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参附益心颗粒对慢性心力衰竭大鼠血清心钠素、脑钠素的影响
引用本文:王永霞,任红杰,朱明军,张群生,李彬.参附益心颗粒对慢性心力衰竭大鼠血清心钠素、脑钠素的影响[J].中国实验方剂学杂志,2011,17(4):118-120.
作者姓名:王永霞  任红杰  朱明军  张群生  李彬
作者单位:1. 河南中医学院第一附属医院心脏中心,郑州,450000
2. 洛阳市中心医院,河南洛阳,471009
基金项目:河南省科技攻关项目,河南省教育厅自然基金,"十一五"国家科技支撑计划
摘    要:目的:观察参附益心颗粒对慢性心力衰竭大鼠的作用。方法:随机将150只雄性SD大鼠分为造模组130只,假手术组20只。造模组结扎左冠状动脉前降支,假手术组手术方法同上,仅在冠状动脉前降支下穿线不结扎。造模8周后,经超声测定大鼠左室射血分数%(left ventricular ejection fraction,LVEF)<50%者随机分为5组(模型组、卡托普利组、氯沙坦组、参附益心颗粒(5.475,21.9 g.kg-1.d-1)2个剂量组),每组10只,另选假手术组大鼠10只。假手术组及模型组以纯净水ig,药物干预组将药物溶于纯净水中ig给药,每天1次,4周后查LVEF、称重,采血检测指标心钠素(atrial natriuretic peptide,ANP)、脑钠素(brain natriuretic peptide,BNP)。结果:21.9 g.kg-1.d-1参附益心颗粒有明显改善LVEF作用、降低左室重量指数(leftventricular mass index,LVMI)、血清ANP值;参附益心颗粒低高2个剂量组均可显著降低血清BNP值。结论:参附益心颗粒具有明显的抗心力衰竭作用,可能具有干预心室重塑的作用。

关 键 词:参附益心颗粒  慢性心力衰竭  心钠素  脑钠素  心室重塑
收稿时间:2010/8/23 0:00:00

Laboratory Observation of Chronic Heart Failure of Shenfu Yixin Granule in Rats
WANG Yong-xi,REN Hong-jie,ZHU Ming-jun,ZHANG Qun-sheng and LI Bin.Laboratory Observation of Chronic Heart Failure of Shenfu Yixin Granule in Rats[J].China Journal of Experimental Traditional Medical Formulae,2011,17(4):118-120.
Authors:WANG Yong-xi  REN Hong-jie  ZHU Ming-jun  ZHANG Qun-sheng and LI Bin
Institution:The First Affiliated Hospital of Henan College of TCM,Zhengzhou 450000,China;The First Affiliated Hospital of Henan College of TCM,Zhengzhou 450000,China;The First Affiliated Hospital of Henan College of TCM,Zhengzhou 450000,China;The Central Hospital of Luoyang,Luoyang 471009,China;The First Affiliated Hospital of Henan College of TCM,Zhengzhou 450000,China
Abstract:Objective: To observe the effect of the Shenfu Yixin Granule on chronic heart failure rats. Method: The chronic heart failure model was established by left anterior descending coronary artery occlusion.in sham operation group (n=20) the sutures were passed under the left anterior descending coronary artery without ligation.After 8 weeks the chronic heart failure rats with the value of left ventricle ejection fraction(LVEF) <50% were randomly assigned to 5 groups (n=10 in each group):model group, captopril group, losartan group, two groups of Shenfu Yixin Granule(5.475,21.9 g ·kg-1 ·d-1).All the medicine was given through gavage once a day for 4 weeks, the rats in model group and sham operation group were administered with equivalent water once a day for 4 weeks.After 4 weeks The LVEF was valued again with Color Doppler Ultrasound, Weighs were measured.The blood was collected to detection index. Result: Shenfu Yixin granule(21.9 g ·kg-1 ·d-1) improved the LVEF obviously,lowered the left ventricular mass index(LVMI) serum ANP and, serum BNP. Conclusion: Shenfu Yixin granule can cure chronic heart failure evidently and may intervene ventricular remodeling.
Keywords:Shenfu Yixin Granule  chronic heart failure  atrial natriuretie peptide  brain natriuretic peptide  myocardial remodeling
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