卵巢癌肿瘤细胞减灭术的危险因素分析

目的:调查与卵巢癌肿瘤细胞减灭术有关的危险因素.方法:收集2010年1月至2013年12月入院的238例行肿瘤细胞减灭术病人的临床资料,统计分析可能导致手术并发症的因素.结果:白蛋白＜35 g·L-1、血红蛋白＜8 g·L-1、术中出血＞ 400 ml、合并症、腹主动脉旁淋巴结清扫和肠切除等6个因素是卵巢癌肿瘤细胞减灭术的危险因素.结论:在准备行卵巢癌肿瘤细胞减灭术时,对以上危险因素应仔细考虑,有目的地控制相关因素,可以减少卵巢癌肿瘤细胞减灭术有关并发症的发生.     

宫颈癌根治术患者盆腔淋巴结转移及5年生存率的影响因素

目的探讨宫颈癌根治术患者盆腔淋巴结转移及5年生存率的影响因素。方法回顾性分析2007年2月至2014年2月于本院行手术治疗的240例宫颈癌患者的临床资料,分析宫颈癌患者术后5年生存率、盆腔淋巴结转移影响因素。结果 240例患者中无淋巴结转移182例(75.83%),有淋巴结转移58例(24.17%);术前血红蛋白<110 g/L、FIGO分期Ⅱ期、淋巴血管间隙侵犯、肿瘤直径≥4 cm是宫颈癌术后淋巴结转移的独立危险因素(OR≥1且P<0.05);240例患者术后5年生存率为83.75%(201例),死亡率为16.25%(39例);术前血红蛋白<110 g/L、淋巴血管间隙侵犯、非鳞癌、淋巴结转移是宫颈癌术后死亡的独立危险因素(OR≥1且P<0.05)。结论术前血红蛋白<110 g/L、FIGO分期Ⅱ期、淋巴血管间隙侵犯、肿瘤直径≥4 cm是宫颈癌术后淋巴结转移的独立危险因素,宫颈癌术后死亡的独立危险因素则包括术前血红蛋白<110 g/L、淋巴血管间隙侵犯、非鳞癌、淋巴结转移。     

宫颈癌根治术并发症的发生原因及护理措施

目的探讨宫颈癌根治术并发症的发生原因及护理经验。方法对2009年1月～2010年1月间在我院接受宫颈癌根治术的患者46例进行前瞻性分析,总结并发症发生原因及护理经验。结果本组46例宫颈癌根治术并发尿潴留31例,淋巴囊肿2例,切口感染1例,切口裂开1例,泌尿道感染2例,下肢静脉栓塞1例。并发症原因主要包括患者因素、手术操作、护理因素等。结论 针对并发症的发生原因实施系统护理措施,能显著减少并发症的发生率。     

宫颈癌根治术中加行腹主动脉旁淋巴结切除在ⅠB2及ⅡA2期宫颈癌治疗中的价值研究

目的:分析探讨在ⅠB2及ⅡA2期宫颈癌接受宫颈癌根治术治疗中加行腹主动脉旁淋巴结切除术的临床效果.方法:参照随机数表法,对2015年8月-2016年4月收治的70例ⅠB2及ⅡA2期宫颈癌患者予以分组,对照组予以常规宫颈癌根治术(35例),研究组则在宫颈癌根治术中加行腹主动脉旁淋巴结切除(35例),对比两组效果.结果:两组的手术时间、出血量及并发症对比无确切差异(P>0.05);研究组术后1年复发率为1例(2.86%),较对照组更低;生存率为29例(82.86%),相对更高(P<0.05).结论:ⅠB2及ⅡA2期宫颈癌患者予以宫颈癌根治术时加行腹主动脉旁淋巴结切除,能有效改善患者的1年生存率和复发率,不会延长手术时间,也不会增加并发症风险.     

宫颈癌根治术后尿潴留相关因素分析

目的 探讨宫颈癌根治术后尿潴留发生的相关因素及防治办法.方法 收集2008年5月～2009年8月我院妇产科收治的因宫颈癌ⅠA～ⅡA期而行宫颈癌根治术的102例患者.回顾性分析宫颈癌根治术后尿潴留发生的相关因素.结果 102例宫颈癌根治术后患者中,37例出现术后尿潴留,发生率36.27%.单因素分析示两组临床分期、病理类型、手术时间均相近(P＞0.05),UR组年龄、手术范围、术中出血量、第一次拨尿管前后未口服特拉唑嗪与溴吡斯的明率、尿路感染率均高于非UR组(P<0.05).多因素Logistic回归分析示年龄、手术范围、第一次拨尿管前后未口服特拉唑嗪与溴吡斯的明、术中出血量、尿路感染等均为UR危险因素.其中手术范围和术后尿路感染者是发生术后尿潴留的高强因素.结论 宫颈癌根治术后尿潴留是是多因素造成的一种暂时性膀胱功能障碍的表现,选择适当的手术范围及采取综合措施早期预防及控制尿路感染等是降低术后尿潴留的关键.     

