低渗非离子造影剂对冠状动脉介入诊疗术患者肾功能影响的前瞻性研究

目的 了解低渗非离子造影剂对冠状动脉介入诊疗术患者肾功能的影响，造影剂肾病(CIN)的发病率及危险因素。 方法 2004年12月至2005年3月期间住院的315例接受冠状动脉介入诊疗手术的患者入选，所有患者均应用低渗非离子造影剂。测定造影前3 d内和术后第1、2、6天肾功能、尿N-乙酰-β氨基葡萄糖苷酶(NAG)、尿渗透浓度，分析造影剂对冠状动脉介入诊疗术患者肾功能的影响。Logistic多因素回归分析影响CIN发生的危险因素。 结果 (1)315例患者中，男性231例，女性84例，平均年龄(63.5±11.6)岁，发生CIN 19例，发病率6.03%。在既有肾功能不全又有糖尿病组中，CIN发病达4/8，与无肾功能不全、有或无糖尿病组比较，差异有统计学意义(P < 0.05，P < 0.01)。(2)19例CIN患者中，造影后第1、2天，尿NAG、Scr均显著高于造影前水平(P < 0.05)，但造影后第6天基本回复至基础水平。(3)CIN组中原有肾功能不全者达9/19，非CIN组为31/296(10.5%)，两组比较差异有统计学意义(P < 0.01)。平均造影剂剂量CIN组为(318.4±153.8) ml，非CIN组为(227.9±121.9) ml， 两组比较差异有统计学意义(P < 0.01)。Logistic逐步回归分析显示，造影剂剂量和合并肾功能不全是CIN的独立危险因素。结论 CIN在原有肾功能不全特别是合并糖尿病的人群中发病率较高。尿NAG可反映早期肾小管功能损害。造影剂剂量和合并肾功能不全是CIN的独立危险因素。     

颈动脉支架植入术中低血流动力学紊乱相关危险因素

目的分析颈动脉支架植入(CAS)术中低血流动力学紊乱(HD)的危险因素。方法回顾性分析121例接受CAS患者,根据CAS术中血压和心率变化评估有无HD;以单因素及多因素logistic回归分析筛选CAS中发生HD的危险因素。结果共42例发生HD(HD组),其中27例见于球囊扩张时,14例见于植入支架时,1例见于以封堵器封堵血管时;79例未见HD(非HD组)。单因素分析显示,组间患者年龄、颈动脉狭窄程度和部位(有无累及球部或分叉部)、血管斑块性质及球囊后扩张差异均有统计学意义(P均<0.05);多元logistic回归结果显示,年龄、狭窄部位、血管斑块性质及球囊后扩张均为HD的独立危险因素(P均<0.05)。结论CAS术中发生HD与患者年龄、颈动脉狭窄部位、血管斑块性质及有无球囊后扩张有关。     

平均血小板体积联合Gensini评分预测ST段抬高型心肌梗死患者急诊经皮冠状动脉介入术近期预后

目的探讨平均血小板体积(MPV)联合Gensini评分预测急性ST段抬高型心肌梗死(STEMI)患者急诊经皮冠状动脉介入术(PCI)近期预后的价值。方法对186例接受急诊PCI治疗的STEMI患者,术前完善相关实验室检查、检测MPV,并根据冠状动脉造影检查结果进行Gensini评分;术后随访记录主要不良心血管事件(MACE)发生情况,并进行统计学分析。结果 186例中,PCI术后36例发生MACE(MACE组),150例未发生MACE(非MACE组)。2组间总胆固醇(TC)、血小板计数(Plt)、D-二聚体、N末端脑钠肽前体(NT-proBNP)、MPV、Gensini评分及病变累及冠状动脉3支血管的比例差异均有统计学意义(P均0.05)。MPV、Gensini评分、Plt、NT-proBNP及病变累及冠状动脉3支血管是STEMI患者PCI术后发生MACE的独立危险因素(P均0.05)。以MPV(阈值0.86 fl)联合Gensini评分(阈值82.17分)预测STEMI患者急诊PCI术后发生MACE的ROC曲线AUC为0.92[95%CI(0.87,0.98)],敏感度为92.70%,特异度为83.33%。结论 STEMI患者急诊PCI术后近期MACE的发生与术前MPV及Gensini评分有关;MPV联合Gensini评分可用于筛查PCI术后高危患者。     

