复方马齿苋片对尖锐湿疣患者复发率与免疫功能的影响

目的：探讨复方马齿苋片治疗尖锐湿疣（CA）的临床疗效。方法：将93例患者随机分为3组,均采用微波除疣的基础上,治疗组采用本院中药制剂室提供的复方马齿苋片治疗;对照Ⅰ组不作其他处理;对照Ⅱ组肌肉注射重组人d2a干扰素。比较3组的临床疗效。结果：治疗组的总有效率明显优于对照Ⅰ组、对照Ⅱ组（P〈0．05）,复发率明显减低,且对血清T淋巴细胞亚群具有明显调节作用（P〈0．05）;3组均无不良反应、安全。结论：复方马齿苋片治疗尖锐湿疣效果较好,可明显降低CA复发率,提高机体免疫功能。     

注射用重组人干扰素alb(赛若金)治疗尖锐湿疣的疗效观察

目的:探讨注射用重组人干扰素alb(赛若金)治疗尖锐湿疣的疗效,为赛若金的推广应用提供参考。方法:选择符合尖锐湿疣诊断标准的患者120例,随机分成治疗组60例和对照组60例,对照组采用单纯CO2激光汽化治疗,治疗组加用赛若金注射治疗1.5个月。结果:治疗后,治疗组疗效明显优于对照组(P<0.05)。随访3个月,治疗组的复发率也明显少于对照组(P<0.05)。结论:赛若金辅助治疗尖锐湿疣能提高临床疗效,降低复发率,值得推广。     

LEEP刀联合咪喹莫特乳膏治疗外阴尖锐湿疣69例疗效观察

目的:探讨高频电波刀(LEEP刀)联合咪喹莫特乳膏治疗外阴尖锐湿疣的疗效.方法:138例外阴尖锐湿疣患者随机分为观察组和对照组,每组69例,对照组采用LEEP刀治疗,观察组采用LEEP刀联合咪喹莫特乳膏治疗,比较两组患者治疗4周时、8周时的总有效率,复发率和不良反应发生率.结果:两组患者治疗8周时的总有效率均明显高于治疗4周时(P<0.05);观察组患者治疗4周时、8周时的总有效率均明显高于对照组(P<0.05).观察组患者复发率、不良反应发生率分别为8.7%(6/69)、60.9%(42/69),均明显低于对照组(P<0.05).结论:LEE P刀联合咪喹莫特乳膏治疗外阴尖锐湿疣具有临床疗效好、复发率低、不良反应少等优点,值得在临床上推广应用.     

除疣汤外洗联合CO2激光治疗尖锐湿疣的临床研究

目的:观察中药除疣汤外洗配合CO2激光治疗尖锐湿疣(CA)的临床疗效及复发率。方法:将34例符合入组标准的CA患者随机分为治疗组(17例)与对照组(17例),分别给予除疣汤外洗配合CO2激光治疗与单纯使用CO2激光治疗;观察其治愈情况及预防复发的临床效果。结果:中药配合CO2激光治疗组在治疗及预防尖锐湿疣复发的临床疗效明显优于对照组(P<0.05)。治愈率分别为:治疗组94.12%,对照组58.82%;平均复发率分别为:治疗组7.84%,对照组33.33%。结论:除疣汤在防治尖锐湿疣方面有很好的效果,临床上值得推广。     

薏苡仁甘草汤防治尖锐湿疣复发68例临床观察

【目的】观察薏苡仁甘草汤对预防尖锐湿疣复发的疗效及其对相关免疫指标的干预作用,为预防微波除疣后的尖锐湿疣复发寻找有效的治疗药物。【方法】34例微波除疣后的尖锐湿疣(CA)患者内服薏苡仁甘草汤,服药后观察其CA复发率情况;并采用双抗夹心法及玫瑰花环法,分别于用药前及用药后动态观察血液中白细胞介素--2(IL-2)、外周血T淋巴细胞亚群等免疫指标的变化,并与安慰剂组(34例)作比较。【结果】治疗组的复发率为20.5％,其防治CA复发的效果明显优于安慰剂组的47.0％(P<0.05);治疗组经治疗后血清IL-2,外周血T淋巴细胞亚群等免疫指标均有明显改善(P<0.05或P<0.01),而安慰剂组则变化不明显(P>0.05)。【结论】薏苡仁甘草汤能有效阻止和减少CA的复发,改善患者的免疫功能。     

