烧伤患者病原菌感染及其耐药性调查

目的了解烧伤患者病原菌感染及耐药性情况,指导临床治疗。方法收集内蒙古医院2007-2009年住院烧伤患者病原学检查资料进行回顾性分析,统计病原菌分布及耐药率。结果检出病原菌共计321株,其中革兰阴性杆菌170株、革兰阳性球菌145株、真菌15株。结论烧伤患者感染主要病原菌为金黄色葡萄球菌、铜绿假单胞菌、大肠埃希菌、鲍氏不动杆菌,其中金黄色葡萄球菌、铜绿假单胞菌、鲍氏不动杆菌耐药率较高。     

医院感染病原菌监测及耐药性观察

目的监测我院医院感染病原菌分布及耐药状况,为指导临床合理用药及控制医院感染提供依据。方法采用全自动细菌鉴定及药敏分析仪,对本医院住院患者的各类标本分离细菌进行鉴定和耐药性分析。结果共分离出病原菌4978株,其中革兰阴性杆菌917株,革兰阳性球菌547株,其余为其他菌株。革兰阴性杆菌以大肠埃希菌、铜绿假单胞菌、肺炎克雷伯菌、鲍曼不动杆菌、阴沟肠杆菌为主,革兰阳性球菌以表皮葡萄球菌、粪肠球菌、金黄色葡萄球菌为主。大肠埃希菌、铜绿假单胞菌对头孢吡肟耐药率分别为48.6%和56.4%,其他革兰阴性杆菌对亚胺培南和美洛培南耐药率<6%。革兰阳性球菌对呋喃妥因和万古霉素均比较敏感,金黄色葡萄球菌对莫西沙星耐药率高达76%。结论医院感染病原菌以革兰阴性杆菌和革兰阳性球菌为主,这些致病菌对常用抗生素耐药率较高,必须加强耐药性监测和药敏试验,指导合理使用抗生素。     

骨折患者伤口分泌物培养病原菌分布及耐药性

目的了解医院骨科感染病原菌的构成及耐药性,为临床合理使用抗菌药物提供指导依据。方法对2013年本院骨科送检的204例分泌物,进行细菌分离鉴定及药敏试验,进行统计分析。结果 204份分泌物分离出致病菌144株,分离率为70.6%。主要感染病原菌为金黄色葡萄球菌、大肠埃希菌、铜绿假单胞菌和肺炎克雷伯菌,分别占20.9%、16.0%、15.2%和13.9%。未发现对万古霉素和替考拉林耐药的金黄色葡萄球菌株,大肠埃希菌和肺炎克雷伯菌对亚胺培南100%敏感。铜绿假单胞菌对头孢吡肟、亚胺培南耐药率为9.1%和13.6%。结论分离菌株对临床常用抗菌药物普遍耐药,应引导临床根据药敏结果科学合理使用抗菌药物,减少院内感染和耐药现象的发生。     

重症监护病房病原菌497株菌群分布及耐药性分析

目的：了解重症监护病房病原菌的种类、分布及耐药性。方法：对重症监护病房感染的病原菌及耐药特征进行回顾性分析。结果：共分离病原菌497株,前3位病原菌分别是铜绿假单胞菌、金黄色葡萄球菌、大肠埃希菌。主要病原菌具有多重耐药特点,耐甲氧西林金黄色葡萄球菌对万古霉素和替考拉宁最敏感。结论：重症监护病房呼吸道感染发生率高,以铜绿假单胞菌和金黄色葡萄球菌为主,呈多重高耐药特点。     

烧伤病区金黄色葡萄球菌和铜绿假单胞菌的流行情况调查分析及控制方案

目的 探讨金黄色葡萄球菌和铜绿假单胞菌在烧伤病区内流行情况,与医院内感染的关系.并制定有效的消毒隔离措施,控制金黄色葡萄球菌和铜绿假单胞菌造成的烧伤病人院内感染.方法 对烧伤病区内病人分泌物及消毒前环境中的金黄色葡萄球菌噬菌体分型和铜绿假单胞菌血清学分型.结果 消毒前烧伤病区内环境金黄色葡萄球菌和铜绿假单胞菌污染较严重,金黄色葡萄球菌和铜绿假单胞菌与病人分泌物的金黄色葡萄球菌和铜绿假单胞菌的噬菌体和血清学分型部分属同型、同群,是造成烧伤病人院内感染的重要菌种.结论 严格按照控制方案采取消毒隔离措施后,金黄色葡萄球菌和铜绿假单胞菌在消毒后的病区环境染菌率明显下降,取得了较好的成效.     