冠心病患者冠状动脉造影与肠系膜上动脉超声多普勒血流显像的相关性研究

目的提高对冠心病患者并发肠缺血的认识,完善冠心病防治规则。方法选择经临床和数字减影血管造影（DSA）检查确诊的47例老年冠心病患者（观察组）与28例中青年冠心病患者（对照组）的肠系膜上动脉彩色多普勒血流显像结果进行对比,分析年龄与肠系膜上动脉之间以及冠状动脉病变程度与肠系膜上动脉病变之间的关系。结果观察组47例中29例（61.7％）发现肠系膜上动脉病变,对照组28例中有7例（25.0％）,两组比较差异有统计学意义（P〈0.05）。观察组冠状动脉多支血管病变27例（57.4％）,对照组有8例（28.6％）,两组比较差异有统计学意义（P〈0.05）。冠状动脉多支血管病变35例,合并肠系膜上动脉病变31例（88.6％）;单支血管病变40例,合并肠系膜上动脉病变5例（12.5％）（P〈0.05）。结论冠心病患者的年龄越大,肠系膜上动脉患病概率越大;冠状动脉病变程度越重,肠系膜上动脉病变程度越高。     

胸腹主动脉扩张性病变平行支架腔内隔绝术内漏发生影响因素分析

目的:分析胸腹主动脉扩张性病变,采用平行支架技术(烟囱支架技术)腔内隔绝术后发生内漏的危险因素,为预防发生提供数据。方法:回顾性分析长海医院血管外科2011年1月至2018年3月胸腹主动脉扩张性病变平行支架技术腔内隔绝术病人50例,分为内漏组和无内漏组,分析内漏的危险因素。结果:本研究共有平行支架部位68个,其中烟囱支架数目90枚。术中造影发现Ⅰ型内漏28个(41.2%),随访发现Ⅰ型内漏12个(17.6%)。单因素分析发现,血管内平行动脉口径比值≥1.44,支架内平行动脉口径比值≤1.53,Gore主体支架与外周覆膜支架平行,这3个因素是内漏的相关因素(P0.05)。Logistic回归分析显示,平行支架数目是内漏发生的相关因素(P0.05)。结论:本研究发现胸腹主动脉扩张性疾病平行支架腔内隔绝术的内漏与平行支架间口径匹配、平行支架数目,及平行支架在血管内平行还是支架内平行有关。     

超声心动图诊断胎儿冠状静脉窦扩张

目的探讨胎儿冠状静脉窦(CS)扩张的超声诊断思路。方法回顾性分析145胎正常冠状静脉窦胎儿(正常组)和72胎CS扩张胎儿(CS组)的资料,于非标准四腔心切面下显示CS长轴,测量CS的矢状切面面积。采用二维超声结合彩色多普勒超声对所有胎儿分别进行胎儿四腔心切面、左右心室流出道切面、三血管切面、大动脉短轴切面、主动脉弓切面、动脉导管弓切面及腔静脉长轴切面扫查,观察CS的特点。结果胎儿CS矢状切面面积与孕周呈正相关(正常组:r=0.954,P0.05;CS组:r=0.904,P0.05),同孕周正常组胎儿CS矢状切面面积小于CS组(P均0.01)。产前超声诊断72胎CS扩张的胎儿中,52胎为永存左上腔静脉,15胎为完全型肺静脉异位引流,5胎右心压力负荷增大。结论胎儿CS矢状切面的面积与孕周呈正相关;胎儿心脏超声检查发现CS扩张时应同时考虑其他心内畸形;临床应通过多切面、多角度扫查,分析和诊断引起CS扩张的病因。     

冠状动脉钙化积分、血压变异性与维持性血液透析患者心血管事件的关系

目的:探讨冠状动脉钙化积分、血压变异性与维持性血液透析患者心血管事件的关系。方法:选取2017年7月—2018年12月于我院进行维持性血液透析的患者169例,根据随访期内是否发生主要不良心血管事件(MACE)分为MACE组和非MACE组(NMACE组),比较两组患者一般临床资料、冠状动脉钙化积分和血压变异性的差异,分析冠状动脉钙化积分和血压变异性与MACE的关系。结果:随访时间内,维持性血液透析患者的MACE发生率为42.01%(71/169)。MACE组患者的年龄、透析时间、冠状动脉钙化积分、收缩压变异系数(SBP-CV)及舒张压变异系数(DBP-CV)明显高于NMACE组(均P0.05)。Logistic多因素回归分析显示年龄(OR=1.827)、SBP-CV(OR=1.589)、DBP-CV(OR=1.691)及冠状动脉钙化积分(OR=1.959)均是维持性血液透析患者发生MACE的危险因素(均P0.05)。SBP-CV、DBP-CV和冠状动脉钙化积分诊断维持性血液透析患者发生MACE的ROC曲线下面积(AUC)分别为0.795、0.829、0.847,三者联合诊断的AUC最高(0.952)(均P0.05)。结论:冠状动脉钙化积分和血压变异性对维持性血液透析患者MACE的发生均具有较高的预测价值,二者的联合检测有助于改善患者预后。     

