福建省青少年肠易激综合征的流行病学调查

目的分析城市中小学生肠易激综合征(IBS)的患病率、分布特征、致病的相关危险因素及焦虑性情绪障碍状况。方法采用多级整群随机抽样方法,对福建省两个地级市中4826名中小学生进行流行病学问卷调查。结果①校正后符合Manning及罗马Ⅱ诊断标准IBS的期间患病率分别是52．16％及17．10％,以高中生居多,男女患病率差异无统计学意义(P>0．05)。②Logistic回归分析揭示,年级、喜食辛辣或生冷食物、胃肠道感染、经常服用抗生素、遗传、经常因IBS症状而就诊、进食时吞咽困难、经常采用吞气来帮助终止打嗝、纳差、心情压抑11种因素为最具可能性的危险因素,其OR值均> 1。③4826名学生中有焦虑性情绪障碍倾向者占22．53％,男性17．84％,女性26．45％,两者差异有统计学意义(P<0．01)。④在儿童焦虑性情绪障碍筛查表(SCARED量表)5个领域的分值比较中,IBS学生高于非IBS学生,IBS就诊学生高于未就诊学生。结论①IBS是城市中小学生的常见病及多发病,患病率随年龄增长而上升;②不良饮食习惯、胃肠道感染、滥用抗生素、遗传及精神心理因素等可能是诱发城市中小学生IBS致病的相关危险因素;③焦虑性情绪障碍倾向发生率随年龄增长而上升。     

广州市居民肠易激综合征及功能性便秘的流行病学调查

目的：探讨广州市居民肠易激综合征（IBS）及功能性便秘的流行病学情况。方法：采用整群随机抽样法抽取广州市居民2892人进行问卷调查,同时问卷普通内科及消化专科门诊连续病例各1006及495例。结果：（1）广州市居民IBS的患病率为5．6％,普通内科门诊及消化专科门诊中IBS所的比例分别为10．1％、34．3％,IBS女性患病率显著高于男性,男女比例为1：1．51（P＝0．27）,年龄对IBS的患病率无显著影响,IBS患者的就诊率为22．4％,男女就诊率差异无显著性。IBS各亚型构成比为：腹泻主导型占63．2％,便秘主导型占27．0％,男女就诊率鞠显著性,IBS各亚型构成比为：腹泻主导型占63．2％,便秘主导型占27．0％,其他型占9．8％,（2）广州市居民功能性便秘的患病率为3．0％,普通内科门诊及消化专科门诊中所占的比例分别为5．4％及4．8％。男性患病率显著低于女性,男女比例为1：1．877。随着年龄的增加,功能性便秘的患病率升高,社区人群中功能性便秘的就诊率为17．6％,男女差异无显著性。结论：广州市居民IBS及功能性便秘的患病率低于国外报道水平。     

老年人便秘流行病学特点的初步分析

目的 探讨老年人便秘患病现状和分布特点。方法 采用多级、整群抽样的方法,对6个城市8252名≥岁的常住老年人进行横断面流行病学调查。结果 老年人便秘总患病率为11．5％,随着年龄的增长患病率增加,60－、65－、70－、75－、80－和85＋年龄组的患病率分别为8．7％、9．6％、11．7％、15．3％、17．1％、19．4％（P＜0．01）;老年人便秘城市患病率为10．9％,农村为12．3％,农村高于城市（P＜0．01）,且地区差异明显（P＜0．01）,北方地区患病率较高,为17．5％;老年人便秘患病率存在职业差别（P＜0．01）,从事家务、行政管理、科教文卫职业者患病率较高,分别为性别、年龄、城乡和地区与便秘患病率密切相关。结论 随年龄增长老年人便秘的患病率增加,北方高于南方,女性高于男性,除年龄因素外,老年人便秘还可能与气候、膳食结构、体力活动量等因素有关。     

