丹参川芎嗪联合低分子肝素预防老年髋关节周围骨折下肢深静脉血栓形成的临床研究

目的观察丹参川芎嗪联合低分子肝素预防老年髋关节周围骨折下肢深静脉血栓形成的临床疗效。方法选取43例老年髋关节周围骨折患者随机分为治疗组和对照组,治疗组22例采用丹参川芎嗪联合低分子肝素预防下肢深静脉血栓形成,对照组21例采用低分子肝素预防。术后彩色多普勒检查评估两组患者下肢深静脉血栓形成情况,并检测患者血D-二聚体。结果两组患者在术后预防下肢深静脉血栓形成疗效上差异有统计学意义(P0.05)。两组患者术前血D-二聚体比较差异无统计学意义(P0.05)。术后第10天查血D-二聚体,治疗组显著低于对照组,差异有统计学意义(P0.05)。此外,治疗期间两组患者均无严重出血,其伤口引流量均由少至无,两组比较差异无统计学意义(P0.05)。结论丹参川芎嗪联合低分子肝素能有效预防老年髋关节周围骨折下肢深静脉血栓形成,其疗效优于单独使用低分子肝素。     

分析低分子肝素钙预防老年下肢创伤骨折患者术后深静脉血栓(DVT)形成的临床效果

目的分析低分子肝素钙预防老年下肢创伤骨折患者术后深静脉血栓(DVT)形成的临床治疗效果。方法择取2017年1月至2018年1月我院收治的50例下肢创伤老年患者,随机均分为观察组与对照组,各为25例。对照组患者施以骨折术后常规治疗;观察组患者加用低分子肝素钙治疗。将两组患者不良反应发生率、凝血功能指标以及DVT形成率。结果观察组患者PT、TT、APTT、FIB均优于对照组(P0.05);观察组患者DVT形成率均明显少于对照组(P0.05);两组患者在治疗期间均未出现严重不良反应。结论低分子肝素钙能够有效改善与预防老年下肢创伤骨折患者术后深静脉血栓(DVT)形成,减少不良反应事件。     

低分子肝素预防老年患者髋部骨折下肢深静脉血栓疗效分析

目的:探讨低分子肝素预防老年患者髋部骨折下肢深静脉血栓(DVT)的疗效.方法:选取老龄髋部骨折患者166例,按入院先后分为治疗与对照2组,治疗组采用低分子肝素结合足底静脉泵物理预防治疗,对照组采用阿司匹林结合足底静脉泵物理预防治疗,对比2组患者用药前后下肢深静脉血栓形成的发生情况及术后1、10 d后血常规、凝血功能变化.结果:治疗组DVT的发生率为5％,对照组DVT的发生率为29.6％,组间比较差异有统计学意义(P＜0.05);2组患者术后血红蛋白均较术前下降(P＜0.01),但组间比较无统计学意义(P＞0.05).结论:老龄患者髋部骨折后早期采用预防深静脉血栓的措施是必要的,低分子肝素能有效的预防早期深静脉血栓形成.     

田七祛瘀胶囊联合低分子肝素预防老年股骨转子间骨折术后下肢深静脉血栓形成的效果观察

目的:观察田七祛瘀胶囊联合低分子肝素预防老年股骨转子间骨折术后下肢深静脉血栓形成的临床效果.方法:选取本院80例老年股骨转子间骨折患者,随机分为两组,每组40例.观察组予以田七祛瘀胶囊口服联合低分子肝素皮下注射预防下肢深静脉血栓,对照组单用低分子肝素皮下注射,疗程均为1周.比较两组患者D-二聚体、凝血酶原时间、活化部分凝血活酶时间变化,以及下肢深静脉血栓发生情况.结果:治疗后,观察组D-二聚体低于对照组(P<0.05),且凝血酶原时间较对照组延长(P<0.05);观察组下肢深静脉血栓发生率为4.0％,低于对照组的12.5％(P<0.05).结论:田七祛瘀胶囊联合低分子肝素预防老年股骨转子间骨折术后下肢深静脉血栓效果显著.     

髋关节周围骨折下肢深静脉血栓的术前预防

目的:观察老年髋部骨折患者术前应用低分子肝素预防下肢深静脉血栓(DVT)的有效性和安全性.方法:选取年龄大于60岁的髋关节周围骨折病人80例随机分为两组,对照组44例,试验组38例.对照组行物理方法预防(踝关节被动或主动运动,按摩下肢,下肢肌肉等长收缩);实验组行物理方法预防+低分子肝素预防.分别于入院时、术前常规行下肢静脉彩超,了解有无下肢静脉血栓形成,记录术中出血量.结果:对照组术前7例DVT形成,发生率为15.9%,试验组发生率为0%,差异有统计学意义(P<0.05);选取病例数较多的股骨头置换术患者进行术中出血量比较,统计学上无差异性(P>0.05),且无一例出现出血并发症.结论:在老年髋部骨折术前应用低分子肝素进行干预,可降低DVT的发生率,且无明显的出血的不良反应.     

