固定矫治正畸治疗中对患者牙周组织影响的临床分析

目的：探讨固定矫治器正畸治疗中对患者牙周组织影响。方法：收集我院门诊正畸矫治病例20例，在固定矫治前进行牙周临床指标：菌斑指数（PLI）、出血指数（BD、探诊深度（PD）等检查，以测得数为基线水准，在固定矫治器安放后1周、2周、4周、8周进行临床牙周指标检查。结果：固定矫治过程中可引起牙周指标显著增高。结论：固定矫治过程中可影响牙周组织健康．应加强正畸患者口腔卫生教育，加强正畸医生规范操作。     

隐形矫治与固定矫治在成人拔牙正畸治疗中前牙区牙齿变化情况比较

目的　比较无托槽隐形矫治器和固定矫治器在成人拔牙正畸治疗中前牙区的变化情况,对比不同矫治器对前牙牙根的控制情况。方法　选取2017年6月至2018年6月于保定市第二医院口腔科就诊的安式Ⅱ类Ⅰ分类正畸拔牙患者40例,年龄18~30岁。将40例患者按照患者意愿分为无托槽隐形矫治器组和固定矫治器组（每组20例）,并设计种植钉增强支抗。应用CBCT测量上下前牙到Y轴的距离（U1-Y、L1-Y、Y1、Y2）即矢状距离,到X轴的距离（U1-X、L1-X、X1、X2）即垂直距离,上下前牙长轴与Y轴所成角度（∠1、∠2）及上下中切牙、上下侧切牙牙轴长度(V1、V2、V3、V4)的变化情况。结果　矫治前,无托槽隐形矫治组与固定矫治器组各指标差异均无统计学意义（P＞0.05）。无托槽隐形矫治组矫治前后各指标差异有统计学意义（P＜0.01）。固定矫治器组矫治前后各指标数据差异有统计学意义（P＜0.01）。矫治后,无托槽隐形矫治组与固定矫治器组Y1、Y2、V1、V3、∠1、∠2差异有统计学意义（P＜0.05）。结论　隐形矫治更利于保护前牙牙根,并且更有利于前牙控根移动。     

种植体支抗以及口腔矫治器联合治疗牙周疾病的临床效果

目的探究并分析种植体支抗联合口腔矫治器在牙周病患者正畸治疗中的临床疗效。方法非同期对比分析100例牙周病患者仅采用MBT矫治器进行矫治（对照组），或在微型种植体为支抗治疗的基础上联合MBT矫治器治疗（观察组）的临床效果。结果观察组患者矫治后头影测量数据较治疗前发生明显变化，SNA、ANB、U1-SN指标较对照组低，而SNl3、L1-MP指标较对照组高；在牙齿松动度方面两组治疗后差异不显著（P〉0．05），而观察组患者治疗后成功率、固定物完好率及牙槽骨高度增高率分别为90．77％、93．85％、98．46％、75．38％，均明显高于对照组（P均〈0．05）；治疗后观察组患者在上中切牙倾角及凸距的减少量上明显多于对照组，且观察组磨牙移位距离较对照组短（P均〈0．05）。结论微型种植体支抗联合术口腔矫治器在牙周病患者正畸治疗中操作简单、可靠性强，疗效显著。     

舌侧Begg矫治技术的临床应用

目的：为满足既想矫治又担忧矫治器暴露影响美观的错 患者的需要。方法与结果：临床应用舌侧Ｂｅｇｇ矫治技术，收到良好的效果。结论：舌侧正畸避免了矫治器暴露，避免了牙唇颊侧的损害以及唇颊侧牙龈过度增生。但舌侧正畸操作复杂，技法要求高；舌侧正畸不利于舌侧的清洁；与唇侧正畸相比更需要病人的配合。     

