改良格栅激光法治疗轻、中度非增殖期糖尿病性黄斑水肿的临床观察

目的探讨改良格栅激光法应用于轻度、中度非增殖期糖尿病视网膜病变黄斑水肿的临床疗效。方法运用眼底荧光血管造影和光学相干断层扫描确诊轻度、中度非增殖期糖尿病视网膜病变黄斑水肿患者共40例（64眼）,运用改良格栅激光法治疗20例（33眼）,运用传统标准格栅激光法治疗20例（31眼）;分别于治疗后1个月、3个月、6个月检查黄斑区视网膜厚度和最佳矫正视力情况。结果改良格栅激光组和传统标准格栅激光组黄斑水肿消退率分别为20眼（60．6％）和12眼（38．7％）,视力提高率分别为24眼（72．7％）和15眼（48_4％）,差异均有统计学意义（P〈0．05）。结论改良格栅样光凝治疗轻度、中度非增殖期糖尿病性黄斑水肿在黄斑水肿消退及视力提高方面优于传统标准黄斑格栅激光治疗。     

氩绿激光治疗糖尿病性黄斑病变的临床观察

目的探讨氲绿激光治疗糖尿病性黄斑病变的对改善视力及黄斑水肿的疗效。方法将对糖尿病性黄斑病变患者按病程分成两组：增殖前期；增殖期。并行眼底荧光血管造影确定视网膜血管渗漏点(区)。对局部渗漏点氩激光点状光凝，弥漫性渗漏区采用格栅样光凝。随访12个月，观察比较两组光凝前后视力及黄斑水肿、渗漏的变化．并进行统计学分析。结果氩绿激光治疗糖尿病性黄斑病变86例136眼，87．50％的眼别提高或保存现有视力，其中对增殖前期的疗效为优；87．95％的黄斑水肿完全或部分消退．增殖前期的黄斑水肿消退尤为明显。两组的视力改善和黄斑水肿消退比较均有统计学意义。结论氩绿激光光凝是治疗糖尿病性黄斑病变的有效手段，有助于提高或保存现有视力．疗效与病变程度有关．早期治疗效果较好。     

糖尿病视网膜病变黄斑水肿激光治疗的疗效观察

目的探讨氩绿激光治疗糖尿病视网膜病变黄斑水肿的疗效。方法对37例(43眼)糖尿病视网膜病变黄斑水肿患者采用氩绿激光(波长为532nm)进行治疗,观察激光前后视力变化,通过眼底荧光血管造影检查评估患者黄斑水肿的变化情况。结果 43眼中有22眼(占51.16%)视力提高2行以上。17眼(39.53%)视力保持稳定,4眼(9.30﹪)视力下降。黄斑水肿19例消退,22例部分消退,不变或加重2例。结论糖尿病视网膜病变黄斑水肿激光治疗效果好,值得推广。     

氩绿激光治疗糖尿病性黄斑病变的临床观察

目的 探讨氩绿激光治疗糖尿病性黄斑病变的对改善视力及黄斑水肿的疗效。方法 将对糖尿病性黄斑病变患者按病程分成两组:增殖前期;增殖期。并行眼底荧光血管造影确定视网膜血管渗漏点(区)。对局部渗漏点氩激光点状光凝,弥漫性渗漏区采用格栅样光凝。随访12个月,观察比较两组光凝前后视力及黄斑水肿、渗漏的变化,并进行统计学分析。结果 氩绿激光治疗糖尿病性黄斑病变86例136眼,87.50%的眼别提高或保存现有视力,其中对增殖前期的疗效为优;87.95%的黄斑水肿完全或部分消退,增殖前期的黄斑水肿消退尤为明显。两组的视力改善和黄斑水肿消退比较均有统计学意义。结论 氩绿激光光凝是治疗糖尿病性黄斑病变的有效手段,有助于提高或保存现有视力,疗效与病变程度有关,早期治疗效果较好。     

氩激光治疗糖尿病视网膜病变

目的：探讨氩激光治疗糖尿病视网膜病变的临床疗效。方法：对56例82眼糖尿病性视网膜病变患者用氩激光行全视网膜光凝治疗及黄斑格珊样光凝，其中非增殖型糖尿病性视网膜病变53眼，增殖型糖尿病性视网膜病变29眼，激光治疗黄斑区为氩绿光，周边则为蓝绿混合光。治疗后3个月作FFA检查，并查视力、眼底情况，随诊3个月至12个月。结果：治疗后视力提高30眼(36.58％)，不变41眼(50.0％)，下降11眼(13.41％)，黄斑水肿消退40眼(76.90％)，总有效率为86.58％。结论：氩激光治疗糖尿病视网膜病变是一种有效的治疗方法。早期治疗效果较好。     

