利培酮与奋乃静治疗老年精神分裂症的对照研究

目的 比较非典型抗精神病药物利培酮与典型抗精神病药物奋乃静治疗老年精神分裂症的有效性及安全性.方法 将126例老年精神分裂症的患者按治疗药物分为两组,利培酮组(67例)和奋乃静组为(59例),比较两组患者的疗效及副反应.结果 在治疗前两组间性别、年龄、病程、PANSS等均无统计学差异(P＞0.05),两组在治疗前后PANSS评分均具显著性差异(P＜0.01),两组间在治疗后PANSS无显著性差异(P＞0.05),而TESS有显著性差异.结论 利培酮治疗老年精神分裂症与奋乃静疗效相当,但利培酮的安全性方面优于奋乃静.     

奥氮平与利培酮治疗女性精神分裂症的对照研究

目的奥氮平与利培酮对女性精神分裂症的疗效及不良反应.方法将符合CCMD-3精神分裂症诊断标准的67例女性患者随机分为两组,分别给予奥氮平与利培酮治疗,疗程为8周.以阳性和阴性症状量表(PANSS)、临床疗效总评量表(CGI)评定疗效,以精神药物副反应量表(TESS)评定不良反应.结果治疗8周后,两组患者的PANSS、CGI评分均明显减少,差异有显著性(P＜0.05).两组间比较PANSS、CGI评分差异无显著性(P＞0.05).奥氮平组不良反应发生率低于利培酮组,差异有显著性(P＜0.05).结论奥氮平与利培酮对女性精神分裂症的疗效相当,有效率分别为85.3%,80.9%,奥氮平锥体外系不良反应和内分泌改变较利培酮少,更适用于女性精神分裂症患者.     

利培酮治疗精神分裂症症状与脑血流的研究

目的 探讨精神分裂症在利培酮治疗前后脑血流的变化及与精神症状的相关关系.方法 2012年1～9月在东风汽车公司茅箭医院住院患者86例在入组时进行阳性与阴性症状量表（PANSS）检查,在第2、4、8周末分别进行PANSS量表检查,在入组时及治疗结束时分别进行经颅超声多普勒（TCD）检查,副作用评定采用副反应量表（TESS）检查.结果 精神分裂症患者大脑动脉血流参数大多表现为治疗前的高灌注状态,大脑前动脉、大脑中动脉血流参数在治疗前后差异有统计学意义（P＜ 0.05或P＜0.01）,而大脑后动脉、椎动脉、小脑后下动脉、基底动脉血流参数在治疗前后差异无统计学意义（P＞0.05）.精神分裂症患者在治疗前后TCD脑血流参数与PANSS评分的阳性症状、阴性症状、一般精神病理和总分均无明显相关性.无明显或严重的副作用.结论 精神分裂症患者大脑前动脉、大脑中动脉血流参数在治疗前后大多差异有统计学意义,精神分裂症患者在治疗前后TCD脑血流参数与PANSS评分各分量表均无明显相关性.     

利培酮合并文拉法辛治疗精神分裂症后抑郁

目的 探讨利培酮合并文拉法辛治疗精神分裂症的临床疗效的对比分析.方法 将68例符合ICD-10 诊断标准的精神分裂症患者随机分为两组,研究组用文拉法辛合并利培酮治疗,对照组用利培酮治疗,疗程2月,用PANSS、BPKS、TESS评定疗效和安全性.结果 治疗2月后文拉法辛合并利培酮组总有效率为88.24%,利培酮组总有效率67.65%,两组比较有显著性差异(P＜0.05).两组治疗前后PANSS,BPR.S评分均有明显下降(P＜0.05).结论 文拉法辛合并利培酮治疗精神分裂症阴性与阳性症状疗效显著,能改善患者的焦虑和抑郁情绪,改善认知功能,作用安全可靠.     

氯氮平、奥氮平与利培酮对精神分裂症患者肾功能的影响对比研究

目的:对比氯氮平、奥氮平与利培酮对精神分裂症患者肾功能的影响。方法:选择精神分裂症患者120例,根据用药情况将其分为三组,氯氮平组40例、奥氮平组40例与利培酮组40例。对比三组治疗前与治疗1个月后肾功能指标的变化以及临床治疗效果。结果:治疗后三组血肌酐(Cr)、尿素氮(BUN)水平高于治疗前,差异有统计学意义(P<0.05),其中氯氮平组Cr、BUN水平均高于奥氮平组与利培酮组,差异有统计学意义(P<0.05)。三组患者治疗1个月后PANSS评分均低于治疗前,差异有统计学意义(P<0.05),但三组PANSS评分对比,差异无统计学意义(P>0.05)。结论:氯氮平、奥氮平与利培酮治疗精神分裂症具有显著的效果,但长期服用三种药物均可以影响肾功能,其中以氯氮平的影响最为明显。     