基因多态性与肠易激综合征的关系及其对药效的影响

目的探讨5-羟色胺转运体（SERT）基因启动子区域（5-HTTLPR）与第2内含子可变数目串联重复序列（VNTRs）多态性在正常人及肠易激综合征（IBS）患者的分布及对替加色罗治疗便秘型IBS（C-IBS）疗效的影响。方法用PCR检测87例IBS和96例对照者外周血2个基因的多态性;给予41例C-IBS患者4周替加色罗6mg,2次／d,治疗前后评估临床症状及便秘程度。结果IBS组5-HTTLPR基因型频率是S／S：52．9％,S／L：31．0％,L／L：16．1％;对照组分别为57．3％,35．4％及7．3％;IBS组VNTRs基因型频率是STin2．10／10：2．3％,STin2．12／10：17．2％,STin2．12／12：80．5％;对照组分别为2．1％,11．4％及86．5％;两组差异无统计学意义（P〉0．05）,但C-IBS组的I／L频率比对照组显著高（25.0％比7.3％,P〈0．05）。治疗后症状缓解率S／S型为85.0％,S／L型为70．0％,均显著优于L／L型的36．4％（P〈0．05）;主体症状评分和单个症状（排便次数、粪便性状、便后排空感等）改善在S／S和L／S型均优于L／L型（P〈0．05）。结论SERT基因多态性总体与IBS发病无关,但L／L型更易患C-IBS。替加色罗对C—IBS的疗效受基因型影响,L／L型疗效较差。     

日照市居民肠易激综合征及功能性便秘的流行病学调查

目的 探讨日照市居民肠易激综合征(IBS)及功能性便秘的流行病学情况。方法适用整群随机抽样法抽取日照市居民2892入进行问卷调查，同时问卷普通内科及消化专科门诊连续病例各1006及495例。结果①日照市居民IBS的患病率为5．6％，普通内科门诊及消化专科门诊中IBS所占的比例分别为10．1％、34．3％。IBS女性病人病率显著高于男性，男女比例为1：1．51(P=0．027)。年龄对IBS的患病率无显著影响。IBS病人的就诊率为22，4％，男女就诊率差异无显著性。IBS各亚型构成比为：腹泻主导型占63．2％，便秘主导型占27、0％，其他型占9．8％。②日照市居民功能性便秘的患病率为3．0％。普通内科门诊及消化专科门诊中所占的比例分别为5．4％和4．8％。男性患病率显著低于女性，男女比例为1：1．77。随着年龄的增加，功能性便秘的患病率升高。社区人群中功能性便秘的就诊率为17．6％，男女差异无显著性。结论日照市居民IBS及功能性便秘的患病率低于国外报道水平。     

剔除过敏食物治疗肠易激综合征的疗效观察

目的探讨依据食物特异性抗体IgG（SIgG）,剔除过敏食物治疗肠易激综合征（IBS）的疗效,进一步证实食物过敏在IBS发病中的作用。方法取腹泻型IBS（D—IBS）患者55例、便秘型IBS（C—IBS）患者32例和健康对照18例的静脉血,应用酶联免疫方法检测14种SIgG。对35例SIgG抗体升高的IBS患者,剔除过敏食物治疗2个月,观察治疗前后患者症状频率和程度的变化以及IBS专用生活质量量表（IBS QOL）积分的改变。结果D—IBS患者SIgG抗体的阳性率为63．6％（35／55）,C—IBS患者SIgG抗体的阳性率为43．8％（14／32）,二者均高于对照组。依据SIgG抗体剔除过敏食物治疗2个月,31．4％的患者症状完全缓解,34．3％的患者症状明显缓解。剔除过敏食物4周后,IBS患者的症状频率、严重程度积分分别由（3．79±1．58）次／周降至（1．67±0．70）次／周,3．18±1．46降至1．52±0．67;8周后,分别由（3．79±1．58）次／周降至（1．53±0．69）次／周,3．18±1．46降至1．45±0．66,差异均有统计学意义（P〈0．05）。IBS QOL 8个维度积分除挑食外其他积分和总体健康积分均比治疗前显著升高。结论IBS患者存在食物特异性IgG抗体介导的免疫异常反应,根据SIgG水平剔除过敏食物治疗IBS是有意义的。     

肠易激综合征的病因及发病机制探讨

肠易激综合征（IBS）是以大便习惯改变为主要特征的一种常见胃肠功能紊乱性疾患。最早于1820年由powell报道。该病在门诊中占胃肠道疾病的50％，多在20～50岁之间发病，男女之比约3：2。在西方国家占胃肠病门诊的10．6％人群患病率为7．1％～13．6％。我国目前缺乏全国性的统计资料，北京城郊人口和广东省（4178人，18～80岁）流行病学调查显示，症状符合IBS Manning标准的患病率分别是7．26％和11．5％符合罗马标准的患病率分别为0．82％和5．67%。IBS是在特殊的基质基础上，以精神、免疫及内分泌系统为中介，以社会心理因素刺激为板机而触发的心身疾病。其病因和发病机制复杂，迄今尚无定论。     

