百色少数民族地区不同人群庚型肝炎病毒感染的研究

应用ＥＬＩＳＡ检测各类人群８２２例血清抗－ＨＧＶ，对５６例抗－ＨＧＶ阳性及１４例抗－ＨＧＶ阴性患者血清应用ＰＴ－ｎＰＣＲ检测ＨＧＶ－ＲＮＡ。结果：ＨＧＶ－Ｍ阳性率肝病组（３７９０％）显著高于肺结核组（１３４０％）和献血员组（７３５％），Ｐ＜００１，三者均显著高于自然人群组（１４０％），Ｐ＜００１；肝病组、肺结核组具有随年龄增长呈递增趋势；自然人群组以２９～３０岁年龄段为高；肝病组男性显著高于女性（Ｐ＜００５），该组男女分别高于其他各组（Ｐ＜００１）；肝病组各临床类型均显著高于自然人群组（Ｐ＜００１）。５６例抗－ＨＧＶ阳性患者ＨＧＶ－ＲＮＡ阳性４５例（８０４％），１４例抗－ＨＧＶ阴性ＨＧＶ－ＲＮＡ阳性５例（３５７％）。认为①本地区存在ＨＧＶ感染，其感染率以肝病组最高，自然人群组以青壮年为高；②ＨＧＶ可与甲～戊肝炎病毒重叠感染；③非甲－戊型肝炎中的ＨＧＶ感染只是一种病因，尚有其他病毒感染；④ＨＧＶ持续感染可能导致肝硬化和肝细胞癌；⑤检测抗－ＨＧＶ对筛查ＨＧＶ感染有一定的价值

Hepatitis G virus infection in Baise city

The serum anti-HGV from 822 individuals were detected by using ELISA, and the serum HGV-RNA from 56 of the positive anti-HGV and 14 of the negative anti-HGV were detected by using PT-nPCR. Results as: the positive rate (37 90%) of HGV-M in hepatitis group was higher than that (13 40%) in the pulmonary tuberculosis group and than that (7 35%) in the blood donor group, P <0 01, moreover, all those in the above three groups were higher than that (1 40%) in the individual group, P <0 01; the crescendo trend of positive rate of HGV-M appeared as the individuals aging in the hepatitis group and in the pulmonary tuberculosis group; and the highest one in the individual group was between 29～30 years old; and in the hepatiris group, male was higher than female( P <0 05), and both were higher than those individuals in other groups, ( P <0 05); all the clinical types in the hepatitis group were higher than those in the individual group ( P <0 01). Of the 56 positive anti-HGV, the positive HGV-RNA was 45 (80 4%). Of the 14 negative anti-HGV, the positive HGV-RNA was 5 (35 7%). It could be concluded that: ① HGV infection occurred in this region, and the highest infected rate appeared in the hepatitis group, the youth and the middle-aged people suffered more in the individual group; ②HGV could be overlappedly infected with hepatitis A-E virus; ③ HGV infection in non-hepatitis A-G virus is a kind of disease resource, and still infected by other virus; ④The continous HGV infection may result in cirrhosis and hepatoma; ⑤The detection of anti-HGV may help to screen HGV infection.