血脂康和脂必妥治疗中老年高脂血症的比较

观察比较血脂康和脂必妥治疗中老年高脂血症病人的调脂作用６２例高脂血症病人随机分成２组，血脂康组３０例，脂必妥组３２例，疗程均为８周，结果两缚对ＨＤＬ－Ｃ上升差别有高度显著性（Ｐ〈０．０１），ＴＧ，ＬＤＬ－ｃ（ＴＣ－ＨＤＬ－ｃ）／ＨＤＬ－ｃ下降差别有显著及高度显著性（Ｐ〈０．０５及０．０１）此外对ＴＣ也有不同程度的作用，未见严重副作用，表明两药皆为安全有效的调脂药物。     

血脂康和多烯康对高脂血症调脂作用的比较

采用血脂康与多烯康分别治疗高脂血症,血脂康组总有效率达９３ ．８ ％ ,用药４ 周 Ｔ Ｃ、 Ｔ Ｇ、 Ｌ Ｄ Ｌ－ Ｃ、动脉粥样硬化指数（ Ａ Ｓ指数） 均有显著下降（ Ｐ＜ ０ ．０１） ,用药８ 周进一步下降（ Ｐ＜ ０ ．０１） , Ｈ Ｄ Ｌ－ Ｃ 明显升高（ Ｐ＜ ０ ．０５） 。多烯康组用药８ 周 Ｔ Ｃ、 Ｔ Ｇ、 Ｌ Ｄ Ｌ－ Ｃ、 Ａ Ｓ指数亦有明显下降,但 Ｈ Ｄ Ｌ－ Ｃ 无显著变化。结论：血脂康调脂作用明显优于多烯康。     

血脂康和多烯康对高脂血症调脂作用的比较

采用血脂康与多烯康分别治疗高脂血症,血脂康组总有效率达９３．８％,用药４周ＴＣ、ＴＧ、ＬＤＬ－Ｃ、动脉粥样硬化指数（ＡＳ指数）均有显著下降（Ｐ〈０．０１）,用药８周进一步下降（Ｐ〈０．０１）,ＨＤＬ－Ｃ明显升高（Ｐ〈０．０５）。多烯康组用药８周ＴＣ、ＴＧ、ＬＤＬ－Ｃ、ＡＳ指数亦有明显下降,但ＨＤＬ－Ｃ无显著变化。结论：血脂康调脂作用明显优于多烯康。     

气功锻炼对高脂血症影响的临床观察

对比观察４７例健康者和１０５例高脂血症者练“小周天”功３个月前后血中总胆固醇（ＣＨ）、甘油三脂（ＴＧ）、高密度脂蛋白（ＨＤＬ）变化，与８０例高脂血症服药组比较，结果高脂血症者练功后ＣＨ、ＴＧ明显下降（Ｐ＜０．００１），ＨＤＬ明显增加（Ｐ＜０．０１）；健康人练功后ＴＧ明显下降（Ｐ＜０．００１），ＣＨ呈下降，ＨＤＬ呈增加趋势。与药物组比较疗效相当，在降ＴＧ作用上优于药物，且无任何毒副反应。提示气功锻炼不仅可以治疗高脂血症，同时具有预防高脂血症的作用。     

维脂泰胶囊治疗高脂血症56例临床观察

观察了维脂泰胶囊对高脂血症的降脂作用。将患者随机分为治疗组５６例，对照组降脂平２５例，月见草效丸３７例，疗程均为４个月。结果，治疗组治疗前后ＴＣ，ＴＧ，ＴＣ－ＨＤＬ－Ｃ／ＨＤＬ－Ｃ均有显著差异，Ｐ〈０．０１，疗效明显优于月见草油丸组，Ｐ〈０．０１；与降脂平组相比，ＨＤＬ－Ｃ及ＴＣ－ＨＤＬ－Ｃ／ＨＤＬ－Ｃ改变有显著差异，Ｐ〈０．０５。     

化脂灵治疗高脂血症的临床研究

用随机、对照的方法，将１８１例原发性高脂血症患者按１：０．８比例分化脂灵组１００例，对照组８１例。治疗前、后１个月分别观察其血甭总胆固醇（ＣＨ）、甘油三酯（ＴＧ）、低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）、极低密度脂蛋白胆固醇（ＶＬＤＬ－Ｃ）的变化。结果，化脂灵组治疗前后比较，效果显著（Ｐ〈０．０５￣０．０１）。两组治疗后比较，其中ＴＧ、ＣＨ、ＬＤＬ－Ｃ化肥灵组优于对照组（Ｐ〈０．０５）。另外，还观察了血     