2007年成都地区糖尿病、糖尿病前期的流行病学调查

目的了解成都地区成年人DM和DM前期患病率的流行病学情况。方法用多级多层整体抽样方法,于2007年调查成都玉林、龙泉两个地区共计2248人。DM诊断采用1999年WHO标准。结果DM和DM前期的总患病率分别为11．1％、14．2％;标化后分别为8．2％、12．2％;男性DM患病率高于女性（P〈0．05）,两性问DM前期患病率无统计学差异（P〉0.05）。DM及DM前期患病率随年龄增长而增加（P〈0．05）。Logistic回归分析显示DM的危险因素有年龄、腰围、静息心率、BP和TG。DM前期危险因素分别为年龄、高血压史、静息心率、BMI、TC、血尿酸。HDL-C为保护性因素。结论成都地区的DM及DM前期患病率均较高,且有进一步增加趋势,须及时采取有效措施,干预糖代谢异常的流行。     

保定地区体检人群高尿酸血症的流行病学调查

目的：了解保定地区体检人群的血清尿酸（ SUA）水平及高尿酸血症（ HUA）的流行状况。方法检测19752例保定地区健康体检者的血清SUA水平,按年龄、性别进行统计学分析。结果保定地区HUA总体患病率为13．24％,男女分别为20．01％和6．53％,男性患病率处于相对较高水平;20～29岁组发病率最高,为26．97％。结论保定地区血清SUA水平及HUA患病率处于较高水平,应重视对青年人的健康宣教工作。     

胃食管反流病与功能性消化不良、肠易激综合征症状重叠的研究

目的探讨胃食管反流病（GERD）重叠功能性消化不良（FD）、肠易激综合征（IBS）症状的发生率，分析糜烂性食管炎（EE）和非糜烂性反流病（NERD）亚型患者重叠FD、IBS症状发生率的异同。方法通过胃镜及24h食管pH监测，将147例GERD患者区分为EE47例、病理性酸反流[NERDpH（＋）]42例和生理性酸反流[NERDpH（-）]58例。根据罗马Ⅱ诊断标准对患者重叠FD、IBS症状的情况进行问卷调查。采用《检验比较不同组间重叠症状发生率。结果147例GERD患者中重叠FD症状54例（36．7％），重叠IBS症状19例（12．9％），其中同时重叠FD、IBS症状10例（6．8％）。EE及NERD组重叠FD症状者分别为11例（23．4％）及43例（43．0％），差异有统计学意义（P〈0．05）。EE及NERDpH（＋）组重叠FD症状者分别为n例（23．4％）及13例（31．O％），差异无统计学意义（P〉0．05）。NERDpH（＋）组及pH（-）组重叠FD症状者分别为13例（31．0％）及30例（51．7％），差异有统计学意义（P〈0．05）。EE及NERD组重叠IBS症状者分别为6例（12．8％）及13例（占13．0％），差异无统计学意义（P〉0．05）。NERDpH（＋）组及pH（-）组重叠IBS症状者分别为4例（9．5％）及9例（15．5％），差异无统计学意义（P〉0．05）。结论部分GERD患者重叠FD、IBS症状。无异常食管酸暴露的烧心患者易合并FD症状。     

Irritable bowel syndrome according to varying diagnostic criteria: are the new Rome II criteria unnecessarily restrictive for research and practice?

OBJECTIVES: It has been suggested that the variation in the prevalence of irritable bowel syndrome (IBS) may be due to the application of different diagnostic criteria. New criteria for IBS have been proposed (Rome II). It is unknown whether persons meeting different criteria for IBS have similar psychological and symptom features. The aim of this study was to measure the prevalence of IBS according to Manning and Rome definitions of IBS and to evaluate the clinical and psychological differences between diagnostic categories. METHODS: A total of 4500 randomly selected subjects, with equal numbers of male and female subjects aged > or = 18 yr and representative of the Australian population, took part in this study. Subjects were mailed a questionnaire (response rate, 72%). Characteristics measured were gastrointestinal symptoms over the past 12 months, neuroticism and extroversion (Eysenck Personality Questionnaire), anxiety and depression (Delusions-Symptoms-States Inventory), mental and physical functioning (SF-12), and somatic distress (Sphere). RESULTS: The prevalence for IBS according to Manning, Rome I, and Rome II was 13.6% (95% confidence interval [CI] = 3.5-5.1%), 4.4% (CI 6.0-7.8%), and 6.9% (CI 12.3-14.8%), respectively [corrected]. Only 12 persons with Rome I did not also meet Rome II criteria; 196 persons with Manning criteria did not meet Rome II cut-offs. Having IBS regardless of which criteria were used was significantly associated with psychological morbidity, but psychological factors were not important in discriminating between diagnostic categories. However, pain and bowel habit severity independently discriminated between diagnostic groups. CONCLUSIONS: IBS is a relatively common disorder in the community. The new Rome II criteria may be unnecessarily restrictive in practice.     

