代谢综合征组分影响心房颤动类型的因素分析

目的探讨代谢综合征(MS)及其组分影响心房颤动(简称房颤)患者类型的因素。方法本研究入选2007年1月至2012年4月,在安贞医院心内科住院的房颤患者1 043例。分为2组:阵发性房颤组615例,持续性房颤组428例。比较两组MS与非MS指标,多因素回归分析影响房颤类型的因素。结果 MS组分数量在持续性房颤组显著大于阵发性房颤组(2.3±1.3 vs 2.1±1.3,P0.01)。持续性房颤组的体重指数显著高于阵发性房颤组(P0.01)。阵发性房颤组和持续性房颤组非MS相关指标的比较,左房内径、左室射血分数、尿酸差异有显著性(P0.01),白细胞差异有显著性(P=0.014)。经校正左房内径、左室射血分数、MS组分的数量、白细胞、尿酸,Logistic多因素回归分析显示左房内径(OR=1.125,95%CI=1.096-1.156,P=0.04)、MS组分的数量(OR=1,95%CI=1.017-1.092,P=0.01)、尿酸(OR=1.006,95%CI=1.004-1.008,P=0.045)与持续性房颤患者呈正相关,左室射血分数(OR=0.955,95%CI=0.938-0.972,P=0.01)呈负相关。结论 MS组分的数量、左房内径、左室射血分数、尿酸是阵发性房颤向持续性房颤进展的独立危险因素。     

阵发性心房颤动局灶性消融治疗后复发的危险因素与预测

目的　确定阵发性心房颤动 (房颤 )局灶性消融治疗后复发的危险因素与预测因子。方法　连续 74例接受局灶性消融治疗的阵发性房颤 ,通过单因素和多因素分析对 11项临床和射频消融指标与房颤复发之间的关系进行研究。结果　平均随访 (12 4± 6 6 )个月 ,5 1例 (6 8 9% )房颤复发。单因素分析确定的与复发有关的因素包括 :年龄 [(5 3 0± 13 9)对 (4 5 0± 11 6 )岁 ,P <0 0 5 ]、左心房前后径 [(39± 5 )对 (36± 3)mm ,P =0 .0 1]、异位灶数目 [(1.6± 0 .7)对 (1.2± 0 .4)个 ,P <0 .0 1]和总X线透视时间 [(4 3± 9)对 (38± 9)min ,P <0 0 5 ]等 4种 ;但经Logistic多因素逐步回归分析后仅有异位灶数目 (OR 3 7;95 %CI 1 2～ 11 1;P <0 0 5 )和左心房前后径 (OR 1 2 ;95 %CI 1 0～ 1 4;P <0 0 5 )为消融后复发的独立预测因子。结论　多异位灶起源和左心房增大是阵发性房颤局灶性消融后复发的独立预测因素     

不同类型非瓣膜性心房颤动与HbA1c的相关性分析

目的分析老年住院病人不同类型的非瓣膜性心房颤动与HbA1c的相关性。方法纳入我科住院的老年非阵发性房颤病人112例和阵发性房颤病人111例,以同时期住院的535例无房颤病人为对照组,比较分析3组血糖、血压、血脂等生化指标及左房直径(LAD)、合并疾病等基线资料。以Logistic回归校正危险因素后分析阵发性和非阵发性心房颤动与HbA1c的相关性。结果阵发性房颤组和非阵发性房颤组的SBP、DBP、白蛋白(ALB)、TC、TG水平明显低于无房颤组,年龄、LAD、脂蛋白(a)[Lp(a)]、hs-CRP、纤维蛋白原(FIB)明显高于无房颤组,差异均有统计学意义(P0.05)。阵发性房颤组LAD、Hcy、FPG、HbA1c、尿微量白蛋白肌酐比值(UACR)水平明显低于非阵发性房颤组(P0.05)。多因素Logistic回归分析示:HbA1c (OR=1.718,95%CI:1.180～2.500,P0.01)、LAD (OR 16.631,95%CI:7.588～36.453,P0.01)与非阵发性房颤呈独立正相关; SBP (OR=0.959,95%CI:0.938～0.981,P0.01)与非阵发性房颤呈独立负相关。LAD(OR=4.212,95%CI:1.829～9.699,P0.05)及心功能不全(OR=7.868,95%CI:1.685～36.742,P0.01)是阵发性房颤进展为非阵发性房颤的独立危险因素。结论非阵发性房颤病人具有显著升高的HbA1c和糖尿病患病率,LAD和心功能不全是阵发性房颤进展为非阵发性房颤的危险因素。     

