自体表皮移植治疗白癜风临床观察

白癜风是一种临床上以皮肤色素脱失为特征的常见皮肤病，全世界发病率1％，其治疗目前尚缺乏特效方法。自Fallabella首次报告采用负压吸疱作自体表皮移植治疗白癜风后，国内外相继开展此项技术并不断改进，取得肯定疗效^[1-3]。近年来，我们用自体表皮移植治疗白癜风32例，特报告如下。     

自体表皮移植联合他克莫司软膏治疗稳定期白癜风疗效观察

目的观察自体表皮移植联合他克莫司软膏治疗稳定期白癜风的疗效及不良反应。方法将60例稳定期白癜风患者随机分成两组。治疗组:给予自体表皮移植联合他克莫司软膏治疗;对照组:单独给予自体表皮移植治疗。疗程均为3个月,疗程结束后根据照片进行临床疗效观察。结果治疗组有效率为93.33%,对照组为70%,两组间疗效比较差异具有统计学意义(P<0.05)。结论自体表皮移植治疗稳定期白癜风安全有效,联合外用他克莫司软膏能进一步提高疗效。     

自体表皮移植术治疗白癜风33例临床报告

白癜风发病率约 1% ,其病因和发病机理复杂 ,临床上表现为局部色素脱失 ,病理表现为局部黑色素细胞明显减少或消失。我科采用加温负压发疱法自体表皮移植术治疗 36例稳定期白癜风患者 ,取得较好效果 ,现报道如下。1　临床资料1·1　一般资料　白癜风患者 33例 ,男 14例 ,女 19例 ;年龄 10～ 38岁 ,平均 2 2 1岁 ;病程 1～ 13年 ,平均7 9年。受移植皮损 93片 ,其中局限型 14例 33片 ,节段型 16例 4 7片 ,泛发型 3例 13片 ,均为面、颈、上肢等暴露部位皮损。所有患者均为稳定型 (近 3个月皮损无扩展趋势 ) ,无疤痕素质 ,以往用过多种药物治疗…     

自体表皮移植治疗白癜风疗效评价与相关因素分析

目的对采用自体表皮移植对患有白癜风的患者进行治疗的效果进行评价以及相关的因素进行分析。方法抽取106例在我院就诊的患有白癜风的临床确诊患者病例,将其分为A、B2组,平均每组53例。A组患者采用薄芝糖肽联合紫外照射的方法进行治疗;B组患者采用自体表皮移植进行治疗。对2组患者的临床治疗效果、并发症和不良反应现象进行比较分析。结果分析结果表明,B组患者的临床治疗效果与A组患者进行比较,其有效率明显高出很多,有显著的统计学差异(P<0.05);2组患者在治疗的过程中,均没有出现比较严重的并发症和不良反应现象,没有显著的统计学差异(P>0.05)。结论采用自体表皮移植对患有白癜风的患者进行治疗的效果十分明显,在治疗和康复的过程中患者不会出现特殊的并发症和不良反应现象,可以做为今后临床对该类患者进行治疗的首选方法,值得进一步使用和推广。     

家用型窄谱中波紫外线白癜风光疗仪的研制与应用

目的：研制和应用窄谱中波紫外线（NB—UVB）白癜风光疗仪治疗白癜风,观察治疗后的临床疗效。方法：根据窄谱中波紫外线治疗皮肤病的原理,研制一种家用型窄谱中波紫外线白癜风光疗仪,应用于白癜风的临床治疗,并研究和分析治疗后临床疗效。结果：应用白癜风光疗仪治疗白癜风33例中的39块皮损,总有效率为74．35％。结论：白癜风光疗仪治疗白癜风具有操作简便、临床疗效好、安全可靠的特点,值得临床上推广和应用。     

自体表皮移植术治白癜风

自体表皮移植术治白癜风张忠田日前，山东医科大学附属医院为一名患有白癜风的女青年进行了自体表皮移植，取得了良好的效果。白癜风是一种常见的、较顽固难治的色素性皮肤病，如皮损发生在暴露部位，则严重影响美容，以至造成患者心理压力和自卑感。目前治本病虽有多种疗...     

信息速递

自体皮肤黑色素细胞移植治疗白癜风白癜风的病因至今尚未完全阐明,其治疗更是医学上的难题之一患者虽然无生理上的痛楚,但心理上的痛苦难以言表解放军北京空军总医院皮肤科和临床实验科协作, 开展自体皮肤黑色素细胞移植治疗白癜风已成功地为     

自体黑色素细胞培养移植治疗30例白癜风的效果分析

目的:探讨自体黑色素细胞培养移植治疗30例白癜风的效果。方法:将60例肢端型白癜风病人平均分为研究组与对照组。对照组应用窄谱中波紫外线进行治疗,研究组应用自体黑色素细胞培养移植治疗。结果:研究组治疗的总有效率为72.92%,明显高于对照组的36.73%(P<0.05)。结论:黑色素细胞培养移植治疗肢端型白癜风疗效显著,值得临床推广与应用。     

