丽参注射液对老年男性冠心病肾虚患者性激素的影响

本研究观察了３２例经丽参注射液治疗前后老年男性冠心病肾虚患者雌二醇（Ｅ２）、睾酮（Ｔ）及Ｅ２／Ｔ的变化。结果表明：肾阳虚和肾阴虚两组Ｔ均降低（Ｐ＜０．０５～０．０１）；肾阴虚组Ｅ２、Ｅ２／Ｔ升高，而肾阳虚组Ｅ２则降低（Ｐ＜０．０１）。治疗后随着肾虚症状改善两组Ｔ均回升，肾阴虚组Ｅ２、Ｅ２／Ｔ回落，肾阳虚组Ｅ２回升（Ｐ＜０．０１），均接近对照组水平。提示老年男性冠心病肾虚患者阴阳失调与性激素紊乱有关，主要表现在血清Ｔ浓度的降低和Ｅ２水平的升高或降低；人参既可调整阴阳改善肾虚症状又可逆转性激素变化，在提高Ｔ水平的同时，对Ｅ２有很好的双向调节作用，有助于人体内环境雌雄性激素的平衡     

肾虚证与血浆中分子及巯基关系初探

本文检测了90例肾虚证(肾阴虚46例,肾阳虚44例)患者的血浆中分子物质(MMS)与巯基(—SH),并与20例正常人对照。结果发现:1.肾虚证患者—SH低于正常人,P<0.01,为肾虚的内在依据之一;2.—SH低下的程度是肾阴虚<肾阳虚,P<0.01.在肾病患者中尤为突出;3.MMS的量变关系反映了肾虚状态下继发“邪实”的程度,依量变关系为肾阴虚<正常人<肾阳虚,肾阳虚组的MMS高于肾阴虚组,P<0.01。作者认为:MMS的升高可作为“邪毒”,—SH作为正气虚损的指标,有助于认识正虚与邪实,肾阴虚与肾阳虚的质量互变关系,值得进一步探讨。     

慢性特发性血小板减少性紫癜肾虚证免疫紊乱的临床研究

目的 探讨慢性特发性血小板减少性紫癜（ＩＴＰ）发病机理中肾虚与免疫紊乱的关键及才者如何参与该病发病机制。方法 根据中医辨证将３８例女性ＩＴＰ患者分为肾虚组和非虚组。肾虚组发为肾阳虚组和肾阴虚组,测定３组的血小板表面相关抗体（ＰＡＩｇＧ）的Ｔ淋巴细胞亚群。结果 肾虚组ＰＡＩｇＧ明显高于非肾虚组,而Ｔ辅助淋巴细胞与Ｔ抑制淋巴细胞（ＴＨ／Ｔｓ）比值明显低于非肾虚组。肾阴虚组ＴＨ／Ｔｓ明显低于肾阳虚组,而     

多囊卵巢综合征的中医证候与内分泌的相关性

目的探讨多囊卵巢综合征（PCOS）患者的中医证型与内分泌指标变化的相关性。方法采用前瞻性研究方法,收集广州市中医医院及广东省中医院2年的住院及门诊的多囊卵巢综合征的中医四诊信息及相关因素。建立数据库,采用数据库软件EPIdata3．2及SPSS13．0软件包对数据进行管理、处理。结果PCOS中医证候类型主要表现为肾阳虚证、肝郁证、痰浊证、肾虚血瘀证和肾阴虚证。不同中医证型的体质量指数（BMI）、腰臀比（WHR）、空腹血糖、空腹胰岛素水平不同,有统计学意义。痰浊证的WHR值较肾阳虚证、肾阴虚证、肝郁证者高,肾虚血瘀证者较肝郁证者高;痰浊证的BMI、空腹胰岛素值较肾阳虚证、肾阴虚证、肝郁证、肾虚血瘀证者高;痰浊证的空腹血糖较肾阴虚证者高,均有统计学意义。PCOS中医辨证为痰浊证和肾虚血瘀证者多表现为中心性肥胖。结论PCOS中医证型与内分泌指标呈现一定的相关性。     

