继承和发展蒙医药,加快蒙医药的研究和发展

蒙医药是中华民族优秀传统文化的重要组成部分。本文介绍了蒙医药的地位和现状，并对如何继承和发展蒙医药科学进行了探讨，为发展蒙医药产业，合理保护、开发和利用蒙医药资源提供研究思路。     

蛛网膜下腔出血与内皮素和降钙基因相关肽

目的 :探讨蛛网膜下腔出血 (SAH)后血液、脑脊液中内皮素 (ET )、降钙基因相关肽 (CGRP )含量变化及与血管痉挛 (CVS)的关系。方法 :用放免法检测 32例不同时期、不同病因、不同病情SAH患者血液、CSF中ET、CGRP含量变化并与对照组比较。结果 :SAH后血浆、CSF中ET比对照组明显升高 (P <0 .0 5 )。CGRP则明显低于对照组 (P <0 .0 1)。ET升高和CGRP降低与病情程度、病后时间有关 ,与引起SAH的原因无关。结论 :ET和CGRP的变化与SAH后脑血管痉挛有关 ,可作为SAH后血管痉挛 (CVS)的一种观察指示     

蛛网膜下腔出血与内皮素和降钙基因相关肽的关系研究

目的：探讨蛛网膜下腔出血（ＳＡＨ）后血液、脑脊液中内皮素（ＥＴ）、降钙基因相关肽（ＣＧＲＰ）含量变化及与血管痉挛（ＣＶＳ）的关系。方法：用放免法检测３２例不同时期、不同病因、不同病情ＳＡＨ患者血液、ＣＳＦ中ＥＴ、ＣＧＲＰ含量变化并与对照组比较。结果：ＳＡＨ后血浆、ＣＳＦ中ＥＴ对照组明显升高,Ｐ〈０．０５。ＣＧＲＰ则明显低于对照组,Ｐ〈０．０１。ＥＴ升高和ＣＧＲＰ降低与病情程度、病后时间有关,与引起ＳＡＨ的原因无关。结论：ＥＴ和ＣＧＲＰ的变化与ＳＡＨ后脑血管痉挛有关,可作为ＳＡＨ后血管痉挛（ＣＶＳ）的一种观察指标。     

猪心肌球蛋白及其轻,重链亚基的纯化和鉴定

采用一种改进的方法，从１００ｇ猪心室肌中提取心肌肌球蛋白３７０ｍｇ，并进一步分离和纯化其亚基成分，分别得到肌球蛋白轻链２４ｍｇ和重链２１０ｍｇ，核酸含量＜１％，不含有肌动蛋白、原肌球蛋白、肌钙蛋白及其它杂蛋白；ＳＤＳＰＡＧＥ显示，猪心肌球蛋白重链为２００～２２０ＫＤ一条带，肌球蛋白轻链则为２７ｋｄ、２１．４ｋｄ、１９ｋｄ三条带；纯化猪心肌球蛋白的Ｃａ２＋激活ＡＴＰ酶活性为０．２４μｍｏｌＰｉ／（ｍｇ·ｍｉｎ），但其分离后的亚基则无此活性。     

Ⅱ型视盘血管炎与视网膜中央静脉阻塞临床对比分析

①目的观察Ⅱ型视盘血管炎（ODV）与视网膜中央静脉阻塞（CRVO）在临床特征与荧光血管造影等方面的异同点,以期正确区分ODV,提高其治疗效果。②方法回顾性地分析了12例ODV与30例CRV0病人在病因、临床表现、荧光血管造影（FFA）、治疗及预后等方面的特点。③结果ODV病人多为青壮年,无高血压、糖尿病等全身疾病史,视力≥0．5（含矫正视力）,皮质类固醇类药物治疗敏感,勿需激光治疗,预后较好,FFA检查未见毛细血管无灌注区;CRVO病人多见于中老年,多伴有高血压、动脉硬化、糖尿病等全身疾病史,视力下降明显,多数视力〈0．1,甚至数指或眼前手动,皮质类固醇类药物治疗无效,预后差,FFA多可见毛细血管无灌注区,病史长者可见新生血管形成。④结论Ⅱ型ODV极易误诊为CRVO,因两者的治疗方式及预后不同,因此,临床上通过二者的病因及辅助检查为其诊断提供依据。     