利培酮(卓菲)对传统抗精神病药治疗无效的精神分裂症患者的疗效

目的探讨国产利培酮在治疗使用传统抗精神病药无效的精神分裂症患者的疗效. 方法对比43例使用过3种和3种以上传统抗精神病药物治疗入组时阳性和阴性症状量表(PANSS)评分大于60分的精神分裂症患者换用利培酮治疗,观察6周,于换用前和换用后2、4、6周末进行PANSS和副反应量表TESS评定. 结果换药4周后PANSS减分率与换药前比较差异有显著性(t=3.12,P＜0.01),副反应量表(TESS)换药前后差异显著(t=2.50,P＜0.05),说明国产利培酮疗效优于传统抗精神病药,不良反应轻微.结论国产利培酮在治疗精神分裂症方面较传统抗精神病药有较好的疗效和安全性.     

齐拉西酮治疗精神分裂症34例临床效果分析

目的:探讨齐拉西酮治疗精神分裂症的临床效果.方法:选择本院精神分裂症患者68例,分为观察组和对照组.观察组给予齐拉西酮,对照组给予利培酮.采用阳性和阴性症状量表(PANSS)对两组患者治疗前后进行评定;观察两组主要不良反应.结果:两组患者治疗后阳性症状评分、阴性症状评分和总分分别与对照组比较,差异无统计学意义(P均＞0.05);两组不良反应发生率比较,差异有统计学意义(P＜0.05).结论:齐拉西酮治疗精神分裂症临床疗效和利培酮相似,但是齐拉西酮不良反应较利培酮少且轻,值得应用.     

舍曲林联合利培酮治疗精神分裂症阴性症状的临床观察

目的 探讨舍曲林联合利培酮治疗精神分裂症阴性症状的疗效和安全性.方法 将60例以阴性症状为主的住院精神分裂症患者随机分为研究组(利培酮合用舍曲林治疗)与对照组(单用利培酮治疗),每组各30例,疗程8周.在治疗前及治疗后4、8周末,采用阳性与阴性症状量表(PANSS)、副反应量表(TESS)评定疗效和副作用.结果 4周末两组PANSS总分、阳性因子分、阴性因子分及8周末两组PANSS总分和各因子分与疗前比较差异有显著性(P＜0.05或P＜0.01).8周末两组间比较PANSS总分及阴性因子分差异有显著性(P＜0.05或P＜0.01).结论 合用合曲林治疗精神分裂症阴性症状有较好的疗效,且安全性好.     

舍曲林联合利培酮治疗精神分裂症阴性症状的临床观察

目的 探讨舍曲林联合利培酮治疗精神分裂症阴性症状的疗效和安全性.方法 将60例以阴性症状为主的住院精神分裂症患者随机分为研究组(利培酮合用舍曲林治疗)与对照组(单用利培酮治疗),每组各30例,疗程8周.在治疗前及治疗后4、8周末,采用阳性与阴性症状量表(PANSS)、副反应量表(TESS)评定疗效和副作用.结果 4周末两组PANSS总分、阳性因子分、阴性因子分及8周末两组PANSS总分和各因子分与疗前比较差异有显著性(P＜0.05或P＜0.01).8周末两组间比较PANSS总分及阴性因子分差异有显著性(P＜0.05或P＜0.01).结论 合用合曲林治疗精神分裂症阴性症状有较好的疗效,且安全性好.     

氨磺必利与利培酮治疗精神分裂症的效果对比

目的研究讨论氨磺必利和利培酮分别在精神分裂症中的治疗效果。方法选取我院94例精神分裂症患者进行研究,按治疗方法分成采用氨磺必利治疗的甲组(n=47),以利培酮治疗的乙组(n=47),比较两组精神分裂症患者治疗疗效。结果甲乙组的治疗总有效率分别为91.48%、82.98%,组间总有效率比较没有明显差异(P0.05);治疗8周末两组的PANSS阴性评分存在显著差异(P0.05);但甲乙组患者治疗8周末的PANSS阳性评分和一般精神病理症状、总分比较没有明显差异(P0.05)。结论氨磺必利、利培酮在治疗精神分裂症方面都有明显疗效,且氨磺必利治疗效果要略优于利培酮。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.