彩色室壁运动分析技术多巴酚丁胺负荷超声心动图对冠心病节段性室壁运动异常的诊断

目的：为评估彩色室壁运动（CK）分析技术多巴酚丁胺负荷超声心动图（CK－DES）对冠动脉粥样硬化性心脏病（CHD）节段性室壁运动异常的诊断价值。方法：采用CK－DSE检测50例可疑CHD患者,分别于静息,多巴酚丁胺低剂量,峰剂量及停药后5min时获取CK图像,每个时间段4个标准切面16个节段的CK图像进行分析,室壁运动异常以静息和负荷试验期间出现的室壁运动减弱为标志,并与冠状动脉造影（CAG）结果相对照。结果：显示CK－DES诊断CHD的敏感性为92．6％,特性为78．3％,准确性为86．0％,试验中未发现严重不良反应。结论：CK－DSE对冠心病节段性室壁运动异常有较高的诊断价值。     

解剖M型超声心动图对冠心病室壁运动异常的判定

目的：了解解剖M型超声心动图对冠心病室壁运动判定的价值。方法：用解剖M型、2DE超声心动图检测了31例冠心病病人与25例正常人（其中17例行冠状动脉造影）的室壁运动，并与冠状动脉造影作比较。结果：31例冠心病病人中，有23例2DE目测判定判定准确；17例正常人中判定正确14例，其敏感性为74．19％，特异性为82．35％；解剖M型超声心动图以增厚率〈25％、搏幅〈5mm作为异常标准，31例检测出25例，假阴性6例，敏感性为80．64％，正常人17例，解剖M型超声心动图判定正确15例，假阳性2例，特异性88．23％。结论：解剖M型超声心动图敏感性、特异性均高于2D超声心动图，对冠心病的筛选有一定的临床价值。     

多巴酚丁胺阿托品负荷超声心动图对冠心病的早期诊断价值

目的应用多巴酚丁胺、阿托品负荷超声心动图，探讨该试验对冠心病的早期诊断价值。方法应用多巴酚丁胺、阿托品负荷超声心动图观察２２例单支轻度冠状动脉狭窄患者负荷试验前后室壁运动改变，并与正常对照组比较。结果多巴酚丁胺负荷超声心动图对轻症冠心病的感性为５９．１％，特异性９４．６％，准确性７５．０％，加用阿托品后其敏感性提高至７７．３％，特异性９４．６％，准确性８５．０％。结论多巴酚丁胺负荷超声心动图对冠心病具有较高的早期诊断价值，加用阿托品可进一步提高试验的敏感性。     

冠心病患者二维超声心动图、心电图与冠状动脉造影对照研究

作者报告 68例拟诊冠心病患者的二维超声心动图(2 DE)室壁运动异常、心电图(ECG)与冠状动脉造影对照分析,评价两者对冠心病的诊断价值。研究结果:2 DE与ECG的敏感性分别为86.7％与63.2％,P<0.05;两者的特异性分别为76.7％与63.2％,P>0.05。冠脉狭窄50％以上的患者,两者的敏感性为93.9％及     

多巴酚丁胺负荷超声心动图诊断冠心病的临床价值

目的:研究多巴酚丁胺(DBA)负荷超声心动图(DSE)诊断冠心病的临床实用价值。方法:临床诊断为冠心病患者和正常对照者各37例,DBA每隔3min以剂量递增的方式持续静注(5、10、20、30、40μg/kg·min),同时用二维超声心动图重点观察室壁运动的变化,采用16节段左室分析方法对室壁各节段半定量计分,计算室壁运动得分指数(WMSI)。结果:用药后心率、收缩压、舒张压、心率与收缩压的乘积(RPP)均增高,冠心病组WMSI明显增加(P<0.01)。DSE诊断冠心病的敏感性为86.5%、特异性为89.1%、准确性为78.12%。不良反应有心慌、恶心以及室早,无需特殊处理。结论:DSE诊断冠心病安全、可靠,具有重要的临床实用价值。     