自体表皮移植治疗白癜风临床疗效观察

白癜风是一种病因不明、常见的、顽固难治的色素脱失性皮肤病，多因发生在暴露的部位而影响美容，治疗的方法很多，但疗效多不理想。我科2002年12月-2006年2月采用自体表皮移植法对36例白癜风患者进行了治疗观察，取得了较满意的临床效果，现将结果报道如下。     

自体表皮移植治疗白癜风43例临床观察

白癜风是一种常见病 ,治疗本病的方法很多 ,但疗效多不理想。负压吸疱自体表皮移植法治疗白癜风 ,已在一些医疗单位开展 ,取得一定疗效。我科应用上海医科大学应用物理研究所生产的ＹＷ -Ⅱ型负压吸引器 ,对 4 3例 (187皮片 )白癜风患者进行治疗 ,取得满意疗效。现报告如下。1　资料及方法1·1　一般资料　 4 3例病人 ,男 2 7例 ,女 16例 ,年龄12～ 4 3岁 ;病程 6月至 30年。选择皮损局限型或节段型静止期患者 ,皮损多见于面、颈、四肢暴露部位 ,其次为躯干部。患者以往曾用多种方法治疗无效 ,近期未内服药者。1·2　方法　取腹部皮肤为供皮…     

Calcium intake in the elderly: validation of a dietary questionnaire

Epidemiological studies of calcium and osteoporosis have been hampered by the lack of a suitable tool for assessing calcium intake. This report describes a new frequency and amount questionnaire for measuring present and past calcium intake in the elderly. The validity of the questionnaire was tested against two commonly used standards of dietary assessment, five-day duplicate diets and seven-day weighed dietary inventories. The resulting correlation coefficients were, respectively, r = 0.76 and r = 0.69, while that for repeatability was r = 0.84. Furthermore, the questionnaire categorized subjects into thirds of the distribution of intake with almost no gross misclassification. It is suggested that the present findings may be extended to the majority of normal, healthy elderly subjects, implying wide application for the questionnaire in the assessment of calcium intake in the elderly.     

The human drama of genetics: 'hard' and 'soft' media representations of inherited breast cancer

This paper examines media coverage of 'breast cancer genetics', and explores its implications for public understanding. We present a content analysis of coverage in British newspapers and look at a variety of popular forms, including women's magazines, television soap opera and radio drama. Genetic/inherited risk receives a great deal of coverage across a wide range of media formats and outlets. Much of this attention has focused on individuals from 'high risk families' and dilemmas around prophylactic mastectomies. Through examining media coverage, combined with interviews with media personnel and their sources, we show why this story proved so attractive to the media and highlight the different production values which influence coverage. Finally, we introduce preliminary findings from focus group discussions to demonstrate how such 'human interest' framing has engaged audience attention and influenced public understandings. The paper concludes by highlighting the implications for analysing, predicting, and engaging with, media representations of science.     

Worker education in the primary prevention of occupational dermatoses

This paper reports the evaluation of a skin care education programmeconducted on a fine chemicals manufacturing site where over1,000 employees are located. Approximately 60% are involvedin chemical manufacture. Over a 12 month period production staffreceived training in prevention of occupational dermatoses linkedto a site-wide poster initiative. The incidence of new casesof occupational dermatoses fell from 0.055 (70 cases in 1,277employees) to 0.021 (27 cases in 1,277 employees) before andafter the intervention respectively (p<0.0001). After otherfactors such as chemicals handled, observer bias and changesin reporting related to socioeconomic climate were taken intoaccount it is concluded that this study demonstrates the importanceof worker education as a tool for primary prevention of disease.Training materials such as video and poster presentations maybe effectively used in the chemical manufacturing industry asan adjunct to prevention and control of exposure to substanceshazardous to the skin. Such methods may also be used in otherindustries where there are significant risks of dermatoses.     

Regional Variation in Travel-related Illness acquired in Africa,March 1997–May 2011

To understand geographic variation in travel-related illness acquired in distinct African regions, we used the GeoSentinel Surveillance Network database to analyze records for 16,893 ill travelers returning from Africa over a 14-year period. Travelers to northern Africa most commonly reported gastrointestinal illnesses and dog bites. Febrile illnesses were more common in travelers returning from sub-Saharan countries. Eleven travelers died, 9 of malaria; these deaths occurred mainly among male business travelers to sub-Saharan Africa. The profile of illness varied substantially by region: malaria predominated in travelers returning from Central and Western Africa; schistosomiasis, strongyloidiasis, and dengue from Eastern and Western Africa; and loaisis from Central Africa. There were few reports of vaccine-preventable infections, HIV infection, and tuberculosis. Geographic profiling of illness acquired during travel to Africa guides targeted pretravel advice, expedites diagnosis in ill returning travelers, and may influence destination choices in tourism.     