Irritable bowel syndrome prevalence varies enormously depending on the employed diagnostic criteria: comparison of Rome II versus previous criteria in a general population.

BACKGROUND: Irritable bowel syndrome (IBS) prevalence estimates are essential for measuring the importance of the problem and the burden of the illness. However, IBS diagnosis is based on clinical criteria which have changed over time. The aim of this study was to assess how the use of different diagnostic criteria influences estimated IBS prevalence and, in particular, to compare how this prevalence varies using the new Rome II criteria and previous diagnostic criteria. METHODS: An epidemiological survey was conducted in the general population using personal interviews in a home setting. Two thousand individuals stratified by gender, age, social class and geographic location were randomly selected from the general population of Spain. Participants were classified as 'potential IBS subjects' (n = 281) or 'non-potential IBS subjects' (n = 1719) as a result of their response to a screening question regarding the presence of abdominal pain, constipation or diarrhoea. Thus, we estimated IBS prevalence according to the following diagnostic criteria: Manning, Rome I, Rome II, Drossman, Talley and Kay & Jorgensen. RESULTS: Prevalences of IBS according to the Manning and Rome I criteria were 10.3% and 12.1%, respectively. These were higher than the prevalences obtained with the other criteria used, which varied from 2.1% to 4.9%. IBS was more prevalent in females than males irrespective of the criteria used (the female:male ratio ranged from 2.33 to 4.33). Subjects who fulfilled the Rome II, Drossman, Talley or Kay & Jorgensen criteria also fulfilled the Rome I and Manning criteria. However, between 44% and 80% of subjects who fulfilled the Rome I or Manning criteria did not fulfil the more stringent diagnostic criteria. CONCLUSIONS: The prevalence of IBS varies enormously depending on the diagnostic criteria employed. Criteria based on the frequency of symptoms, such as the Rome II criteria, produce much lower prevalence values compared to criteria based solely on the presence of symptoms. In fact, more than two-thirds of subjects who fulfilled the Rome I criteria would not have been diagnosed with IBS if Rome II criteria had been employed.     

Irritable Bowel Syndrome Prevalence Varies Enormously Depending on the Employed Diagnostic Criteria: Comparison of Rome II Versus Previous Criteria in a General Population

Background: Irritable bowel syndrome (IBS) prevalence estimates are essential for measuring the importance of the problem and the burden of the illness. However, IBS diagnosis is based on clinical criteria which have changed over time. The aim of this study was to assess how the use of different diagnostic criteria influences estimated IBS prevalence and, in particular, to compare how this prevalence varies using the new Rome II criteria and previous diagnostic criteria. Methods: An epidemiological survey was conducted in the general population using personal interviews in a home setting. Two thousand individuals stratified by gender, age, social class and geographic location were randomly selected from the general population of Spain. Participants were classified as 'potential IBS subjects' ( n = 281) or 'non-potential IBS subjects' ( n = 1719) as a result of their response to a screening question regarding the presence of abdominal pain, constipation or diarrhoea. Thus, we estimated IBS prevalence according to the following diagnostic criteria: Manning, Rome I, Rome II, Drossman, Talley and Kay & Jorgensen. Results: Prevalences of IBS according to the Manning and Rome I criteria were 10.3% and 12.1%, respectively. These were higher than the prevalences obtained with the other criteria used, which varied from 2.1% to 4.9%. IBS was more prevalent in females than males irrespective of the criteria used (the female:male ratio ranged from 2.33 to 4.33). Subjects who fulfilled the Rome II, Drossman, Talley or Kay & Jorgensen criteria also fulfilled the Rome I and Manning criteria. However, between 44% and 80% of subjects who fulfilled the Rome I or Manning criteria did not fulfil the more stringent diagnostic criteria. Conclusions: The prevalence of IBS varies enormously depending on the diagnostic criteria employed. Criteria based on the frequency of symptoms, such as the Rome II criteria, produce much lower prevalence values compared to criteria based solely on the presence of symptoms. In fact, more than two-thirds of subjects who fulfilled the Rome I criteria would not have been diagnosed with IBS if Rome II criteria had been employed.     