住院心房颤动患者血管性认知障碍及相关危险因素分析

目的:探讨住院心房颤动(房颤)患者血管性认知功能障碍(VCI)的发生率及相关危险因素。方法:选择兰州大学第二医院住院的房颤患者303例,根据简易智能状态检查量表(MMSE)评分分为无VCI组216例,VCI组87例。评估住院房颤患者VCI的发生率,并对VCI进行单因素及多因素分析。结果:与无VCI组比较,VCI组年龄较大,CHA2DS2-VASC评分≥2分、持续/永久性房颤、合并糖尿病及心力衰竭的比例、收缩压、平均动脉压、脉压,左心房前后径及血肌酐较高,男性比例及左心室舒张末内径较低,差异具有统计学意义(P0.05或P0.001)。住院房颤患者VCI发生率为40.3%,随着年龄的增大、CHA2DS2-VASC评分的增高,VCI发生率增加,女性VCI发生率高于男性,持续及永久性房颤患者VCI发生率高于阵发性房颤患者(P0.05或P0.001)。多元线性回归分析显示,年龄(OR=-0.1135,95%CI:-0.1708~-0.0562,P=0.0001)、女性(OR=-1.2528,95%CI:-2.2056~-0.3000,P=0.0105)、文化水平(小学OR=3.2193,95%CI:1.8446~4.5940,P0.0001;初中及以上OR=5.9104,95%CI:4.6055~7.2154,P0.0001)、心力衰竭(OR=-1.9357,95%CI:-3.5522~-0.3192,P=0.0196)、脑卒中(OR=-1.6349,95%CI:-2.7517~-0.5181,P=0.0044)及左心房前后径(OR=-0.1252,95%CI:-0.1962~-0.0541,P=0.0006)与住院房颤患者VCI发生相关。结论:住院房颤患者VCI发生率高,高龄、女性、较低文化水平、心力衰竭、脑卒中及左心房前后径扩大是房颤患者发生VCI的相关危险因素。     

心脏起搏术后阵发性转为持续性心房颤动的影响因素分析

目的分析心脏起搏术后阵发性心房颤动(简称房颤)进展为持续性房颤的风险及可能影响因素。方法109例慢快综合征和30例快慢综合征患者,分别植入VVI(R)或DDD(R)起搏器。根据房颤进展情况分为持续性房颤组(进展组)和非持续性房颤组(非进展组)。分析心脏永久起搏术后房颤进展情况及影响因素。结果平均随访(5.1±2.2)年,51例进展为持续性房颤。单因素分析显示预测房颤进展的危险因素包括左房内径、未使用抗心律失常药物、VVI起搏、高房颤负荷及慢快综合征。多因素Logistic回归分析显示左房内径(HR=1.103,95%CI1.085~1.124,P0.05)、未使用抗心律失常药物(HR=1.975,95%CI 1.336~2.813,P0.001)、VVI起搏(HR=2.156,95%CI1.458~3.157,P0.001)及慢快综合征(HR=1.875,95%CI1.326~3.025,P0.001)是房颤进展的独立预测因素。Kaplan-Meier分析示慢快综合征进展为持续性房颤快于快慢综合征(P=0.034)。结论慢快综合征、左房内径、未使用抗心律失常药物、VVI起搏是阵发性房颤进展为持续性房颤的独立预测因素。     

