鼻内镜下保留钩突切除后囟门扩大开放上颌窦窦口治疗上颌窦病变的临床观察

目的比较单纯向后切除后囟门扩大开放上颌窦窦口与传统全部切除钩突对中鼻道、上颌窦术腔黏膜的转归影响。方法将46例双侧上颌窦病变患者分为试验组与对照组,每例患者左侧鼻腔为试验组,右侧为对照组,试验组施行经鼻内镜单纯向后切除上颌窦后囟门扩大开放上颌窦窦口的术式,对照组施行传统经鼻内镜鼻窦开放术式。结果 2组治疗随访1年以上的治愈率和好转率无差异（P〉0.05）,但是术后2个月术腔的黏膜情况差异有统计学意义（P〈0.05）。结论单纯向后切除后囟门扩大开放上颌窦窦口能更好保护鼻腔黏膜,减少了对正常鼻腔、鼻窦黏膜功能的损伤,对鼻腔、鼻窦黏膜恢复正常功能有积极的作用。     

量表评分判断保留钩突的鼻内镜手术疗效分析

目的对保留钩突鼻内镜手术患者与切除钩突患者术后恢复情况进行比较,观察鼻内镜手术中保留钩突是否对手术预后造成不良影响.方法对我科部分保留钩突与切除钩突鼻内镜手术病人进行术后复查随访,通过视觉模拟评分(VAS)和鼻内镜检查计分(Lund-Kennedy 评分)、鼻腔鼻窦结局测试-20(SNOT-20),比较两组病人术后生存质量(QOL)情况.结果保留钩突与切除钩突鼻内镜手术病人均预后良好,QOL 明显改善,两组 VAS 评分、Lund-Kennedy 评分、SNOT-20均无显著差异(均 P >0.05).保留钩突未造成额窦、上颌窦引流障碍,未引发额窦、上颌窦炎症,未对术腔造成不良影响.结论对于钩突功能正常,未被病变累及的病人,在鼻窦手术中应该尽量保留钩突.     

部分保留钩突与全切钩突对鼻内镜术后术腔黏膜的转归对比

目的比较鼻内镜手术中部分保留钩突与全切钩突对鼻窦术腔黏膜的转归影响。方法将43例慢性鼻窦炎患者分为试验组与对照组,每例患者右侧鼻腔为试验组,左侧为对照组,试验组为经鼻内镜部分保留钩突的鼻窦开放术,对照组为经鼻内镜全部切除钩突的经典FESS术式。结果全部患者均随访1年以上。治愈：试验组38例（88.4%）,对照组36例（83.7%）;好转：试验组6例（11.6%）,对照组8例（16.3%）。术后2个月门诊鼻内镜检查术腔黏膜情况,试验组和对照组筛窦及或中鼻道黏膜囊泡样水肿分别为3例和10例,2组差异有统计学意义（P〈0.05）。结论部分保留钩突一定程度上避免了开放的术腔在手术后受到气流的直接冲击,减少了气流中夹带的治病物质直接进入鼻窦,减少了术腔黏膜转归阶段发生的新生病变,对鼻腔、鼻窦黏膜的良性转归有积极的影响。     

保留部分钩突功能性鼻内镜手术临床观察

目的 探索新的内镜鼻窦手术方式,使之更加适应鼻腔、鼻窦生理学特征,更加符合结构重建的内镜鼻窦手术理论.方法 30例单纯型慢性鼻窦炎患者作为观察组,在鼻内镜下自钩突膝部开始,沿上颌线切除钩突膝部和水平部,显露上颌窦,行鼻窦开放.30例单纯型慢性鼻窦炎患者采取经典钩突切除术作为对照组.术后按照主观症状恢复情况和鼻内镜下局部状态综合评价疗效.结果 两组临床疗效有显著性差异(P<0.01),术后1个月、6个月并发症也有明显差异.结论 保留部分钩突的功能性鼻内镜手术基本维护了鼻腔原有结构,可对开放的鼻窦具有保护并防止吸人气流的直接冲击的作用,减少了术后并发症的发生,在同等条件下行保留部分钩突的功能性鼻内镜手术更符合微创手术理念及功能性鼻内镜手术理念.     