The irritable bowel syndrome and psychiatric disorders in the community: is there a link?

OBJECTIVE: Psychiatric morbidity is high among patients who present to referral centers with irritable bowel syndrome (IBS). However, few studies have investigated the relationship between psychiatric disturbance and IBS in community samples. We hypothesized that psychiatric disorders are linked to IBS in the general community, but this is influenced by the criteria used to establish a diagnosis of IBS. METHODS: The data were collected from a birth cohort born in Dunedin (New Zealand) between April 1972 and March 1973. This cohort consisted of 1037 members (52% male), who were assessed at ages 3, 5, 7, 9, 11, 13, 15, 18, 21, and 26 yr. GI symptoms were recorded at age 26 yr, using an abbreviated version of the Bowel Symptom Questionnaire; psychiatric history was obtained at ages 18 and 21 yr, using a modified version of the Diagnostic Interview Schedule. RESULTS: The prevalence of IBS was 12.7% according to the Manning criteria and 4.3% according to the Rome II criteria. The IBS was not significantly related to a diagnostic history for psychiatric illness overall, nor to a history of anxiety disorders, depressive disorders, and substance dependence. These results were independent of the IBS criteria used; there was no association between psychiatric history and IBS when IBS was defined according to the Manning criteria (p = 0.11 to 0.98) or the Rome criteria (p = 0.18 to 0.92): Rome and Manning criteria subjects did not significantly differ from each other in terms of psychiatric history (p = 0.16 to 0.89). CONCLUSION: In a cohort of young adults with IBS from New Zealand, IBS appears to not be related to psychiatric disorders.     

A comparison of the Rome and Manning criteria for case identification in epidemiological investigations of irritable bowel syndrome

OBJECTIVE: The aim of this study was to estimate the prevalence of irritable bowel syndrome using different standard definitions (Rome and Manning criteria) and to determine the degree of agreement between these definitions. METHODS: A population-based, cross-sectional survey study was conducted by mailing a valid, reliable questionnaire to an age- and gender-stratified random sample of residents of Olmsted County, MN, aged 30-69 yr. The threshold for a positive diagnosis of irritable bowel was varied from two to four of the six Manning criteria and from two to three of the five defecation disorders in the Rome criteria. Unadjusted as well as age- and gender-adjusted prevalence rates were calculated for each of the five definitions of IBS. Percent agreement and kappa statistics were calculated to assess agreement between the definitions. RESULTS: Questionnaires were returned by 643 of 892 eligible subjects (72% response rate). The age- and gender-adjusted prevalence of IBS varied from 20.4% using a threshold of two symptoms in the Manning criteria to 8.5% using a threshold of three defecation disorders in the Rome criteria. The percent agreement for each comparison of Manning and Rome definitions was always >90%. The kappa values ranged from 0.55 to 0.78, with the best agreement occurring between a threshold of three symptoms of Manning and two defecation disorders in Rome. CONCLUSIONS: The prevalence of IBS varied substantially depending on the specific definition of IBS used. The range of prevalence estimates in Olmsted County was similar to other published figures when IBS definition was accounted for. These findings are useful in interpreting epidemiological and clinical studies of IBS.     

Definition and epidemiology of irritable bowel syndrome]

Irritable bowel syndrome (IBS) is characterized by abdominal discomfort, bloating and disturbed defecation in the absence of any identifiable physical, radiologic or laboratory abnormalities indicative of organic gastrointestinal disease. Diagnosis is based on the identification of symptoms according to Manning, Rome I and Rome II criteria and exclusion of alarm indicators. Approximately, 10-20% of the general population has IBS, and it affects female more often than male for unexplained pathophysiologic reasons. In Korea, it has been reported that the prevalence of IBS is 2.2-6.6% by Rome II criteria and 22.3% by Manning criteria. The health care-seeking population was only 28.6% of community population. Although most patients do not seek medical help, the disease accounts for huge costs for both patients and health-care systems and worsens patients' quality of life significantly.     

