经尿道电气化切除术治疗前列腺增生症(附289例报告)

目的:总结和评价经尿道电气化切除术(TUVP)治疗良性前列腺增生症(BPH)的疗效。方法:回顾性分析289例经尿道前列腺电气化切除术治疗患者的临床资料。结果:最大尿流率(Qmax)由术前(6.6±3.5)ml/s到术后(16.4±3.8)ml/s;国际症状评分由术前(27.2±3.1)分到术后(10.3±2.9)分;生活质量评分由术前(6.1±2.9)分到术后(2.2±1.2)分。结论:TUVP治疗BPH创伤小,出血少,疗效好,术后恢复快。     

经尿道电汽化切除术治疗前列腺增生症(附405例报告)

目的评价经尿道电汽化切除术(TUVP)治疗前列腺增生症(BPH)的疗效.方法应用铲状电极经尿道电汽化切除405例前列腺.结果最大尿流率(Qmax)由术前(7.1±3.7)mL/s到术后(17.8±3.1)国际前列腺症状评分(IPSS)由术前(28.5±3.5)分到术后(8.8±2.8)分;术后尿失禁1例,前尿道狭窄5例,无电切综合征.结论 TUVP治疗BPH创伤小,疗效好,并发症少.     

经尿道气化切割术治疗前列腺增生症

目的：探讨经尿道气化切割术(TUVP)治疗前列腺增生症(BPH)的疗效。方法：64例BPH患者采用德国WOLF气化电切镜经尿道行气化切割术治疗。结果：平均手术时间50min,无大出血,无电切综合征(TURS),术后随访2～12月,排尿功能恢复良好．国际前列腺症状评分9分．最大尿流率15.4ml／s。结论：应用铲状电极气化切割前列腺组织,安全有效,迅速．并发症少．值得临床推广。     

三维空间~(125)I粒子组织间植入术治疗前列腺癌的疗效观察

目的探讨^125I粒子组织间植入治疗前列腺癌的临床价值。方法在经直肠B超引导定位下，经会阴部穿刺前列腺^125I粒子植入治疗前列腺癌5例，其中3例合并骨转移。结果5例手术均顺利，平均植入^125I粒子40例，平均手术时间75min，平均住院时间6d。术后随访3-11个月，平均5个月，完全反应3例，部分反应1例，病情恶化1例。PSA无进展生存率为80％（4／5），无严重并发症发生。结论^125粒子组织间植入治疗前列腺癌是一种安全、创伤小、并发症低且疗效肯定的微创方法。     

Urethra,prostate

<正>209578 Diagnosis and treatment of posterior urethral stricture:twenty-year clincal experience/Zhang Jiong(张炯,Dept Urol 6th Peop Hosp Shanghai Jiaotong Univ,     

Urethra. prostate

The usefulness of percentage of free prostate specific antigen/prostate specific antigen density in the diagnosis of prostate cancer; Relationship between screening by stratifying cases into groups on prostate specific antigen level and the positive rate of transrectal ultrasound guided systematic sextant prostate biopsy; Construction of shRNA expression vectors targeting against NKX3.1 and silencing of NKX3.1 mediated by the vectors;Differential expression of clusterin throughout the cell cycle in prostate cancer cell line; Combined use of oral estramustine phosphate and oral etoposide in patients with hormone refractory prostate carcinoma; Impaction of different prostate biopsy strategies on tumor detection;……     

Urethra, prostate

Questionnaire survey of Chinese urologists concerning the diagnosis and treatment of chronic prostatitis; Clinical value of high grade prostatic intraepithdial neoplasia for predicting prostate cancer; Accuracy of Partin tables to predict final pathological features in prostate cancer of Chinese population     

Urethra, prostate

Diagnostic and differential value of 3D ^1H MR spectroscopy in prostate cancer;Construction and expression of replication-deficient recombinant adenoviral vector carrying prostate specific membrane antigen gene;Transurethral suspendplasma resection of prostate for treatment of benign prostatic hyperplasia patients;Three-dimensional computer reconstruction of male canine prostatic duct system;Clinical pathological study on biologic markers for prostate cancer     

Urethra, prostate

Comparison of treatment planning by carbon ion radiotherapy and by intensity-modulated radiotherapy for prostatic adenocarcinoma, Pedicled rectus abdominis muscle flap for suspending the bulbar urethra in the treatment of male acquired urinary incontinence： an experimental and clinical study, Effect of mifepristone on cell cycle arrest and its regulators in prostate cancer cell line PC- 3, Extraperitoneai laparoscopic radical prostatectomy for prostate cancer and functional recovery of urinary continence, Comparison of intermittent versus continuous androgen blockade in the treatment of advanced prostate eaneer     

