560例乳腺肿块针吸细胞学检查与组织学诊断对比观察

目的分析针吸细胞学检查在乳腺肿块中的诊断价值。方法对560例乳腺肿块经针吸细胞学检查且经组织学检查的病例进行对比分析。结果560例中良性病变157例,诊断特异性为94.27%,误诊率为5.73%;恶性肿瘤403例,敏感性为96.77%,漏诊率为3.23%。结论针吸细胞学检查对乳腺肿块诊断有独特价值,其方法快速、简便,能为临床医生提供诊疗方案,值得推广应用。     

330例乳腺肿块针吸细胞学检查与病理组织学诊断的临床意义

目的分析针吸细胞学检查在乳腺肿块诊断中的应用价值。方法对330例乳腺肿块针吸细胞学检查经病理组织学诊断的病例进行分析总结。结果良性病变93例,诊断特异性100%,误诊率0;恶性肿瘤213例,敏感性97%,误诊率3%。结论针吸细胞学检查对乳腺肿块的诊疗具有独特价值。其方法可靠、简便、快速,能为临床医生提供诊疗方案。     

132例乳腺肿块针吸细胞学诊断与病理组织学诊断对比分析

目的比较乳腺肿块针吸细胞学检查在临床中的应用价值。方法分析132例乳腺肿块针吸细胞学诊断,并与术后病理组织学诊断结果相对比。结果针吸细胞学检查良性病变101例,乳腺癌31例,其中肯定为癌者29例,疑为癌2例,阳性率为93.9%,假阴性诊断2例,占6.1%,无假阳性报告。结论乳腺肿块针吸细胞学在乳腺肿块良恶性病变的鉴别中具有较高的应用价值。     

乳腺肿块63例可疑癌的针吸细胞学与病理对照分析

目的 探讨乳腺肿块细针针吸细胞学(FNAC)检查中可疑癌的诊断与临床病理关系。方法 总结1115例乳腺肿块FNAC检查中63例可疑癌的诊断标准及特点。结果 1115例乳腺肿块FNAC检查中，有328例获病理组织学对照，FNAC总正确率96．3％，总误诊率3．7％，假阴性率4．8％，潜在假阳性率1．7％。63例可疑癌占乳腺肿块的5．7％(63／l115)，正确率96．8％(6l／63)，误诊率3．2％(2／63)。结论 FNAC对可疑乳腺癌有较高确诊率。63例可疑癌中大多数为乳腺癌，良性病变少。     

193例乳腺肿块针吸细胞学检查诊断分析及体会

目的：总结乳腺肿块针吸细胞学检查结果。方法：针吸细胞学检查193例乳腺肿块获得病理证实者122例。结果：乳腺癌33例，良性病变89例。结论：乳腺癌针吸细胞学诊断准确率为91％，良性疾患为92％。     

细针吸取细胞学在乳腺癌临床诊断中的意义

目的：探讨细针吸取细胞学（FNAC）在乳腺癌临床治疗中的诊断价值,提高乳腺癌的诊治水平。方法：对2000～2007年公司在职和内退女工体检中检出的＂乳腺肿块＂152例178个乳腺肿块,进行细针细胞学检查。结果：152例共178个乳腺肿块,12例乳腺肿块术后病理诊断为乳腺癌。FNAC与常规病理学检查对照,12例乳腺癌中两者诊断相符9例,术前FNAC检出可疑2例,最后确诊乳腺者1例,术前FNAC未检出癌细胞的166个乳腺肿块,术后病理诊断确诊乳腺癌者2例,其中原位癌1例,乳腺增生症恶变1例。12例乳腺癌肿块直径≤2cm者7例,其中阳性者5例（71.4%）,肿块〉2cm者5例,FNAC阳性4例（80%）,两者比较：敏感性为75%,准确率为83.3%。本组细针穿刺无感染,血肿及溃疡等并发症。结论：FNAC对乳腺癌诊断具有方法简便易行,节省费用,速度快,确诊为癌细胞后可直接实施乳腺癌根治术。且细针针吸穿刺对乳腺癌预后无不利影响等优点。     