甘露聚糖肽胶囊联合光动力治疗尖锐湿疣临床疗效的研究

目的:探讨甘露聚糖肽胶囊联合光动力治疗尖锐湿疣（CA）的临床疗效。方法:145例CA患者随机分为三组,对照组（CO₂激光组,45例）、治疗1组（CO₂激光+甘露聚糖肽胶囊组,50例）、治疗2组（CO₂激光+甘露聚糖肽胶囊联合光动力组,50例）,分别观察各组的疗效和复发情况。结果:对照组、治疗1组、治疗2组治愈率分别为64.4%、88.0%和92.0%。治疗2组疗效明显优于治疗1组和对照组（P<0.05）。痊愈患者均随访半年,对照组、治疗1组、治疗2组的复发率分别为41.4%、20.1%和10.1%,治疗2组复发率明显低于治疗1组和对照组（P<0.05）。3组患者除局部反应外,均未见全身不良反应。结论:甘露聚糖肽胶囊联合光动力治疗CA可提高临床疗效,降低复发率,不良反应少。     

薄芝糖肽联合电离子治疗尖锐湿疣疗效观察

目的:探讨薄芝糖肽联合电离子治疗尖锐湿疣(CA)的疗效及安全性。方法:随机将67例CA患者分为两组,A组37例,单纯应用电离子法治疗;B组30例,薄芝糖肽联合电离子治疗。结果:A组和B组复发率分别为62.16%、33.33%(χ2=5.51,P<0.05)。结论:薄芝糖肽联合电离子法治疗CA疗效明显高于单纯应用电离子治疗。     

复方竹叶草脂联合白细胞介素-2治疗尖锐湿疣312例

目的:观察复方竹叶草脂联合白细胞介素-2(IL-2)治疗尖锐湿疣的疗效和安全性。方法:尖锐湿疣420例分别采用复方竹叶草脂联合IL-2治疗(312例),或单独使用复方竹叶草脂治疗(108例),观察其疗效和不良反应。结果:联合治疗组有效311例(99.7%),复发6例(1.9%),单用竹叶草脂组有效106例(98.1%),复发23例(21.3%),联合治疗组复发率明显低于单纯使用复方竹叶草脂组(P<0.05),两组均未发现严重不良反应。结论:复方竹叶草脂联合IL-2治疗尖锐湿疣有效率高,复发率低,是较好的治疗尖锐湿疣方案。     

鼻内镜手术治疗慢性鼻窦炎患者的临床疗效分析

目的:探讨鼻内镜手术治疗慢性鼻窦炎患者的临床效果。方法:选取我院2012年-2014年间行手术的110例慢性鼻窦炎患者,分成观察组(60例)和对照组(50例),观察组进行鼻内镜手术,对照组采取常规鼻外径手术治疗,术后随访1年,评定患者恢复情况,对比两组疗效。结果:观察组患者治疗总有效率明显优于对照组,组间比较差异具有统计学意义(P<0.05);I、II型治疗总有效率明显高于III型,比较差异具有统计学意义(P<0.05),I型治愈率明显高于II型,两者比较差异具有统计学意义(P<0.05)。观察组复发率明显低于对照组,组间比较差异具有统计学意义(P<0.05)。结论:鼻内镜手术治疗慢性鼻窦炎具有良好效果,该手术后复发率较低,临床分型越轻,其治疗有效率则越高,应尽早给予患者手术治疗,以进一步提高疗效。     

CO2激光联合胸腺肽治疗尿道外口尖锐湿疣临床分析

目的 观察二氧化碳激光联合胸腺肽治疗尿道外口尖锐湿疣(condyloma acumina- tum CA)的疗效和复发率.方法 收治尿道外口尖锐湿疣患者58例,治疗组28例采用二氧化碳激光联合胸腺肽治疗,对照组30例单纯采用二氧化碳激光治疗,观察两组治愈率及复发率.结果 临床治疗后3个月,治疗组治愈率为85.7%,对照组治愈率为66.6%,治疗组治愈率高于对照组,具有统计学意义(P＜0.05);两组复发率分别为10.7%,36.6%;治疗组复发率显著低于对照组,具有统计学意义(P＜0.05).结论 二氧化碳激光联合胸腺肽治疗尿道外口CA疗效肯定,复发率低,是目前治疗及预防尖锐湿疣复发的有效方法之一.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Dr.Zhang Ren's Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.