冠状动脉CT血管造影评估冠状动脉慢性完全性闭塞

目的 观察冠状动脉CT血管造影(CCTA)评估冠状动脉慢性完全闭塞(CTO)的可靠性。方法 回顾性分析201例经有创冠状动脉造影(ICA)确诊的CTO患者共207处病变的CCTA资料,观察CCTA与ICA显示CTO特征的一致性、差异及符合率,包括冠状动脉闭塞段头端形态(钝形/锥形),闭塞段内有无钙化、纡曲、近端分支及闭塞段长度是否≥20 mm。结果 CCTA与ICA检出冠状动脉闭塞段头端钝形(Kappa=0.50)、闭塞段内有无钙化(Kappa=0.48)、闭塞段近端有无分支(Kappa=0.56)及病变长度≥20 mm(Kappa=0.53)与否的结果具有中度一致性(P均＜0.01),二者判断闭塞段是否纡曲的一致性好(Kappa=0.80,P＜0.01)。CTA与ICA对冠状动脉闭塞段钙化[38.65%(80/207)vs.21.74%(45/207)]及闭塞近端分支[31.40%(65/207)vs.43.48%(90/207)]的检出率差异有统计学意义(P均＜0.01),对闭塞段头端钝形[35.75%(74/207)vs.36.71%(76/207)]、闭塞段纡曲[20.29%(42/207)vs.23.19%(48/207)]及病变长度≥20 mm[38.65%(80/207)vs.41.06%(85/207)]的检出率差异均无统计学意义(P均＞0.05)。CCTA与ICA检出冠状动脉闭塞段头端钝形、钙化、纡曲、近端存在分支及长度≥20 mm的符合率分别为76.81%(159/207)、77.29%(160/207)、93.24%(193/207)、79.23%(164/207)及77.29%(160/207)。结论 利用CCTA能可靠评估CTO病变特征。     

经尿道输尿管球囊扩张术治疗肾盂输尿管连接部狭窄58例疗效分析

目的探讨经尿道输尿管镜下球囊扩张法治疗肾盂输尿管连接部狭窄的有效性及安全性。方法回顾性分析2012年2月至2017年10月行经尿道输尿管镜球囊扩张治疗的58例先天性肾盂输尿管连接部狭窄患者的临床资料,通过术后随访结果将患者进行分组,采用单因素分析法及Logistic回归分析探讨影响手术预后的危险因素。结果 58例患者中37例术后2年内未发生再狭窄,有效率为63.79%(37/58)。单因素分析结果显示:狭窄段长度、狭窄程度、球囊扩张时间、留置输尿管支架管条数及带管期间有无感染5项指标在手术有效组与无效组间比较,差异均有统计学意义(P均0.05)。Logistic回归分析发现狭窄长度、狭窄程度及留置2根输尿管支架是影响手术预后的独立危险因素(P0.05)。结论输尿管镜直视下的球囊扩张术可作为狭窄段1.5cm的肾盂输尿管连接部狭窄患者的首选治疗方案,术中留置双根输尿管支架管可有效降低术后再狭窄发生率。     