辛伐他汀治疗原发性高脂血症185例疗效观察

目的观察辛伐他汀对原发性高脂血症患者调节血脂的强度和不良反应。方法 经健康体检筛选出１８５例高脂血症患者，随机分为两组，即服辛伐他汀组和服烟酸肌醇酯对照组。４－８周复查血脂，用卡方检验和ｔ检验进行统计学处理。结果 两组治疗前后组内比较，ＴＣ，ＴＧ，ＬＤＬ－Ｃ及ＨＤＬ－Ｃ差异均有显著性，组间比较ＴＣ及ＨＤＬ－Ｃ差异有显著性；治疗后两组总有效率比较，ＴＣ降低，ＨＤＬ－Ｃ升高辛他汀组显著，ＴＧ降低差异无     

欣露治疗高脂血症49例疗效观察

我们用随机方法观察比较欣露与力平脂治疗７７例原发性高脂血症病人的治疗效果，结果表明：两组均可显著降低血清总胆固醇（ＴＣ）和低密度脂蛋白胆固醇（ＬＤＬ－Ｃ），降ＴＣ总有效率均达９５％，对甘油三酯（ＴＧ）和高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）亦有显著影响。两组均未发现明显副作用。     

黄花倒水莲对高脂血症患者高、低密度脂蛋白等的影响

运用黄花倒水莲口服液（ＰＡＤ）治疗原发性高脂血症,以诺衡为对照,观察其对高密度脂蛋白（ＨＤＬＣ）低密度脂蛋白（ＬＤＬ－Ｃ）等的影响。结果;两组治疗后ＬＤＬ－Ｃ,ＴＣ－ＨＤＬ－Ｃ／ＨＤＬ－Ｃ等均有明显下降ＨＤＬ－Ｃ则有明显提高,与治疗前比较均有非常显著性差异（Ｐ〈０．０１）,但对照组有３例出现肝功能损害,结论：ＰＡＤ治疗原发性高脂血症有确切的调脂作用,其疗效与诺衡相当,且有副作用少,病人易于接受等特     

非高脂血症冠心病患者血脂,脂蛋白及载脂蛋白浓度分析

目的 研究非高脂血症冠心病（ＣＨＤ）患者血浆脂质、脂蛋白及载脂蛋白（ａｐｏ）ＡＩ、Ｂ１００浓度豪华。方法 选择总胆固醇（ＴＣ）〈６．０ｍｋｍｏｌ／Ｌ,甘油三酯（ＴＧ）〈２．０ｍｍｏｌ／Ｌ的ＣＨＤ患者５０例和健康对照者３０例,采用酶法测定了血浆ＴＧ,ＴＣ,高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）及其亚组分（ＨＤＬ２－Ｃ,ＨＤＬ３－Ｃ）,并计算出ＨＤＬ－Ｃ／ＴＣ及低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）;采用ＥＬＩＳ     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.     

Possible Spread of adenovirus type 3 from poultry to humans ：indirect evidence from an outbreak in China

Objective:To explore the epidemiology and etiology for an outbreak of acute respiratory tract infection that occurred in one county of Jiangsu Province, China 2004. Methods: Only cases meeting the case definition were included in the study. We reviewed the medical records of the cases who were admitted to the local hospitals, interviewed cases by a standard questionnaire, and then described the epidemiotogic features and analyzed risk factors by means of a case-control study. We collected pharyngeal swab specimens and sent them to different laboratories for isolation and culture. The laboratory used different detection methods such as DIP, PCR, electron microscope examination and microneutralization assay, to identify and then type the positive specimens. Results:A total of 871 cases were reported during the period from April 18 to July 4,2004. The distribution of onset times presented two peaks, one in late May and another in middle June. The epidemic occurred mainly in the elementary and junior high schools in ten townships of one county, and the mean age of the cases was 12 years (range 7 months to 18 years). The course of the disease was acute, and was characterized by fever accompanied with sore throat and tonsillitis. The WBC count of cases was normal or elevated. The mean duration of illness was 5 days (range 2 to 12 days). No fatalities from illness were reported. A case-control study indicated that the possible risk factors were close contact with a case and/or poultry before onset and sharing of towels among members of the family. The typical CPE was observed through inoculating pharyngeal swab specimens into the HEP-2 cell cultures in different laboratories. An infection of adenovirus type 3 was verified by detecting positive specimens in different methods. Conclusion:This investigation demonstrated that the acute respiratory infection in cases was caused by adenovirus type 3. Cases occurred in over 70 schools in ten townships in 2004, and the route of transmission was possibly close contact with cases or droplet transmission.