95例乳腺癌全数字化X线钼靶诊断分析

目的分析全数字化乳腺钼靶X线摄影在乳腺癌诊断中的价值。方法回顾性分析95例乳腺癌患者的临床资料。结果 95例均经数字化乳腺钼靶X线摄影诊断为乳腺癌,并经手术病理证实。其中直接征象仅有肿块者54例,肿块伴钙化33例,腺体结构紊乱9例,局部致密影6例,仅有钙化7例。间接征象异常血管征33例,腋窝淋巴结肿大21例,皮肤增厚29例,乳头凹陷21例,主乳导管扩张4例。浸润性导管癌73例,浸润性小叶一导管癌6例,导管原位癌10例,混合性癌3例,粘液癌2例,Pagets病1例。结论全数字化乳腺钼靶X线摄影诊断乳腺癌的诊断及鉴别诊断有重要意义。     

不同病理类型伴钙化乳腺癌X线征象

目的研究比较不同病理类型伴钙化乳腺癌的X线征象,提高对乳腺癌的诊断水平。方法搜集术前行数字化钼靶X线检查术后经病理证实的伴钙化乳腺癌患者82例,将不同病理类型乳腺癌的X线征象进行对照。结果伴钙化乳腺癌中,单纯钙化多见于导管原位癌和浸润性导管癌,钙化伴肿块在各种病理类型乳腺癌中均可见,以浸润性导管癌为多,钙化伴结构紊乱者多见于浸润性导管癌。结论乳腺钼靶X线检查可作出乳腺癌组织类型的初步诊断。     

Mammographic characteristics of breast cancers with calcification of different pathological type

目的 研究比较不同病理类型伴钙化乳腺癌的X线征象,提高对乳腺癌的诊断水平.方法 搜集术前行数字化钼靶X线检查术后经病理证实的伴钙化乳腺癌患者82例,将不同病理类型乳腺癌的X线征象进行对照.结果 伴钙化乳腺癌中,单纯钙化多见于导管原位癌和浸润性导管癌,钙化伴肿块在各种病理类型乳腺癌中均可见,以浸润性导管癌为多,钙化伴结构紊乱者多见于浸润性导管癌.结论 乳腺钼靶X线检查可作出乳腺癌组织类型的初步诊断.     

全数字化乳腺摄影对妇女致密型乳腺癌诊断的应用价值

目的探讨全数字化乳腺摄影对妇女致密型乳腺癌的诊断价值。方法回顾性分析67例全数字化乳腺摄影且经病理证实的致密型乳腺癌的X线表现。结果 67例致密型乳腺癌,右侧34例,左侧33例,均为单侧发病。其中浸润性导管癌29例,浸润性小叶癌19例,导管内癌15例,乳头状癌3例,髓样癌1例。X线征象包括肿块或结节、钙化、局限性致密浸润阴影、结构扭曲等。结论全数字化乳腺摄影对妇女致密型乳腺癌的诊断具有较高的临床应用价值。     

伴钙化乳腺癌X线征象的研究

目的研究乳腺癌X线征象,提高对乳腺病变尤其是乳腺癌的诊断水平。方法搜集术前行钼靶X线检查术后经病理证实的伴钙化的乳腺癌患者82例及伴钙化的乳腺良性病变患者12例进行回顾性分析,将伴钙化的不同病理类型乳腺癌的X线征象进行对照;以伴钙化的乳腺癌为研究对象,设对照组,对其钙化的大小、形态、密度是否一致进行分析。结果不同病理类型乳腺癌其钼靶X线表现不一,含有钙化的病变多见于导管原位癌和浸润性导管癌,钙化伴肿块在各种病理类型乳腺癌中均可见,以浸润性导管癌为多,钙化伴结构紊乱者多见于浸润性导管癌;乳腺癌的钙化多为细钙化,且形态、密度不一致。掌握这一特征,可发现隐匿性及早期乳腺癌。结论钼靶乳腺摄影是诊断和鉴别诊断乳腺癌的重要方法。     

全数字化乳腺摄影对乳腺癌的诊断意义

目的 探讨全数字化乳腺X线摄影对早期乳腺癌诊断的应用意义.方法 收集经手术及病理证实的早期乳腺癌50例,全部病例均采用全数字化乳腺X线摄影.结果 42例扪及肿块的乳腺癌中,浸润性导管癌30例,髓样癌6例,黏液腺癌4例,浸润性小叶癌2例.8例未扪及肿块的乳腺癌中,导管原位癌3例,导管浸润癌3例,小叶原位癌2例.结论 全数字化乳腺X线摄影能清晰显示乳房各个层次,对发现早期乳腺癌具有重大价值.     