前列腺癌与前列腺增生的分类预测及癌症风险因素分析

背景 前列腺癌是男性泌尿生殖系统最常见的恶性肿瘤之一,其与前列腺增生之间的快速鉴别是临床面临的难题之一,需要可靠方法进行分类预测.目的 基于XGBoost算法构建前列腺癌与前列腺增生的分类预测模型,识别癌症风险因素并分析其在早期诊断中的应用价值.方法 于"前列腺癌数据集"(2019年由解放军总医院国家临床医学科学数据中心,国家人口与健康科学数据共享平台提供)中获取前列腺癌与前列腺增生患者的临床数据,在数据预处理基础上按照7:3划分训练集和测试集;应用XGBoost算法构建前列腺癌与前列腺增生的分类模型;基于训练集确定模型参数,并在测试集上完成模型的有效性验证,利用SHAP方法分析模型特征的临床意义.结果 共纳入前列腺癌患者1224例、前列腺增生患者1255例,平均年龄分别为65.86岁、67.70岁;选取年龄、体质量指数、前列腺特异性抗原(prostate specific antigen,PSA)系列指标及其他生化检验指标共23个特征构建分类模型.模型对前列腺癌预测的曲线下面积、准确率、召回率、精确率和F1值分别为0.81、0.74、0.70、0.72、0.74;游离PSA/总PSA、总PSA、无机磷、游离PSA是前列腺早期诊断中最重要的4个指标;SHAP分析结果表明游离PSA/总PSA≤0.132与无机磷 ≥1.09 mmol/L是前列腺癌诊断中需要被关注的分界值.结论 应用XGBoost算法可构建前列腺癌预测的有效分类模型,利用SHAP分析获取的特征指标分界值可为前列腺癌的临床早期筛查提供有益参考.     

Urethra, prostate

207671 Establishement of RNA interfering retrovirus vector targeting CXCR4 gene driven by human prostate- specific antigen promoter and its biological effects on prostate cancer cells/Du Yuefeng(杜岳峰,Dept Urol U- nion Hosp Affil Tongji Med Col ,Huazhong Univ Sci Technol ,Wuhan 430022)…∥Chin J Oncol .-2007 ,29 (7) .-489 ~494 Objective To construct RNAinterfering retrovirus vector targeting CXCR4 gene driven by human prostate- specific antigen promoter andinvestigateits targetedi…     

Urethra, prostate

206644Different effects of various mutants of PAK6kinase on the proliferation of prostate cancer cells/ WenXingqiao(温星桥,Dept Urol ,3rd Affil Hosp,Sun Yat-sen Univ,Guangzhou510630)…∥ChinJ Urol .-2006 ,27(8) .-552 ~555ObjectiveTo evaluate the effects of various mu-tants of PAK6 kinase onthe proliferation of prostate can-cer cells and their roles in the pathology of prostate can-cer .MethodsVariant mutants of PAK6 kinase ,includ-ing wildtype ( WT) ,kinase activated type (SN) and k…     

Urethra,prostate

<正>210516 Prevalence of benign prostatic hyperplasia in Beijing:a multicentre community-based cross-sectional survey/Tian Ye(田野,Dept Urol Beijing Friendship Hosp,Cap Med Univ,Beijing 100050)…Chin J Urol.-2010,31(3).-194～198Objective To investigate the prevalence of benign prostatic hyperplasia(BPH)in Beijing.Methods A cross-sectional study was performed at beijing communities in men aged over 50 years.     

Urethra, prostate

Identification of the nanobacteria in prostatic fluid of CPPS,Differentiation of helper T lymphocyte in type Ⅲ prostatitis,Relationship between sennn prostate specific antigen and asymptomatic prostatic inflammation,Efficacy and safety of Qianliejiedu capsule in the treatment of chronic prostatitis,     

Urethra, prostate

Down-regulation of kallikrein in prostate cancer; Comparison of transperitoneal and extraperitoneal laparoscopic radical prostatectomy; Risk factors for positive surgical margins in extraperitoneal laparoscopic radical prostatectomy.     