氩激光光凝治疗糖尿病性视网膜病变黄斑水肿效果分析

目的：观察氩激光光凝对糖尿病视网膜病变黄斑水肿的治疗效果。方法：对32例(43只眼)，采用黄斑区氩激光光凝进行治疗。并从视力、黄斑区水肿消退情况观察疗效。结果：激光治疗43只眼中，保持原有视力30只眼(69.8％)；提高2行以上11只眼(25．5％)。下降2行以下有2只眼(4．70％)；32眼(74．4％)黄斑渗漏消失，水肿完全吸收；9只眼(20.9％)水肿大部分吸收，2只眼(4．7％)黄斑渗漏仍存在，原有水肿无明显吸收。结论：氩激光光凝术治疗糖尿病视网膜病变黄斑水肿效果显。     

光学相干断层扫描技术在激光治疗糖尿病性黄斑水肿中的应用价值

目的 探讨激光治疗糖尿病性黄斑水肿(DME)应用光学相干断层扫描技术检查(OCT)的临床价值.方法 2015年2月至2016年1月来云浮市人民医院眼科就诊的糖尿病视网膜病变DME患者42例56眼,激光治疗前、治疗后3个月时采用OTC进行检查,分析其治疗前OCT影像特点及治疗后视力、黄斑中心凹视网膜厚度变化.结果 距黄斑中心凹500μm范围内,局限性渗漏22眼,弥漫性渗漏20眼,囊样水肿14眼;治疗后3个月视力上升患者例数显著多于视力平稳与视力下降患者,差异有显著统计学意义(P<0.01);黄斑中心凹视网膜厚度为(252.44±116.11)μm,较治疗前的(326.22±115.21)μm显著降低,差异有显著统计学意义(P<0.01).结论 OCT用于DME激光治疗患者的检查,可在早期对病情做出较为准确的诊断和病情评估,并进行疗效监测,值得推广.     

不伴黄斑水肿的重度非增生性糖尿病视网膜病变的激光治疗

目的观察不伴黄斑水肿的重度非增生性糖尿病视网膜病变患者在行全视网膜光凝治疗前后黄斑中心厚度及视力的变化,探讨治疗的安全性。方法收集我院26例(52眼)不伴黄斑水肿的重度非增生性糖尿病视网膜病变(Non-proliferative diabetic retinopathy,NPDR)的2型糖尿病患者(视力≥0.8),行每周1次的全视网膜光凝(Panretinal pho-tocoagulation,PRP)治疗,分四期完成。记录术前、术后3、6个月视力(visual acuity,VA),并使用光学相干断层扫描(opticalcoherence tomography,OCT)检测黄斑中心厚度。结果 26例重度NPDR患者(52眼)中,行PRP术后3个月、6个月VA与术前比较无统计学意义(P>0.05),术后3、6个月黄斑中心凹厚度与术前比较,差异有统计学意义(P<0.05),PRP治疗后黄斑中心厚度较治疗前轻度增加。结论对不伴黄斑水肿的重度NPDR行PRP治疗安全有效,术后黄斑中心厚度轻度增加。     

糖尿病性视网膜黄斑水肿氪黄激光治疗的临床分析

目的分析氪黄激光治疗糖尿病性视网膜病变黄斑水肿的临床疗效,并探讨氪黄激光治疗黄斑水肿的时机. 方法对50例68眼非增殖期糖尿病性视网膜病变黄斑水肿患者,根据FFA提示黄斑水肿的形态及范围,分别行氪黄激光黄斑部视网膜局部光凝术或“C”形格珊状光凝术. 结果术后视力提高者45眼（66.2%）,不变者18眼（26.5%）,下降5眼（7.3%）,黄斑水肿完全消退者28眼（41.2%）,部分消退者32眼（47.1%）,不变者8眼（11.8%）. 结论氪黄激光光凝为治疗糖尿病性视网膜病变黄斑水肿的安全有效方法.建议对非增殖期糖尿病性视网膜病变黄斑水肿患者及早行氪黄激光治疗.     

