| 鼻咽癌染色体端粒长度变化的研究 |
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| 引用本文： | 肖林,周宏远,严军,刘永惠,宋毅.鼻咽癌染色体端粒长度变化的研究[J].四川大学学报(医学版),1999,30(3):262-264. |
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| 作者姓名： | 肖林 周宏远 严军 刘永惠 宋毅 |
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| 作者单位： | 1. 华西医科大学附属第一医院肿瘤中心,肿瘤研究所,成都,610041
2. 附属第一医院,耳鼻咽候科 |
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| 摘 要： | 为探讨人鼻咽癌染色体端粒行为异常与癌变的关系，应用 Ｓｏｕｔｈｅｒｎ 印迹杂交对 ３０ 例鼻咽癌和３０例与之年龄、性别配对的正常对照进行了分析。结果：鼻咽癌的端粒长度与对照相比显著缩短。在鼻咽癌中，１６１７％ 显示端粒伸长，７６．６７％ 显示端粒缩短，而６．６７％ 显示与对照相同的端粒长度。分析了 ３０ 例正常人外周血淋巴细胞端粒长度的变化，可见染色体端粒的长度随年龄增长而逐渐缩短（ｒ＝ － ０．３９１３， Ｐ＜ ０．０５），并且端粒每年平均缩短 ３９ｂｐ 的核苷酸。结果提示：人鼻咽癌染色体不稳定可能与端粒长度缩短有关。
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| 关 键 词： | 鼻咽癌 端粒长度缩短 端粒酶 染色体不稳定性 |
Changes of Telomere Length in Human Nasopharyngeal Carcinoma |
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| Xiao Lin,Zhou Hongyuan,Yan Jun,Liu Yonghui,Song Yi.Changes of Telomere Length in Human Nasopharyngeal Carcinoma[J].Journal of West China University of Medical Sciences,1999,30(3):262-264. |
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| Authors: | Xiao Lin Zhou Hongyuan Yan Jun Liu Yonghui Song Yi |
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| Abstract: | Using Southern hybridization, we analysed the telomere length from thirty patients with nasopharyngeal carcinoma and demonstrated telomere reduction in these individuals when compared with their age matched controls. Of the 30 samples, 16.67% had telomere elongation, 76.67% had telomere reduction and 6 67% exhibited equal lengths as compared with the controls.Analysis of leukocytes from 30 controls indicated that the telomere length decreased (average 39 base Pairs Per year)with aging and a statistically significant correlation between the length and age was noted ( r=-0.3913,P<0.05) .These results suggest that the consequences of telomere shortening in nasopharyngeal carcinoma may lead to chromosome instability |
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| Keywords: | Nasopharyngeal carcinoma Telomere shortening Telomerease Chromasome instability |
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