慢性化脓性中耳炎的病原菌及耐药性分析

目的 研究慢性化脓性中耳炎主要病原菌的种类及对抗生素的耐药情况。方法对98例慢性化脓性中耳炎患者的耳分泌物进行细菌培养,对分离的病原菌进行药物敏感试验。结果分离出病原菌103株,以金黄色葡萄球菌(38株)和铜绿假单胞菌(33株)为主,金黄色葡萄球菌对青霉素和红霉素的耐药率分别为100％和66％,对氨基糖甙类、氟喹诺酮类敏感性较高;铜绿假单胞菌对氨苄西林、头孢类抗生素耐药率较高,对氟喹诺酮类、氨基糖甙类抗生素敏感。结论 金黄色葡萄球菌和铜绿假单胞菌是青岛地区慢性化脓性中耳炎的主要致病菌,二者对青霉素类抗生素有较高的耐药率。临床医师不能仅凭经验,而应根据细菌培养和药敏结果用药,以防耐药菌株产生。     

2006年我院感染病原菌的分布与常见细菌耐药性分析

目的了解我院2006年度临床感染病原菌的分布情况及常见细菌的耐药现状。方法收集2006年我院临床各科送检标本,采用美国德灵MicroScan WalkA Way-40全自动微生物分析仪同时进行菌株鉴定与药敏测定。结果共分离出病原菌4554株,排在前五位的病原菌共2449株,其中铜绿假单胞菌730株、大肠埃希菌532株、肺炎克雷伯菌498株、白假丝酵母菌421株、金黄色葡萄球菌268株。从药敏结果看,大肠埃希菌和肺炎克雷伯菌对亚胺培南的敏感率最高,分别为96.8%和96.0%;铜绿假单胞菌对丁胺卡那霉素的耐药率最低为15.5%;真菌感染有上升趋势;利福平对金黄色葡萄球菌的耐药率较低为18.7%,未发现耐万古霉素的金黄色葡萄球菌。结论几种我院临床常见分离细菌耐药现象仍然严重,应加强医院内感染病原菌的耐药性监测,合理使用抗菌药物及减缓多重耐药菌的产生。     

烧伤病区金黄色葡萄球菌和铜绿假单胞菌的流行情况调查分析及控制方案

目的探讨金黄色葡萄球菌和铜绿假单胞菌在烧伤病区内流行情况，与医院内感染的关系。并制定有效的消毒隔离措施，控制金黄色葡萄球菌和铜绿假单胞菌造成的烧伤病人院内感染。方法对烧伤痛区内病人分泌物及消毒前环境中的金黄色葡萄球菌噬菌体分型和铜绿假单胞菌血清学分型。结果消毒前烧伤病区内环境金黄色葡萄球菌和铜绿假单胞菌污染较严重，金黄色葡萄球菌和铜绿假单胞菌与病人分泌物的金黄色葡萄球菌和铜绿假单胞菌的噬菌体和血清学分型部分属同型、同群，是造成烧伤病人院内感染的重要菌种。结论严格按照控制方案采取消毒隔离措施后，金黄色葡萄球菌和铜绿假单胞菌在消毒后的病区环境染菌率明显下降，取得了较好的成效。     

2006年我院感染病原菌的分布与常见细菌耐药性分析

目的 了解我院2006年度临床感染病原菌的分布情况及常见细菌的耐药现状.方法 收集2006年我院临床各科送检标本,采用美国德灵MicroScan WalkA Way-40全自动微生物分析仪同时进行菌株鉴定与药敏测定.结果 共分离出病原菌4554株,排在前五位的病原菌共2449株,其中铜绿假单胞菌730株、大肠埃希菌532株、肺炎克雷伯菌498株、白假丝酵母菌421株、金黄色葡萄球菌268株.从药敏结果看,大肠埃希菌和肺炎克雷伯菌对亚胺培南的敏感率最高,分别为96.8%和96.0%;铜绿假单胞菌对丁胺卡那霉素的耐药率最低为15.5%;真菌感染有上升趋势;利福平对金黄色葡萄球菌的耐药率较低为18.7%,未发现耐万古霉素的金黄色葡萄球菌.结论 几种我院临床常见分离细菌耐药现象仍然严重,应加强医院内感染病原菌的耐药性监测,合理使用抗菌药物及减缓多重耐药菌的产生.     