男性原发性骨质疏松肾虚三证与血液流变学变化关系的临床研究

目的 探讨男性原发性骨质疏松（primary osteoporosis:POP)肾虚三证与血液流变学变化的关系为临床辨证施治提供客观诊断依据。方法 选择96例有肾虚见证的老年男性为研究对象,其中肾气虚36例,肾阴虚32例,肾阳虚28例,另选正常对对照组30例,同步检测全血粘度ηb、（高切）、血浆粘度ηp、血沉SR、红细胞压积HCT,并进行统计学分析。结果 与对照组相比,肾虚三型全血粘度,血浆粘度显著增高（P＜0．01）,肾阳虚证的血沉值、红细胞压积显著上升（P＜0．05）,其余两型升高无显著性,肾气虚、肾阳虚、肾阴虚三个证型的ηb,ηp,SR,HCT水平组间差异不显著（P＞0．05）。结论 （1）男性POP肾虚三证患者ηb,ηp的含量较对照组显著升高。（2）男性POP患者血液粘、凝状态变化与肾虚三证关系密切,其变化依肾阴虚、肾气虚、肾阳虚逐渐明显。（3）本研究揭示血液流变学水平变化可作为判断男性POP肾虚三型的客观指标,活血化瘀应作为治疗POP的基本方法。     

强直性脊柱炎证型与HLA-B27及免疫炎症指标相关性研究

目的探讨强直性脊柱炎（AS）证型与HLA～B27及免疫炎症指标间的相关性。方法随机选取2010年3月～2012年3月于本院及协作医院中医科、骨科、内科和康复科进行治疗的的AS患者60例,其中肾虚湿热痹阻型、肾阴虚型、肾阳虚型各20例。比较三种证型患者在HLA—B27表达、血沉（ESR）、C反应蛋白（CRP）、血小板计数（PLT）、免疫球蛋白水平等的差异。结果肾虚湿热痹阻型、肾阴虚型、肾阳虚型的强直性脊柱炎的HLA—B27的阳性率分别为95％、55％、35％,肾虚湿热痹阻型强直性脊柱炎患者的ESR、CRP、PLT水平与肾阴虚型和。肾阳虚型比较,均明显高于后二者的水平（P〈0．05）,但三种证型间免疫球蛋白水平差异无统计学意义（P〉0．05）。结论强直性脊柱炎证型与HLA—B27、ESR、CRP、PLT间具有一定的相关性。     

肾虚型月经失调患者宫颈粘液变化40例临床分析

目的：为探讨肾虚型月经失调患者宫颈粘液在月经周期中性质及量的变化。方法：观察并记录40例肾虚型月经失调患者的宫颈粘液量，拉丝度及结晶情况变化，结果：发现肾阴虚，肾阳虚在宫颈粘液的变化上有不同表现：肾阴虚组排卵期粘液量明显少于肾阳虚组和正常组；肾阳虚组在排卵前粘液的拉丝度显著高于肾阴虚和正常组，而肾阴虚组在排卵期及其前后拉丝度均较低；肾阳虚组在估计排卵前粘液结晶不如肾阴虚组和正常组典型，而在估计排卵后则较两组明显典型，结论：认为该病病机实质及辨证分型有一定关系。     

