吲达帕胺缓释片单独或联合阿托伐他汀治疗老年单纯收缩期高血压的疗效比较

目的 比较吲达帕胺缓释片单独或联合阿托伐他汀治疗老年单纯收缩期高血压降压效果的差异。方法 随机、单盲、阳性药物对照平行研究。选取血脂正常老年单纯收缩期高血压患者81例，随机单盲分为两组：吲达帕胺治疗组（A组，40例），每日口服钠催离1．5mg；吲达帕胺联合阿托伐他汀治疗组（B组，41例），每日口服钠催离1．5mg和立普妥10mg。两组均经2周安慰荆洗脱期后进入治疗，随访8周。观察肝肾功能、电解质、血脂、血压的变化。结果 A组和B组的高血压治疗达标率分别为73％和78％，两组对比无显著性差异，分别降低收缩压27．8mmHg和33．0mmHg，组内前后对比呈高度显著性差异（P〈O．01）。两组的降压值相比，B组可额外降低收缩压5．2mmHg，具有显著性意义（P〈0．05）。结论 B组较A组可进一步降低血压。阿托伐他汀可能存在一定程度的降压作用。     

吲达帕胺与卡托普利合用降压的疗效观察

目的观察卡托普利与吲达帕胺舍用的降压疗效及其对生物化学代谢的影响。方法原发性高血压病患者59例,随机分成2组。卡托普利组29例：单用卡托普利25～50mg,3次／天;吲达帕胺与卡托普利合用组30例：卡托普利25～50mg,3次／天,加吲达帕胺2．5mg,1次／天。2组疗程均为8周。观察2组治疗前后的血压和24h动态血压及生物化学指标变化。结果吲达帕胺与卡托普利合用降压总有效率及血压、24h动态血压的变化均明显优于卡托普利组,且治疗前后心率和生物化学指标无明显改变。结论吲达帕胺与卡托普利联合应用降压效果较单用卡托普利更为有效,且对代谢无影响,二者合用为合理可靠的治疗高血压方案。     

科素亚与吲哒帕安治疗原发性高血压的疗效比较

目的：观察科素亚和吲哒帕安单用或合用对原发性高血压（EH）的降压作用和不良反应。方法：坐位舒张压（SDBP）在95～114mmHg的EH病人86例分为2组,科素亚组46例,眼科素亚50mg,qd（2周后如SDBP＞95mmHg时加服吲哒帕安2．5mg．qd）共6周;对照组40例．服吲哒帕安2．5mg,qd,连续用药6周。结果：两药合用降压疗效明显增强．不良反应少。结论：西药对EH有效,合用效佳,降压平稳且安全。     

蚓哒帕胺致低钾血症17例临床分析

目的:对蚓哒帕胺致低钾血症进行分析,并探讨其引起低钾血症的常见原因。方法:单独以蚓哒帕胺降压治疗的147例高血压患者,分析其低钾血症的发生率,低钾血症的发生与用药剂量、用药时间的关系。结果:使用蚓哒帕胺后引起低钾血症与年龄因素明显相关,随年龄增大,其发生比例增加,随用药剂量增加,低钾血症发生率增加。结论:老年高血压患者长期大剂量使用蚓哒帕胺时低钾血症的不良反应明显,临床中使用蚓哒帕胺时应注意小剂量使用。     

吲哒帕胺治疗老年高血压的疗效分析

目的：观察小剂量与常规剂量吲达帕胺对老年高血压的疗效和安全性。方法：选择我院164例1、2级老年高血压患者，随机分为小剂量（A组）和常规剂量（B组）各82例。A组服吲达帕胺1．25mg，B组服2．5mg，均1次／日，疗程为8周。所有患者均在治疗前、后测血压、血电解质、血糖、血脂及血尿酸，并进行比较。结果：A组和B组的降压总有效率分别为83．3％和89．6％（P〉0．05）。两组的血钾、血钙、血糖、胆固醇、甘油三酯、血尿酸治疗前、后均无明显变化（P〉0．05）。结论：小剂量与常规剂量吲达帕胺治疗老年高血压疗效相近，但小剂量治疗更经济、不良反应少、更安全。     

缓释异搏定治疗老年单纯收缩期高血压临床疗效观察

目的：探讨缓释异搏定对老年纯收缩期高血压的疗效。方法：46例病人停服降压药2周后给予缓释异搏定由120mg渐增至360mg日一次口服，疗程四周，观察治疗前后降压疗效、降压幅度、心率变化及不良反应。结果：46例病人降压总有效率达89．2％，血压下降16％，心率下降10％，不良反应较少，且均能耐受。结论：缓释异搏定治疗老年纯收缩期高血压疗效好、顺应性好。     