Urethra, prostate

Effects of phenylephrine on proliferation and apoptosis of in vitro cultured human prostatic smooth muscle cells , Evaluation of detrusor function and its clinical significance in patient with acute urinary retention secondary to benign prostatic hyperplasia , The clinical significance of PLM-1 mRNA detection in prostate cancer , Mechanism of the effects of progesterone and mifepristone on human prostate cancer PC-3 cells     

Urethra, prostate

Preliminary experience in managing renal ca. lyceal calculi with actively deflectable, flexible ureteroscopy; Primary repair of iatrogenic injury to the ureter; Study of tension-free vaginal tape for surgical treatment of female stress urinary incontinence and prevention of its complications; Cell cycle arrest and apoptosis of androgen independent prostate cancer cell line PC-3 induced by curcumin in vitro; Expression of AMACR and p63 in prostate cancer and its diagnostic value; Effect of nitric oxide on the prostatic prolifer. ation apoptosis in rats;Molecular mechanism underlies LNCaP-flu cell line＇s flutamide insensitivity;……     

Urethra,prostate

<正>209268 Diagnostic value of perfusion weighted magnetic resonance imaging in prostate cancer and benign prostatic hyperplasia/Zhao Xin(Dept Radiol,Tianjin Med Univ Gen Hosp,Tianjin 300052)…∥Chin J Urol.-2009,30(3).-207~209Objective To evaluate the diagnosis and differential diagnostic value of perfusion weighted magnetic resonance imaging for prostate cancer(PCa)and benign prostatic hyperplasia(BPH).Methods Fifty-three cases were divided into 3 groups:group 1 including 23 cases of PCa,group 2 including 22 cases of BPH,and 8 healthy men enrolled in group 3 as normal control.The differences of perfusion related parameters(including rNEI,rMTE and rMSD)among the 3 groups were studied and analyzed.Results In peripheral zone,the value of rNEL in PCa patients was higher than that in BPH patients(t=11.64,P<0.001)and control healthy men(t=11.79,P<0.001).The value of rMTE of PCa patients was lower than that in BPH patients(t=3.50,P=0.002)and control(t=3.78,P=0.001).In central zone,the value of rNEI in PCa patients was higher than that in BPH patients(t=6.99,P<0.001)and control(t=10.32,P<0.001).According to ROC,the rNEI had the best differential diagnostic value.The optimal threshold was 6.44 with sensitivity of 91.3% and specificity of 81.8%for the PCa differentiation with BPH.Conclusion rNEI is and effective parameter to differentiate PCa from BPH.6 refs,2 tabs.     

Urethra,prostate

<正>209429 Clinical significance of differential expression of inflammatory factors in chronic non-bacterial prostatitis/chronic pelvic pain syndrome/Zhou Qing(周青,Dept Trad Chin Med Surg,1st Affil Hosp,Human Univ TCM,Changsha 410007)…∥Chin J Urol.-2009,30(6).-386～389Objective To investigate the role of inflammatory cytokines in the pathogenesis of chronic non-bacterial prostatitis/chronic pelvic pain syndrome(CAP/CPPS)patients.Methods The 38 cases with CAP/CPPS patients(18 cases of CAP and 20 cases of CPPS)and 20 cases of healthy controls were selected.The differential expressions of 40 kinds of inflammatory cytokines were detected by antibody arrays in prostate fluid.Results The inflammatory cytokines which increased more than1.5 times expression were found.There were seven kinds in CAP including monocyte chemoattractant protein(MCP)-1,solution tumor necrosis factor receptor Ⅱ(s TNF R Ⅱ),platelet-derived growth factor-BB(PDGF-BB),interleukin(IL)-1β,IL-11,IL-6,MCP-2 and five kinds in CPPS groups including MCP-1,PDGF-BB,MCP-2,s TNF R Ⅱ,IL-11 respectively,compared with healthy control group.The cluster analysis results showed that protein expression of Monocyte chemoattractant protein 1(MCP-1)and platelet-derived growth factor BB(PDGF-BB)were significantly increased in CAP(3.47 and 2.07 times)and CPPS(2.25 and 2.19 time)compared with helathy control group and were the final polymerization of inflammatory cytokines.The protein expression of interleukin 1 β(IL-1β),MCP-1 and soluble tumor necrosis factor Ⅱ(s TNF R Ⅱ)in CAP group was increased more than 1.85,1.55,1.67 times compared with CPPS group.Conclusion Elevated expression of inflammatory cytokines may play an impotant role in the course of CAP/CPPS disease.The extent of the inflammatory response of CAP was higher than that of CPPS.The inflammatory factors of MCP-1 and PDGF-BB could serve as a novel diagnostic marker.12 refs,2 tabs.