缬沙坦治疗慢性心力衰竭73例疗效观察

缬沙坦是非肽类选择性血管紧张素Ⅱ(AngⅡ)1型受体(AT1)拮抗剂，本文对73例慢性充血性心力衰竭(CHF)患者用缬沙坦治疗，现将结果报告如下。     

1例结节性脂膜炎误诊分析

结节性脂膜炎以皮下结节为主要临床特征，常伴有发热、食欲减退、肌肉关节疼痛、甚或内脏损害，易误诊误治。现将本院1例结节性脂膜炎患者误诊情况分析如下。     

龙胆泻肝汤在皮肤科的应用

龙胆泻肝汤最早见于宋代《太平惠民和剂局方》，近代多用《医宗金鉴》方。其方由龙胆草、黄芩、栀子、木通、车前子、泽泻、当归、生地、柴胡、甘草组成。因其有泻肝胆实火，清三焦湿热之功，故广泛应用于临床，在皮肤疾病中，对带状疱疹、急性湿疹、脂溢性皮炎、丹毒、药疹、接触性皮炎、急性女阴溃疡、红皮病、足癣继发感染等，均有独特疗效。兹举三案浅要介绍如下。     

综述列题

Apoptin-肿瘤基因治疗的新选择；BRLF1-EBV的一种立即早期基因的研究进展；E-选择素及其配体与肿瘤关系的研究进展；gp96与肿瘤免疫研究进展；IL-12抗肿瘤基因治疗的研究进展；p73基因与人类肿瘤的研究进展；RNA千扰技术的应用；Survivin基因及其与肿瘤靶向治疗；T淋巴瘤侵袭转移诱导因子1与肿瘤侵袭转移的研究进展；表皮生长因子受体信号通路及其靶向肿瘤治疗；单核苷酸多态性与肿瘤转移的关系；反应停抗肿瘤作用研究进展。[编者按]     

一起A3型流行性感冒暴发调查

2004-05-13/2004-05-24名山县某中学发生群体性不明原因的发热性疾病流行.经流行病学调查、临床症状和实验室检查,确认为1起A3型流行性感冒(以下简称流感)暴发,现将调查处理报告如下.     

服用灵芝孢子粉胶囊致CA72—4升高1例

1病例报告 患者男性，65岁，诊断高血压病6年、糖尿病4年，坚持口服药治疗，病情稳定。于2008年8月常规查体时发现CA72—4明显升高达335．18U／ml，其余各项肿瘤标记物检测均正常，既往未发现如此升高现象。因患者无明显其他表现，     

Influence of moderate hypothermia on cerebral oxygenation in pigs with intracranial hypertension

BACKGROUND: Moderate hypothermia is one of the effective therapeutic methods for head injury in recent years, there are many mechanisms of moderate hypothermia for brain protection, and its influence on cerebral oxygenation is also one of them. OBJECTIVE: To observe the influence of moderate hypothermia on cerebral oxygenation of animals with acute intracranial hypertension, and further investigate the protective mechanism of moderate hypothermia. DESIGN: A randomized controlled trial. SETTING: Department of Neurosurgery, Renji Hospital affiliated to the Medical College of Shanghai Jiao Tong University. MATERIALS: Twenty healthy little pigs, either male or female, weighing 4.5–5.5 kg, were used. Neurotrend-typed multiparameter monitoring system (Diametrics Company, British); CMA/100 micro-injection pump (Carnegie Company, Sweden). METHODS: The experiment was conducted in the Changzheng Hospital affiliated to the Second Military Medical University of Chinese PLA in November, 2001. The pigs were randomized into two groups: the normothermia group (control group, n =10) and moderate hypothermia group (n =10). ① Bilateral femoral arteries were separated, one was connected to pressometer for monitoring mean arterial pressure (MEP), and the other for analysis of blood gases [including peripheral blood pH value, arterial partial pressure of carbon dioxide (PaCO2), arterial partial pressure of carbon dioxide (PaCO2), HCO3–]. ② Rectal temperature was monitored with mercurial thermometer. ③ Intracranial pressure was monitored using Camino optic ICP probe placed in the subdural space. ④ Neurotrend multiparameter monitoring sensor was inserted into the white matter for about 4 cm to determine cerebral perfusion pressure (CPP, CPP=MAP(ICP), brain tissue partial oxygen pressure (PO2), partial pressure of carbon dioxide (PCO2), HCO3– and brain temperature. The rectal temperature of animals in the moderate hypothermia group was lowered to 34 ℃ using ice bags, and the body temperature was maintained at 33–35 ℃ for 2 hours. The changes of the parameters were observed continuously, and the pigs in the normothermia group were not treated with cooling. MAIN OUTCOME MEASURES: ① MAP, ICP, rectal temperature, CCP; Indexes of cerebral oxygenation detected with Neurotrend-typed multiparameter monitoring system; ② Results of blood gases analysis in the moderate hypothermia group. RESULTS: All the 20 pigs were involved in the analysis of results. ① MAP, ICP, rectal temperature, CCP and indexes of cerebral oxygenation: In the moderate hypothermia group, the ICP after cooling was obviously lower than that before cooling [(3.31±1.19), (5.33±0.95) kPa, P < 0.05], CCP was higher, brain tissue PCO2 [(12.03±1.73), (10.59±2.01) kPa, P < 0.05], and brain tissue pH value was higher [(7.03±1.63), (9.40±1.30) kPa, P < 0.05], whereas the brain temperature was decreased as compared with that before cooling [(34.9±0.3), (37.2±0.2) ℃, P < 0.05]. ② Results of blood gases analysis in the moderate hypothermia group: There were no significant differences in the parameters of peripheral arterial blood gases analysis before and after cooling in the moderate hypothermia group (P > 0.05) CONCLUSION: Moderate hypothermia will not impair the cerebral oxygenation, and it can reduce brain tissue CO2 and decrease brain tissue acidosis.