持续性心房颤动危险因素的单中心研究

目的探讨阵发性心房颤动(房颤)进展为持续性房颤的相关危险因素。方法收集本院2013年1~12月住院的房颤患者320例,分为阵发性房颤组116例,持续性房颤组204例,用多因素logistic逐步回归分析及ROC曲线分析阵发性房颤进展为持续性房颤的危险因素。结果与阵发性房颤组比较,持续性房颤组年龄[(75.7±8.2)岁vs(69.1±10.3)岁]偏大,血肌酐[(101.0±40.0)μmol/L vs(91.4±26.7)μmol/L]、TG[1.2(0.8,1.5)mmol/L vs 1.0(0.7,1.1)mmol/L]、高敏C反应蛋白[17.8(2.0,18.8)mg/L vs 8.4(1.2,9.2)mg/L]、血尿酸[460.8(348.0,521.1)μmol/L vs 322.1(255.0,377.2)μmol/L]、冠心病(57.8%vs 31.0%)、心脏瓣膜病(34.3%vs8.6%)及慢性心力衰竭(68.6%vs 24.1%)比例偏高(P<0.05),LVEF偏低[(46.0±12.0)%vs(57.0±9.0)%,P<0.05];年龄、血尿酸是阵发性房颤进展为持续性房颤的独立危险因素(OR=1.056,95%CI:1.014~1.103,P=0.009;OR=1.008,95%CI:1.005~1.022,P=0.001);ROC曲线显示,年龄最佳截断点为71.5岁(敏感性76.5%,特异性52.5%,ROC曲线下面积0.684,95%CI:0.624~0.745,P=0.000),血尿酸最佳截断点为394μmol/L(敏感性61.8%,特异性20.7%,ROC曲线下面积0.756,95%CI:0.702~0.809,P=0.001)。结论阵发性房颤进展为持续性房颤受多种因素影响,其中年龄、血尿酸可能是阵发性颤动进展为持续性房颤的独立危险因素。     

中国人非瓣膜性心房颤动脑卒中危险因素的病例-对照研究

目的　本研究通过回顾性病例对照研究分析中国人心房颤动 (房颤 )脑卒中的危险因素。方法　在全国 1 8家医院共登记房颤患者 4 51 1例 ,其中风湿瓣膜性房颤 1 0 86例 ,非瓣膜性房颤 342 5例。通过比较房颤合并脑卒中与房颤无脑卒中患者 ,筛选房颤发生脑卒中的危险因素。结果　中国人房颤脑卒中的患病率 2 4 81 % ,房颤合并脑卒中组年龄明显高于对照组 (P <0 0 0 1 ) ,且患病率随年龄增长而明显增加。多因素Logistic分析显示 :年龄≥ 75岁 (OR 1 76 ,95 %CI 1 0 8～ 2 98) ,高血压病史 (OR 1 52 ;95 %CI 1 2 8～ 1 80 ) ,糖尿病史 (OR 1 39,95 %CI 1 1 1～ 1 76) ,动脉收缩压升高(OR 1 71 ,95 %CI1 2 1～ 2 2 8) ,左房血栓 (OR 2 77,95 %CI 1 2 5～ 6 1 3)是脑卒中的独立危险因素。结论　中国人非瓣膜性房颤脑卒中的独立危险因素为年龄、高血压病史、糖尿病史、左房血栓、动脉收缩压升高 ,上述因素对决定房颤患者的抗栓治疗策略具有重要意义     