铜绿假单胞菌的临床分离及耐药性变迁

目的了解铜绿假单胞菌在临床的感染、分离情况及近年来铜绿假单胞菌的耐药性变迁。方法以API20NE鉴定系统及VITEK32细菌鉴定系统进行菌种鉴定,以纸片扩散法进行分离菌株的药敏试验。结果铜绿假单胞菌以呼吸系统标本分离率最高,在临床标本中分离率呈逐年上升趋势,其耐药性普遍呈现多重耐药,对临床常用抗生素的耐药率逐年上升。结论应重视临床铜绿假单胞菌的感染与分离,谨防多重耐药铜绿假单胞菌的院内感染及暴发流行。     

Staphylococcus aureus prophylaxis and trends in gram-negative infections in peritoneal dialysis patients.

OBJECTIVE: To examine gram-negative exit-site infection and peritonitis rates before and after the implementation of Staphylococcus aureus prophylaxis in peritoneal dialysis (PD) patients. DESIGN: Prospective data collection with periodic implementation of protocols to decrease infection rates in two PD programs. PATIENTS: 663 incident patients on PD. INTERVENTIONS: Implementation of S. aureus prophylaxis, beginning in 1990. MAIN OUTCOME MEASURES: Rates of S. aureus, gram-negative, and Pseudomonas aeruginosa exit-site infections and peritonitis. RESULTS: Staphylococcus aureus exit-site infection and peritonitis rates fluctuated without significant trends during the first decade (without prophylaxis), then began to decline during the 1990s subsequent to implementation of prophylaxis, reaching levels of 0.02/year at risk and zero in the year 2000. Gram-negative infections fell toward the end of the 1980s, due probably to the implementation of better connectology. However, there have been no significant changes for the past 6 years. There was little change in P. aeruginosa infections over the entire time period. Pseudomonas aeruginosa is now the most common cause of catheter infection and catheter-related peritonitis. CONCLUSIONS: Prophylaxis against S. aureus is highly effective in reducing the rate of S. aureus infections but has no effect on gram-negative infections. Pseudomonas aeruginosa is now the most serious cause of catheter-related peritonitis.     

医院感染菌群分布趋势及耐药性分析

目的了解医院感染病原菌的菌群分布、流行趋势及其对常用抗菌药物的耐药情况,为临床合理应用抗菌药物提供依据。方法常规培养、分离细菌,应用VITEK-Compact 2全自动细菌分析仪鉴定细菌。常规药敏试验采用K-B纸片法。结果从2008—2010年共分离出5 138株病原菌,感染标本主要来源于痰、分泌物及中段尿,三者之和占年度的85%以上;分离的病原菌以肺炎克雷伯菌、大肠埃希菌、绿脓杆菌、金黄色葡萄球菌和白色假丝酵母菌为主,3年间分别占感染菌株分离率的73.6%、70.2%、62.8%;大肠埃希菌和肺炎克雷伯菌产ESBLs的阳性率均在60%以上,对头孢哌酮/舒巴坦和亚胺培南的耐药率均在10.8%以下;非发酵菌对孢哌酮/舒巴坦和亚胺培南的耐药率均在19.6%以下;未检出耐万古霉素的阳性球菌。结论医院内感染标本的来源主要以呼吸道和泌尿生殖道为主。肠杆菌科细菌已成为医院内感染的重要病原菌,肺炎克雷伯菌、大肠埃希菌、绿脓杆菌、金黄色葡萄球菌和白色假丝酵母菌为感染的流行菌。肠杆菌科细菌产ESBLs状况十分严重,临床对产酶菌引起的重症感染应首选头孢哌酮/舒巴坦或亚胺培南治疗。对非发酵菌引起的重症感染应选择含酶抑制剂复合药物(如哌拉西林/他唑巴坦、头孢派酮/舒巴坦)联合丁胺卡那进行治疗;对MRSA、MRSE引起的重症感染应首选万古霉素来治疗。     

Antimicrobial resistance in urinary tract pathogens in Canada from 2007 to 2009: CANWARD surveillance study

