碎裂QRS波群在经皮冠状动脉介入治疗急性前壁心肌梗死病人中的预测价值

目的探讨经皮冠状动脉介入治疗急性前壁心肌梗死病人出院时心电图碎裂QRS波群对预后的判断价值。方法回顾性纳入了213例经皮冠状动脉介入治疗的急性前壁心肌梗死病人,根据病人出院前心电图是否存在碎裂QRS波群,将病人分为碎裂QRS波群组(107例)和非碎裂QRS波群组(106例)。碎裂QRS波定义为标准12导联心电图至少存在对应冠状动脉供血区域2个或2个以上连续导联的QRS波群上存在多种RSR'波型(≥1个R'波,R波的顶部或S波的底部出现顿挫波),伴有或不伴有Q波。结果两组平均随访时间对比差异无统计学意义(P=0.319)。经过1年的临床随访,本研究主要复合终点事件发生率在两组间比较差异有统计学意义(P=0.001);全因病死率在碎裂QRS波群组为7.48%,在非碎裂QRS波群组为0.94%(P=0.019);心源性病死率在碎裂QRS波群组和非碎裂QRS波群组分别为5.61%和0.94%(P=0.098);随访期间两组再发性急性冠脉综合征发生率和冠状动脉血运重建率对比具有相似的发生率。心力衰竭发生率在两组之间也相似。结论在经皮冠状动脉介入治疗急性前壁心肌梗死病人中,出院时心电图中存在碎裂QRS波的病人主要复合终点事件发生率明显高于非碎裂QRS波的病人,其中全因病死率在存在碎裂QRS波的病人中明显升高。     

伴有心电图碎裂QRS波的老年高血压患者左心室功能与结构的特点分析

目的探讨伴有心电图碎裂QRS波(fQRS)的老年高血压患者左心室功能与结构的临床特点。方法选取165例老年高血压患者为病例组,按照心电图fQRS检出情况分为fQRS组和非fQRS组;另选年龄、性别相匹配的100例健康者为对照组。比较各组超声心动图检查指标。结果病例组fQRS检出率高于对照组(P<0.05)。fQRS组舒张早期二尖瓣E峰速度(E)、E/A比值、二尖瓣环舒张早期组织运动速度(e′)低于非fQRS组,而舒张晚期二尖瓣A峰速度(A)、E峰减速度时间、E/e′高于非fQRS组(均P<0.05)。fQRS组左心室舒张末期内径、舒张末期室间隔厚度、舒张末期左心室后壁厚度、左心室质量指数均高于非fQRS组(均P<0.05)。将高血压患者分为不同靶器官组,左心室肥厚组、左心室舒张功能不全组fQRS检出率均高于对应组(均P<0.05)。结论老年高血压患者fQRS检出率较高,伴有fQRS的高血压患者左心室肥厚和左心室舒张功能受损较为明显,可能是患者发生心室重构的预警信号。     

探讨心电图碎裂QRS波在急性心肌梗死患者中的诊断价值

目的探讨心电图碎裂QRS波在急性心肌梗死患者中的诊断价值。方法选择本院2017年3月至2019年4月收治的130例心肌梗死(AMI)患者,对所有患者进行心电图检查及冠脉造影治疗,并对患者的心电图检测结果进行回顾性分析,使用本院自拟的调查量表,分别统计记录患者心电图结果中碎裂QRS波、病理性Q波、碎裂QRS+病理性Q波的数据,比较分析三种心电图类型在敏感性、特异性、阳性预测值、阴性预测值之间数据的相关性。结果患者碎裂QRS波与病理性Q波比较,敏感性、阴性预测值数据比较差异不明显(P0.05),无统计深意义;特异性、阳性预测值比较,碎裂QRS波显著高于病理性Q波,数据差异比较,P0.05,有统计学意义。患者心电图碎裂QRS波与碎裂QRS波+病理性Q波比较,患者心电图碎裂QRS波的敏感性、阳性预测值数据明显低于碎裂QRS波+病理性Q波,数据间差异比较,P0.05,有统计学意义;其特异性、阴性预测值数据与患者心电图碎裂QRS波+病理性Q波相比,差异不明显(P0.05),无统计学意义。结论数据的比较分析结果表明,患者心电图碎裂QRS波对急性心肌梗死患者的临床诊断有明显辅助作用;与患者心电图病理性Q波联合使用,可显著提高临床诊断的准确率。     