Self-reported health problems among Swedish miners one year after unemployment

Unemployment is considered to be a public health concern sincedeterioration in the health of the unemployed is often anticipated.However, for some groups, such as miners, unemployment mightimprove health due to a cessation of potentially harmful occupationalexposures. This study evaluates the health of 79 miners in oneSwedish iron-ore mine, and 226 age-matched controls from thegeneral population, during one year after the closure of themine. The participants received a questionnaire regarding medicalhistory and subjective symptoms at the beginning of the studyperiod, and after one year. Statistically significant negativeeffects on self-reported health attributable to unemploymentwere not found, although neuropsychiatric symptoms were morecommon among the unemployed miners. The miners reported a statisticallysignificant improvement in grip force (p=0.031). They had asignificantly higher prevalence of symptoms associated withmining related exposures when compared with the population controls;pain in the upper extremities [relative risk (RR)=2.27, 95%confidence interval (Cl)=1.44–3.59), back pain (RR=1.84;Cl=1.237–2.75), vasospastic disease of the fingers (RR=2.05;Cl=1.18–3.57) and obstructive respiratory symptoms (attacksof dyspnea and wheezing: RR=3.67; Cl=1.167–11.6).     

Excès de cas humains et animaux de tularémie en France au cours de l’hiver 2007–2008 : émergence ou phénomène isolé ?

Context

Tularemia is a zoonosis affecting humans and hares in France. We describe the results of surveillance in both species, in 2007 and 2008.

Methods

Human tularemia cases are mandatorily notifiable in France since 2003. In hares, surveillance relies on volunteer hunter associations in all districts of the country. Data from mandatory reports and volunteer surveillance in 2007/2008 were analyzed and compared with previous results.

Results

In 2007/2008, 144 cases were reported in humans and 117 cases in hares. This was a 100% increase compared to previous years. Human cases differed from those of previous years only by the frequency of contact with breeding animals. Human cases without any documented risk exposure were also more frequent.

Conclusion

An increase of tularemia cases occurred in 2007/2008 in both species. Complementary studies are needed to identify the species reservoir in France to understand the causes of this peak of cases.     

深圳公立医院管理体制改革制度设计

深圳公立医院管理体制改革实行政事分开、管办分开,在理事会架构下按法定机构模式组建市医管中心,落实公立医院运营管理自主权.作者从当前公立医院管理体制的弊端入手,介绍了深圳市进行公立医院管理体制改革的基本思路及改革方案设计的主要举措,深入剖析了的改革方案的特点,并对改革效果进行了预测.     

Effects of nitrogen dioxide on red blood cells of rats: Changes in components of red cell membranes during in vivo exposure to NO2

Red cell membranes, prepared from red blood cells of rats exposed to 4, 10, or 20 ppm nitrogen dioxide (NO₂) for 1 to 10 days, were examined for evidence of changes in membrane components. Appreciable changes were not found in contents of phospholipid and cholesterol during exposure to 10 ppm NO₂. By contrast, protein content altered with the time of exposure. Moreover, changes in protein composition were observed by employing sodium dodecyl sulfate — polyacrylamide gel electrophoresis. Twenty-four-hour exposure to NO₂ at the concentration above 10 ppm resulted in a marked increase in the percentage of lysophosphatidylethanolamine (LysoPE) to the total phospholipids. The prolonged exposure to 10 ppm NO₂ gave rise to a further increase in LysoPE, whereas the percentage of phosphatidylethanolamine (PE) showed a gradual decrease. A 1-day exposure to 4.0 ppm NO₂ also caused an increase in sialic acid content and decreases in those of PE and hexose. In addition to contents of these components the percentage of LysoPE increased 5 days after exposure and the elevated values were maintained up to the end of exposure period. These results demonstrate that red blood cells in circulation exhibit different membrane properties in terms of lipid and carbohydrate composition during 10 days of exposure to 4.0 ppm NO₂.     

The design of hazard risk assessment matrices for ranking occupational health risks and their application in mining and minerals processing

Two hazard risk assessment matrices for the ranking of occupational health risks are described. The qualitative matrix uses qualitative measures of probability and consequence to determine risk assessment codes for hazard-disease combinations. A walk-through survey of an underground metalliferous mine and concentrator is used to demonstrate how the qualitative matrix can be applied to determine priorities for the control of occupational health hazards. The semi-quantitative matrix uses attributable risk as a quantitative measure of probability and uses qualitative measures of consequence. A practical application of this matrix is the determination of occupational health priorities using existing epidemiological studies. Calculated attributable risks from epidemiological studies of hazard-disease combinations in mining and minerals processing are used as examples. These historic response data do not reflect the risks associated with current exposures. A method using current exposure data, known exposure-response relationships and the semi-quantitative matrix is proposed for more accurate and current risk rankings.