From January 2007 to December 2009, an annual Canadian national surveillance study (CANWARD) tested 2,943 urinary culture pathogens for antimicrobial susceptibilities according to Clinical and Laboratory Standards Institute guidelines. The most frequently isolated urinary pathogens were as follows (number of isolates, percentage of all isolates): Escherichia coli (1,581, 54%), enterococci (410, 14%), Klebsiella pneumoniae (274, 9%), Proteus mirabilis (122, 4%), Pseudomonas aeruginosa (100, 3%), and Staphylococcus aureus (80, 3%). The rates of susceptibility to trimethoprim-sulfamethoxazole (SXT) were 78, 86, 84, and 93%, respectively, for E. coli, K. pneumoniae, P. mirabilis, and S. aureus. The rates of susceptibility to nitrofurantoin were 96, 97, 33, and 100%, respectively, for E. coli, enterococci, K. pneumoniae, and S. aureus. The rates of susceptibility to ciprofloxacin were 81, 40, 86, 81, 66, and 41%, respectively, for E. coli, enterococci, K. pneumoniae, P. mirabilis, P. aeruginosa, and S. aureus. Statistical analysis of resistance rates (resistant plus intermediate isolates) by year for E. coli over the 3-year study period demonstrated that increased resistance rates occurred only for amoxicillin-clavulanate (from 1.8 to 6.6%; P < 0.001) and for SXT (from 18.6 to 24.3%; P = 0.02). For isolates of E. coli, in a multivariate logistic regression model, hospital location was independently associated with resistance to ciprofloxacin (P = 0.026) with higher rates of resistance observed in inpatient areas (medical, surgical, and intensive care unit wards). Increased age was also associated with resistance to ciprofloxacin (P < 0.001) and with resistance to two or more commonly prescribed oral agents (amoxicillin-clavulanate, ciprofloxacin, nitrofurantoin, and SXT) (P = 0.005). We conclude that frequently prescribed empirical agents for urinary tract infections, such as SXT and ciprofloxacin, demonstrate lowered in vitro susceptibilities when tested against recent clinical isolates.     

Skin and soft tissue infections in Latin American medical centers: four-year assessment of the pathogen frequency and antimicrobial susceptibility patterns

We report the results of pathogen frequency and antimicrobial susceptibility of isolates collected from skin and soft tissue infections (SSTIs) in Latin American medical centers during the first 4 years (1997-2000) of the SENTRY Antimicrobial Surveillance Program. Ten laboratories participated each year distributed among nine cities in six countries. A total of 1,789 bacterial isolates were susceptibility tested by reference broth microdilution at the coordinating central laboratory. Results from isolates collected during the year 2000 were compared with those from isolates collected during the prior three years. Selected carbapenem-resistant Pseudomonas aeruginosa were genotyped by automated ribotyping to evaluate the occurrence of clonal, epidemic dissemination. The five most frequently isolated species were (n/%): Staphylococcus aureus (584/32.8%), Escherichia coli (233/13.1%), P. aeruginosa (211/11.9%), Enterococcus spp. (137/7.7%), and Klebsiella spp. (127/5.8%). The most problematic antimicrobial resistances were related to the high prevalence of multi-drug resistant (MDR) Gram-negative bacilli. Carbapenem resistance among non-fermentative Gram-negative bacilli was much higher than that reported in other regions evaluated in the SENTRY Program. Only 74.9% of P. aeruginosa and 84.9% of Acinetobacter spp. were considered susceptible to imipenem. The antimicrobial susceptibility rates of P. aeruginosa decreased during the study period for most antimicrobial agents evaluated. More than 40% of K. pneumoniae and nearly 10% of E. coli showed an extended spectrum beta-lactamase phenotype. Only 73.4% of E. coli and 76.0% of Enterobacter spp. were susceptible to ciprofloxacin. The molecular typing of carbapenem-resistant P. aeruginosa demonstrated clonal dissemination in two institutions. These reported results indicate that rates of resistance among isolates causing SSTI continue to raise in Latin America, with specific concerns for the high prevalence of MDR Gram-negative bacilli. National and international surveillance programs as a guide to focusing intervention strategies should assist in the control of escalating antimicrobial resistance in this geographic area.     

