中西医结合方案对老年单纯收缩期高血压患者血管内皮功能及超敏C反应蛋白的影响

Effect of a Integrative Medical Regimen on Levels of Vascular Endothelial Function and Hypersensitive C-Reactive Protein in Elderly Patients with Isolated Systolic Hypertension

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中文关键词: 老年单纯收缩期高血压中西医结合血管内皮功能炎症因子

英文关键词:elderly patients with isolated systolic hypertension integrated traditional Chinese and Western medicine vascular endothelial function inflammatory factor

基金项目:国家十一五科技攻关课题(No.2007BAI20B072);国家中医药管理局专项资助项目(No.02-03LP49);首都医学发展科学基金科技联合攻关项目(No.03Ⅱ01)

作者	单位
李浩	中国中医科学院西苑医院
赵文明	中国中医科学院西苑医院
韩永祥	北京市延庆县中医院
刘剑刚	中国中医科学院西苑医院
姚明江	中国中医科学院西苑医院
刘丽	中国中医科学院西苑医院
王雪梅	中国中医科学院西苑医院
沈雁鹏	北京市延庆县中医院
刘兴东	北京延庆县社区服务中心

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中文摘要:

目的观察中西医结合方案(降压胶囊联合尼莫地平胶囊)对老年单纯收缩期高血压(elderly patients with isolated systolic hypertension,EISH)患者血压水平、中医症状、血管内皮功能及超敏C反应蛋白(hs-CRP)的影响。方法采用随机、双盲、对照的试验设计方法,将135例EISH患者随机分中西医结合组(简称结合组,给予降压胶囊联合尼莫地平胶囊)、中药组(给予降压胶囊+尼莫地平胶囊模拟药)及西药组(给予尼莫地平胶囊+降压胶囊模拟药)3组,疗程为4周。观察各组患者治前后血压水平及症状改善情况,血清一氧化氮(NO),血浆内皮素-1(ET-1)、血栓素B2(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)以及hs-CRP含量变化。结果与治疗前比较,各组收缩压水平显著降低,症状明显改善;治疗后各组血清(浆)NO、6-keto-PGF1α水平显著升高,ET-1、TXB2、hs-CRP水平显著降低(P<0.05,P<0.01);结合组降低收缩压的作用优于中药组或西药组(P<0.05),改善症状的作用优于西药组(P<0.01);结合组升高血清NO含量及降低血浆TXB2含量作用明显优于西药组(P<0.05)。结论中西医结合方案(降压胶囊联合尼莫地平)降压疗效显著,能够显著改善患者症状、血管内皮细胞功能并抑制炎症因子水平。

英文摘要:

Objective To observe the effect of a integrative medical regimen(IMR),i.e.combined use of Jiangya Capsule(JYC) and Nimodipine(ND),on blood pressure,TCM clinical symptoms,and blood levels of vascular endothelial function and hypersensitive C-reactive protein(hs-CRP) in elderly patients with isolated systolic hypertension(EISH).MethodsAdopting randomized,double-blinded and controlled principle,a trial was conducted on 135 patients with EISH by randomized them into three groups,they were administered IMR(Group A),JYC plus ND simulator(Group B) and ND plus JYC simulator(Group C) respectively,for 4 weeks.Changes of blood pressure and TCM symptoms,as well as the levels of serum nitric oxide(NO),plasma endothelin-1(ET-1),6-keto-prostaglandin 1α(6-keto-PGF1α),thromboxane B2(TXB2) and hs-CRP were observed before and after treatment.ResultsAfter treatment the systolic blood pressure reduced and clinical symptoms improved,with serum NO and 6-keto-PGF1α lelels elevated,plasma ET-1,TXB2 and serum hs-CRP decreased in all the three groups(P<0.05 or P<0.01).But the inter-group comparisons showed that the effect in Group A was superior to the other two groups in decreasing systolic pressure,and superior to Group C in improving clinical symptoms,elevating serum NO and decreasing plasma TXB2(P<0.05).ConclusionThe integrative medical regimen of combined use JYC and ND has markedly effect in lowering blood pressure,it could obviously improve the symptoms and vascular endothelial function,and inhibit the level of inflammatory factor in patients with EISH.

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