正畸固定矫治器对牙龈指数和口腔卫生指数的影响

目的探讨临床正畸治疗中患者并发牙龈炎的原因以及预防方法。方法选取临床固定矫治患者126例,年龄12～28岁,平均（17.6±0.8）岁,分别在患者戴用固定矫治器前及其后6个月检测其牙龈指数（GI）,口腔卫生指数（OHI）。结果戴固定矫治器牙龈指数明显上升,与戴矫治器前比较差异有统计学意义（P〈0.01）,说明在矫治过程中牙龈炎患病人数明显增加。而患者自身口腔卫生状况不佳和口内矫治器附件的不良刺激是导致牙龈炎的主要原因。结论 在固定正畸治疗期间,积极加强对患者的口腔卫生宣教,正畸医生在矫治过程中的耐心、仔细以及熟练的技术对于降低正畸治疗中牙龈炎的发生都有积极的作用。     

大龄患者错he畸形的矫治

目的：通过对12．例30岁以上非牙周病性错he畸形的矫治,了解到大龄患者的正畸特点和矫治中常遇到的问题及解决方法。方法：12．例中采用拔牙矫治者9例。8例采用固定矫治器,2例活动 固定矫治器。结果：12．例中除1例因病复诊困难效果欠佳外,11例效果良好。结论：大龄人对矫治器适应慢,牙移动启动期长,对矫治力敏感度高,口腔条件差,对正畸效果期望高,但如果处理得当,一般均能收到良好的矫治效果。     

改良式导弓治疗儿童乳前牙反胎的头影测量分析

目的：探讨儿童乳前牙反牙合矫治的最佳时机及改良式导弓活动矫治器的治疗效果。方法选择3～5岁乳前牙反牙合患儿50例,采用改良式导弓活动矫治器进行正畸治疗,治疗前后拍头颅侧位片,通过头影测量分析,观察并比较患儿矫治前及矫治后上、下颌骨的位置变化（SNA、SNB、ANB、SN-Pg）、恒牙牙胚位置变化（U1/SN、U1/NA、I1-NB、I1/NB、U1-NA）及软硬组织变化。结果在经过14～75 d的矫治后,50例患儿均取得了良好的疗效。SNA增加（2．51±0．18）°,SNB减少（2．1±0．4）°,SNG增加（1．78±0．9）°,NLA减少（2．04±3．87）°,治疗后上下颌骨、恒切牙牙胚位置、软组织均得到不同程度改善。结论采用改良式导弓活动矫治器对乳前牙反牙合进行矫治,能够有效改善上下颌骨、恒切牙牙胚及软组织位置,并且疗程短,见效快,疗效满意。     

Twin-block矫治器矫治安氏Ⅱ类错He

安氏Ⅱ类错He是口腔正畸临床中发病率高，对颌面影响较大的一种错He畸形。临床上使用功能性矫治器矫治生长发育期安氏Ⅱ类等错He变得越来越普遍。功能性矫治器通过建立新的“肌肉运动型”而产生的新的“功能型”及“形态型”，将颌面异常生长方式导向正常。本文探讨的是Twin-block矫治器治疗安氏Ⅱ类错He的疗效。     

方丝弓矫治器矫治中的支抗保护

方丝弓矫治器是一种高效能矫治器，以其三维定向控制牙齿移动的特点为正畸临床广泛使用C”，但在治疗过程中常常遇到支抗的丧失而使正畸医生处于尴尬的位置。支抗在口腔正畸治疗中是很重要的概念，正畸移动牙齿的过程也就是支抗控制过程，支抗控制得好，就能够取得良好的治疗效果。相反，如在矫治器设计中支抗不充分，就会出现在矫治牙移动     

可摘矫治器在直丝弓矫治器中的临床应用

可摘矫治器：是一种由患者自行摘戴的矫治装置，是一种灵活多变的矫治器，可摘矫治器制作简便、原材料易得、技术易于推广，在口腔正畸临床矫治中占有很重要的地位。但是可摘矫治器由于矫治方向多为倾斜移动，所以对牙齿移动范围大、整体移动或控根移动的病例难以实现良好的矫治效果。因而，可摘矫治器在临床应用中有一定的局限性。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.