第三代双源CT个体化“双低”技术在冠状动脉成像中的应用

目的探讨第三代双源CT冠状动脉成像中应用低对比剂剂量、低对比剂注射流率技术的个体化注射方案对图像质量及辐射剂量的影响。方法将120例接受CT冠状动脉成像的患者随机分为2组。试验组:按照公式对比剂剂量=体质量×0.6ml/kg、流率=对比剂剂量/(5+扫描曝光时间),计算对比剂剂量和流率;对照组:对比剂50ml,流率5.0ml/s。2组均采用前瞻性心电门控窄窗技术扫描,比较2组图像质量的客观和主观评价指标及辐射剂量。结果试验组与对照组患者性别、年龄、体质量、体质量指数差异均无统计学意义(P均0.05)。试验组与对照组注射对比剂剂量和对比剂流率差异均有统计学意义(P均0.001)。2组图像SNR、冠状动脉图像质量评分和冠状动脉的可评价率差异均无统计学意义(P均0.05)。心率≤70次/分、70次/分心率≤80次/分及心率80次/分时,试验组和对照组患者有效辐射剂量差异均有统计学意义(P均0.05)。结论第三代双源CT冠状动脉血管成像个体化注射方式可在满足临床诊断的前提下最大程度地减少对比剂用量。     

Similar survival 15 years after coronary artery surgery irrespective of left main stem stenosis

Abstract

Objectives. To evaluate 15-year survival after coronary artery bypass grafting (CABG) in relation to grade left main stenosis (LMS) and right coronary artery (RCA) obstruction. Design. Coronary angiographic findings were prospectively collected in 977 patients who had CABG for stable angina during 1994–1995 and were included in the Swedish Coronary Revascularization – Swedish Council of Technology Assessment study. Results. Significant LMS was present in one fifth of the patients and significant RCA obstruction was found in 61% of those with LMS and in 68% of patients without LMS. The patients were categorized as no LMS (Group I), LMS without RCA obstruction (Group II) or significant LMS with significant right coronary artery (RCA) obstruction (Group III). Early mortality did not differ in the three groups and was 1.2, 1.2% and 0.8% in group I, II and III, respectively. Corresponding survival at 15 years was similar 51%, 47% and 47%, respectively. In multivariable analysis older age, smoking, severe angina, positive stress test, hypertension, diabetes mellitus and ejection fraction < 50% were risk factors for death at 15 years. Conclusions. Death 15 years after CABG correlated to clinical variables but was not predicted from presence of LMS with or without significant associated RCA obstruction.     

Surgical treatment of coronary artery aneurysms

Introduction

Coronary artery aneurysms (CAA) are rare. We present our experience with the surgical treatment of patients with CAAs.

Methods

Between March 2000 and October 2016, 15 patients with CAA underwent surgery.

Results

Mean age of patients was 60 ± 16 years and 47% (n = 7) were male. Kawasaki syndrome was present in two (13%) patients and 7% (n = 1) patients had Marfan syndrome. Isolated CAAs were found in 73% (n = 11) and involvement of multiple vessels was present in 27% (n = 4) of patients. Coronary arteries (CA) affected by aneurysms were: 19% (n = 4) left main stem, 33% (n = 7) left anterior descending, 14% (n = 3) left circumflex, and 33% (n = 7) right coronary artery. The majority of patients (93%, n = 14) were operated on pump with a mean cross‐clamp time of 51 ± 23 min. 53% (n = 8) of patients received total arterial CA bypass grafting, while the remaining patients (47%, n = 7) received venous ± internal thoracic artery grafts. Resection/ligation of CAA was performed in 27% (n = 4) of patients. In‐hospital mortality was 0% (n = 0). Follow‐up was complete for 100% of patients and comprised a total of 80 patient‐years. During follow‐up, only one patient (7%) required re‐intervention.

Conclusion

Surgical treatment of CAA has good short‐ and long‐term results.     

CT测量腹部脂肪相关参数诊断冠心病

目的 探讨CT测量腹部脂肪相关参数对诊断冠心病的价值。方法 对211例疑诊冠心病患者于30天内行冠状动脉造影及腹部CT平扫，分析冠心病发生危险因素，采用ROC曲线观察各危险因素单独及联合诊断冠心病的效能。结果 211例中，经冠状动脉造影明确诊断冠心病112例，非冠心病99例。单因素分析结果显示，冠心病与非冠心病患者间年龄、性别、吸烟、糖尿病、高血压、高密度脂蛋白胆固醇（HDL-C）、内脏脂肪（VAT）面积、皮下脂肪（SAT）面积及VAT面积/SAT面积（VAT/SAT）差异均有统计学意义（P均<0.05），体质量指数（BMI）、腹围（WC）及腹部总脂肪（TAT）面积差异均无统计学意义（P均>0.05）。多元Logistic回归分析结果显示，年龄、吸烟、糖尿病及VAT/SAT为冠心病独立危险因素（P均<0.01）。ROC曲线显示年龄、吸烟、糖尿病及VAT/SAT诊断冠心病的AUC分别为0.67、0.61、0.62及0.73，4者联合的AUC为0.80，高于各参数单独检测（P均<0.05）。结论 CT测量的腹部脂肪相关参数可用于诊断冠心病。     

