疹后遗神经痛疗效评价及对血清IgM、IgE和IgA的影响

目的：研究穴位注射治疗带状疱疹后遗神经痛患者的临床疗效及对血清IgE、IgM和IgA抗体的影响。方法：按随机数字法分为对照组及治疗组,治疗组根据带状疱疹发病的部位,选择相应的穴位分点注射混悬液（复方倍他米松1mL＋维生素B12注射液0．5mg＋盐酸利多卡因注射液6mL）1．5～2mL日1次,对照组给予双氯芬酸钠缓释片150mg口服日2次,维生素B．片10mg口服日3次,连续10天后进行疗效观察：采用ELISA法测定PHN患者治疗前及治疗后血清中IgE、IgM和IgA抗体水平。结果：PHN患者治疗10天后,治疗组患者疼痛不同程度缓解,总有效率86．18％,对照组总有效率56．92％,治疗组血清IgE、IgM和IgA水平显著低于治疗前（P〈0．01）,且明显低于对照组水平（P〈0．01）。结论：穴位注射治疗带状疱疹后遗神经痛有明显疗效,且临床副作用少。血清IgM、JgE和IgA水平与后遗神经痛密切相关。     

润燥止痒胶囊联合异维A酸胶丸治疗中、重度寻常痤疮疗效观察

目的探讨润燥止痒胶囊联合异维A酸胶丸治疗中、重度寻常痤疮的疗效。方法将114例患者随机分为两组,对照组57例,予异维A酸胶丸10mg,2次/d;治疗组57例,在对照组的基础上加用润燥止痒胶囊2g,3次/d。两组均外用克林霉素磷酸酯凝胶,2次/d,疗程均为4周。结果治疗组有效率为87.72%,对照组为70.18%,两组比较差异有统计学意义(P<0.05)。结论润燥止痒胶囊联合异维A酸胶丸治疗中、重度寻常痤疮疗效良好。     

Efficacy of low dose gabapentin in acute herpes zoster for preventing postherpetic neuralgia: a prospective controlled study

Postherpetic neuralgia (PHN) is a sequela of herpes zoster that adversely affects quality of life seriously. The risk factors for PHN are well known but the effective interventions that reduce the incidence of PHN are less studied. The objective of this study is to evaluate the efficacy of treatment with gabapentin in patients with acute herpes zoster for preventing PHN. We performed a prospective randomized controlled study of 120 participants diagnosed with acute herpes zoster, aged 50 and over and complaining moderate to severe pain. All patients were treated with valacyclovir and acetaminophen. Half of the participants were assigned to the gabapentin group and received gabapentin 300 mg three times a day additionally. The intensity of pain at every visit and the incidence of PHN in both groups were measured. Total 52 and 49 patients in the gabapentin group and the control group, respectively, had completed 12 weeks of follow‐up period. Although the incidence of PHN was higher in the control group, the difference was not statistically significant (6.1% vs. 3.8%, p = 0.67). Our results indicate that the use of low‐dose gabapentin in acute herpes zoster seems not effective in the prevention of PHN.     

大黄蛰虫丸联合消炎痛治疗急性单纯型结节性红斑疗效观察

目的 观察大黄蛰虫丸联合消炎痛治疗急性单纯型结节性红斑的疗效方法60例患者随机分成两组,治疗组30例采用大黄蛰虫丸口服,3g/次,2次,d,同时口服消炎痛25mg/次,3次/d;对照组30例仅口服消炎痛,25mg/次,3次/d,疗程同治疗组.结果 治疗组有效率96.67%,对照组73.33%,两组比较差异有统计学意义(P＜0.05).结论 大黄蛰虫丸联合消炎痛治疗急性单纯型结节性红斑有效.     

阿维A联合他扎罗汀治疗原发性皮肤淀粉样变病疗效观察

目的观察阿维A联合他扎罗汀治疗原发性皮肤淀粉样变病的疗效。方法 45例原发性皮肤淀粉样变病患者随机分为两组。治疗组(24例)和对照组(21例)均给予阿维A30mg/d,分3次服用,连续服用4周,改为20mg/d,分2次服用,再服用4周,最后改为10mg/d维持治疗,连用4周,治疗组同时联合外用他扎罗汀,每晚使用1次。两组还同时使用依巴斯汀10mg/d口服、卤米松乳膏每天外用1次。结果疗程结束后治疗组和对照组的有效率分别为70.83%和28.57%,差异有显著性(P<0.05)。结论阿维A联合他扎罗汀治疗原发性皮肤淀粉样变的疗效优于单用阿维A治疗。     