阵发性房颤随访情况和阵发性房颤进展的危险因素

目的 观察阵发性房颤的随访情况和分析阵发性房颤进展的危险因素。方法 对216例阵发性房颤患者进行随访,观察其主要结局（是否发生房颤进展）和临床事件（卒中、心力衰竭、再住院和出血事件）,再按是否房颤进展分为房颤进展组（n=87）和房颤未进展组（n=129）。采用巢式病例对照研究方法,进行单因素分析和多因素分析（采用多因素Logistic回归模型）,分析影响房颤进展的危险因素。结果 216例阵发性房颤患者经过3.45年（中位数）随访发生房颤进展者87例,其发生进展率为40.2%,年进展率为11.7%。房颤进展组脑卒中、心力衰竭、房颤相关的再住院发生率均显著高于房颤未进展组（分别17% vs. 6%,18% vs. 5%,37% vs. 17%, 分别P<0.05,P<0.01和P<0.01）;两组间病死率及出血发生率差异未达到显著水平。多因素分析显示,年龄(OR 1.082,95%CI 1.016-1.392,P<0.05)、左房内径>45 mm(OR 2.339,95%CI 1.445-3.785,P<0.05)、CHADS2评分>3分(OR 1.382,95%CI 1.081-1.987,P<0.05)以及超敏C反应蛋白（hs-CRP）水平(OR 1.124,95%CI 1.005-2.345,P<0.05 )是房颤进展的独立危险因素。结论 阵发性房颤进展的年发生率为11.6%。影响房颤进展的独立危险因素为年龄、左房内径、hs-CRP水平及CHADS2评分。     

心力衰竭患者持续性心房颤动危险因素的单中心研究

目的探讨心力衰竭患者阵发性心房颤动(房颤)进展为持续性房颤的相关危险因素。方法收集南京高淳人民医院2013年1月至12月住院房颤及心力衰竭的患者168例,分为阵发性房颤组28例,持续性房颤组140例。应用多因素Logistic逐步回归分析及受试者工作特征(receiver operator characteristic,ROC)曲线分析心力衰竭患者阵发性房颤进展至持续性房颤的危险因素。结果与阵发性房颤组比较,持续性房颤组的左心房内径(left atrial diameter,LAD)[(48.11±7.74)mm vs.(40.42±7.13)mm]、三酰甘油[1.04(0.81~1.13)mmol/L vs.0.87(0.66~1.12)mmol/L)]、总胆固醇[(4.24±0.69)μmmol/L vs.(3.64±0.95)μmmol/L]、血尿酸[444.00(365.00~579.10)μmmol/L vs.374.20(272.00~412.00)μmmol/L)]、男性(52.5%vs.28.6%)、心脏瓣膜病(41.4%vs.21.4%)比例偏高,差异有统计学意义(P0.05);左心室射血分数(45.07%±11.69%vs.50.93%±13.74%)]偏低,差异有统计学意义(P0.05)。多因素Logistic回归分析结果显示,LAD、血尿酸是心力衰竭患者阵发性房颤进展至持续性房颤的独立危险因素(OR=1.270,95%CI:1.131~1.426,P=0.000;OR=1.007,95%CI:1.001~1.012,P=0.009);ROC曲线显示LAD最佳截断点为47.5mm(敏感性47.1%,特异性14.3%,ROC曲线下面积0.788,95%CI:0.691~0.885),血尿酸最佳截断点为433.00μmmol/L(敏感性57.1%,特异性14.3%,ROC曲线下面积0.726,95%CI:0.630~0.821)。结论心力衰竭患者阵发性房颤进展至持续性房颤受多种因素影响,其中LAD、血尿酸可能是心力衰竭患者阵发性房颤进展至持续性房颤的独立危险因素。     

吸烟与老年阵发性心房颤动的相关性研究

目的探讨吸烟与老年阵发性心房颤动(房颤)的关系。方法连续入选2019年1月～2020年6月在天津市第五中心医院心内科住院的老年阵发性房颤患者141例作为房颤组,同期住院的非房颤患者140例作为对照组。记录2组一般临床资料、实验室检查指标,进行超声心动图检查,采用多因素logistic回归分析房颤的影响因素。结果房颤组吸烟(29.1%vs7.1%)和高血压(78.7%vs50.7%)比例、左心房内径及右心房内径较对照组增加,游离三碘甲状腺素原氨酸(FT3)水平[(3.92±0.82)mmol/Lvs(4.28±0.68)mmol/L]较对照组降低,差异有统计学意义(P0.05,P0.01)。多因素logistic回归分析,吸烟(OR=6.297,95%CI:2.836～13.980,P=0.000)、高血压(OR=3.266,95%CI:1.827～5.838,P=0.000)为老年阵发性房颤发生的独立相关因素,FT3(OR=0.479,95%CI:0.323～0.710,P=0.000)与老年阵发性房颤呈负相关。结论吸烟与老年阵发性房颤独立相关,两者的可能机制有待进一步研究。     

