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1.
目的:定性并定量地分析高血压、高胆固醇和吸烟对心肌梗死后(PMI)患者运动时心脏负荷能力的影响。方法:46例未服用β-阻断剂的PMI患者根据其冠心病危险指数(Dundeerank,DR)(由血压、血胆固醇数值和吸烟状况得出)被分成三组:DR<60(1组,14例)、6070(3组,17例),然后在跑台上进行递增负荷实验(改良Bruce方案)。运动中每3min记录一次主观用力感觉和血压,每30s测量一次摄氧量(VO2)和心率,由VO2计算得出代谢当量(METs),并连续监测12导心电图。结果:运动时间、METs与DR之间存在高度正相关(P<0.01)。最大运动能力为7.5METs(运动"低危层")时DR的对应数值为70。在心脏康复早期只有部分患者(39.1%)可达到低危层的METs值。结论:DR与METs之间的高度相关意味着患者运动中的危险层次可以通过血压、血液胆固醇和吸烟状况被预测出来,这将有助于康复专业人员利用METs值为患者设定适宜的运动水平。  相似文献   

2.
目的探讨CYP2C19基因型与PMI发生的相关性。方法选取我院283例行择期PCI术的冠心病患者,根据其CYP2C19基因型分为快代谢型、中间代谢型和慢代谢型,比较各基因型PMI的发生率。结果慢代谢型患者PMI发生率明显高于其他类型患者(P0.05);CYP2C19慢代谢型与PMI存在正相关性(P0.05)。结论 CYP2C19基因慢代谢型患者更易发生PMI,临床应加强对此类患者的预防。  相似文献   

3.
急性心肌梗死(AMI)以持续性胸骨后疼痛或心前区压榨性疼痛为临床特征,临床上常遇部分老年患者无胸痛症状甚至无任何症状,称之为无痛性心肌梗死(PMI) [1].PMI起病急、发展迅速,自始至终均无特征性胸痛,易被临床医生忽视,造成误诊、漏诊而贻误治疗.  相似文献   

4.
急性心肌梗死(AMI)以持续性胸骨后疼痛或心前区压榨性疼痛为临床特征,临床上常遇部分老年患者无胸痛症状甚至无任何症状,称之为无痛性心肌梗死(PMI) [1].PMI起病急、发展迅速,自始至终均无特征性胸痛,易被临床医生忽视,造成误诊、漏诊而贻误治疗.  相似文献   

5.
急性心肌梗死(AMI)以持续性胸骨后疼痛或心前区压榨性疼痛为临床特征,临床上常遇部分老年患者无胸痛症状甚至无任何症状,称之为无痛性心肌梗死(PMI) [1].PMI起病急、发展迅速,自始至终均无特征性胸痛,易被临床医生忽视,造成误诊、漏诊而贻误治疗.  相似文献   

6.
急性心肌梗死(AMI)以持续性胸骨后疼痛或心前区压榨性疼痛为临床特征,临床上常遇部分老年患者无胸痛症状甚至无任何症状,称之为无痛性心肌梗死(PMI) [1].PMI起病急、发展迅速,自始至终均无特征性胸痛,易被临床医生忽视,造成误诊、漏诊而贻误治疗.  相似文献   

7.
急性心肌梗死(AMI)以持续性胸骨后疼痛或心前区压榨性疼痛为临床特征,临床上常遇部分老年患者无胸痛症状甚至无任何症状,称之为无痛性心肌梗死(PMI) [1].PMI起病急、发展迅速,自始至终均无特征性胸痛,易被临床医生忽视,造成误诊、漏诊而贻误治疗.  相似文献   

8.
急性心肌梗死(AMI)以持续性胸骨后疼痛或心前区压榨性疼痛为临床特征,临床上常遇部分老年患者无胸痛症状甚至无任何症状,称之为无痛性心肌梗死(PMI) [1].PMI起病急、发展迅速,自始至终均无特征性胸痛,易被临床医生忽视,造成误诊、漏诊而贻误治疗.  相似文献   

9.
急性心肌梗死(AMI)以持续性胸骨后疼痛或心前区压榨性疼痛为临床特征,临床上常遇部分老年患者无胸痛症状甚至无任何症状,称之为无痛性心肌梗死(PMI) [1].PMI起病急、发展迅速,自始至终均无特征性胸痛,易被临床医生忽视,造成误诊、漏诊而贻误治疗.  相似文献   

10.
急性心肌梗死(AMI)以持续性胸骨后疼痛或心前区压榨性疼痛为临床特征,临床上常遇部分老年患者无胸痛症状甚至无任何症状,称之为无痛性心肌梗死(PMI) [1].PMI起病急、发展迅速,自始至终均无特征性胸痛,易被临床医生忽视,造成误诊、漏诊而贻误治疗.  相似文献   

11.
Objective: To identify patterns of nonfatal and fatal penetrating trauma among children and adults in New Mexico using ED and medical examiner data.
Methods: The authors retrospectively sampled in 5-year intervals all victims of penetrating trauma who presented to either the state Level-1 trauma center or the state medical examiner from a 16-year period (1978–1993). Rates of nonfatal and fatal firearm and stabbing injury were compared for children and adults.
Results: Rates of nonfatal injury were similar (firearm, 34.3 per 100,000 person-years; stabbing, 35.1). However, rates of fatal injury were significantly different (firearm, 21.9; stabbing, 2.7; relative risk: 8.2; 95% confidence interval: 5.4, 12.5). From 1978 to 1993, nonfatal injury rates increased for children (p = 0.0043) and adults (p < 0.0001), while fatal penetrating injury remained constant. The increase in nonfatal injury in children resulted from increased firearm injury rates. In adults, both stabbing and firearm nonfatal injury rates increased.
Conclusions: Nonfatal injury data suggest that nonfatal violence has increased; fatal injury data suggest that violent death rates have remained constant. Injury patterns vary by age, mechanism of trauma, and data source. These results suggest that ED and medical examiner data differ and that both are needed to guide injury prevention programs.  相似文献   