关于乳腺癌术前诊断中针吸细胞学检查的应用价值探讨

目的探讨针吸细胞学检查(Fine Needle Aspiration Cytology,FNAC)在乳腺癌术前诊断中的应用价值。方法选取我院2011年2月至2012年6月收治的女性乳腺肿块患者114例,行改良根治术或保守性手术,术前均行FNCA检查,术后均有病理学诊断。结果 114例乳腺肿块患者诊断的总正确率为93.86%(107/114例)。其中,假阴性率为4.39%(5/114例);FNAC诊断为可疑恶性,而常规病理诊断为良性病变,即潜在假阳性率为10.94%(7/64例);所有患者乳腺肿块诊断的总误诊率为10.53%(12/114例)。结论应用FNAC对乳腺癌进行术前诊断,具有操作简单、创伤性小、安全快速、准确率高等优点,值得临床推广。     

针吸印片细胞学和冷冻切片检查在乳腺肿块联合诊断中的应用研究

目的探讨提高乳腺肿块诊断准确率及阳性率的方法.方法对120例乳腺肿块进行术前针吸细胞学检查、术中印片细胞学检查及冷冻切片检查,并与术后常规石蜡切片进行对照.结果针吸细胞学诊断阳性率为94.3%,印片细胞学诊断阳性率为97.6%,冷冻切片诊断阳性率为98.9%,针吸、印片细胞学与冷冻切片结合诊断阳性率为100%.结论针吸细胞学检查是乳腺肿块术前初步诊断的重要方法,术中冷冻切片结合印片细胞学检查可提高乳腺肿块诊断准确率及阳性率.     

对针吸细胞学诊断乳腺肿块的评价(附1264例)

本文对1264例乳腺肿块针吸细胞学诊断结果进行了总结分析;在1264例中,针吸细胞学明确诊断1258例,诊断率为99.5％,未明确诊断6例占0.5％。诊断为良性肿块1189例占 93.6％。诊断乳癌74例占5.9％。309例与病理组织切片活检对照,诊断良性肿块符合率为99.2％,诊断乳腺癌符合率为100％,其正确诊断率为99.4％,误诊率为0.6％。在讨论中认为针吸细胞学检查在乳腺肿块中的正确诊断率是很高的,同时重点对影响其正确诊断率的因素进行了探讨,认为1,取材不当;2.坏死癌;3.小细胞癌是主要的影响因素,以及简要的对其临床实用价值进行了评价。     

乳腺细针针吸细胞学检查在基层医院应用的可行性分析

目的 分析基层医院乳腺细针针吸细胞学(fine needle aspiration cytology,FNAC)诊断的准确性,评价该检查方法在基层医院应用的可行性.方法 回顾北京市怀柔区中医医院有组织病理学结果的145例乳腺肿物细针针吸病例,将细胞学结果与组织学结果对照分析.结果 145例乳腺针吸病例中乳腺癌27例,纤维腺瘤45例,乳腺腺病40例,其他良性病变33例.针吸细胞学诊断乳腺癌的敏感性为92.6％,特异性为100％,准确性为98.6％.结论 FNAC检查操作简便,诊断准确性高,可以作为基层医院乳腺肿物的常规检查项目.     

乳腺肿块细针穿刺细胞学检查的临床应用价值

目的探讨细针穿刺细胞学诊断在乳腺肿块中的临床应用价值。方法细针穿刺乳腺肿块吸取组织细胞涂片,采用瑞氏染色,显微镜下观察细胞排列、结构、背景特点、细胞形态等方面对乳腺肿块性质进行判定,并与病理组织学诊断进行对比分析。结果乳腺肿块216例细针穿刺,其中175例与病理组织学对照分析,恶性肿瘤诊断的敏感性为97.9%,良性肿瘤诊断的特异性为95.2%,总准确率为97.1%。结论细针穿刺细胞学诊断对于临床诊断乳腺病变有独到价值,而且对恶性病例诊断更为可靠,此诊断技术简便,安全快速,特异性高,临床应用前景广阔。     

乳腺肿块针吸细胞学检查682例临床分析

目的探讨针吸细胞学检查在乳腺肿块诊断中的临床应用价值。方法针吸细胞学检查乳腺肿块682例,其中500例与病理组织学检查结果对照。结果与组织病理学对照分析,针吸细胞学检查恶性肿瘤诊断的敏感性为98．7％,良性肿瘤诊断的特异性为95．5％,总准确率为97．4％。结论针吸细胞学检查对于临床诊断乳腺病变有独到价值,而且对恶性病例诊断更为可靠,此诊断技术简便,安全快速,特异性高,临床应用前景广阔。     