盐酸依匹斯汀每日/隔日疗法治疗慢性荨麻疹临床观察

[摘要] 目的 观察盐酸依匹斯汀每日-隔日疗法治疗慢性荨麻疹的疗效和安全性。方法 80例患者被随机分为试验组和对照组,各40例。前者先服盐酸依匹斯汀片10mg,1次/d,连续4周,后改为10mg,隔日1次,再服4周;后者口服盐酸依匹斯汀片10mg,1次/d,连续8周。结果 试验组的有效率、不良反应发生率分别为82.05%、7.69%,对照组依次为89.47%、5.26%,两组有效率、不良反应发生率比较均无统计学意义(Ｐ均>0.05)。试验组的成本-效果比低于对照组,且服药次数明显减少。结论 盐酸依匹斯汀每日-隔日疗法治疗慢性荨麻疹疗效好、安全、经济且方便。     

复方甘草酸苷联合光化学疗法治疗斑秃30例疗效观察

目的探讨复方甘草酸苷联合光化学疗法(PUVA)治疗斑秃的疗效和安全性。方法 90例斑秃患者随机分为3组,治疗组30例,外涂0.1%8-甲氧补骨脂溶液30min后,用UVA照射患处,2次/周,同时每天服用复方甘草酸苷75mg,3次/d;对照Ⅰ组30例,每天服用复方甘草酸苷;对照Ⅱ组30例,外涂0.1%8-甲氧补骨脂溶液30min后,用UVA照射患处,2次/周。3组疗程均为8周,观察疗效及不良反应。结果治疗组、对照Ⅰ组和对照Ⅱ组有效率分别为93.33%,70.00%和73.33%,治疗组与两对照组比较差异均有统计学意义(P均<0.05)。结论复方甘草酸苷联合光化学疗法治疗斑秃具有良好的疗效和较高的安全性。     

复方甘草甜素片联合盐酸西替利嗪治疗慢性特发性荨麻疹的疗效观察

目的观察复方甘草甜素片联合盐酸西替利嗪治疗慢性特发性荨麻疹的疗效。方法将110例慢性特发性荨麻疹患者分为两组,治疗组68例口服复方甘草甜素片75 mg,3次/d,盐酸西替利嗪10 mg,1次/d,对照组48例口服盐酸西替利嗪10 mg,1次/d。两组疗程均为4周,均于治疗后第14,30天复诊。结果14天时两组疗效比较,治疗组有效率50.00%,对照组有效率31.25%,两组有效率无显著性差异(χ2=1.24,P>0.05);30天时两组疗效比较,治疗组有效率82.26%,对照组有效率58.33%,两组有效率差异有显著性(χ2=7.65,P<0.01)。结论复方甘草甜素片联合盐酸西替利嗪治疗慢性特发性荨麻疹,疗效满意,值得在临床上应用。     

A double-blind comparison of acitretin and etretinate in combination with bath PUVA in the treatment of extensive psoriasis

Thirty-four patients with extensive psoriasis were treated in a double-blind parallel fashion with either acitretin plus bath PUVA (trimethylpsoralen bath + UVA) or etretinate plus bath PUVA. Each group consisted of 17 patients. The dose of retinoid was 40 mg/day during the 2-week monotherapy phase and subsequently 20 mg/day during the combination treatment. Bath PUVA was given three times a week starting with a UVA dose of 0.06 J/cm2. Remission (greater than 90% improvement) was achieved in all patients in 6-10 weeks. There were no significant differences in clinical response between the two groups; the mean +/- SD PASI score (psoriasis area and severity index) before treatment was 22.6 +/- 7.1 in the acitretin-PUVA group and 19.4 +/- 7.8 in the etretinate-PUVA group. The corresponding figures after treatment were 0.6 +/- 0.6 and 1.0 +/- 0.5, respectively. Side-effects related to retinoid treatment were frequent in both groups but they were usually mild and well-tolerated. There was only one case of diffuse alopecia after 8 weeks in the etretinate-PUVA group. Scaling of the palms and soles was seen in six patients in the acitretin-group but only in two patients in the etretinate-group. Triglycerides were elevated in about half of the patients in both groups. The present study shows that acitretin is as effective as etretinate in the combination with bath PUVA.     

强力脉痔灵联合曲安奈德益康唑乳膏治疗肛周湿疹疗效观察

目的观察强力脉痔灵联合曲安奈德益康唑乳膏治疗肛周湿疹的临床疗效。方法采用随机法将99例患者分为两组,治疗组50例,予强力脉痔灵2片口服,同时外用曲安奈德益康唑乳膏,均2次/d,连用3周。对照组49例,仅外用曲安奈德益康唑乳膏,连用3周。两组均治疗结束时观察近期疗效,痊愈者随访3个月观察远期疗效。结果治疗组近期疗效有效率80.00%,对照组为71.43%,差异无显著性(P>0.05);痊愈病例随访3个月,治疗组复发率20.0%,对照组57.9%,差异有显著性(P<0.01)。结论强力脉痔灵联合曲安奈德益康唑乳膏治疗肛周湿疹疗效好。