| Pathogenesis of acute lung injury in severe acute pancreatitis |
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| 作者姓名： | 石磊 岳媛 张梅 潘承恩 |
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| 作者单位： | [1]Department of Hepatobiliary Surgery, Xi＇an Jiaotong University First Hospital, Xi＇an 710061, China |
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| 基金项目： | Supported by the National Natural Science Foundation of China（ No. 30371398） |
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| 摘 要： | Objective：To study the pathogenesis of acute lung injury in severe acute pancreatitis （SAP）. Methods：Rats were sacrificed at 1, 3, 5, 6, 9 and 12 h after establishment of inducing model. Pancreas and lung tissues were obtained for pathological study, microvascular permeability and MPO examination. Gene expressions of TNF-α and ICAM-1 in pancreas and lung tissues were detected by RT-PCR. Results： After inducing SAP model, the injury degree of the pancreas and the lung increased gradually, accompanied with gradually increased MPO activity and microvascular permeability. Gene expressions of TNF-α and ICAM-1 in pancreas rose at 1 h and reached peak at 7 h. Relatively, their gene expressions in the lungs only rose slightly at 1 h and reached peak at 9-12 h gradually. Conclusion：There is an obvious time window between SAP and lung injury, when earlier protection is beneficial to prevent development of acute lung injury.
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| 关 键 词： | 病理机制 急性肺损伤 急性胰腺炎 临床表现 |
| 收稿时间： | 2005-03-26 |
| 修稿时间： | 2005-06-26 |
Pathogenesis of acute lung injury in severe acute pancreatitis |
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| Dan Lei;Yue Yuan;Zhang Mei;Pan ChengEn.Pathogenesis of acute lung injury in severe acute pancreatitis[J].Journal of Medical Colleges of PLA(China),2005,20(4):228-231. |
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| Authors: | Dan Lei;Yue Yuan;Zhang Mei;Pan ChengEn |
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| Abstract: | |
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| Keywords: | pathogenesis severe acute pancreatitis acute lung injury |
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