高敏肌钙蛋白T联合心电图碎裂QRS波对急性心肌梗死的早期诊断价值

目的 探讨高敏肌钙蛋白T(hs-TnT)联合心电图碎裂QRS波对急性心肌梗死(AMI)的早期诊断价值.方法 选取2017年10月至2018年10月本院心血管内科收治的102例AMI患者作为AMI组,并选取同期在本院健康体检者78名作为对照组,比较两组血清hs-TnT水平及心电图碎裂QRS波发生率;比较AMI组中69例ST段抬高型心肌梗死(STEMI)患者(STEMI组)和33例非ST段抬高型心肌梗死(NSTEMI)患者(NSTEMI组)血清hs-TnT水平及心电图碎裂QRS波发生率,比较hs-TnT、心电图碎裂QRS波及两者联合监测对AMI诊断效能.结果 AMI组血清hs-TnT水平明显高于对照组,差异有统计学意义(P<0.05);STEMI组血清hs-TnT水平明显高于NSTEMI组,差异有统计学意义(P<0.05);AMI组碎裂QRS波发生率明显高于对照组,差异有统计学意义(P<0.05);STEMI组碎裂QRS波发生率明显高于NSTEMI组,差异有统计学意义(P<0.05);hs-TnT联合心电图碎裂QRS波对AMI诊断效能明显优于单独监测hs-TnT、心电图碎裂QRS波.结论 高敏肌钙蛋白T、心电图碎裂QRS波联合检测早期诊断急性心肌梗死灵敏度与准确性较高,能为临床诊治急性心肌梗死提供有价值的参考信息.     

心电学的新理念——碎裂QRS波

碎裂QRS波是指两个相关导联QRS波群(<120 ms)呈RSR′型(≥1个R′波、或R波、S波存在切迹),但并无典型束支传导阻滞的心电图图型。碎裂QRS波常见于急性心肌梗死,但其检出率尚待进一步研究;而在陈旧性心肌梗死的诊断中它优于病理性Q波;它是心脏事件的独立预测因子,可作为高危患者预警的心电图新指标;它是非透壁性心肌瘢痕的标志;左侧胸导联出现碎裂QRS波是室壁瘤的标志。     

碎裂QRS波在评估原发性高血压左心室肥厚中的价值

目的：探讨碎裂QRS波（fragmented QRS complex, fQRS）在原发性高血压中的发生率，及其与左心室肥厚的关系，对于原发性高血压的防治和治疗的意义。方法：回顾性纳入样本医院收治的112例原发性高血压患者作为研究对象，根据心电图特征分为fQRS波组和无fQRS波组，计算fQRS波的发生率，比较两组患者间心脏彩超检查的参数。结果：fQRS波在本研究纳入的高血压患者中的检出率为44.6%,fQRS波组患者左心室肥厚的发生率明显高于无fQRS组（P<0.001）。logistic回归分析显示，fQRS波（OR=4.26）、高血压病程（OR=1.08）、高血压分级（OR=2.94）是左心室肥厚的独立危险因素。结论：在原发性高血压患者中，fQRS波是一种常见的心电图表现，fQRS波的出现与左心室肥厚密切相关。     