12.
Ranganath C  Heller AS  Wilding EL 《NeuroImage》2007,35(4):1663-1673
Although substantial evidence suggests that the prefrontal cortex (PFC) implements processes that are critical for accurate episodic memory judgments, the specific roles of different PFC subregions remain unclear. Here, we used event-related functional magnetic resonance imaging to distinguish between prefrontal activity related to operations that (1) influence processing of retrieval cues based on current task demands, or (2) are involved in monitoring the outputs of retrieval. Fourteen participants studied auditory words spoken by a male or female speaker and completed memory tests in which the stimuli were unstudied foil words and studied words spoken by either the same speaker at study, or the alternate speaker. On "general" test trials, participants were to determine whether each word was studied, regardless of the voice of the speaker, whereas on "specific" test trials, participants were to additionally distinguish between studied words that were spoken in the same voice or a different voice at study. Thus, on specific test trials, participants were explicitly required to attend to voice information in order to evaluate each test item. Anterior (right BA 10), dorsolateral prefrontal (right BA 46), and inferior frontal (bilateral BA 47/12) regions were more active during specific than during general trials. Activation in anterior and dorsolateral PFC was enhanced during specific test trials even in response to unstudied items, suggesting that activation in these regions was related to the differential processing of retrieval cues in the two tasks. In contrast, differences between specific and general test trials in inferior frontal regions (bilateral BA 47/12) were seen only for studied items, suggesting a role for these regions in post-retrieval monitoring processes. Results from this study are consistent with the idea that different PFC subregions implement distinct, but complementary processes that collectively support accurate episodic memory judgments.  相似文献   

13.
14.
Delineating the Concept of Hope   总被引:2,自引:0,他引:2  
  相似文献   

15.
Three supplementary perspectives are presented arguing that interprofessional collaboration is both necessary and desirable. Nonetheless, there are often too many serious intra-professional barriers and obstacles to interprofessional collaboration to make it successful. Some of these barriers, it is argued and illustrated, are found in the multiple ways in which professional identity is tacitly acquired and embodied in the practitioners' habitual, everyday practice. The paper then explores ways in which reflection, especially Second order reflection, can help to elucidate and overcome these obstacles, as well as increasing professional adaptability and competence.  相似文献   

16.
ABSTRACT

The Cochrane Library of Systematic Reviews is published quarterly as a DVD and monthly online. The January 2011 issue (first quarterly DVD for 2011) contains 4515 complete reviews, 1985 protocols for reviews in production, and 13,521 one-page summaries of systematic reviews published in the general medical literature. In addition, there are citations of 641,000 randomized controlled trials, and 14,018 cited papers in the Cochrane methodology register. The health technology assessment database contains over 9300 citations. One hundred and seven new reviews have been published in the last 3 months, of which five have potential relevance for practitioners in pain and palliative medicine.  相似文献   

17.
Because of the extensile nature and familiarity of the standard posterior-lateral approach to the hip, a family of "micro-posterior" approaches has been developed. This family includes the Percutaneously-Assisted Total Hip (PATH) approach, the Supercapsular (SuperCap) approach and a newer hybrid approach, the Supercapsular Percutaneously-Assisted Total Hip (SuperPATH) approach. Such approaches should ideally provide a continuum for the surgeon: from a "micro" (external rotator sparing) posterior approach, to a "mini" (external rotator sacrificing) posterior approach, to a standard posterior approach. This could keep a surgeon within his comfort zone during the learning curve of the procedure, while leaving options for complicated reconstructions for the more practiced micro-posterior surgeons. This paper details one author's experiences utilizing this combined approach, as well as permutations of this entire micro-posterior family of approaches as applied to more complex hip reconstructions.  相似文献   

18.
This is a new method for the determination of creatine kinase isoenzyme MB activity in serum. The method uses direct activity measurement of creatine kinase B subunit activity after blocking of CK-M subunit activity by inhibiting antibodies. The test takes no longer than 15 min. The method yields an intra-serial C.V. of 2.0-12.9%, and a C.V. from day to day of 5.5%. The detection limit is 3.4 U/l creatine kinase MB. In the 95 cases with proven myocardial infarction several types of creatine kinase MB activity kinetics could be determined. The percentage of creatine kinase MB of peak CK-total is 6-25%, with a mean of 11.1%. The amount of creatine kinase MB with respect to total CK activity after reinfarction is higher than the amount after initial infarction.  相似文献   

19.
20.
Structure and function of "metalloantibiotics"   总被引:2,自引:0,他引:2  
Although most antibiotics do not need metal ions for their biological activities, there are a number of antibiotics that require metal ions to function properly, such as bleomycin (BLM), streptonigrin (SN), and bacitracin. The coordinated metal ions in these antibiotics play an important role in maintaining proper structure and/or function of these antibiotics. Removal of the metal ions from these antibiotics can cause changes in structure and/or function of these antibiotics. Similar to the case of "metalloproteins," these antibiotics are dubbed "metalloantibiotics" which are the title subjects of this review. Metalloantibiotics can interact with several different kinds of biomolecules, including DNA, RNA, proteins, receptors, and lipids, rendering their unique and specific bioactivities. In addition to the microbial-originated metalloantibiotics, many metalloantibiotic derivatives and metal complexes of synthetic ligands also show antibacterial, antiviral, and anti-neoplastic activities which are also briefly discussed to provide a broad sense of the term "metalloantibiotics."  相似文献   

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