MUTAGENICITY AND TERATOGENICITY OF CHLORPROMAZINE AND SCOPOLAMINE

Mutagenicity and teratogenicity of chlorproma-zine and scopolamine with indicators of chromoso-mal aberration, sister chromatid exchange (SCE) andteratogenesis test of gestation in mice are presentediii this paper. Chlorpromazine and scopolaminewere divided into five (0.25, 0.5, 1.0, 1.5 and 2 vg/niD and six (0.5, 1.0, 2.0, 5.0, 10 atlcl 20 yg/ml)dosage groups respectively. Each was added directlyto peripheral lymphocyte cultures of 10 healthyadults. Cultures treated with saline and mitomycinserved as normaland positive controls. The chromo-somal aberration and SCE were simultaneouslystudied. The frequency of chromosomal aberrationand SCE in the chlorpromazine groups were marked-ly higher than these of the normal controls (p<0.01or p<0.05). Those of the scopolamine groups werealso significantly higher. The results showed thatchlorpromazine damages DNA. Usual clinical dosesof scopolamine do not damage DNA, but lar~;e dosesdo. Using l/50 and l/10 0f the LDr)n dose (i.e., 1.8and 9.2 vg of chlorpromazine or 4.6 and 59 vg ofscopolamine per gram of body weight), their terato-genicity was tested in mice. Saline and cod-liver oiltreated mice were used as normal and positivecontrols respectively. The incidences of malformedfetus;es were 38.570 and 42.7To with chlorpromazineor 3.8To and 8.2To with scopolamine, while those innomal and positive controls were o and 28.6U/。respectively. The results showed that the teratogeniceffe--t of chlorpromazine in mice was greater thanthat of scopolamine.     

脾胃升降与胃病

用脾胃升降理论,对胃病治疗,按胃气以降为和六腑以通为补,胃腑宜通的原则,归纳为疏肝降胃、宣肺舒胃、升脾益胃、益阴和胃、泻肝清胃、活血化淤、消食泻胃等七法。     

城乡居民的肥胖率超重率及与高血压病的关系

应用统一标准对城乡居民的肥胖率、超重率进行了调查;并对超重与高血压病的关系进行了研完。结果表明,城市居民的肥胖率(18.75%)、超重率(33.68%)高于农民渔民的肥胖率(9.03%)(P<0.01)、超重率(15.28%)(P<0.01)。而农民与渔民之间无显著性差别(P>0.05)。超重者高血压病的患病率高于不超重者(P<0.01);病例组超重者占的比例高于对照组,OR(?)=3.70(P<0.01)。超重与高血压病有明显联系。城乡居民,尤其城市居民应采取措施防止超重,以预防高血压病的发生。     

EFFECTS OF SIDE-TO-SIDE PORTACAVAL SHUNT ON SERUM AND LIVER ZINC AND COPPER CONCENTRATIONS AND THEIR CORRECTIONEXPERIMENTAL AND CLINICAL TRIALS

The mechanism and clinical significance of abnormal metabolism of zinc and copper in liver cirr-hosis patients are a problem to clinical workers.We performed experiments on 30 healthy dogs andstudied 35 liver cirrhosis patients with portal hyper-tension who underwent either limited side-tosideportacaval shunt or nonshunt procedures, in orderto investigate the effect of changes in portal hemo-dynamics on zinc and copper metabolism, andmethods for their correction. The results showedthat liver cirrhosis patients present with zinc deficiency and copper accumulation, and the concentra-tion of zinc closely correlates with the liver function.Serum and liver zinc concentration are decreasedafter portacaval shunt. the rate and duration ofdecrease are associated with the stomal size. Oralzinc can increase the zinc level, decrease copperaccumulation, improve liver function and protecthepatocytes from ischemic injury after portacavalshunt.     

肥胖型与非肥胖型多囊卵巢综合征的内分泌代谢特征及其治疗

①目的 探讨肥胖型和非肥胖型多囊卵巢综合征（PCOS）的内分泌代谢特征及分型治疗。②方法 选择30例PCOS不孕病人为观察组，30例非PCOS不孕病人为对照组，测定两组体质量指数（BMI）、腰臀围比值（WHR）、多毛评分（F-G评分）及生殖内分泌激素、糖代谢指标等。观察组根据BMl分为肥胖组和非肥胖组，比较上述各项指标的不同。同时观察组又根据胰岛素抵抗程度分为胰岛素抵抗组和非胰岛素抵抗组，分别应用二甲双胍和复方醋酸环丙孕酮治疗12周后，重复测定上述指标并比较其变化。③结果 观察组治疗前BMI、WHR、F-G评分、促黄体生成素（LH）、睾酮（T）、雄烯二酮（A）、空腹胰岛素（FI）、胰岛素抵抗指数（HomaIR）等较对照组增高，胰岛素样生长因子、性激素结合球蛋白（SHBG）较对照组降低，差异均有显著性（t=2．25～5．66，P〈0．05）。肥胖组FI、Homa IR高于非肥胖组，LH、SHBG低于非肥胖组，差异均有显著性（t=2．06～3．14，P〈0．05）。胰岛素抵抗组治疗后FI、HomaIR、胰岛素曲线下面积、A降低；而非胰岛素抵抗组治疗后LH、A降低，SHBG升高，差异均有显著性（t=2．16～3．19，P％0．05）。④结论 肥胖型PCOS主要表现为高胰岛素血症及胰岛素抵抗，而非肥胖型PCOS则以促黄体生成素异常为主。二甲双胍治疗胰岛素抵抗PCOS效果较好，复方醋酸环丙孕酮治疗非胰岛素抵抗PCOS有效。     