Predictors of Early and Late Recurrence of Atrial Fibrillation after Catheter Ablation of Paroxysmal Atrial Fibrillation

INTRODUCTION: The outcome of patients with early recurrence of atrial fibrillation (AF) (within one month) after ablation procedure is controversial. Furthermore, the predictors of early and late (up to mean follow-up 30 months) recurrence of AF are not investigated in depth. AIMS OF THE STUDY: The aim of the present study was to investigate the predictors of early and late recurrence of AF after catheter ablation of arrhythmogenic foci initiating AF in patients with paroxysmal AF. METHODS AND RESULTS: The study included 207 patients (155 men; mean age 62 +/- 13 years) who received catheter ablation of paroxysmal AF. Eighty-one (39%) patients had early recurrence of AF. Five clinical variables were related to the early recurrence of AF: (1) old age (>/=65 years) ( P = 0.004); (2) presence of associated cardiovascular disease ( P = 0.01); (3) presence of multiple AF foci ( P = 0.004); (4) presence of AF foci from left atrial free wall ( P = 0.039); (5) left atrial enlargement ( P = 0.038). Multivariate analysis demonstrated that presence of multiple AF foci could predict early recurrence of AF ( P = 0.013; ratio = 2.24; 95% CI 1.18 to 4.25). During the follow-up period (30 +/- 11 months), 70 (34%) patients had late recurrence of AF, and two clinical variables were related to the late recurrence of AF: (1) presence of early recurrence of AF ( P = 0.025); (2) presence of multiple AF foci ( P = 0.034). Multivariate analysis found that presence of early recurrence of AF could predict late recurrence of AF ( P = 0.046; hazard ratio = 1.62; 95% CI 1.01 to 2.59). Late recurrence of AF happened in 35 (43%) of the 81 patients with early recurrence of AF, and in 35 (28%) of the 126 patients without early recurrence of AF. CONCLUSIONS: Early AF recurrence could predict late AF recurrence.     

1 041例非瓣膜性心房颤动患者左心房内径的分析

目的:了解非瓣膜性心房颤动(房颤)患者左心房内径与房颤类型、房颤病程、左心房血栓及血栓栓塞危险因素等方面的关系. 方法:选择2001-01至2008-01在我院住院的非瓣膜性房颤患者共1 041例,入选条件:①心电图或24小时动态心电图证实的房颤发作;②超声心动图证实的非瓣膜性心脏病.分组情况:按左心房有无血栓分为无左心房血栓组(,n=950)与有左心房血栓组(n=91). 结果:1 041例患者中,男性666例,女性375例,平均年龄为(64.26 ±12.43)岁.左心房增大的有658例(63.2%).左心房内径随着病程出现阵发性、持续性、永久性房颤而增加,左心室射血分数随着病程出现阵发性、持续性、永久性房颤而降低,持续性房颤和永久性房颤与阵发性房颤比较,差异均有统计学意义(P<0.05).左心房内径的大小随着房颤病程延长而增加.有左心房血栓组的房颤病程、左心房内径大于无左心房血栓组,差异有统计学意义(P<0.05),且具有房颤血栓栓塞危险因素的发生率有随着左心房内径增大而增加的趋势. 结论:房颤是左心房扩大的原因之一,房颤持续时间越长,左心房扩大越明显.左心房扩大在其血栓形成中起着重要作用.     