吲达帕胺缓释片单独或联合阿托伐他汀治疗老年单纯收缩期高血压的疗效比较

目的:比较吲达帕胺缓释片单独或联合阿托伐他汀治疗老年单纯收缩期高血压降压效果的差异。方法:随机、单盲、阳性药物对照平行研究。选取血脂正常老年单纯收缩期高血压患者81例,随机单盲分为二组:吲达帕胺治疗组(A组40例),每日口服钠催离1.5mg;吲达帕胺联合阿托伐他汀治疗组(B组41例),每日口服钠催离1.5mg和立普妥10mg。二组均经2周安慰剂洗脱期后进入治疗,随访8周。观察肝肾功能、电解质、血脂、血压的变化。结果:A组和B组的高血压治疗达标率分别为73%和78%,两组对比无显著性差异,分别降低收缩压27.8mmHg和33.0mmHg,组内前后对比呈高度显著性差异(P<0.01)。两组的降压值相比,B组可额外降低收缩压5.2mmHg,具有显著性意义(P<0.05)。结论:B组较A组可进一步降低血压。阿托伐他汀可能存在一定程度的降压作用。     

吲达帕胺缓释片单独或联合阿托伐他汀治疗老年单纯收缩期高血压的疗效比较

目的比较吲达帕胺缓释片单独或联合阿托伐他汀治疗老年单纯收缩期高血压降压效果的差异。方法随机、单盲、阳性药物对照平行研究。选取血脂正常老年单纯收缩期高血压患者81例,随机单盲分为两组:吲达帕胺治疗组(A组,40例),每日口服钠催离1.5mg;吲达帕胺联合阿托伐他汀治疗组(B组,41例),每日口服钠催离1.5mg和立普妥10mg。两组均经2周安慰剂洗脱期后进入治疗,随访8周。观察肝肾功能、电解质、血脂、血压的变化。结果A组和B组的高血压治疗达标率分别为73%和78%,两组对比无显著性差异,分别降低收缩压27.8mmHg和33.0mmHg,组内前后对比呈高度显著性差异(P<0.01)。两组的降压值相比,B组可额外降低收缩压5.2mmHg,具有显著性意义(P<0.05)。结论B组较A组可进一步降低血压。阿托伐他汀可能存在一定程度的降压作用。     

缬沙坦联合吲达帕胺治疗老年收缩期高血压疗效观察

目的 观察缬沙坦联合吲达帕胺治疗老年收缩期高血压的疗效.方法 将90例老年收缩期高血压随机分为两组,对照组和治疗组各45例.所有患者均采用饮食干预、运动干预、控制血脂、血糖及支持对症等治疗措施.治疗组加用缬沙坦、吲达帕胺片治疗,对照组加用其他两种(或以下)非同样组合降血压药物治疗,药物用法用量个体化,每日8:00、12:00、16:00、20:00分别测血压1次观察,观察时间为8周.结果 治疗组的显效率明显高于对照组,差异有统计学意义(χ2=20.51,P<0.01).结论 缬沙坦联合吲达帕胺对老年收缩高血压阻力机制和容量机制有双重阻断作用,不但能更有效的降低老年收缩期高血压,同时还可以改善其病理生理功能,使降血压更平稳、迅速,是目前治疗老年收缩期高血压的理想方法之一.     

氨氯地平治疗原发性高血压临床观察

62例高血压病Ⅰ、Ⅱ期患者分别服用氨氟地平（AM）及吲达帕胺（IN）治疗，观察降压效果及对心率（HR）、脂代谢、糖代谢、肌酐、尿酸、血电解质影响。采用随机、单盲、平行对照法。治疗组32例服氨氯地平初始剂量5～10mg／d，维持量5mg／d。对照组30例，服吲达帕胺初始剂量2．5～5mg／d．维持量2．5mg／d。均随访2年。每月查诊室血压（CBP）。每年查血、尿常规、心电图、血脂、血糖、肌酐、血尿酸、血电解质。结果显示：两种药物均能有效地降低血压，治疗组显效率87．5％，有效率12．5％；对照组显效率91％，有效率9％，组间降压效果比较差异无显著性，AM具有长半衰期，病人耐受性良好，因此，与IN一样，AM亦为有前途的长效抗高血压药物。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.