VAGINAL METASTASIS OFCHORIOCARCINOMA AND INVASIVE MOLE CLINICAL AND PATHOLOGICAL CHARACTERISTICS, DIAGNOSIS AND TREATMENT

From 1949 through 1975, 429 patients with choriocarcinoma and 441 with invasive mole were treated. In these patients vaginal metastasis occurred in 119(27.7'70) and 70(15.9%) respectively. According to the location of lesions, vaginal metastases were divided into two types (189 patients), metastasis to the lower vagina (172 0r 91.OTo) and metastasis to the vaginal fornix (17 0r 9U/o). The metastatic tumors were mostly located iri the an- terior waU underneath the urethra or at the urethral orifice. Of the 172 patients, 114 had single me- tastasis, and 58 multiple metastases. The size of tumor mass varied greatly. but tumors of l-3 cm in diameter were common (50%). The small metastatic tumors caused no symptoms, and were found only by digital palpation, whereas the big ones often ruptured, giving rise to severe bleeding. Dysuria Qc curred owing to pressure of the tumor underneath the urethra. The metastatic tumors in the vaginal fornix were seen only in 17 patients, of which 15 were secondary to parametrial or pelvic metastasis. Pathological examinations of 62 patients showed that the metastatic tumor of the lower vagina wasinitiated from tumor emboli inside the veins of the vagina. On further development, tumor cells damaged the veins and invaded the neighboring tissues, thus developing into a metastatic tumor. Hence, this type of metastasis may be called "venous metastasis", which is different from the other metastases such as metastases to the brain, liver, spleen and lttngs. All of the latter conditions were initiated from embolism of the arteries, and were called "arterial metastasis". Slow intravenous infusion of 5-FU is the most preferable method of treatment. When rupture oc curs, vaginal packing with gauze is employed to stop bleeding. Usually after 5-6 days of 5-Fu treatment, bleeding is stopped and after l-3 courses, the mc tastatic tumor disappears. AlI patients treated have been followed up periodically for over 5 years, and of them 16 0ver 20 years. No recurrence was found.     

糖尿病辨证分型与血糖,尿糖关系初探

将６７例糖尿病分为五个证型，检测其患者的血糖和尿糖。结果表明，糖尿病各个证型的血糖和尿糖检测值均有不同程度的差别，其中主要表现为“热证”的燥热伤津和胃热津亏两型，血糖值的升高属于重度增高，尿糖定性强阳性为多；主要表现为“虚证”的气阴两虚、阴阳两虚和阴虚阳浮三型，血糖值的升高属于中度增高，尿糖定性强阳性较少。证明糖尿病在“虚”和“热”两方面与血糖尿糖有一定的关系。揭示血糖和尿糖检测结果的不同可为糖尿     

中药复方肾康片和维尔康补肾片对大鼠内分泌激素的影响及急性毒性研究

本文研究了中药复方肾康片和维尔康补肾片大鼠内分泌激素的影响.结果表明,口服肾康片(0.25g/kg·d)能升高大鼠血中T_3、T_4、GH及性激素,口服维尔康补肾片(0.50g/kg·d)对大鼠T_3、T_4、GH无影响,对雄性大鼠睾酮亦无影响,但能升高雌性大鼠血中雌二醇浓度.两药均使动物体重增加明显.急性毒性试验表明,肾康片的LD_(50)>60g/kg,维尔康补肾片的LD_(50)>80g/kg.     

LIPOPROTEIN AND APOPROTEIN Al LEVELS IN DIABETICS AND CORONARY HEART DISEASE PATIENTS AND CONTROLS

We set up the first radial immuno-diffusion assay for Apoprotein AI(ApoAI) in China and com- pared the Iipoprotein and ApoAI levels among Non insulin-dependent diabetics, coronary heart disease patients (CHD) and Weight/Age matched controls. Compared to the controls, diabetics and CHD patients had significantly higher triglycerides levels (TG), lower high density lipoprotein-cholesterol (HDLC) levels, lower ratios of HDLC to LDLC Oow density lipoprotein-cholesterol) and lower ApoAI levels. These suggested that the abnormalities of ApoAI and Iipoproteins in diabetics may be related to the higher frequency of CAD in diabetics. Our data show that ApoAI levels in Chinese controls and NIDDM patients are higher than in American controls and NIDDM patients, and CHD frequency is lower in Chinese than in Americans. This may be related to the higher ApoAI levels in Chinese.     

CHINESE SCIENTIFIC AND BIOMEDICAL LITERATURE AND ITS COVERAGE IN INTERNATIONAL BIBLIOGRAPHIC AND ABSTRACTING SERVICES

The world's total reported number of papers and books on science and technology increased from 4.5 million in 19681 t0 12 million in 19832. The available statistics for the total number of biomedical works was augmented from 0.9 million in 19673 t0 2.4 million in 1983. It was reported that the People's Republic of China pub- lished 260,000 scientific and technical work.s in 1983 including 52,000 0n biomedical problems.