IMPROVED ACCURACY RATES OF FNAC INTERPRETATION IN BENIGN BREAST LESIONS

We carried out a retrospective study of 194 biopsy proved benign breast lesions comparing the fine needle aspiration cytology (FNAC) diagnosis offered earlier. We reviewed the cytology smears based on recently advocated criteria and offered our fresh diagnosis. It was observed that we still overdiagnosed five cases of fibroadenomas and underdiagnosed four cases of fibrocystic change. However the quantum of such discrepancies decreased considerably than seen earlier. We could correctly diagnose two tubular adenomas and two intraductal papillomas. We also reduced the number of nonspecific diagnosis of benign breast disease from 24 to 08. Hence we could register an overall improvement of accuracy rate to 84.5% as compared to 58.8% achieved earlier.KEY WORDS: Benign breast disease, Biopsy, FNAC     

1731例乳腺肿块细针穿刺诊断的临床应用分析

目的：探讨乳腺肿块细针穿刺细胞学检查（FNAC）的临床应用价值。方法：对2006～2010年的1 731例乳腺肿块细针穿刺细胞学检查结果进行对比分析。结果：1 731例乳腺细针穿刺病例,2009～2010年的病例及阳性病例明显高于2006～2008年,其中924例做了活检对照,恶性肿瘤敏感性为96.68%（233/241）,假阴性率为3.32%（8/241）,无假阳性。FNAC诊断的总准确率为97.29%（899/924）。结论：乳腺肿块细针穿刺诊断技术,操作简易、快速、安全、可靠、价格低廉,可在基层医院及乳腺癌筛查中大力推广。     

端粒酶活性检测在乳腺癌诊断中的意义

[目的 ]探讨细针穿刺乳腺肿瘤组织的端粒酶活性检测在乳腺癌诊断中的意义 .[方法 ]用聚合酶链反应 酶联免疫吸附测定法检测 79例术前乳腺肿瘤细针穿刺活检标本和大体标本的端粒酶活性 ,并与病理诊断进行比较 .[结果 ]乳腺癌 6 5例中穿刺组织端粒酶呈阳性的为 5 7例 ,阳性率为 88% ;大体组织端粒酶呈阳性的为 5 4例 ,阳性率为 83% .淋巴结转移者端粒酶活性高于无淋巴结转移者 .乳腺良性疾病 14例中端粒酶呈阳性的为 2例 ,阳性率为 14 % .[结论 ]术前乳腺肿瘤穿刺组织的端粒酶活性检测有利于乳腺肿瘤的早期诊断及鉴别诊断 .     

3种辅助检查诊断涎腺肿瘤符合率的比较研究*

目的 通过研究口腔涎腺肿瘤不同检查的诊断符合率,为临床提供术前快速、简便、有效、低成本 的诊断方法。方法 回顾性分析274例常见涎腺肿瘤B超检查、细针吸取细胞学和术中冷冻切片镜检,并与术后组织病理学检查进行对比。结果 ①B超与石蜡切片对比总的定性诊断符合率为83.2%,其中良性肿瘤的诊断符合率为85.2%,恶性肿瘤符合率为73.3%。②细针吸取细胞学与石蜡切片对比总的定性诊断符合率为87.0%,其中良性肿瘤为88.6%,恶性肿瘤为79.2%;明确诊断总的符合率为63.8%,其中良性肿瘤为64.0%,恶性肿瘤为62.5%。③冷冻切片与石蜡切片对比总的定性诊断符合率为94.9%,其中良性肿瘤为97.4%,恶性肿瘤为83.0%。结论 术中冷冻切片对于涎腺肿瘤的诊断符合率较细针吸取细胞学及B超检查的符合率高,但细针吸取细胞学与B超在术前诊断和治疗计划中有很好的辅助作用。     

The experience with fine needle aspiration cytology in the management of palpable breast lumps in the University Hospital Kuala Lumpur