Patterns of coronary artery ectasia and short-term outcome in acute myocardial infarction

Objective. To assess the relationship between hematological inflammatory signs, cardiovascular risk (CV) factors and prognosis in patients presenting with acute myocardial infarction (AMI) and coronary artery ectasia (CAE). Design. We investigated 3321 AMI patients who required urgent primary percutaneous intervention in two centres in the United Kingdom between January 2009 and August 2012. Thirty patients with CAE were compared with 60 age- and gender-matched controls. Blood was collected within 2 h of the onset of chest pain. CV risk factors were assessed from the records. Major acute cardiac events and/or mortality (MACE) over 2 years were documented. Results. CAE occurred in 2.7% and more often affected the right (RCA) (p = 0.001) and left circumflex artery (LCx) (0.0001). Culprit lesions were more frequently related to atherosclerosis in non-CAE patients (p = 0.001). Yet, CV risk factors failed to differentiate between the groups, except diabetes, which was less frequent in CAE (p = 0.02). CRP was higher in CAE (p = 0.006), whereas total leucocyte, neutrophil counts and neutrophil/lymphocyte ratio (N/L ratio) were lower (p = 0.002, 0.002 and 0.032, respectively) than among non-CAE. This also was the case in diffuse versus localised CAE (p = 0.02, 0.008 and 0.03, respectively). The MACE incidence did not differ between CAE and non-CAE (p = 0.083) patients, and clinical management and MACE were unrelated to the inflammatory markers. Conclusion. In AMI, patients with CAE commonly have aneurysmal changes in RCA and LCx, and their inflammatory responses differ from those with non-CAE. These differences did not have prognostic relevance, and do not suggest different management.     

Surgical management of multiple giant coronary artery aneurysms determining myocardial ischemia

Coronary artery aneurysms (CAAs) are rare lesions in which the optimal management is poorly defined. We present a series of three patients with diffuse symptomatic coronary artery disease and giant CAAs, on the circumflex branch (6 × 5 cm - Patient 1), on the proximal right coronary artery (5 × 6 cm - Patient 2) and on the proximal left anterior descending (LAD) (4 × 5 cm - Patient 3). Standard coronary artery bypass grafting (LIMA-on-LAD plus sequential saphenous vein) and associated CAA exclusion by proximal and distal ligation was performed according to the coronary anatomy. Six month follow-up computed tomography scan control showed complete exclusion of the CAA in all three patients.     

Congenital coronary artery fistulas: clinical considerations and surgical treatment

BACKGROUND: Coronary artery fistulas are uncommon abnormalities that can cause significant cardiac morbidity. Indications for operation vary, particularly, for asymptomatic patients. Early surgical correction is indicated because of the high incidence of late symptoms and complications. METHODS: From January 1981 to December 2001, all 15 patients who underwent surgical management of congenital coronary artery fistulas at the Tri-Service General Hospital, Taipei, Taiwan, China were included in the present retrospective study. RESULTS: Twelve patients were symptomatic at the time of the diagnosis. Coronary artery fistulas involved the right coronary artery in five patients, left coronary artery in nine, and both the right and the left coronary arteries in one. Coronary artery fistula drained into the right ventricle in seven patients, right atrium in three, pulmonary artery in two, left ventricle in one, left atrium in two, and coronary venous sinus in one. The value of pulmonary blood flow/systemic blood flow ranged from 0.98 to 2.1. Six patients had associated cardiac anomalies. All patients received surgical correction. Nine patients received cardiopulmonary bypass during operation. There was zero operative mortality and operative morbidity was low. All patients had a stable condition and were asymptomatic during a mean postoperative follow-up of 13.3 years. CONCLUSIONS: Early surgical treatment for coronary artery fistulas is safe and effective. The risk of operative correction appears to be considerably less than the potential for development of serious and potentially fatal complications, even in asymptomatic patients.     