经鼻内窥镜下钩突切除术

功能性内窥镜鼻窦手术 (ｆｕｎｃｔｉｏｎａｌｅｎｄｏｓｃｏｐｉｃｓｉｎｕｓｓｕｒ ｇｅｒｙ ,ＦＥＳＳ)由 3部分构成 ,即彻底清除不可逆病变 ,尽可能保留窦内黏膜 ,尤其要保留中鼻甲 ;建立良好的以筛窦为中心的各窦通畅引流 ,最重要的是开放上颌窦自然窦口 ;建立良好的鼻腔通气。手术成功的关键之一是充分扩大进入术腔的入口 ,即切除钩突、鼻丘气房及中鼻甲前附着端和鼻外侧壁所成夹角的部分黏膜和骨质[1 ] 。钩突切除术是内窥镜下筛窦开放与上颌窦扩大自然开口术的第一步。我们总结了山东大学齐鲁医院耳鼻咽喉科 1999年 1月至 12月经鼻…     

鼻内窥镜下保留上颌窦口黏膜处理方式疗效110例分析

目的:比较保留上颌窦口黏膜和不保留上颌窦口黏膜的两种上颌窦手术方法对慢性上颌窦炎治愈率的差异。方法:将慢性上颌窦炎病例110例随机分为对照组和治疗组,每组55例,采用鼻内窥镜下行上颌窦手术。对照组清理中鼻道阻塞因素、切除钩突后,扩大上颌窦骨性窦口并切除上颌窦口黏膜;治疗组清理中鼻道阻塞因素、切除钩突后,扩大上颌窦骨性窦口但保留上颌窦口黏膜贴于骨性创口。结果:随访12个月以上。依照海口1997年标准,对照组72侧,治愈65侧,治愈率为90.3%,治疗组77侧,治愈70侧,治愈率为90.9%;对照组好转4侧,好转率为5.6%,治疗组好转4侧,好转率为5.2%。结论:鼻内窥镜下两种上颌窦炎处理方法疗效相同。     

经鼻内镜中鼻道置管治疗慢性上颌窦炎观察

目的 探寻经鼻内镜最适上颌窦口处理方法.方法 选择各型慢性鼻窦炎双侧均有上颌窦炎者220例.同一患者右侧在鼻内镜下切除上颌窦口处钩突尾端部分,将带有前叶及尾叶的硅胶管,放置于上颌窦口处,于术后2～12 W取出置管.左侧行单纯窦口扩大,术后复查第6个月时对比评价窦口开放,分泌物引流情况.结果 置管后窦口开放率在92%,单纯窦口扩大窦口开放率在86%,分泌物引流明显优于单纯窦口扩大侧.结论 经鼻内镜上颌窦自然窦口置管最大可能保留了上颌窦的引流结构与功能,疗效肯定,值得推广.     

鼻内镜术中保留或部分保留钩突的手术体会

目的：研究保留或部分保留钩突在鼻内镜术中的临床意义。方法：确诊为双侧慢性鼻窦炎及（或）鼻息肉的患者分为实验组与对照组,每组45例,患者的左侧鼻腔作为实验组,右侧为对照组。实验组为经鼻内镜行保留或部分保留钩突的鼻窦开放术。对照组用经典的FESS术。结果：术后1年时随访。治愈：实验组40例（88.8%）,对照组38例（84.4%）;好转：实验组5例（11.1%）,对照组7例（15.6%）。结论：鼻窦开放术中保留或部分保留钩突维持了鼻腔的正常解剖学形态,同时避免吸入性气流对鼻窦的直接冲击,预防鼻腔粘连。术后的术腔黏膜恢复和临床治愈率与经典的FESS术无明显差异。     

钩突成形术在慢性上颌窦炎手术治疗中的应用

自从功能性鼻窦内窥镜手术开展以来,上颌窦口扩大术就成为治疗慢性鼻窦炎的经典术式,完整切除钩突也作为上颌窦口扩大术以及功能性鼻窦内窥镜手术的第一步得以广泛开展。在临床实践中进行单纯慢性鼻窦炎手术时发现,部分病人钩突尾端残留,甚至完整保留钩突并不影响手术效果。许庚研究表明,保留或重塑钩突的鼻窦开放术维护或重建鼻腔原有结构,可对开放的鼻窦具有保护并防止吸人气流直接冲击的作用。     

钩突尾端切除术治疗单纯性上颌窦炎86例（160侧）报告

目的：应用钩突尾端切除术替代钩突切除术治疗病变仅限于上颌窦的单纯性上颌窦炎,以提高治愈率、降低并发症发生率。方法：在钩突前方约中点偏下始切口,沿钩突弧形向后下方切开钩突前缘黏膜,以弯剥离器伸入钩突下段外侧,将之分离,在切口起始点处水平剪断钩突骨质及黏膜,完整取出钩突尾端,扩大上颌窦口,将窦口病变予清除。结果：对我科2002年4月～2005年7月收治的单纯性上颌窦炎104例患者,采取钩突切除术治疗者18例（33侧）,钩突尾端切除术治疗者86例（160侧）进行观察,对治愈率和并发症发生率进行统计学分析,两者具有明显差异,钩突尾端切除术疗效明显好于钩突切除术,且手术并发症风险前者明显小于后者。结论：钩突尾端切除术对于单纯性上颌窦炎患者,具有损伤小、保留正常组织多、并发症少、疗效好的特点,符合微创手术理念及功能性鼻内镜手术理念,应是治疗单纯性上颌窦炎的首选术式。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.