Interatrial Mechanical Dyssynchrony Worsened Atrial Mechanical Function in Sinus Node Disease With or Without Paroxysmal Atrial Fibrillation

Introduction: Atrial electromechanical dysfunction might contribute to the development of atrial fibrillation (AF) in patients with sinus node disease (SND). The aim of this study was to investigate the prevalence and impact of atrial mechanical dyssynchrony on atrial function in SND patients with or without paroxysmal AF. Methods: We performed echocardiographic examination with tissue Doppler imaging in 30 SND patients with (n = 11) or without (n = 19) paroxysmal AF who received dual‐chamber pacemakers. Tissue Doppler indexes included atrial contraction velocities (Va) and timing events (Ta) were measured at midleft atrial (LA) and right atrial (RA) wall. Intraatrial synchronicity was defined by the standard deviation and maximum time delay of Ta among 6 segments of LA (septal/lateral/inferior/anterior/posterior/anterospetal). Interatrial synchronicity was defined by time delay between Ta from RA and LA free wall. Results: There were no differences in age, P‐wave duration, left ventricular ejection fraction, LA volume, and ejection fraction between with or without AF. Patients with paroxysmal AF had lower mitral inflow A velocity (70 ± 19 vs 91 ± 17 cm/s, P = 0.005), LA active empting fraction (24 ± 14 vs 36 ± 13%, P = 0.027), mean Va of LA (2.6 ± 0.9 vs 3.4 ± 0.9 cm/s, P = 0.028), and greater interatrial synchronicity (33 ± 25 vs 12 ± 19 ms, P = 0.022) than those without AF. Furthermore, a lower mitral inflow A velocity (Odd ratio [OR]= 1.12, 95% Confidence interval [CI] 1.01–1.24, P = 0.025) and prolonged interatrial dyssynchrony (OR = 1.08, 95% CI 1.01–1.16, P = 0.020) were independent predictors for the presence of AF in SND patients. Conclusion: SND patients with paroxysmal AF had reduced regional and global active LA mechanical contraction and increased interatrial dyssychrony as compared with those without AF. These findings suggest that abnormal atrial electromechanical properties are associated with AF in SND patients.     

老年心血管病患者房颤反复发作的预测

目的　为明确老年心血管疾病患者窦性心律时发生阵发性房颤的危险因素并寻找反复心房颤动发作的预测因子。方法　测量 71例有阵发性房颤发作史的老年心血管疾病患者 (PAF组 )及 73例无阵发性房颤发作史的老年心血管疾病患者 (对照组 )窦性心律时的 12导联ECG ,分别测定最大P波时限 (Pmax)及最小P波时限 (Pmin)并计算其P波离散度 (Pd) ,心脏超声测量左房内径 (LAD)和左室射血分数 (LVEF) ,随访PAF组房颤反复发作情况。结果　PAF组的Pd及Pmax分别为 ( 4 7.0 7± 12 .3 5 )ms和 ( 12 1.2 5± 13 .2 4)ms,较对照组明显延长 (P <0 .0 1) ;PAF组反复房颤发作者 ,Pd≥40ms时相对危险度 3 .3 3 ,Pmax≥ 110ms时相对危险度 2 .48。结论　窦性心律时Pd、Pmax增加是预测老年心血管病患者是否发生房颤及房颤反复发作的有效且无创的临床方法     

Pre-procedural predictors of atrial fibrillation recurrence after circumferential pulmonary vein ablation.