心电图检测中碎裂QRS波对临床冠心病诊断的临床价值分析

目的：探讨心电图检测中碎裂QRS波对冠心病诊断的临床价值。方法选取经冠状动脉造影确诊的冠心病患者60例作为冠心病组,另选取同一时间接受检查镜冠状动脉造影明确为阴性患者60例为对照组,对2组患者心电图检测中碎裂QRS波发生率和发生部位进行比较。结果冠心病组碎裂QRS波检出率为66.7%,对照组为35.0%,差异有统计学意义（P<0.05）,且心脏下壁是碎裂QRS波易发生的位置,与前壁和侧壁比较差异有统计学意义（P<0.05）。结论心电图检测中碎裂QRS波对冠心病诊断具有较高的检出率,可作为心电图诊断冠心病的一个新的标志,从而提高冠心病心电图诊断的准确率,减少漏诊。     

西宁地区藏族急性心肌梗死患者碎裂QRS波与近期预后的关系

目的:探讨西宁地区藏族急性心肌梗死(急性心梗)患者碎裂QRS波与近期预后的关系.方法:对143例确诊为“急性心梗”的藏族患者,根据是否出现碎裂QRS波分为两组,分别统计其发生近期死亡事件(RDI)、室性心律失常事件(VAI)、B型钠尿肽(BNP)、左室射血分数(LVEF)及左室舒张末期内径(LVDD)值,比较两组间差异.结果:碎裂QRS波发生率21.7％.两组间VAI、RDI、BNP、LVEF有显著差异;两组间LVDD无显著差异.结论:西宁地区藏族急性心梗患者碎裂QRS波发生率较低;常规12导联心电图上存在碎裂QRS波是急性心梗患者近期死亡和室性心律失常事件、左心功能受损的强有力指标.     

心功能不全CMRI、心电图表现及其诊断价值研究

目的分析心功能不全患者心脏磁共振成像(CMRI)、心电图表现及其诊断价值。方法选取2019年5月至2020年6月我院收治的心功能不全患者68例为研究对象,均行CMRI、心电图检查,观察其影像学特点,依据有无症状分为有症状组、无症状组,对比两组的CMRI、心电图检查结果,并分析CMRI与心电图的诊断价值。结果CMRI、心电图下不同疾病类型的心功能不全患者均有一定影像学特点;CMRI上有症状组左室射血分数(LVEF)高于无症状组,而左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)、左心室舒张末期内径(LVEDD)低于无症状组(P<0.05),两组每搏输出量(SV)、心排血量(CO)、左心室质量(LVM)比较差异无统计学意义(P>0.05);有症状组、无症状组心电图QRS电压值、QRS时限值、QTc间期及窦性心动过速、ST-T改变、Q波异常率比较差异无统计学意义(P>0.05);心功能不全患者中,QRS时限值≥120ms者的LVEF较QRS时限值<120ms者低,而LVEDV、LVEDD大于QRS时限值<120ms者(P<0.05)。结论心功能不全患者CMRI及心电图有一定影像学表现,对于无症状的心功能不全患者经心电图可能未能发现异常,但联合CMRI检查可发现其心功能改变,将两者结合有利于提高诊断价值。     

高血压伴U波倒置临床意义分析

目的:探讨高血压伴U波倒置的临床意义。方法:选择我院2010年6月至2012年行心电图检查的高血压患者223例,其中发现U波倒置67例作为观察组,以及U波非倒置的156例作为对照组,考察观察组U波倒置心电图表现及与高血压级别关系,利用心脏彩超比较两组患者左心功能。结果:观察组患者U波倒置均为初始型,主要集中于左胸前导联,其中46例为V3～V6导联明显,6例为肢体导联明显,另有15例为胸导联、肢体导联均明显。观察组高血压分级:Ⅰ级9例,Ⅱ级21例,Ⅲ级37例,U波倒置深度与高血压的严重程度呈现正相关,高血压Ⅲ级患者倒置深度明显高于Ⅰ级和Ⅱ级(P0.05),差异有统计学意义。观察组E/A值明显低于对照组,其左心室舒张功能明显降低(P0.05)。结论:U波倒置可作为高血压早期诊断征象之一,也可成为判断血压控制是否得当的指标之一。     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.