55例乳腺癌全数字化乳腺摄影X线表现及病理对照分析

目的:了解全数字化乳腺摄影X线诊断乳腺癌与病理结果的符合率,提高乳腺癌的全数字化乳腺摄影X线诊断水平。方法:总结了经手术证实的55例乳腺癌,X线表现与病理对照分析。结果:钼靶诊断乳腺癌47例,符合率85.45%(47/55),浸润性导管癌发病率最高,占85.45%;其次是导管内癌5.45%。结论:不同的X线表现是以不同的病理基础;全数字化乳腺摄影X诊断与病理诊断符合率高,有助于提高影像诊断乳腺癌的诊断水平。     

乳腺钼靶摄影成像对乳腺癌的诊断价值

目的探讨乳腺钼靶摄影成像对乳腺癌的诊断价值。方法回顾性分析经手术病理证实并行乳腺钼靶摄影的乳腺癌60例,其X线征象对乳腺癌的诊断价值。结果浸润性导管癌48例,浸润性小叶癌5例,浸润性黏液腺癌3例,导管内癌4例。腋窝淋巴结转移29例。其中结节9例,边界欠清6例,边界清楚3例。肿块48例,其中毛刺征9例、分叶征17例,透亮环征2例,边缘模糊30例、边界清晰2例,合并钙化30例,其中成簇泥沙样钙化9例、小杆状钙化3例、小叉状钙化1例,沿导管分布线性钙化1例,混合型钙化16例。单纯成簇泥沙样钙化1例。结构扭曲紊乱伴钙化1例。片状致密影1例。结论乳腺钼靶摄影成像对乳腺癌的早期发现、早期诊断具有重要价值。     

乳腺癌不同阶段钙化X线征像分析

目的  研究钙化在乳腺癌不同阶段X线征像。方法  收集行全数字化乳腺X线摄影出现钙化并经手术病理证实的乳腺癌277例,回顾性分析钙化X线征像,并与病理进行对照研究。 结果  乳腺癌钙化形态、分布、数目及伴随情况在导管原位癌、导管原位癌伴微浸润、浸润性导管癌差异有统计学意义（P<0.05）。结论  根据钙化X线征像初步鉴别不同阶段乳腺癌,为临床提供诊疗依据。

     

乳腺疾病数字化X线诊断分析

目的：分析全数字化乳腺摄影（Full-field Digitalization Mammography,FFDM）诊断乳腺疾病的X线征象。方法：收集2008年2月-2010年4月经手术病理证实有完整临床资料的乳腺疾病患者共102例,其中21例在乳腺体检中发现病变,所有患者均行全数字化乳腺摄影,结合病理进行影像学分析。结果：102例乳腺病变中乳腺癌31例,乳腺良性病变71例。31例乳腺癌中浸润型导管癌19例,浸润型导管癌并Paget病1例,浸润型小叶癌4例,髓样癌3例,黏液腺癌2例,富脂质癌1例,导管内癌1例;71例乳腺良性病变中纤维腺瘤42例,囊肿4例,导管乳头状瘤4例,脂肪瘤3例,淋巴结慢性炎症2例,浆细胞性乳腺炎2例,乳腺腺病14例。临床触及肿块者63例,未触及肿块者39例。影像表现为肿块73例,单纯簇状微小钙化4例,结构紊乱并粗长毛刺2例,结构紊乱并微小钙化1例,局部片状致密21例,平片无明显影像表现1例。结论：全数字化乳腺摄影能清晰显示乳腺疾病的X线征象,尤其能够显示乳腺癌的主要X线征象,对临床未触及肿块的早期乳腺癌具有重要的临床价值。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.