1995-2004年下呼吸道感染病原菌变迁

目的了解1995—2004年湘雅医院呼吸科下呼吸道感染住院患者病原菌及其药敏变迁情况。方法对呼吸病房下呼吸道感染住院患者痰菌（或支纤镜吸取分泌物）培养阳性标本结果进行回顾性统计分析。结果分离出细菌2158株，其中革兰阴性杆菌占84．9％，病原菌主要为铜绿假单胞菌、肺炎克雷伯菌、鲍曼不动杆菌和大肠埃希菌；革兰阳性球菌占15．1％，主要病原菌为金葡菌和肺炎链球菌。20世纪90年代中后期和2000年以后相比革兰阴性杆菌有所减少，而革兰阳性球菌有所增加。药敏试验结果提示主要革兰阴性杆菌对美罗培南、头孢哌酮-舒巴坦均较敏感。铜绿假单胞菌对阿米卡星耐药率也低，对头孢噻肟、头孢曲松耐药率较高；肺炎克雷伯菌对头孢他啶也较敏感，对头孢哌酮、头孢噻肟、头孢曲松耐药率较铜绿假单胞菌低；主要革兰阳性球菌对阿奇霉素、红霉素、青霉素及克林霉素耐药率均较高。其中金葡菌对万古霉素均敏感；肺炎链球菌对美罗培南、左氧氟沙星耐药率低。结论近10年下呼吸道感染病原菌以革兰阴性杆菌为主，但有逐渐减少的趋势。主要病原菌对部分抗菌药物的耐药率有逐渐增高的趋势，临床应合理应用抗菌药，以延缓细菌耐药性的产生。     

老年危重症监护病区患者呼吸道感染病原菌特点与耐药性分析

目的探讨医院老年危重症监护病区(ICU)患者呼吸道病原菌分布特点与耐药性,为临床用药与医院感染防控提供依据。方法回顾性分析医院2012年1月至2014年12月老年ICU呼吸道感染患者病原菌分离情况与其耐药性。结果 501例呼吸道感染患者中革兰阴性杆菌感染350例,以铜绿假单胞菌、鲍曼不动杆菌为主;革兰阳性球菌感染50例,以金黄色葡萄球菌为主;合并真菌感染101例,以白色念珠菌为主。其中铜绿假单胞菌对亚胺培南非敏感性情况呈上升趋势(P0.05),鲍曼不动杆菌对常用抗菌药物耐药率较高,经统计学分析药敏趋势无明显变化(P0.05)。呼吸道感染老年患者中亚胺培南耐药鲍曼不动杆菌(IRAB)、产超广谱β-内酰胺酶(ESBLs)大肠埃希菌、甲氧西林耐药金黄色葡萄球菌(MRSA)均超过各自构成比的50%。结论老年ICU呼吸道感染患者常分离出多重耐药菌,耐药率维持较高水平,临床医生应结合实验室报告合理选药,提高对多重耐药菌的防控及管理,减少院内感染发生。     

2014~2019年郑州大学第一附属医院血培养分离病原菌临床分布及耐药性分析

目的　了解郑州大学第一附属医院血培养病原菌的构成及耐药性。方法　回顾性分析郑州大学第一附属医院 2014年 1月 ~2019年 12月间临床血培养分离的 13 456株细菌药敏结果,按照 CLSI2019年标准,使用 WHONET 5.6软件进行数据分析。结果　血培养分离前 5位的细菌分别为大肠埃希菌 3 121株（23.2%）、凝固酶阴性葡萄球菌 2 822株（21.0%）、肺炎克雷伯菌 2 038株（15.1%）、金黄色葡萄球菌 844株（6.3%）和屎肠球菌 727株（5.4%）。大肠埃希菌对亚胺培南、厄他培南的耐药率分别为 3.7%和 4.2%。肺炎克雷伯菌对亚胺培南、厄他培南的耐药率分别为 43.5%和 47.6%。鲍曼不动杆菌对大多数测试抗生素耐药性高,而铜绿假单胞菌对大多数抗生素保持较高的敏感性。耐甲氧西林金黄色葡萄球菌（ MRSA）和耐甲氧西林凝固酶阴性葡萄球菌（ MRCNS）的检出率分别为 42.1%和 84.2%,未发现万古霉素耐药的金黄色葡萄球菌。结论　郑州大学第一附属医院血培养分离细菌耐药情况较为严重,临床应合理应用抗生素,主动开展细菌耐药性监测,遏制细菌耐药性的上升。     