AIMS: The success rate of circumferential pulmonary vein ablation (CPVA) to treat atrial fibrillation (AF) ranges from 60 to 90%, depending on the series. The objective of the study was to identify predictors of AF recurrence after a standardized CPVA procedure. METHODS AND RESULTS: A series of 148 consecutive patients undergoing CPVA for symptomatic paroxysmal (60.8%), persistent (23.6%), or permanent (15.5%) AF refractory to antiarrhythmic drugs were included in the study. CPVA with the creation of supplementary block lines along the posterior wall and mitral isthmus was performed and a minimum of 6 months follow-up completed in all patients. Structural heart disease was present in 19.6% and hypertension in 33.8% of patients. After 13.1 +/- 8.4 months follow-up, 73.6% of patients were free of AF recurrences after a mean of 1.18 +/- 0.45 procedures/patient (one procedure in 85.2%, two procedures in 14.8%, and three procedures in 2.7%). Univariable analysis showed that the risk of AF recurrence increases with age (HR 1.03; 95% CI 1.00-1.06, P = 0.031), with the presence of previous hypertension (HR 2.7; 95% CI 1.43-5.07, P = 0.002), and if AF is permanent (HR 2.23; 95% CI 1.08-4.59, P = 0.042). In addition, larger anteroposterior left atrial diameter (LAD) (HR 1.11; 95% CI 1.05-1.18, P = 0.001) and larger left ventricular end-systolic diameter (HR 1.07; 95% CI 1.00-1.15, P = 0.029) prior to the procedure were associated with AF recurrence after CPVA. Cox regression analysis showed that hypertension (OR = 2.8; 95% CI 1.5-5.4; P = 0.002) and LAD (OR = 1.1; 95% CI 1.05-1.19, P < 0.001) were independent predictors of AF recurrence. The mean predicted proportion of patients with AF recurrence after CPVA of the multivariable model showed a linear relationship with the increase in LAD prior to the procedure. The presence of hypertension further increased the mean predicted proportion of patients with AF recurrence at each LAD. CONCLUSION: Hypertension and LAD are independent pre-procedural predictors of AF recurrence after CPVA to treat AF. These data may help in patient selection for AF ablation.     

Predictors of early recurrence and delayed cure after segmental pulmonary vein isolation for paroxysmal atrial fibrillation without structural heart disease

Background Early recurrence of atrial fibrillation (ERAF) and delayed cure are commonly observed after atrial fibrillation (AF) ablation. The purpose of this study was to determine the predictors of ERAF and delayed cure after a single pulmonary vein isolation (PVI) performed in paroxysmal AF patients without structural heart disease.Methods and results In 108 consecutive patients (93 men, 15 women; mean age 51 ± 8 years) with paroxysmal AF and no structural heart disease, segmental PVI guided by a Lasso catheter was performed. Forty-one percent (44/108) AF patients had ERAF after a single PVI. Univariate analysis revealed that left atrial diameter (p = 0.004), age (p = 0.024) and P-wave dispersion (p = 0.045) were significantly related to ERAF. Logistic regression analysis revealed that left atrial enlargement was the only independent predictor of ERAF (odds ratio [OR] 1.17; 95% confidence interval [CI] 1.04–1.30, p = 0.006). Delayed cure occurred in 32% (14/44) patients with ERAF. P-wave dispersion (p = 0.001), left atrial diameter (p = 0.008) were significantly related to delayed cure. P-wave dispersion was the only independent predictive factor of delayed cure (OR 0.91; 95% CI 0.85–0.97, p = 0.004).Conclusions Elderly patients with left atrial enlargement and a high dispersion of P wave are susceptible to ERAF after a single PVI. Left atrial enlargement is the only independent predictor of ERAF. Among patients with ERAF, those with less P-wave dispersion and less left atrial diameter have a higher probability of delayed cure. P-wave dispersion can independently predict delayed cure.This study was supported by National Natural Science Foundation of China. (NSFC No.30470704). There is not any potential conflict of interest.     

Left Ventricular Diastolic Dysfunction in Atrial Fibrillation: Predictors and Relation with Symptom Severity