激光联合复方血栓通胶囊治疗糖尿病视网膜病变合并黄斑水肿的疗效观察

目的 探讨激光联合复方血栓通胶囊治疗糖尿病视网膜病变合并黄斑水肿的疗效.方法 64例糖尿病视网膜病变合并糖尿病性黄斑水肿的患者,随机分为激光联合中药复方血栓通胶囊组(观察组)32例(55眼)和单纯激光组(对照组)32例(58眼),两组患者均采用原有的降血糖及降血压等内科治疗.待控制空腹血糖≤7mmoL/L,血压≤140/90 mmHg(1 mmHg=0.133 kPa)后,观察组采用激光治疗并加用复方血栓通胶囊,每次1.5 g,3次/d.对照组只采用激光治疗.疗程均为3个月.观察两组视力、玻璃体混浊及黄斑水肿等情况.结果 观察组与对照组治疗后比较视力、玻璃体混浊、黄斑水肿差异均有显著性(P<0.05).结论 激光联合复方血栓通胶囊治疗糖尿病视网膜病变合并黄斑水肿有较好的疗效.     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

Development on Adjustable Calibration Marker for Shock Wave Focus

Shock wave lithotripsy （SWL） is a treatment of choice for upper urinary stones. However, this procedure is inappropriate for obese patients because the focus is often unable to reach the target owing to the limited focal distance in shock wave source. Although treating such patients in a blast path may increase the application length of shock wave source, it＇s difficult to find this path on the lithotripter monitor. For this reason, we invented an adjustable calibration marker in order to set an effective focus in the shock wave hath.     

Study on the TCM Pathogenesis of Angiopathic Complications of Type II Diabetes

Excess production of reactive oxygen species(ROS)of mitochondrion mediated by hyperglycemia is the common pathogenesis of angiopathic complications of diabetes.TCM holds that the damp from the dysfunction of spleen.kidney and liver is the causative factor of complications of diabetes.This is similar to the mechanism of Ros resulting in angiopathic complications of diabetes.When the angiopathic complications of type II diabetes mellitus(T2DM)are difierentiated as caused by turbid damp in TCM can be explained as ROS.Since the obstruction of pathogenic damp in channels and collaterals is said to be the main pathogenesis,the treating principle should be dissolving the damp to remove the obstruction.     

Leptin, Ghrelin and TNF-α before and after Hypo-caloric Traditional Chinese Diet and Auricular Acupuncture

INTRODUCTION Obesity is a complex emergent problem, which can be possibly solved not only by the diet but also by the life style and promotion of a constant physical exercise. 1, 2 No doubt careful attentions must be given to the nutritional condition of obese people, the dietary habits, the somatic build (i.e. distribution of fat mass) and the organic functions linked to formation of the fat mass. All the parameters should be constantly monitored before, during and after a diet treatment. 3, 4, 5     

Relationship between Dysglycemia and Carotid Atherosclerosis in Tibetan Population

People with dysglycemia are at high risk for atherosclerotic diseases. This study aims at investigating the atherosclerotic vascular damage in dysglycemia and its metabolic origin in Tibetan population.     

APPLICATION OF LORNOXICAM TO PATIENT-CONTROLLED ANALGESIA IN PATIENTS UNDERGOING ABDOMINAL SURGERIES

FOR anesthesiologis s ,treatingpostoperativepainhas alwaysbeen a problem.Althoughopioidshave been provedtobe effective,theirsideeffectscouldnotbeignored.With thedevelopmentofscienceand pharmacology,many drugs with aspectsof satisfactoryanalgesicefficacyand couldbe welltoleratedby patientshave been developed.And lornoxicamisone of them, which isa non-steroidalanti-inflammatorydrug (NSAID ), with analgesic, anti-infl-ammatory,andantipyreticproperties.Itseliminationhalf-time(3 to 5 hours) isle…     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

CLINICAL SIGNIFICANCE OF SERUM CYTOKINES IL-1β,sIL-2R,IL-6,TNF-α,AND IFN-v IN ACUTE CORONARY SYNDROME

Objectives To explore serum cytokines levels (including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v) and their significance in patients with acute coronary syndrome (ACS) and the subsequent follow-ups, with attempt to estimate the role of various serum inflammatory markers in the diagnosis and assessment of ACS.Methods The study population include 40 patients with acute myocardial infarction (AMI), 40 patients with unstable angina pectoris (UAP), and 40 controls. Among the 80 patients, 60 patients attended a follow up 4 months later. Serum inflammatory markers including IL-1 β, sIL-2R, IL-6, TNF-α, and IFN-v were measured by enzyme linked immunosorbent assay.Results Serum IL- 1 β, sIL-2R, IL-6, TNF-α were significantly higher in AMI group or UAP group compared to the control group and became significantly lower 4 months later in the follow-up patients. Serum levels of IFN-v shows no significant difference between AMI group or UAP group and controls, also showing no significant change when measured in follow up patients. There was no correlation between serum creatine kinase-MB isoenzyme levels and serum inflammatory markers either in UAP or AMI group. Furthermore, when divided into two subgroups using Wagner's QRS scoring system in the AMI group, there is no difference of each serum inflammatory marker between ≤ 6 scores group and ＞ 6 scores group.Conclusion Serum levels of certain inflammatory markers may have some diagnostic value for ACS, and can be a useful marker reflecting disease stability.