动静脉泵联合低分子肝素预防下肢长管状骨骨折术后深静脉血栓形成的临床研究

目的:研究低分子肝素联合动静脉泵(AV泵)在下肢长管骨骨折术后深静脉血栓预防中的效果。方法:将下肢长管状骨骨折术后患者143例随机分成实验组75例、对照组68例,按常规使用低分子肝素和统一康复指导。实验组于术后14～20h开始使用AV泵,应用时间根据患者情况确定2,次/d,每次1小时。对照组不使用AV泵。每天观察两组患者下肢肿胀程度,使用双重超声测定下肢远、近端的静脉血栓。结果:实验组发生深静脉血栓形成4例,对照组15例,经统计学处理差异有显著性(P<0.01)。结论:低分子肝素联合AV泵能够有效减少下肢长管状骨骨折术后深静脉血栓的发生。     

穴位贴敷疗法联合磺达肝癸钠预防THA术后DVT形成的疗效观察

目的:研究股骨颈骨折的老年患者在人工股骨头置换术后采用穴位贴敷疗法联合磺达肝癸钠预防下肢深静脉血栓的效果。方法:选择2020年4月至2021年5月在珠海市中西医结合医院接受人工股骨头置换术治疗的老年股骨颈骨折患者40例,根据术后下肢深静脉血栓预防方法的不同将其分成对照组和治疗组,术后采用低分子肝素联合穴位贴敷安慰剂方式预防下肢深静脉血栓形成的20例为对照组,术后采用磺达肝癸钠联合穴位贴敷活血通络膏方式预防下肢深静脉血栓形成的20例为治疗组。比较两组术后下肢深静脉血栓形成情况、手术操作时间、术后疼痛消失时间、术后住院时间、髋关节功能恢复正常时间、骨折手术治疗效果、凝血功能、D-二聚体水平、血液流变学、血小板聚集率、血小板计数、心理状态、睡眠质量、生活质量评分。结果:治疗组术后下肢深静脉血栓形成少于对照组,差异有统计学意义(P<0.05);手术操作时间、术后疼痛消失时间、术后住院时间、髋关节功能恢复正常时间短于对照组,差异有统计学意义(P<0.05);骨折手术治疗总有效率高于对照组,差异有统计学意义(P<0.05);治疗前后凝血功能、血液流变学、血小板计数、血小板聚集率、生活质量、心理状态、睡眠质量评分的改善幅度高于对照组,差异有统计学意义(P<0.05)。结论:股骨颈骨折的老年患者在人工股骨头置换术后采用穴位贴敷疗法联合磺达肝癸钠进行治疗,可以预防下肢深静脉血栓形成,缩短手术操作时间、术后疼痛消失时间、术后住院时间、髋关节功能恢复正常时间,帮助改善凝血功能、血液流变学、血小板计数、血小板聚集率、生活质量、睡眠质量,使患者保持良好心态,提高疾病治疗效果。     

LMWH对ICU患者下肢深静脉血栓形成的预防作用

目的：观察低分子肝素对 ICU患者下肢深静脉血栓形成的预防作用。方法：将2013年7月～2014年7月于我院ICU收治的102例住院时间≥48小时的患者作为研究对象,分为低分子肝素组和常规治疗组,比较2组患者下肢深静脉血栓形成的发生率和凝血指标结果。结果：低分子肝素组的DVT发生率小于常规组DVT发生率,2组间的差异有统计学意义。结论：低分子肝素可以安全并有效的预防ICU患者下肢深静脉血栓的形成。     

低分子肝素在预防大隐静脉曲张术后患肢深静脉血栓形成中的作用

目的探讨低分子肝素在预防大隐静脉曲张术后患肢深静脉血栓形成中的作用。方法分析200例大隐静脉曲张术后应用低分子肝素抗凝患者(观察组)及200例术后未应用低分子肝素抗凝患者(对照组)下肢深静脉血栓形成发生情况及术后患肢皮下血肿的发生情况。结果两组患者术后患肢深静脉血栓形成的发生率比较差异有统计学意义(P<0.05),术后患肢皮下血肿发生率比较差异无统计学意义(P>0.05)。结论大隐静脉曲张术后应用低分子肝素抗凝治疗,可显著降低下肢深静脉血栓形成的发生,同时不增加患肢术后出血的风险。     

术前应用低分子肝素对预防老年髋关节置换术后深静脉血栓形成的安全性与有效性研究

目的观察术前应用低分子肝素钙(low molecular weight heparin calcium injection,LMWH)预防人工髋关节置换术后深静脉血栓形成的安全性、有效性。方法选取山西省某煤矿三甲医院2014年1月~2015年12月期间符合标准的60例人工髋关节置换术后患者为研究对象,并随机分为两组。试验组:给予腹部皮下注射低分子肝素钙5000 IU。术后每天皮下注射1次,剂量同术前,共治疗7 d。对照组:术前不采用任何预防方法,术后处理同试验组。检测术后输血量、血小板计数、术后引流量、红细胞、血红蛋白、活化部分凝血酶原时间、彩色多普勒检测深静脉血栓、患者术后DVT发生率。结果试验组1例发生深静脉血栓,对照组6例发生深静脉血栓,两组下肢深静脉血栓发生率比较,差异有统计学意义(P0.05);两组术后输血量、血小板计数、血红蛋白、活化部分凝血酶原时间等比较,差异均无统计学意义(P0.05)。结论术前应用低分子肝素钙可为预防老年患者人工髋关节置换术后深静脉血栓的发生提供了一种安全、有效的措施。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.