Autosomal dominant polycystic kidney disease and coronary artery dissection or aneurysm: a systematic review

Importance Autosomal dominant polycystic kidney disease (ADPKD) has been associated with cardiovascular abnormalities such as intracranial and aortic aneurysms. Objective To systematically review the case reports and case series of ADPKD patients with coronary artery dissection or aneurysm. Evidence review Systematic review registration number: CRD42015015723. Data sources: MEDLINE, Web of Science and OpenGrey, reference lists of studies. Study selection: Published case reports and case series. Data extraction: Two parties analyzed the studies. Disagreements were solved by consensus or by a third party. Funding: none. Findings The reports of 23 patients (22 from 17 studies – six with coronary artery dissection and 16 with coronary artery aneurysm – and one with coronary dissection) were analyzed and reported here. Most patients were symptomatic. Coronary dissection showed female and left descending anterior artery predominance, features similar to non-ADPKD patients, but a median diagnostic age below expected (41 vs. 50 years old). Coronary aneurysms had male and right coronary artery predominance but lower median diagnostic age (44 years old) and higher rate of multiple vessel affection than reported for non-ADPKD patients. Conclusion and relevance Clinical disparities may suggest a different mechanism of aneurysm formation compared to the population without ADPKD. Nevertheless, lack of access to data of one patient and text of one article limited our conclusions. Coronary aneurysms and dissections represent a source of coronary syndromes and death in ADPKD. Mutation of ADPKD-related genes may predispose to coronary abnormalities, especially aneurysms. Further analysis regarding this association is necessary.     

Mid-term outcomes of coronary endarterectomy combined with coronary artery bypass grafting

Open in a separate window OBJECTIVESThe aim of this study was to evaluate the mid-term outcome of coronary endarterectomy (CE) combined with coronary artery bypass grafting (CABG) and explore the potential risk factors for adverse events.METHODSA total of 208 consecutive patients underwent CE between 2008 and 2018 in our centre, of which 198 were included in this retrospective cohort study. The primary end point was major adverse cardiovascular and cerebrovascular events (MACCEs). Kaplan–Meier analysis was performed to evaluate event-free survival, whereas subgroup analysis and Cox regression were used to explore risk factors for the outcomes.RESULTSThe median follow-up time was 34.7 months. CE + CABG was performed mainly on the left anterior descending artery (42.3%) or right coronary artery (42.3%). Both operative mortality and incidence of perioperative myocardial infarction were 1.5%. The overall survival at 3 and 5 years was 98.0% and 95.9%, whereas the MACCE-free survival was 93.7% and 89.4%, respectively. No significant difference in the incidence of MACCE was observed between on-pump and off-pump CE (P = 0.256) or between left anterior descending artery and non-left anterior descending artery endarterectomy (P = 0.540). Advanced age (>65 years) was associated with a higher risk of MACCE both in univariate [hazard ratio (HR) 3.62, 95% confidence interval (CI) 1.37–9.62; P = 0.010] and multivariate analysis (HR 3.59, 95% CI 1.32–9.77; P = 0.013).CONCLUSIONSWhen performed by experienced surgeons, CE + CABG could be an acceptable approach to achieve complete revascularization of diffusely diseased coronary arteries with satisfactory outcomes, although advanced age might increase the risk of MACCE.     

采用双冠状动脉导丝法建立先天性心脏病介入治疗复杂路径轨道

目的探讨以双冠状动脉导丝法建立先天性心脏病(简称先心病)介入治疗复杂路径轨道的价值。方法回顾性分析12例应用双冠状动脉导丝法建立介入治疗轨道的先心病患儿的临床资料,其中肺动脉闭锁伴室间隔缺损(PA/VSD)矫治术后肺动脉狭窄5例,法洛四联症(TOF)矫治术后肺动脉狭窄1例,大动脉转位(TGA)术后肺动脉狭窄1例,粗大体肺侧支(MAPCAs)3例,复杂型肺动静脉瘘1例及左冠状动脉回旋支-右心房瘘1例;分析先心病介入治疗复杂路径特点。结果采用双冠状动脉导丝均成功建立输送轨道。对PA/VSD矫治术后肺动脉狭窄、TOF术后肺动脉狭窄、TGA术后肺动脉狭窄患儿成功进行球囊扩张,对MAPCAs、复杂型肺动静脉瘘及左冠状动脉回旋支-右心房瘘患儿均封堵成功,未出现瓣膜损伤、血管损伤、心包填塞及死亡等严重并发症。结论以双冠状动脉导丝法建立先心病介入治疗复杂路径轨道方法安全、有效,可调控性强,能提供足够支撑力通过纡曲段,有利于提高介入治疗成功率,值得临床推广应用。