Left Ventricular Diastolic Dysfunction in Atrial Fibrillation Background: Left ventricular diastolic dysfunction (LVDD) is common in the general population, but its prevalence in atrial fibrillation (AF), predictors for LVDD in AF and the association between LVDD and AF‐related symptom severity has not been well studied. Methods: In 124 consecutive patients (mean age 61 ± 11years, 60% male) with paroxysmal (n = 70) or persistent AF (n = 54) referred for AF catheter ablation, LVDD was evaluated according to current guidelines using transthoracic echocardiography. AF‐related symptom severity was quantified using the European Heart Rhythm Association score. Results: LVDD was present in 46 patients (37%). In uni‐ and multivariable regression analysis, age (OR 1.068 per year, 95% CI 1.023–1.115, P = 0.003) and persistent AF (OR 2.427 vs. paroxysmal AF, 95% CI 1.112–5.3, P = 0.026) were associated with LVDD. LVDD was found in 11% with mild AF symptoms (n = 27) as opposed to 44% in patients with moderate–severe AF symptoms (n = 97, P = 0.002). Thus, the OR for moderate–severe AF symptoms was 6.368 (1.797–22.568, P = 0.004) in the presence of LVDD. Conclusions: LVDD (1) occurs frequently in AF, (2) is associated with advancing age and AF progression and (3) is correlated with symptom severity in AF. (J Cardiovasc Electrophysiol, Vol. 23 pp. 1073‐1077, October 2012)     

血压变异性与心房颤动相关性研究

［］ 目的 探讨血压变异性(BPV)对心房颤动发生及左心结构的影响。方法 随机选取我科2013年6月至2015年10月就诊患者120例患者,其中永久性房颤40例,持续性房颤40例,阵发性房颤40例,选取同期住院的窦性心律患者40例,测24h动态心电图、动态血压、超声心动图对160例患者检测,比较四组患者血压变异性及左房内径。 结果 心房颤动组的血压变异性、左房内径较正常对照组明显增加,房颤组内比较,永久性房颤组较持续性房颤组、阵发性房颤组血压变异性明显增大。 结论 心房颤动的患者血压变异性明显增加,且心房颤动的严重程度与血压变异性呈正相关。#$NL［关键词］心房颤动;血压变异性;左房内径     

厄贝沙坦对高血压并阵发性房颤患者房颤复发的影响

目的:评价厄贝沙坦对高血压并发阵发性房颤(PAF)患者的抗心律失常效应.方法:选取99例高血压并发PAF患者,分成厄贝沙坦治疗组(A组)49例和氨氯地平治疗组(B组)50例,在口服胺碘酮的基础上分别加用厄贝沙坦、氨氯地平治疗12个月.比较2组治疗后第3、6、12个月房颤复发率和治疗后第6、12个月的左心房内径(LAD)...     

Predictors of Atrial Fibrillation Recurrence After Radiofrequency Catheter Ablation: A Systematic Review

AF Recurrence After RFA: Systematic Review. Introduction: The relationship between success of radiofrequency ablation for atrial fibrillation (AF) and patient characteristics has not been systematically evaluated. Methods and Results: We searched MEDLINE and Cochrane Central Trials Registry databases from 2000 through 2008 for studies reporting preprocedure predictors and AF recurrence after radiofrequency ablation. We extracted multivariable analyses and univariable data on predictors and AF recurrence. Eligible studies were highly heterogeneous, particularly regarding ablation technique and definition of AF recurrence. Among 25 studies with multivariable analyses, two‐thirds to 90% of studies found that AF type, ejection fraction, left atrial diameter, structural heart disease, hypertension, and AF symptom duration did not predict AF recurrence (among patients with ejection fraction above 40% and left atrial diameter below about 55 mm). Studies found that gender and age were not predictors (in patients between 40 and 70 years old). Meta‐analyses of univariable AF recurrence rates by AF type in 31 studies found that studies were statistically heterogeneous, but that nonparoxysmal AF predicted AF recurrence compared to paroxysmal AF (relative risk 1.59; 95% confidence interval 1.38–1.82; P < 0.001); meta‐analyses of persistent or permanent versus paroxysmal AF yielded similar findings. Conclusion: Nonparoxysmal AF may be a clinically useful proxy for a combination of confounded variables, none of which alone is an independent predictor of AF recurrence. Evaluation of predictors was limited by exclusion of patients with severe heart disease or at the age extremes; thus, the evidence may not be as applicable to these populations. (J Cardiovasc Electrophysiol, Vol. 21, pp. 1208‐1216, November 2010)