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| 牛白藤的化学成分及其免疫抑制活性研究 | |
| 引用本文： | 张甜甜,高莎莎,侯俊杰,周永芹,周杰文,王小刚,秦楠,陈家春,段宏泉,方进波.牛白藤的化学成分及其免疫抑制活性研究[J].中国中药杂志,2015,40(12):2357-2362. |
| 作者姓名： | 张甜甜 高莎莎 侯俊杰 周永芹 周杰文 王小刚 秦楠 陈家春 段宏泉 方进波 |
| 作者单位： | 1. 华中科技大学同济医学院药学院,天然药物化学与资源评价湖北省重点实验室,湖北武汉430030 2. 湖北省食品药品监督检验研究院,湖北武汉,430064 3. 华中科技大学同济医学院基础医学院,湖北武汉,430030 4. 天津医科大学药学院,基础医学研究中心,天津300070 |
| 摘 要： | 研究茜草科耳草属植物牛白藤Hedyotis hedyotidea(DC.) Merr.干燥藤茎的化学成分及免疫抑制活性,为进一步开发利用牛白藤提供依据.以硅胶、凝胶柱色谱、制备高效液相色谱进行分离纯化,并应用MS和NMR技术分析鉴定化合物结构,分离得到11个化合物吐叶醇(6S,9S-vomifoliol,1),桦木酮酸(betulonic acid,2),白桦脂酸(betulinic acid,3),白桦醇(betulin,4),表白桦脂酸(3-epi-betulinic acid,5),乌苏酸(ursolic acid,6),β-谷甾醇(β-sitosterol,7),stigmast-4-en-3-one (8),7β-hydroxysitosterol(9),(3β,7β)-7-methoxystigmast-5-en-3-ol(10)和巴戟醚萜(morindacin,11).化合物1,2,4,8～ 11均首次从该植物中分得,化合物1,2,8 ～ 11均首次从耳草属植物中分得,化合物9,10均首次从茜草科植物中分得.通过体外淋巴细胞转化实验测试化学成分的免疫抑制活性,化合物4,6,9均有较强的免疫抑制活性. |
| 关 键 词： | 牛白藤 (6S 9S)-vomifoliol 环烯醚萜 三萜 甾体 免疫抑制活性 |
| 收稿时间： | 2015/1/13 0:00:00 |
Chemical constituents from stems of Hedyotis hedyotidea and their immunosuppressive activity |
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| ZHANG Tian-tian,GAO Sha-sh,HOU Jun-jie,ZHOU Yong-qin,ZHOU Jie-wen,WANG Xiao-gang,QIN Nan,CHEN Jia-chun,DUAN Hong-quan and FANG Jin-bo.Chemical constituents from stems of Hedyotis hedyotidea and their immunosuppressive activity[J].China Journal of Chinese Materia Medica,2015,40(12):2357-2362. | |
| Authors: | ZHANG Tian-tian GAO Sha-sh HOU Jun-jie ZHOU Yong-qin ZHOU Jie-wen WANG Xiao-gang QIN Nan CHEN Jia-chun DUAN Hong-quan and FANG Jin-bo |
| Institution: | School of Pharmacy, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China,School of Pharmacy, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China,Hubei Institute for Food and Drug Control, Wuhan 430064, China,School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China,School of Pharmacy, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China,School of Pharmacy, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China,School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China,School of Pharmacy, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China,School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China and School of Pharmacy, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China |
| Abstract: | |
| Keywords: | Hedyotis hedyotidea (6S 9S)-vomifoliol iridoids triterpenes sterols immunosuppressive activity |