糖类抗原CA125水平测定在结核性腹膜炎诊治中的意义

目的了解和评价CA125检测对结核性腹膜炎的诊断和治疗价值。方法采用电化学发光法检测了35例结核性腹膜炎患者和28例恶性腹水患者血清和腹水的CA125水平,并与非活动性肺结核组和正常对照组进行比较。结果结核性腹膜炎组和恶性腹水组血清CA125水平分别为（243.29±131.60）U/mL和（309.05±245.38）U/mL,组间差异无统计学意义（P〉0.05）,但均明显高于正常对照组血清CA125水平（7.13±4.50）U/mL,（P〈0.01）。结核性腹膜炎组和恶性腹水组腹水CA125水平分别为（590.17±275.18）U/mL和（732.39±362.56）U/mL,组间差异无统计学意义（P〉0.05）。结核性腹膜炎组血清和腹水CA125水平均增高者达74.6%,抗结核治疗6个月后,结核性腹膜炎组血清CA125水平下降至（8.47±5.28）U/mL,与对照组相比差异无统计学意义（P〉0.05）。结论CA125水平检测对结核性腹膜炎的诊断价值有限,动态观察CA125水平变化可能有助于预后的判断。

Significance of carbohydrate antigen 125 level measurement in tubercular peritonitis

Objective To study the value of carbohydrate antigen 125 （CA125） level measurement in diagnosis and treatment of tubercular peritonitis. Methods Serum CA125 and ascites levels were measured in 35 patients with tubercular peritonitis and 28 patients with electrochemiluminescence method. The results were compared with those measured in non-active pulmonary tuberculosis and control groups. Results The serum CA125 level was 243.29±131.60U/mL and 309.05±245.38U/mL in tubercular peritonitis group and malignant ascites group, respectively, with no statistical difference between the 2 groups （P0.05）. However, the serum CA125 level was significantly higher in both tubercular peritonitis and malignant ascites groups than in control group （7.13±4.50U/mL, P0.01）. The ascites CA125 level was 590.17±275.18U/mL and 732.39±362.56U/mL in tubercular peritonitis group and malignant ascites group, respectively, with no statistical difference between the 2 groups （P0.05）. However, both serum and ascites levels were as high as 74.6% in tuberculosis peritonitis group. Six months after anti-tuberculosis treatment, the serum CA125 level in tubercular peritonitis group was decreased to 8.47±5.28U/L, compared to that in control group （7.13±4.50U/mL, P0.05）. Conclusion The value of CA125 in diagnosis of tubercular peritonitis is limited. However, dynamic observation of changes in CA125 level may help to evaluate the prognosis of patients with tubercular peritonitis.