宫颈癌根治术后尿潴留的护理

子宫颈癌是最常见的妇科恶性肿瘤,严重威胁妇女的生命.思者年龄分布呈双峰,35～39岁和60～64岁;平均年龄为52.2岁,由于宫颈癌有较长癌前病变阶段,因此宫颈细胞学检查可使宫颈癌得到早期论断与早期治疗.近40年来,由于国内外均已普遍开展宫颈脱落细胞学筛查,使宫颈癌患病率明显下降,病死率也随之不断下降.其发病与早婚、性生活紊乱、性生活过早,早年分娩、密产、多产、经济状况、种族和地理环境等因素有关.宫颈癌根治术对盆腔组织及神经损伤大,尿潴留是术后最常见的并发症之一.我院2008～2010年施行宫颈癌根治术76例,术后发生并发症27例.其中并发尿潴留者8例,经护理,效果良好.报告如下:     

低剂量氯胺酮配合右美托咪定对宫颈癌根治术病人术后疲劳程度及疼痛介质、免疫功能状态的影响

目的:观察低剂量氯胺酮配合右美托咪定对宫颈癌根治术病人术后疲劳程度及疼痛介质、免疫功能状态的影响.方法:选取接受宫颈癌根治术病人150例,以简单随机化法分为观察组(n=75)和对照组(n=75).2组均采取全麻,对照组麻醉诱导前静注0.5μg/kg右美托咪定,而后以0.5μg·kg-1·h-1输注至术毕前0.5 h,观...     

老年妇女宫颈癌根治术122例临床分析

目的 :探讨老年宫颈癌患者行宫颈癌根治术的疗效、并发症及预后 ,以评价手术治疗的可行性 ,提高老年患者的治疗效果和生活质量。方法 :对 6 0岁以上行宫颈癌根治术 12 2例临床资料进行分析。结果 :12 2例患者手术过程顺利 ,术中出血 >70岁组与≤ 70岁组相比差异有极显著性 (P<0 .0 1)。术后并发症膀胱麻痹 11例 (9.0 2 % ) ,淋巴囊肿 7例 (5 .74 % ) ,切口感染 8例 (6 .5 6 % ) ,经治疗后均好转。 期 5 8例中 3年生存 5 3例 (91.38% ) ,5年生存 5 2例 (89.6 6 % ) ; 期 6 4例中 3年生存 5 5例 (85 .94 % ) ,5年生存 5 2例 (81.2 5 % )。结论 :对行宫颈癌根治术的老年患者 ,加强围手术期的处理以减少并发症的发生 ,老年早期宫颈癌患者手术治疗可取得良好的效果。但对 >70岁患者采取手术治疗应慎重     

宫颈癌患者根治术后并发肠梗阻的危险因素分析及护理对策

目的 分析和探讨宫颈癌根治术后患者并发肠梗阻的危险因素及护理对策。 方法 选择2016年3月—2018年7月西北妇女儿童医院收治的进行宫颈癌根治术的146例患者,根据患者宫颈癌根治术后是否发生肠梗阻,分为观察组和对照组,其中14例宫颈癌根治术后并发肠梗阻的患者为观察组,132例宫颈癌根治术后未发生肠梗阻的患者为对照组。为保证收集的资料真实有效,本研究由医生和护士共同收集危险因素,对2组年龄、体质量指数(body mass index,BMI)、盆腹腔手术史、术前肠道准备、手术方式、麻醉方式、手术时间、术后血钾水平、术后禁食时间、术后感染等情况进行统计,并采用单因素分析和logistic回归分析分析宫颈癌根治术后患者并发肠梗阻的危险因素。 结果 单因素分析和logistic回归分析结果显示:年龄、盆腹腔手术史、术前肠道准备、手术方式、麻醉方式、手术时间、术后血钾水平、术后禁食时间、术后感染是宫颈癌根治术后患者并发肠梗阻的危险因素。 结论 年龄、盆腹腔手术史、术前肠道准备、手术方式、麻醉方式、手术时间、术后血钾水平、术后禁食时间、术后感染是宫颈癌根治术后患者并发肠梗阻的影响因素,临床中要重视这些因素,改善护理质量,做好预防性治疗,避免肠梗阻的发生。      

宫颈癌根治术后并发症的护理

宫颈癌根治术由于手术范围广、创面大,术后常会出现各种并发症,增加患者的痛苦,影响宫颈癌的治愈率.2007年10月1日～2008年9月30日,我们对238例宫颈癌根治术后产生的并发症原因进行回顾性分析,并采取相应的预防及护理措施,结果报告如下. 1 临床资料     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.