A total of 676 palpable breast lumps seen in the Breast Clinic, University Hospital, Kuala Lumpur from August 1993 to August 1994 were subjected to fine needle aspiration cytology. Fifty-four were reported as inadequate, 501 benign, 95 malignant and 26 suspicious. One hundred and eighty-seven aspirates had histological correlation, while 34 of the malignant aspirates had clinical correlation. The majority of the other 455 patients were followed up for a period of 60 to 72 months without any malignancies becoming apparent. For analysis, only the 221 cases with histological or clinical correlation were included, (the suspicious category was included into the positive group and the inadequate cases were excluded), giving a sensitivity of 91.7%, a specificity of 91.7% and a diagnostic accuracy of 91.7%. Breast cytology was an accurate and rapid method of diagnosis of breast diseases, and in a busy surgical unit with limited operating time, it allowed for the triage of patients with breast complaints in deciding which cases needed early open biopsy. A negative cytology does not exclude the possibility of cancer, as there was a false negative rate of 11%. However by utilising a diagnostic triad of clinical examination, radiological assessment and fine needle aspiration cytology, the risk of missing a malignancy is small.     

1500例乳腺肿块细针吸取细胞学检查的临床应用

目的探讨细针吸取细胞学检查在乳腺肿块中的应用价值。方法复习乳腺肿物细针吸取细胞学检查1500例。与其中手术后获病理组织学诊断的415例做对照比较。结果1500例全部为女性，年龄11-88岁，平均38．6岁。415例手术病例中组织学为良性病变的197例中，细胞学诊断有1例不符，诊断为癌。组织学诊断为恶性肿瘤的218例，细胞学诊断有6例不符，诊断为良性。本组的敏感性、特异性、总准确度、假阴性和假阳性分别为97．25％，99．49％，98．31％，2．75％，和0．51％。结论细针吸取细胞学对乳腺肿物诊断具安全、可靠等优点，可作为乳腺肿物常规检查手段，值得推广应用。     

Fine needle aspiration biopsy cytology of superficial lymph nodes: comparative with histopathology

Fine needle aspiration biopsy cytology was done in 215 lymph nodes involving cervical, submandibular, supraclavicular, axillary and inguinal regions. One hundred and forty of these were diagnosed by histopathology after excisional biopsy or surgery, including 46 cases of metastatic tumor, 57 of lymphoma (46 were non-Hodgkin's lymphoma and 11 were Hodgkin's disease), and 37 of benign lymphadenopathy. Diagnosis of metastatic malignancy was easily made by aspiration biopsy cytology with a total sensitivity of 95.7% (44/46). The diagnosis of lymphoma was less satisfactory with a total sensitivity of 82.5% (47/57). The specificity for diagnosis of benign lymphadenopathy was 97.3% (36/37) with one false positive. The concordance of cell type in aspiration biopsy cytology and histopathology was 75% (33/44) in metastatic malignancy, and 73.5% (28/38) in lymphoma. Typical Reed-Sternberg giant cells were detected in 4 of 11 cases of Hodgkin's disease by aspiration cytology. Out of the 37 cases of benign lymphadenopathy diagnosed by aspiration cytology, 7 were cases of tuberculous lymphadenitis, of which typical Langhans' giant cells were found in 2, and acid fast stain bacilli in 3 cases. There was no complication or needle tract spreading throughout the procedure. We concluded that aspiration biopsy cytology is a simple, safe, reliable, and quick diagnostic method.     

DNA倍体分析系统在乳腺包块针吸细胞学诊断中的应用

目的用全自动倍体分析系统判别乳腺肿瘤恶性程度。方法对51例妇女乳腺包块行穿刺针吸细胞涂片，做瑞氏染色行常规细胞学检查，用Feulgen染色做全自动DNA图像分析。结果常规细胞学和DNA倍体分析系统对19例良性乳腺疾病诊断一致。常规细胞学可对32例乳腺癌作出正确诊断，而DNA倍体分析系统只诊断出27例乳腺癌。乳腺癌早期，细胞核为2倍体（DNA定量为2C），核面积略大；而乳腺癌晚期，可出现5C，甚至9C异倍体细胞，核面积明显增大。结论DNA倍体分析系统对判断乳腺肿瘤恶性程度有一定意义。