氢化可的松致肾虚证小鼠模型的建立及相关指标的评价

目的 建立氢化可的松致肾阳虚、肾阴虚小鼠模型,并探讨其相关评价指标。方法 采用氢化可的松灌胃建立肾阳虚及肾阴虚小鼠模型;观察肾阳虚、肾阴虚模型小鼠生存状态,测定各组模型小鼠体重变化;采用放射免疫法检测HPA轴中促肾上腺皮质激素（ACTH）、皮质醇（Cor.）、HPT轴中甲状腺激素（TSH）、三碘甲腺原氨酸（T3）、甲状腺素（T4）、HPG轴中促卵泡素（FSH）、雌二醇（E2）、睾酮（T）含量。结果 肾阳虚、肾阴虚模型小鼠体重均下降,肾阳虚模型小鼠血清ACTH、Cor.、TSH、T3、T4水平降低,血清FSH、E2、T水平升高,且差异均有显著性（P<0.01）;而肾阴虚模型则反之。结论 肾虚小鼠内分泌系统中ACTH、Cor.、TSH、T3、T4、FSH、E2、T各激素水平均发生了改变,其中Cor.可作为评价糖皮质激素法建立肾虚模型的重要指标。     

六味地黄丸汤对肾阴虚型癌症患者某些检验指标的影响(附46例病例分析)

本文通过对肾阴虚、肾阳虚及非肾虚三组常见临床指标的观察,提示肾阴虚的肿瘤患者肾脏功能优于肾阳虚组,而肝功不及肾阳虚组。一些化验指标显示六味地黄丸对肾阴虚组的作用大于肾阳虚组及非肾虚组。     

噪声对高频听力损伤的影响

目的：探讨稳态、脉冲噪声及接噪工龄对作业工人高频（１０～２０ｋＨｚ）听力的影响。方法：应用频率范围（０．５～２０ｋＨｚ）的纯音听力计对３７４ 名１８～２５ 岁噪声作业工人的高频听力进行检测,以同年龄５０ 名健康人作为对照组。结果：脉冲组的高频阈值明显高于稳态组（Ｐ＜ ０．００１）,两组高频听阈的出现率较正常组明显下降。接噪工龄５ 年之内,各工龄组间的高频阈值没有明显的变化,与正常组比较差异显著（Ｐ＜ ０．００１）。结论：噪声性质对高频听力有影响,脉冲噪声比稳态噪声对内耳高频听力危害更大,噪声工龄对高频听力的影响主要发生在接触噪声第一年。同时对噪声引起高频听力下降的机理进行初步探讨。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

Acupuncture Combined with Spinal Tui Na for Treatment of Primary Dysmenorrhea in 30 Cases

Objective: To observe the therapeutic effects in acupunture treatment of primary dysmenorrhea combined with spinal Tui Na, and study its mechanism. Methods: Thirty cases of the treatment group were treated by acupuncture combined with spinal Tui Na, and thirty cases in the control group were treated by routine acupuncture. Results: The total effective rate was 93.3% in the treatment group, and 73.3% in the control group, with a significant difference between the two groups (P<0.05). Conclusions: Acupuncture combined with spinal Tui Na has good prospects for treatment of primary dysmenorrhea.     

Luo Lingjie's Experience in Treating Chronic Nephropathy

In treating chronic nephropathy,Luo Lingjie,a chief physician,pays attention to regulating the balance between yin and yang,treating infection if present,and removing pathogenic factors.He prescribes gentle drugs and uses carefully strongly warming-tonifying ones,emphasizes the importance of persuading the patient to persist in treatment with medication and nurse one's health for recuperation,and is good at combined use of TCM and western medicine therapy and brings the merits of various therapies into full play,with obvious theraoeutic effects.     

Dr.Zhang Ren's Experience in the Acupuncture Treatment of Different Diseases with the Same Therapeutic Principle

Dr.Zhang Ren,the chief physician,is the chairman of Shanghai Acupuncture and Moxibustion Association.Having been engaged in medicine for about 40 years,he is experienced in treating various intractable diseases.In his long years of clinical practice,he advocates taking the TCM differentiation as the basis to seek for the acupuncture method for treatment of modern intractable diseases.The author of this essay had the fortune to follow Dr.Zhang in study.The following is a summary of Dr.Zhang's experience in the acupuncture treatment for different intractable diseases with the same therapeutic principle.