多巴酚丁胺阿托品负荷超声心动图对冠心病的早期诊断价值

目的 应用多巴酚丁胺、阿托品负荷超声心动图，探讨该试验对冠心病的早期诊断价值。 方法 应用多巴酚丁胺、阿托品负荷超声心动图观察２２例单支轻度冠状动脉狭窄患者负荷试验前后室壁运动改变，并与正常对照组比较。结果 多巴酚丁胺负荷超声心动图对轻症冠心病的敏感性为５９．１％，特异性９４．６％，准确性７５．０％，加用阿托品后其敏感性提高至７７．３％，特异性９４．６％，准确性８５．０％。结论 多巴酚丁胺负荷超声     

彩色室壁运动技术在多巴酚丁胺负荷超声心动图诊断冠心病中的应用

目的：为冠心病早期诊断提供一种无创、准确的可定量方法。方法：应用彩色室壁运动(CK) 技术,对临床45例可疑冠心病患者进行多巴酚丁胺负荷超声心动图（DSE）检查,并对其诱发的室壁运动异常（WMA）结果与冠脉造影结果进行对照。结果：冠脉造影发现冠心病(冠心病组)29例,正常(正常组)16例;而CK-DSE检测方法发现冠心病29例（其中假阳性一例）,正常16例（其中假阴性一例）。CK-DSE诊断冠心病敏感性、特异性、准确性及一致性分别为96.5%、93.7%、95.5%及90.3%。冠心病阳性、阴性预测值分别为96.5%、93.7%。45例受试者用药(多巴酚丁胺)后心率、收缩压及心率与收缩压的乘积（RPP）均明显增高（P<0.05）。室壁运动计分指数冠心病组较用药前明显增加（P<0.001）,正常对照组差异无显著性（P>0.05）。结论：CK-DSE为冠心病早期诊断提供了一种安全准确的定量方法。     

超声心动图诊断冠心病与踏车运动实验比较研究

对９８例怀疑冠心病患者同时作超声心动图与踏车心电图运动实验。通过超声心动图观察室壁节段性异常诊断冠心病，其结果与踏车运动实验比较，敏感性较低（４９％），但特异性较高（９７％）。此外超声心动图显示冠心病的合并症或并发症优于踏车实验     

超声心动图多巴酚丁胺负荷试验

采用超声心动图多巴酚丁胺负荷试验，对３０例怀疑或确诊的冠心病患者的室壁情况进行了研究，多已酚丁胺初始剂量为５μｇ／ｋｇ·ｍｉｎ，每３ｍｉｎ递增５μｇ／ｋｇ·ｍｉｎ，最大剂量为４０μｇ／ｋｇ·ｍｉｎ。超声心动图阳性标准为：出现新的室壁运动异常或有室壁运动异常加重，心电图ＳＴ—Ｔ段水平或下斜压低２ｍｍ为典型心绞病发作。结果本试验对冠心病诊断的敏感性为８３％，特异性８６％，心电图的诊断敏感性是６６％，提示多巴酚丁胺超声心动图负荷试验对冠心病的诊断具有较高的安全性和准确性，值得临床应用和推广。     

腺苷与多巴酚丁胺超声心动图负荷试验诊断冠心病的应用比较

目的比较腺苷、多巴酚丁胺超声心动图负荷试验诊断冠心痔的敏感性、特异性与安全性。方法将临床拟诊冠心病者64例随机分为两组,分别行腺苷或多巴酚丁胺超声心动图负荷试验,同时记录室壁运动、患者症状和不良反应的发生等。左室16节段中出现室壁运动异常为阳性。64例患者于试验后1周内行冠状动脉造影,并以其为金标准,分别计算腺苷、多巴酚丁胺超声心动图负荷试验敏感性、特异性等。结果腺苷超声心动图负荷试验与多巴酚丁胺超声心动图负荷试验诊断CAD的敏感性分别为67％、73％,特异性分别为85％、80%,准确性均为75％。不良反应发生率分别为59％、45％,差异均无统计学意义。结论腺苷超声心动图负荷试验与多巴酚丁胺超声心动图负荷试验比较同样是较理想诊断冠心病的无创检查方法。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.