The irritable bowel syndrome has origins in the childhood socioeconomic environment

BACKGROUND: The childhood socioeconomic environment has been linked to adult health status in several studies. However, its role in the pathogenesis of adult irritable bowel syndrome (IBS) remains unknown. We aim to assess the influence of the childhood environment on adult IBS, using data from a New Zealand birth cohort study. METHODS: The Dunedin birth cohort was assembled in 1972-1973 and has been followed prospectively to age 26 (n = 980). IBS was classified according to both Rome and Manning criteria, using self-reported symptom data obtained at age 26 yr. Childhood social class was used as a proxy measure of the quality of the childhood socioeconomic environment and was assigned according to the highest average socioeconomic (SES) level of either parent from interviews across the first 15 yr of life. RESULTS: Childhood social class was significantly associated with IBS according to Manning Criteria (p = 0.05) and Rome II Criteria (p = 0.05). The prevailing trend was identical for both measures of IBS in the sex-adjusted models: this trend can be characterized as a general, and near-linear decrease in the odds of IBS across decreasing levels of social class. Contrasts with the reference group were significant on all comparisons for Manning Criteria IBS (high vs upper middle, p = 0.04; lower middle, p = 0.04; low, p = 0.01), and on comparisons involving the two lower social class groups for Rome II Criteria IBS (high vs lower middle, p = 0.03; low, p = 0.03). The associations were attenuated, but not eliminated by further adjustment for adult social class. CONCLUSIONS: An affluent childhood environment is an independent risk factor for adult IBS.     

Epidemiology of irritable bowel syndrome in Chinese

Irritable bowel syndrome (IBS) is common in Caucasians and Japanese, but its epidemiology has not been studied in urbanized Chinese populations. Our aim was to compare diagnostic criteria and study the epidemiology of IBS in Hong Kong Chinese. In all, 964 subjects from public housing and 334 subjects from private housing were recruited for face-to-face interviews in Shatin, Hong Kong. A structured questionnaire was used to measure the prevalence of IBS according to the Manning, Rome I, and Rome II criteria. The SF-36 scale was used to measure quality of life (QOL) in subjects with IBS and in normal controls. The results were compared by the analysis of covariance (ANCOVA). Relevant medical consultations and absence from work were recorded. There was fair agreement between the Manning and Rome II criteria ( = 0.23; P < 0.001), but good agreement between the Rome I and Rome II criteria ( = 0.5; P < 0.001). The prevalence of IBS, based on the Rome II criteria, was 3.6% (95% CI = 2.0–5.2) in men and 3.8% (95% CI = 2.5–5.2) in women. Men with IBS had significantly lower vitality scores on the SF-36 scale than the controls (P < 0.05 by ANCOVA), and women with IBS had significantly lower mental health scores than controls (P < 0.05 by ANCOVA). In conclusion, IBS is quite prevalent in Hong Kong Chinese, and the QOL of subjects with IBS was significantly affected.     

Frequency of functional bowel disorders among healthy volunteers in Mexico City

BACKGROUND: The frequency of functional bowel disorders (FBD) in Mexico using the Rome II criteria is unknown. METHODS: The Rome II Modular Questionnaire (RII-MQ) was translated into Spanish in coordination with the Rome Committee and their Latin American program. Volunteers were recruited by advertisement in Mexico City, and administered the RII-MQ. RESULTS:The study population consisted of 324 healthy volunteers, with a mean age of 35.7; 66% were female. The most prevalent disorders were heartburn 35%, irritable bowel syndrome (IBS) 35%, functional bloating 21%, proctalgia fugax 21%, and functional constipation 19%. Based on gender, IBS-C was 4 times more frequent in females than males (19 vs. 4.6%) and functional bloating 3 times more frequent (10 vs. 3.7%). Differences according to occupation included a higher prevalence of ulcer-like dyspepsia (p = 0.04), IBS-C (p = 0.018) and proctalgia fugax (p = 0.034) among students. CONCLUSIONS: This is the first study to use RII-MQ to determine the prevalence of FBD in urban Mexico. The prevalence of IBS was significant and is related to a number of factors, including the stress of living in an overpopulated city. Selection bias is likely operative. A community-based study is warranted.