铜绿假单胞菌和鲍曼不动杆菌感染分布特征及耐药性分析

目的 探讨铜绿假单胞菌和鲍曼不动杆菌的分布特征及对多种抗菌药物的耐药性变迁。方法 收集2012年1月至2014年12月该院分离的铜绿假单胞菌和鲍曼不动杆菌,采用琼脂扩散法做药物敏感试验,比较其对抗菌药物的耐药性变迁。结果共分离出病原菌3 710例,铜绿假单胞菌分离214株(5.8%),鲍曼不动杆菌分离347株(9.4%)。铜绿假单胞菌3年感染率分别为7.3%、6.6%、4.7%,呈逐年减少趋势,鲍曼不动杆菌感染率分别为7.6%、8.8%、10.3%,呈逐年增加趋势。标本来源主要以痰液、创面分泌物、尿液为主。铜绿假单胞菌和鲍曼不动杆菌感染菌株以重症监护室(ICU)检出率最高,分别为27.6%和34.9%。铜绿假单胞菌对头孢他啶、阿米卡星、亚胺培南的耐药率均有逐年增高趋势;鲍曼不动杆菌对哌拉西林/他唑巴坦、亚胺培南耐药率逐年增高;多粘菌素B耐药率逐年下降。结论 铜绿假单胞菌和鲍曼不动杆菌对抗菌药物耐药率逐年增高,尤其对碳青霉烯类耐药情况日趋严重,因此需加强对铜绿假单胞菌及鲍曼不动杆菌的耐药性监测,指导临床合理应用抗菌药物。     

不同年龄阶段真菌性鼻窦炎患者病原菌分布特点及耐药情况分析

目的探讨不同年龄阶段真菌性鼻窦炎患者病原菌分布特点以及耐药情况。方法选取2013年1月至2018年12月于该院耳鼻喉科诊治的680例真菌性鼻窦炎患者作为研究对象,并根据患者年龄进行分组,年龄<40岁者共210例(A组),年龄为40~<65岁者共223例(B组),年龄≥65岁者共247例(C组),对3组患者的病原菌分布情况进行分析,并对3组不同年龄段真菌性鼻窦炎患者的合理用药情况进行分析。结果3组患者金黄色葡萄球菌、铜绿假单胞菌、肺炎克雷伯菌、大肠埃希菌、产气肠杆菌、阴沟肠杆菌以及脆弱类杆菌检出率差异有统计学意义(P<0.05)。病原菌对亚胺培南-西司他丁钠均未存在耐药情况,对哌拉西林他唑巴坦、莫西沙星、头孢哌酮舒巴坦的耐药率较低,对青霉素、甲硝唑以及头孢曲松的耐药率较高。结论中青年真菌性鼻窦炎患者感染病原菌主要为大肠埃希菌,老年患者则以感染金黄色葡萄球菌以及革兰阴性菌为主,可采用哌拉西林他唑巴坦、莫西沙星以及头孢哌酮舒巴坦对患者进行治疗。     

Respiratory tract pathogens isolated from patients hospitalized with suspected pneumonia in Latin America: frequency of occurrence and antimicrobial susceptibility profile: results from the SENTRY Antimicrobial Surveillance Program (1997-2000)

In spite of the recent medical advances, lower respiratory tract infections are still the most frequent infectious causes of mortality worldwide. The objective of this study was to determine the frequency of occurrence and antimicrobial susceptibility of bacterial isolates collected from hospitalized patients with pneumonia in Latin American medical centers during the first four years of the SENTRY Program. The five most frequently isolated species were (n/%): Pseudomonas aeruginosa (659/26.3%), Staphylococcus aureus (582/23.3%), Klebsiella pneumoniae (255/10.2%), Acinetobacter spp. (239/9.6%), and Enterobacter spp. (134/5.4%). P. aeruginosa demonstrated high rates of resistance to most of the antimicrobials tested. Against P. aeruginosa, the most active agents were meropenem (MIC(50), 1 microg/ml; 71.6% susceptible), amikacin (MIC(50), 4 microg/ml; 71.0% susceptible), and piperacillin/tazobactam (MIC(50), 16 microg/ml; 70.4% susceptible). Imipenem (MIC(50), 1 microg/ml; 84.1% susceptible) and meropenem (MIC(50), 2 microg/ml; 84.9% susceptible) were the most active agents against Acinetobacter spp. followed by tetracycline (MIC(50), 相似文献